JPS54135792A - Manufacture of cephalosporin compound - Google Patents
Manufacture of cephalosporin compoundInfo
- Publication number
- JPS54135792A JPS54135792A JP2128779A JP2128779A JPS54135792A JP S54135792 A JPS54135792 A JP S54135792A JP 2128779 A JP2128779 A JP 2128779A JP 2128779 A JP2128779 A JP 2128779A JP S54135792 A JPS54135792 A JP S54135792A
- Authority
- JP
- Japan
- Prior art keywords
- manufacture
- cephalosporin compound
- cephalosporin
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1508271A GB1399086A (en) | 1971-05-14 | 1971-05-14 | Cephalosporin compounds |
GB4588471 | 1971-10-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54135792A true JPS54135792A (en) | 1979-10-22 |
Family
ID=26251025
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4714872A Pending JPS531280B1 (en) | 1971-05-14 | 1972-05-12 | |
JP7426977A Granted JPS5328141A (en) | 1971-05-14 | 1977-06-22 | Production of novel carboxylic acid |
JP2128779A Pending JPS54135792A (en) | 1971-05-14 | 1979-02-24 | Manufacture of cephalosporin compound |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4714872A Pending JPS531280B1 (en) | 1971-05-14 | 1972-05-12 | |
JP7426977A Granted JPS5328141A (en) | 1971-05-14 | 1977-06-22 | Production of novel carboxylic acid |
Country Status (22)
Country | Link |
---|---|
JP (3) | JPS531280B1 (en) |
AT (1) | AT336786B (en) |
BE (1) | BE783449A (en) |
CA (1) | CA1027554A (en) |
CH (1) | CH591497A5 (en) |
CS (2) | CS245753B2 (en) |
CY (1) | CY971A (en) |
DE (2) | DE2265234C2 (en) |
DK (1) | DK155187C (en) |
ES (2) | ES402651A1 (en) |
FR (2) | FR2137900B1 (en) |
GB (1) | GB1399086A (en) |
HK (1) | HK66078A (en) |
IE (1) | IE38172B1 (en) |
IL (1) | IL39429A (en) |
KE (1) | KE2895A (en) |
MY (1) | MY7800466A (en) |
NL (1) | NL166688C (en) |
NO (1) | NO154797C (en) |
PH (1) | PH11205A (en) |
SE (1) | SE457795B (en) |
YU (2) | YU41807B (en) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4033950A (en) * | 1971-05-14 | 1977-07-05 | Glaxo Laboratories Limited | 3-Hydroxymethyl-7β-(2-alkoxy-or benzyloxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
US4079178A (en) * | 1971-05-14 | 1978-03-14 | Glaxo Laboratories Limited | Cephalosporins having (α-etherified oximino) acylamido groups at the 7-position |
GB1445979A (en) * | 1972-10-25 | 1976-08-11 | Glaxo Lab Ltd | Cephalosporin derivatives |
US4138555A (en) | 1971-05-14 | 1979-02-06 | Glaxo Laboratories, Limited | (6R,7R)-7-[2-aryl-2-(etherified oximino)acetamido]-3-carbamoyloxymethylceph-3-em-4-carboxylic acid 1-oxides |
US4064346A (en) * | 1971-05-14 | 1977-12-20 | Glaxo Laboratories Limited | 3-Acetoxymethyl-7β-(2-carboxy-methoxyimino-2-arylacetamido)ceph-3-em-4-carboxylic acids and salts thereof |
AR208283A1 (en) * | 1973-03-15 | 1976-12-20 | Fujisawa Pharmaceutical Co | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 2-ALKYL-2-O 3-FEFEM-4-CARBOXYL ACID |
HU172234B (en) * | 1973-12-21 | 1978-07-28 | Glaxo Lab Ltd | Process for producing new derivatives of 7-beta-acylamido-ceph-3-eme-4-carboxylic acid |
US4095021A (en) | 1973-12-21 | 1978-06-13 | Glaxo Laboratories Limited | 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof |
US4144392A (en) | 1973-12-21 | 1979-03-13 | Glaxo Laboratories Limited | Cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyimino-arylacetamido group and at position-3 the residue of a sulphur nucleophile |
GB1512957A (en) * | 1974-08-23 | 1978-06-01 | Glaxo Lab Ltd | Gephalosporin antibiotics |
DK154939C (en) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF |
US4200746A (en) | 1974-12-20 | 1980-04-29 | Glaxo Laboratories, Ltd. | Cephalosporins |
GB1522140A (en) * | 1974-12-20 | 1978-08-23 | Glaxo Lab Ltd | Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them |
PH15487A (en) * | 1975-02-04 | 1983-01-31 | Fujisawa Pharmaceutical Co | 7((2-hydroxyamino-2-disubstituted phenyl-acetamido)-)3-heterocyclithio-3-cephem-4-carboxylic acids |
GB1555471A (en) * | 1975-06-19 | 1979-11-14 | Glaxo Lab Ltd | 7 carbamoylalkoxyimino acetamido 3 em 4 carboxylic acidsand derivatives thereof |
SE440655B (en) * | 1976-01-23 | 1985-08-12 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID |
DE2760123C2 (en) | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them |
IE44888B1 (en) * | 1976-03-09 | 1982-05-05 | Fujisawa Pharmaceutical Co | 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation theroef |
GB1575803A (en) | 1976-03-09 | 1980-10-01 | Fujisawa Pharmaceutical Co | 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof |
US4165430A (en) | 1976-03-19 | 1979-08-21 | Glaxo Laboratories Limited | Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group |
FR2345153A1 (en) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
DK162391C (en) * | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS |
DE2715385A1 (en) * | 1976-04-14 | 1977-11-10 | Takeda Chemical Industries Ltd | CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
US4066762A (en) * | 1976-07-12 | 1978-01-03 | Smithkline Corporation | Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid |
US4278670A (en) * | 1976-07-12 | 1981-07-14 | Smithkline Corporation | 7-Alpha-oxyiminoacylcephalosporins |
FR2361895A1 (en) * | 1976-08-20 | 1978-03-17 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CARBAMOYLOXYMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
GB1592149A (en) * | 1976-10-08 | 1981-07-01 | Fujisawa Pharmaceutical Co | 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof |
FR2381053A1 (en) * | 1977-02-18 | 1978-09-15 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
JPS53103493A (en) * | 1977-02-18 | 1978-09-08 | Takeda Chem Ind Ltd | Cephalosporin derivatives and process for their preparation |
PH17188A (en) | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
FR2384779A1 (en) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | NEW OXIMES DERIVED FROM 3-CHLORO OR 3-METHOXY 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
SE439312B (en) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID |
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
DE2716677C2 (en) | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephem derivatives and processes for their preparation |
NL7805715A (en) * | 1977-06-03 | 1978-12-05 | Hoffmann La Roche | METHOD FOR PREPARING ACYL DERIVATIVES. |
IT1192287B (en) * | 1977-11-14 | 1988-03-31 | Fujisawa Pharmaceutical Co | PHARMACEUTICAL ACTION DERIVATIVES OF CEPHALOSPORANIC ACID AND RELATED PREPARATION PROCEDURE |
FR2438051A2 (en) * | 1978-10-05 | 1980-04-30 | Roussel Uclaf | 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79) |
SE445350B (en) * | 1978-04-14 | 1986-06-16 | Roussel Uclaf | OXIMO DERIVATIVES OF 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID AND ITS USE AS ANTIBIOTICS |
DE2822860A1 (en) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | CEPHEM DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
AR229883A1 (en) | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC (6R, 7R) -7 - ((Z) -2- (2-AMINOTIAZOL-4-IL) -2- (2-CARBOXIPROP-2-OXIIMINO) -ACETAMIDO) -3- (1 -PIRIDINOMETIL) -CEF-3-EM-4-CARBOXYLATE |
DE2822861A1 (en) * | 1978-05-26 | 1979-11-29 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
US4268509A (en) * | 1978-07-10 | 1981-05-19 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds and processes for preparation thereof |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
ES485938A1 (en) * | 1978-11-15 | 1980-07-01 | Glaxo Group Ltd | Cephalosporin antibiotics |
DE2914327A1 (en) * | 1979-04-09 | 1980-10-30 | Hoechst Ag | CEPHEM DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
EP0088454B1 (en) * | 1979-09-03 | 1986-03-05 | Fujisawa Pharmaceutical Co., Ltd. | New starting compounds for preparing cephem compounds and processes for their preparation |
US4341777A (en) * | 1979-09-10 | 1982-07-27 | Glaxo Group Limited | Cephalosporin antibiotic |
EP0027599B1 (en) * | 1979-10-12 | 1984-10-03 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
EP0104671B1 (en) * | 1980-02-18 | 1990-05-23 | Roussel-Uclaf | Oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-amino-thiazolylacetamido-cephalosporanic acid, their preparation, their use as medicines and compositions containing them |
FR2476087A1 (en) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | NOVEL OXIMES DERIVED FROM 3-ALKYLOXY OR 3-ALKYL-THIOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS |
EP0037797A3 (en) * | 1980-03-11 | 1981-12-16 | Ciba-Geigy Ag | Cephalosporin derivatives, process for their preparation, pharmaceutical compositions containing them and their application |
ZA813787B (en) * | 1980-06-18 | 1982-07-28 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
GR75644B (en) * | 1980-06-18 | 1984-08-02 | Fujisawa Pharmaceutical Co | |
IL63207A (en) * | 1980-07-24 | 1985-09-29 | Lonza Ag | Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters |
US4443444A (en) * | 1980-08-11 | 1984-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
EP0156118A1 (en) * | 1980-08-29 | 1985-10-02 | Fujisawa Pharmaceutical Co., Ltd. | New starting compounds for the preparation of cephem compounds and processes for preparation thereof |
US4416879A (en) * | 1980-09-08 | 1983-11-22 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
IL63965A (en) * | 1980-10-10 | 1985-01-31 | Sparamedica Ag | 7-(2-(2-amino-4-selenazoyl)acetamido)cephalosporin derivatives,and intermediates therefor,their preparation and pharmaceutical compositions containing them |
FR2494274A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW THIOVINYL-3 CEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM |
FR2494279A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW OXACEPHALOSPORINS, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
FR2494280A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR PREPARATION |
FR2494276A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW VINYL-3 CEPHALOSPORINS, AND THEIR PREPARATION |
FR2494275A2 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF VINYL-3 CEPHALOSPORINS AND THEIR PREPARATION |
GR76342B (en) * | 1981-02-02 | 1984-08-06 | Fujisawa Pharmaceutical Co | |
FR2499995A1 (en) * | 1981-02-13 | 1982-08-20 | Roussel Uclaf | 7-2-2-Amino-4-thiazolyl 2-hydroxy:imino-acetamido 3-cephem derivs. - 3-substd. by alkoxy- or alkyl-thio-methyl are antibiotics active against gram positive and gram negative bacteria |
JPS6011917B2 (en) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | Novel cephalosporin compounds |
FR2505338A1 (en) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps. |
FR2505339A1 (en) * | 1981-05-11 | 1982-11-12 | Rhone Poulenc Sante | 3-Substd. thio-vinyl 1-oxa-ceph-3-em-4-carboxylic acid antibacterials - esp. having 7-2-2-amino-4-thiazolyl-2-methoxy:imino-acetamido Gp., 3-thio substits. include thiadiazolyl and triazinyl Gps. |
EP0070803A3 (en) * | 1981-07-16 | 1984-05-02 | Ciba-Geigy Ag | Antibiotically active aminotriazolylcephalosporin derivatives and their preparation |
GR76701B (en) * | 1981-09-08 | 1984-08-29 | Lilly Co Eli | |
US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
JPS5859992A (en) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | Novel cephen compound, its preparation and preventing agent and remedy for microbism |
MA19602A1 (en) * | 1981-09-30 | 1983-04-01 | Ciba Geigy Ag | AMINO-OXAZOLYL COMPOUNDS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR APPLICATION |
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US4394503A (en) | 1981-12-07 | 1983-07-19 | Bristol-Myers Company | Cephalosporin derivatives |
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US4457929A (en) * | 1982-03-29 | 1984-07-03 | Bristol-Myers Company | 3-Quaternary ammonium methyl)-substituted cephalosporin derivatives |
PH19163A (en) * | 1982-04-06 | 1986-01-16 | Daiichi Seiyaku Co | Cephalosporin derivatives |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
JPS5910593A (en) | 1982-06-28 | 1984-01-20 | Bristol Mayers Kenkyusho Kk | Cephalosporin derivative |
GB2125033B (en) * | 1982-07-23 | 1985-08-29 | Servipharm Ltd | Cephalosporins |
IE55406B1 (en) * | 1982-08-07 | 1990-09-12 | Tanabe Seiyaku Co | Novel cephalosporin compounds and preparation thereof |
US4546101A (en) * | 1982-09-10 | 1985-10-08 | Fujisawa Pharmaceutical Co., Ltd. | New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof |
FR2533216A1 (en) * | 1982-09-22 | 1984-03-23 | Toyama Chemical Co Ltd | New cephalosporins and their salts. |
JPS5973043A (en) * | 1982-10-19 | 1984-04-25 | House Food Ind Co Ltd | Method for modifying quality of hardly soluble gelling agent |
US4486586A (en) * | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
US4525473A (en) * | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
US4492694A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Indolylglycyl cephalosporin derivatives |
US4492693A (en) * | 1983-04-12 | 1985-01-08 | Eli Lilly And Company | Benzothienylglycyl cephalosporin derivatives |
AU2673884A (en) * | 1983-04-12 | 1984-10-18 | Eli Lilly And Company | Naphthylglycyl cephalosporin derivatives |
US4482553A (en) * | 1983-04-12 | 1984-11-13 | Eli Lilly And Company | Benzothienylglycyl cephalosporin derivatives |
DE3330605A1 (en) * | 1983-08-25 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | CEPHALOSPORINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
JPS60190783A (en) * | 1983-12-21 | 1985-09-28 | Sumitomo Seiyaku Kk | Cephem compound |
JPS60132983A (en) * | 1983-12-21 | 1985-07-16 | Tanabe Seiyaku Co Ltd | Thiazoleacetic acid derivative and its production |
JPS60142987A (en) * | 1983-12-29 | 1985-07-29 | Mochida Pharmaceut Co Ltd | Cephalosporin derivative |
DE3485860T2 (en) * | 1983-12-29 | 1993-01-14 | Mochida Pharm Co Ltd | CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS. |
GB8411954D0 (en) * | 1984-05-10 | 1984-06-13 | Glaxo Group Ltd | Cephalosporin antibiotics |
FI851934L (en) * | 1984-05-30 | 1985-12-01 | Ici Plc | KEFALOSPORINDERIVAT. |
IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
EP0182633A3 (en) * | 1984-11-20 | 1987-09-02 | Ici Pharma | Cephalosporin derivatives |
JPS61145186A (en) * | 1984-12-20 | 1986-07-02 | Meiji Seika Kaisha Ltd | Novel cephem compound and preparation thereof |
EP0452987B1 (en) * | 1984-12-27 | 1995-03-01 | Banyu Pharmaceutical Co., Ltd. | Isoindoline derivatives |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
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US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
US4814328A (en) * | 1986-03-19 | 1989-03-21 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives, and antibacterial agents |
DE3623921A1 (en) * | 1986-07-16 | 1988-01-21 | Basf Ag | OXIMETHER AND FUNGICIDES CONTAINING THEM |
ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
JPS63132893A (en) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | Novel cephalosporin derivative, production thereof and antibacterial agent containing said derivative as active ingredient |
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EP0272827A3 (en) * | 1986-12-23 | 1990-02-07 | ZENECA Pharma S.A. | 3-heterocyclicthiomethyl cephalosphorins |
US5189157A (en) * | 1987-06-16 | 1993-02-23 | Hoffmann La Roche Inc. | Antibacterial cephalosporin compounds |
DE3854684T2 (en) * | 1987-07-23 | 1996-03-28 | Zeneca Pharma Sa | Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them. |
ATE131824T1 (en) * | 1987-07-23 | 1996-01-15 | Zeneca Pharma Sa | CEPHALOSPORIN COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME |
KR900006811B1 (en) * | 1988-05-11 | 1990-09-21 | 주식회사 럭 키 | Cephalosphorin derivatives and its process |
US5202315A (en) * | 1989-05-11 | 1993-04-13 | Lucky, Ltd. | Cephalosporin compounds |
GB8927871D0 (en) * | 1989-12-08 | 1990-02-14 | Beecham Group Plc | Novel compounds |
IN189046B (en) | 1998-03-30 | 2002-12-14 | Ranbaxy Lab Ltd | |
AU2820700A (en) * | 1999-03-09 | 2000-09-28 | Ranbaxy Laboratories Limited | Process for the preparation of cefuroxime |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE311519B (en) * | 1962-12-14 | 1969-06-16 | Astra Ab | |
GB1208014A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
GB1208015A (en) * | 1967-03-23 | 1970-10-07 | Glaxo Lab Ltd | Cephalosporins |
GB1241657A (en) * | 1967-08-21 | 1971-08-04 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin compounds |
GB1279402A (en) * | 1968-06-14 | 1972-06-28 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
DK143853C (en) * | 1971-01-29 | 1982-04-05 | Glaxo Lab Ltd | METHOD OF ANALOGY FOR THE PREPARATION OF CEPHALOSPORINE COMPOUNDS OR UNTOXIC SALTS OR HYDRATES THEREOF |
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
-
1971
- 1971-05-14 GB GB1508271A patent/GB1399086A/en not_active Expired
-
1972
- 1972-05-12 CS CS723209A patent/CS245753B2/en unknown
- 1972-05-12 JP JP4714872A patent/JPS531280B1/ja active Pending
- 1972-05-12 IL IL39429A patent/IL39429A/en unknown
- 1972-05-12 DE DE2265234A patent/DE2265234C2/en not_active Expired
- 1972-05-12 CH CH705972A patent/CH591497A5/xx not_active IP Right Cessation
- 1972-05-12 DK DK237372A patent/DK155187C/en active
- 1972-05-12 CA CA141,965A patent/CA1027554A/en not_active Expired
- 1972-05-12 IE IE644/72A patent/IE38172B1/en unknown
- 1972-05-12 NL NLAANVRAGE7206403,A patent/NL166688C/en not_active IP Right Cessation
- 1972-05-12 SE SE7206296A patent/SE457795B/en unknown
- 1972-05-12 YU YU1267/72A patent/YU41807B/en unknown
- 1972-05-12 CS CS72839A patent/CS245754B2/en unknown
- 1972-05-12 CY CY971A patent/CY971A/en unknown
- 1972-05-12 DE DE2223375A patent/DE2223375C2/en not_active Expired
- 1972-05-12 BE BE783449A patent/BE783449A/en not_active IP Right Cessation
- 1972-05-12 ES ES402651A patent/ES402651A1/en not_active Expired
- 1972-05-12 NO NO721705A patent/NO154797C/en unknown
- 1972-05-15 FR FR7217284A patent/FR2137900B1/fr not_active Expired
- 1972-05-15 FR FR7217283A patent/FR2137899B1/fr not_active Expired
- 1972-05-15 AT AT420872A patent/AT336786B/en not_active IP Right Cessation
-
1974
- 1974-08-23 PH PH16206A patent/PH11205A/en unknown
- 1974-09-16 ES ES430104A patent/ES430104A1/en not_active Expired
-
1977
- 1977-06-22 JP JP7426977A patent/JPS5328141A/en active Granted
-
1978
- 1978-10-19 KE KE2895A patent/KE2895A/en unknown
- 1978-11-16 HK HK660/78A patent/HK66078A/en unknown
- 1978-12-30 MY MY466/78A patent/MY7800466A/en unknown
-
1979
- 1979-02-24 JP JP2128779A patent/JPS54135792A/en active Pending
- 1979-12-28 YU YU03213/79A patent/YU321379A/en unknown
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