DE3854684T2 - Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them. - Google Patents

Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them.

Info

Publication number
DE3854684T2
DE3854684T2 DE3854684T DE3854684T DE3854684T2 DE 3854684 T2 DE3854684 T2 DE 3854684T2 DE 3854684 T DE3854684 T DE 3854684T DE 3854684 T DE3854684 T DE 3854684T DE 3854684 T2 DE3854684 T2 DE 3854684T2
Authority
DE
Germany
Prior art keywords
processes
preparation
pharmaceutical preparations
substituted
preparations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3854684T
Other languages
German (de)
Other versions
DE3854684D1 (en
Inventor
Jean Claude Arnould
Thomas Geoffrey Colerick Bird
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Original Assignee
Zeneca Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Pharma SA filed Critical Zeneca Pharma SA
Application granted granted Critical
Publication of DE3854684D1 publication Critical patent/DE3854684D1/en
Publication of DE3854684T2 publication Critical patent/DE3854684T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporins having a 3-position substituent of the formula: <CHEM> are described, wherein R<5> is hydrogen, alkenyl, alkyl or substituted alkyl, Q is a mono- or bicyclic heterocyclic ring, variously substituted, Y is variously substituted alkylene, Y min represents various linking groups, m and n are independently zero or one, and P is a benzene ring with two ortho groups, one of which is hydroxy or an in-vivo hydrolysable ester thereof and the other is hydroxy, an in vivo hydrolysable ester thereof, carboxy, sulpho, hydroxymethyl, NHSO2CH3 or -NHCONH2; or P is a particularly substituted pyridone or pyranone. The use of such compounds as antibacterial agents is described, as are processes for their preparation.
DE3854684T 1987-07-23 1988-07-12 Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them. Expired - Fee Related DE3854684T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401720 1987-07-23

Publications (2)

Publication Number Publication Date
DE3854684D1 DE3854684D1 (en) 1995-12-21
DE3854684T2 true DE3854684T2 (en) 1996-03-28

Family

ID=8198239

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3854684T Expired - Fee Related DE3854684T2 (en) 1987-07-23 1988-07-12 Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them.

Country Status (5)

Country Link
US (1) US5013730A (en)
EP (1) EP0304155B1 (en)
JP (1) JPS6440488A (en)
AT (1) ATE130299T1 (en)
DE (1) DE3854684T2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149803A (en) * 1988-05-10 1992-09-22 Imperial Chemical Industries Plc Intermediates for cephalosporin compounds
GB8811056D0 (en) * 1988-05-10 1988-06-15 Ici Plc Antibiotic compounds
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5491139A (en) * 1988-10-24 1996-02-13 The Procter & Gamble Company Antimicrobial quinolonyl lactams
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US5180719A (en) * 1988-10-24 1993-01-19 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl lactam esters
US5273973A (en) * 1988-10-24 1993-12-28 Norwich Eaton Pharmaceuticals, Inc. Antimicrobial quinolonyl esters
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER &amp; GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
ATE193890T1 (en) * 1990-04-18 2000-06-15 Procter & Gamble Pharma ANTIMICROBIAL QUINOLONYL LACTAMES
EP0544166A3 (en) * 1991-11-26 1993-11-03 Hoffmann La Roche Cephalosporinderivatives
EP1359918A1 (en) * 2000-12-29 2003-11-12 Alteon, Inc. Method for treating glaucoma iiib
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
DE3581891D1 (en) * 1984-11-12 1991-04-04 Banyu Pharma Co Ltd CEPHALOSPORINE DERIVATIVES.
EP0182633A3 (en) * 1984-11-20 1987-09-02 Ici Pharma Cephalosporin derivatives
ES8704943A1 (en) * 1984-12-27 1987-04-16 Banyu Pharma Co Ltd Cephalosporin derivatives.
DE3775798D1 (en) * 1986-03-19 1992-02-20 Banyu Pharma Co Ltd CEPHALOSPORINE COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS.
ATE110386T1 (en) * 1986-04-14 1994-09-15 Banyu Pharma Co Ltd CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND ANTIBACTERIAL PREPARATIONS.
EP0272827A3 (en) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-heterocyclicthiomethyl cephalosphorins

Also Published As

Publication number Publication date
EP0304155A2 (en) 1989-02-22
JPS6440488A (en) 1989-02-10
EP0304155A3 (en) 1990-10-31
DE3854684D1 (en) 1995-12-21
ATE130299T1 (en) 1995-12-15
EP0304155B1 (en) 1995-11-15
US5013730A (en) 1991-05-07

Similar Documents

Publication Publication Date Title
DE3850321T2 (en) Cephalosporins, processes for their preparation and pharmaceutical preparations containing them.
DE3854684T2 (en) Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them.
DE69032681T2 (en) Cephalosporins and their homologues, processes for their preparation and pharmaceutical preparations
DE3788306D1 (en) Cephalosporin derivatives, processes for their preparation and corresponding pharmaceutical preparations.
EP0267733A3 (en) Cephalosporin compounds, process for their preparation and pharmaceutical compositions containing them
DE68919273T2 (en) Cephalosporins, processes for their preparation and pharmaceutical preparations.
DE69027718D1 (en) Cephalosporins, processes for their preparation, pharmaceutical preparations containing them and their intermediates
AU554959B2 (en) Triazolo(4,3-a) quinazolin-5-ones
DE68920474D1 (en) Cephalosporins, processes for their preparation and pharmaceutical preparations.
DE3750673D1 (en) Cephalosporins, processes for their preparation and pharmaceutical preparations.
ATE9584T1 (en) BETA-LACTAM ANTIBACTERIAL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE33392T1 (en) CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND ANTIBIOTIC MEDICATIONS CONTAINING THEM.
DE68919433D1 (en) Cephalosporins, processes for their preparation, intermediates and pharmaceutical preparations.
DE3854804T2 (en) Cephalosporin compounds, processes for their preparation and pharmaceutical preparations containing them
DE3171431D1 (en) Derivatives of 7-beta-(ketoximinoacylamido)-ceph-3-em-4-carboxylic acids, process for their preparation and their pharmaceutical compositions containing them
FI911616A0 (en) SUBSTITUTES 3-TIA-ELLER 3-OXA-ALKYL-FLAVONER, FOER FARAND FOR DERASE FRAMSTAELLNING, DERAS ANVAENDNING, PAO DESSA FOERENINGAR BASERADE FOR CEILINGS SAMT MELLANPRODUKTER.
EP0300664A3 (en) Cephalosporin compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee