FR2438051A2 - 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79) - Google Patents

3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)

Info

Publication number
FR2438051A2
FR2438051A2 FR7828465A FR7828465A FR2438051A2 FR 2438051 A2 FR2438051 A2 FR 2438051A2 FR 7828465 A FR7828465 A FR 7828465A FR 7828465 A FR7828465 A FR 7828465A FR 2438051 A2 FR2438051 A2 FR 2438051A2
Authority
FR
France
Prior art keywords
disinfectants
carboxylic acid
cephem
azido
broad
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7828465A
Other languages
French (fr)
Other versions
FR2438051B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7828465A priority Critical patent/FR2438051A2/en
Priority to SE7902286A priority patent/SE445350B/en
Priority to OA56774A priority patent/OA06223A/en
Priority to GR58820A priority patent/GR73581B/el
Priority to US06/028,372 priority patent/US4420478A/en
Priority to NO791218A priority patent/NO791218L/en
Priority to ES479552A priority patent/ES479552A1/en
Priority to DK150879A priority patent/DK150879A/en
Priority to FI791183A priority patent/FI791183A/en
Priority to CS792474A priority patent/CS213385B2/en
Priority to IL57064A priority patent/IL57064A0/en
Priority to DE19792914827 priority patent/DE2914827A1/en
Priority to AU46052/79A priority patent/AU4605279A/en
Priority to NL7902922A priority patent/NL7902922A/en
Priority to CH355879A priority patent/CH640858A5/en
Priority to PT69490A priority patent/PT69490A/en
Priority to AT0276479A priority patent/AT365198B/en
Priority to IT48726/79A priority patent/IT1164673B/en
Priority to LU81156A priority patent/LU81156A1/en
Priority to PL21488079A priority patent/PL214880A1/xx
Priority to DD79212244A priority patent/DD143260A5/en
Priority to GB7913258A priority patent/GB2018758B/en
Priority to ES484224A priority patent/ES484224A1/en
Publication of FR2438051A2 publication Critical patent/FR2438051A2/en
Application granted granted Critical
Publication of FR2438051B2 publication Critical patent/FR2438051B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Abstract

3-Azidomethyl-7- 2-(2-amino-4-thiazolyl)-2-oximino-acetamido -3-c- ephem-4-carboxylic acid derivs. (syn isomers) of formula (I) and their acid-addn. salts are claimed: (where R is H, opt. unsatd. 1-4C alkyl, (CH2)nR1 or benzoly; R1 is COOA' or NH2; n = 1-4; A and A' are H, an equiv. of an alkali(ne earth) metal, Mg, NH4 or organic ammonium cation, or a readily cleavable ester residue). Also claimed are new intermediates for the prepn. of (I). (I) are active against Gram-positive and -negative Lacteria, e.g. with MIC values of =0.5 mu g/ml against Staph. aureus, E. coli, K. pneumoniae, Proteus mirabilis and Salm. typhimurium, including antibiotic-resistant strains of these spp. They can be used as antibacterial medicaments and disinfectants.
FR7828465A 1978-04-14 1978-10-05 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79) Granted FR2438051A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR7828465A FR2438051A2 (en) 1978-10-05 1978-10-05 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)
SE7902286A SE445350B (en) 1978-04-14 1979-03-14 OXIMO DERIVATIVES OF 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID AND ITS USE AS ANTIBIOTICS
OA56774A OA06223A (en) 1978-04-14 1979-03-31 Process for the preparation of novel oximes derived from 3-azidomethyl 7-amino thiazolyl acetamido cephalosporanic acid.
GR58820A GR73581B (en) 1978-04-14 1979-04-06
US06/028,372 US4420478A (en) 1978-04-14 1979-04-09 Novel oximes
NO791218A NO791218L (en) 1978-04-14 1979-04-10 PROCEDURES FOR THE PREPARATION OF NEW OXIMERS OF 3-AZIDOMETHYL-7-AMINOTHIAZOLYLACETAMIDO-CEPHALOSPORANIC ACID
DK150879A DK150879A (en) 1978-04-14 1979-04-11 PROCEDURE FOR THE PREPARATION OF OXIMI DERIVATIVES OF 3-AZIDOMETHYL-7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
FI791183A FI791183A (en) 1978-04-14 1979-04-11 FOERFARANDE FOER FRAMSTAELLNING AV NYA OXIMER HAERLEDDA FRAON 3-AZIDOMETHYL-7-AMINO-THIAZOLYL-ACETAMIDOCEPHALOSPORANSYRA
CS792474A CS213385B2 (en) 1978-04-14 1979-04-11 Method of making the new oxime derivatives of the 3-azidomethyl-7-aminothiazolylacetamidocephalospooran acid
IL57064A IL57064A0 (en) 1978-04-14 1979-04-11 New oxime derivatives of'3-azidomethyl 7-amino thiazolyl acetamido cephalosporanic acid their process of preparationand pharamceutical compositions containing them
DE19792914827 DE2914827A1 (en) 1978-04-14 1979-04-11 OXIME DERIVATIVES OF 3-AZIDOMETHYL-7-AMINOTHIAZOLYLACETAMIDO-CEPHALOSPORANIC ACID, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS
ES479552A ES479552A1 (en) 1978-04-14 1979-04-11 Novel oximes
AU46052/79A AU4605279A (en) 1978-04-14 1979-04-12 Oxime derivatives of 3-azidomethyl 7-amino thiazolyl acetamido cephalosporanic acid, their process of preparation and pharmaceutical compositions containing them
CH355879A CH640858A5 (en) 1978-04-14 1979-04-12 OXIMES DERIVED FROM 3-AZIDOMETHYL ACID 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIQUE, THEIR PREPARATION METHODS AND THE MEDICINAL PRODUCTS CONTAINING THEM.
PT69490A PT69490A (en) 1978-04-14 1979-04-12 PROCESS FOR THE PREPARATION OF NOVEL OXIMES DERIVED FROM 3-AZIDOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID
AT0276479A AT365198B (en) 1978-04-14 1979-04-12 METHOD FOR PRODUCING NEW OXIME DERIVED FROM 3-AZIDOMETHYL-7-AMINOTHIAZOLYLACETAMIDOCEPHALOSPORANIC ACID
NL7902922A NL7902922A (en) 1978-04-14 1979-04-12 NEW OXIM COMPOUNDS OF 3-AZIDOMETHYL-7-AMINOTHIA-ZOLYL-ACEETAMIDOCEPHALOSPORANIC ACID, METHOD FOR THEIR PREPARATION, THEIR USE AS MEDICINAL PRODUCTS AND PHARMA-CEUTIC COMPOUNDS CONTAINING THESE COMPOUNDS.
LU81156A LU81156A1 (en) 1978-04-14 1979-04-13 NEW OXIMES DERIVED FROM 3-AZIDOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICINAL PRODUCTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT48726/79A IT1164673B (en) 1978-04-14 1979-04-13 NEW OXYMS DERIVED FROM THE ACID 3-AZIDOMETHY 7-AMINO THIAZOLYL ACETAMIDE CEPHALOSPORANIC, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PL21488079A PL214880A1 (en) 1978-04-14 1979-04-13
DD79212244A DD143260A5 (en) 1978-04-14 1979-04-16 PROCESS FOR THE PREPARATION OF ZEPHALOSPHORIN DERIVATIVES
GB7913258A GB2018758B (en) 1978-04-14 1979-04-17 Oxime derivatives of 3-azidomethyl-7-aminothiazolyl-acetamido-cephalosporanic acid
ES484224A ES484224A1 (en) 1978-04-14 1979-09-17 Novel oximes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7828465A FR2438051A2 (en) 1978-10-05 1978-10-05 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)

Publications (2)

Publication Number Publication Date
FR2438051A2 true FR2438051A2 (en) 1980-04-30
FR2438051B2 FR2438051B2 (en) 1981-12-11

Family

ID=9213369

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7828465A Granted FR2438051A2 (en) 1978-04-14 1978-10-05 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)

Country Status (1)

Country Link
FR (1) FR2438051A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2137899A1 (en) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2348219A1 (en) * 1976-04-12 1977-11-10 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2137899A1 (en) * 1971-05-14 1972-12-29 Glaxo Lab Ltd
FR2348219A1 (en) * 1976-04-12 1977-11-10 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY

Also Published As

Publication number Publication date
FR2438051B2 (en) 1981-12-11

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