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Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
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Publication date
Application filed by Takeda Chemical Industries LtdfiledCriticalTakeda Chemical Industries Ltd
Priority to JP51001246ApriorityCriticalpatent/JPS5931516B2/en
Publication of JPS5283862ApublicationCriticalpatent/JPS5283862A/en
Publication of JPS5931516B2publicationCriticalpatent/JPS5931516B2/en
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Cephalosporin Compounds
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PURPOSE: Title compounds of formula I (R3 is methyl, acethoxymethyl, carbamoyloxymethyl, alkoxymethyl, alkylthiomethyl, 2-carboxy-1-ethenyl, quaternary ammonium methyl, heterocyclic thiomethyl; R2 is H, halogen; R4 is amino which may be protected); for example, 7α-methoxy-7β-(2-aminothiazol-4-yl acetamido)-3-(1-methyl-1H-tetrazol-5-yl thiomethyl)-3-cephem-4carboxylic acid Na.
Crystalline salt of 7 beta -[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acid and HCl or HBr
METHOD FOR PREPARING A CRYSTALLIZED ACID ADDITION SALT OF 7- (2- (2-AMINO-4-THIAZOLYL) -2-METHOXYIMINOACETAMIDO) -2-CARBOXY-3- (2- (5,6-DIOXO-4-FORMYLMETHYL)) 4,5,6-TETRAHYDRO-1,2,4-TRIAZIN-3-YL) -THIOVINYL) -8-OXO-5-THIA-1-AZABICYCLO (4.2.0) -2-OCTEN (SYN-ISOMER, FORM E)