JPH11508048A - 特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法 - Google Patents
特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法Info
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- JPH11508048A JPH11508048A JP9503618A JP50361897A JPH11508048A JP H11508048 A JPH11508048 A JP H11508048A JP 9503618 A JP9503618 A JP 9503618A JP 50361897 A JP50361897 A JP 50361897A JP H11508048 A JPH11508048 A JP H11508048A
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Classifications
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
- G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for
- G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for as tracers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/42—Arrangements for detecting radiation specially adapted for radiation diagnosis
- A61B6/4208—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
- A61B6/4258—Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
- G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
- G01T1/29—Measurement performed on radiation beams, e.g. position or section of the beam; Measurement of spatial distribution of radiation
- G01T1/2914—Measurement of spatial distribution of radiation
- G01T1/2985—In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis)
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K1/00—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating
- G21K1/02—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators
- G21K1/025—Arrangements for handling particles or ionising radiation, e.g. focusing or moderating using diaphragms, collimators using multiple collimators, e.g. Bucky screens; other devices for eliminating undesired or dispersed radiation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Dentistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine (AREA)
- Measurement Of Radiation (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 共通ソース焦点(O)を有するコリメーティング構造(120)と組合 わされた複数のデテクタ(110)と、少なくとも軽度に角度的に相関する2つ の一致放出される放射事象を検出するため前記デテクタ(110)の出力におい て「AND」型の組合わせ論理機能を実行する処理手段(300)とを含む事を 特徴とする非侵入性分析装置。 2. 放射性放射事象を計数するための手段を含む事を特徴とする請求項1に 記載の装置。 3. さらに被検体(C)を支持しこの被検体とデテクタセット(110)と の間の制御された相対移動を生じるように設計された手段(200)を含む事を 特徴とする請求項1または2のいずれかに記載の装置。 4. 前記デテクタ(110)が焦点(O)の回りの少なくとも2πステラジ アンに等しい空間場をカバーする事を特徴とする請求項1乃至3のいずれかに記 載の装置。 5. デテクタ(110)が二十面体の各面に配置される事を特徴とする請求 項1乃至4のいずれかに記載の装置。 6. 15本のデテクタ(110)を含む事を特徴とする請求項1乃至5のい ずれかに記載の装置。 7. 各デテクタ(110)がコリメータ(120)、シンチレータ(130 )、光学ガイド(135)および光電子倍増管(140)を含む事を特徴とする 請求項1乃至6のいずれかに記載の装置。 8. 各コリメーティング構造(120)が円錐形放射方向孔(124)を含 む事を特徴とする請求項1乃至7のいずれかに記載の装置。 9. デテクタセット(110)を支持し、末端において相互に連接されたバ ー(152)から成る枠組の形を成す構造(150)を含む事を特徴とする請求 項1乃至8のいずれかに記載の装置。 10. 被検体(C)とデテクタセット(110)との間において制御され3 直交軸線に基づいて識別される相対移動を実施する事のできる手段(200)を 含む事を特徴とする請求項1乃至9のいずれかに記載の装置。 11. 処理手段(300)を含み、前記処理手段は事象エネルギーに比例す る信号の形で検出事象を符号化する事のできるエネルギー/時間変換手段(32 0)を含む事を特徴とする請求項1乃至10のいずれかに記載の装置。 12. 前記処理手段(320)は、 − 光電子倍増管(140)による信号出力を積分する事のできるコンデンサ (321)と、 − 光電子倍増管(140)の出力信号デテクタ(322)と、 − 前記デテクタ(322)によって初期化される遅延セル(323)と、 − コンデンサ(322)に対して並列に接続され遅延セル(323)の出力 によって駆動される電流ソース(324)と、 − 一方の入力が接地され他方の入力がコンデンサ(321)に接続され、出 力がエネルギー/時間変換装置の出力を成す比較器(325)と、 − 比較器(325)によって制御されまたコンデンサ(321)を放電させ る事のできるスイッチ(326)とを含む事を特徴とする請求項11に記載の装 置。 13. 処理手段(300)はタイマー(334、335)を含み、これらの タイマーはクロック(333)によって駆動されまたエネルギー/時間変換手段 (320)によって出力される信号のトリップ時間を限定するように設計される 事を特徴とする請求項11または12のいずれかに記載の装置。 14. 前記タイマー(334、335)はエネルギー/時間変換器(320 ) から出力される信号の前端と後端のデテクタ(331、332)によって制御さ れる事を特徴とする請求項13に記載の装置。 15. パーフォレーション(124)を備えた板(122)の堆積から成る 事を特徴とする放射線撮像分析装置のコリメータ。 16. 各板(122)中に備えられたパーフォレーション(124)は相似 的累進を示す事を特徴とする請求項15に記載のコリメータ。 17. パーフォレーション(124)は化学的加工によって形成される事を 特徴とする請求項15または16のいずれかに記載のコリメータ。 18. 板(122)はタングステンから成る事を特徴とする請求項15乃至 17のいずれかに記載のコリメータ。 19. 板(122)の厚さ(d)はコリメータの内側入口面(123)中の パーフォレーション(124)の直径より小であり、またパーフォレーション( 124)の間隔は板(12)の厚さより大である事を特徴とする請求項15乃至 18のいずれかに記載のコリメータ。 20. 少なくとも一部の板(122)は2つの同型のパーフォレーション・ スクリーンの重ね合せによって形成される事を特徴とする請求項15乃至19の いずれかに記載のコリメータ。 21. − 少なくとも軽度に角度的に相関する2つの一致放出される放射事 象を発生する事のできるマーカを被検体(C)の中に注入する段階と、 − 共通ソース焦点(O)を有するコリメーティング構造(120) と組合わされた複数のデテクタ(110)と、少なくとも軽度に角度的に相関す る2つの一致放出される放射事象を検出するた前記デテクタ(110)の出力に おいて「AND」型の組合わせ論理機能を実行する処理手段(300)とを含む 分析装置を使用してこれらの放射事象を検出する段階とを含む事を特徴とする分 析法。 22. 使用されるマーカは、原子起源(atomic origin)(電子捕獲または内 部変換の結果として放出されるX線)または原子核起源(nuclear origin)(原子 核のアイソバリック脱励起中に放出されるガンマー線)の少なくとも軽度に角度 的に相関する2つの一致放出放射事象を放出するように設計される事を特徴とす る請求項21に記載の方法。 23. 使用されるマーカが123I、125Iおよび111Inから成るグループか ら選定される事を特徴とする請求項21または22のいずれかに記載の方法。 24. 被検体の画像がvoxelごとに構築される事を特徴とする請求項2 1乃至23のいずれかに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9507345A FR2735874B1 (fr) | 1995-06-20 | 1995-06-20 | Dispositif d'analyse non invasif par radio-imagerie, notamment pour l'examen in vito de petits animaux, et procede de mise en oeuvre |
FR95/07345 | 1995-06-20 | ||
PCT/FR1996/000945 WO1997001108A1 (fr) | 1995-06-20 | 1996-06-19 | Dispositif d'analyse non invasif par radio-imagerie, notamment pour l'examen in vivo de petits animaux, et procede de mise en ×uvre |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004285020A Division JP4198660B2 (ja) | 1995-06-20 | 2004-09-29 | 特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11508048A true JPH11508048A (ja) | 1999-07-13 |
Family
ID=9480170
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9503618A Pending JPH11508048A (ja) | 1995-06-20 | 1996-06-19 | 特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法 |
JP2004285020A Expired - Fee Related JP4198660B2 (ja) | 1995-06-20 | 2004-09-29 | 特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004285020A Expired - Fee Related JP4198660B2 (ja) | 1995-06-20 | 2004-09-29 | 特に小動物の生体検査用の放射線撮像による非侵入性分析装置及びその使用方法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US6225631B1 (ja) |
EP (2) | EP1195619A3 (ja) |
JP (2) | JPH11508048A (ja) |
DE (1) | DE69623622T2 (ja) |
FR (1) | FR2735874B1 (ja) |
WO (1) | WO1997001108A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2021532372A (ja) * | 2018-08-29 | 2021-11-25 | シャンドン マディク テクノロジー カンパニー リミテッドShandong Madic Technology Co., Ltd. | 全身のpetとctを組み合わせた検出器、及びそれの装置と方法 |
WO2022091749A1 (ja) * | 2020-11-02 | 2022-05-05 | 株式会社堀場製作所 | 放射線検出モジュール、及び放射線検出装置 |
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AT3834U1 (de) * | 1999-05-21 | 2000-08-25 | Plansee Ag | Thermisch hochbelastbares bauteil |
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US8571881B2 (en) | 2004-11-09 | 2013-10-29 | Spectrum Dynamics, Llc | Radiopharmaceutical dispensing, administration, and imaging |
WO2008010227A2 (en) | 2006-07-19 | 2008-01-24 | Spectrum Dynamics Llc | Imaging protocols |
US7968851B2 (en) | 2004-01-13 | 2011-06-28 | Spectrum Dynamics Llc | Dynamic spect camera |
EP1766550A2 (en) | 2004-06-01 | 2007-03-28 | Spectrum Dynamics LLC | Methods of view selection for radioactive emission measurements |
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- 1996-06-19 EP EP02000824A patent/EP1195619A3/fr not_active Ceased
- 1996-06-19 EP EP96922950A patent/EP0834088B1/fr not_active Expired - Lifetime
- 1996-06-19 WO PCT/FR1996/000945 patent/WO1997001108A1/fr active IP Right Grant
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2021532372A (ja) * | 2018-08-29 | 2021-11-25 | シャンドン マディク テクノロジー カンパニー リミテッドShandong Madic Technology Co., Ltd. | 全身のpetとctを組み合わせた検出器、及びそれの装置と方法 |
WO2022091749A1 (ja) * | 2020-11-02 | 2022-05-05 | 株式会社堀場製作所 | 放射線検出モジュール、及び放射線検出装置 |
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EP0834088B1 (fr) | 2002-09-11 |
US6407391B1 (en) | 2002-06-18 |
US6225631B1 (en) | 2001-05-01 |
JP4198660B2 (ja) | 2008-12-17 |
DE69623622T2 (de) | 2003-08-07 |
FR2735874A1 (fr) | 1996-12-27 |
EP1195619A3 (fr) | 2003-02-12 |
FR2735874B1 (fr) | 1997-08-22 |
WO1997001108A1 (fr) | 1997-01-09 |
EP1195619A9 (fr) | 2003-06-25 |
EP0834088A1 (fr) | 1998-04-08 |
JP2005099027A (ja) | 2005-04-14 |
EP1195619A2 (fr) | 2002-04-10 |
US20020024024A1 (en) | 2002-02-28 |
DE69623622D1 (de) | 2002-10-17 |
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