JPH10509589A - プロテアーゼ阻害剤および他の生物活性物質の新しい系 - Google Patents
プロテアーゼ阻害剤および他の生物活性物質の新しい系Info
- Publication number
- JPH10509589A JPH10509589A JP8514314A JP51431496A JPH10509589A JP H10509589 A JPH10509589 A JP H10509589A JP 8514314 A JP8514314 A JP 8514314A JP 51431496 A JP51431496 A JP 51431496A JP H10509589 A JPH10509589 A JP H10509589A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- substance according
- activity
- sequence
- elastase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1、Limnatis Niloticaから得られるプロテアーゼ阻害活性 を有する物質、同様な活性を有する該物質の断片または誘導体。 2、タンパク質状またはポリペプチド様であることを特徴とする請求項1記載 の物質。 3、少なくとも下記のアミノ酸配列のうちの1つの部分: または1つ以上の通常のアミノ酸置換を含む前記配列を含んでなることを特徴と する請求項2記載のタンパク質状またはポリペプチド様物質。 4、特にエラスターゼ、キモトリプシン、トリプシン、トロンビン、またはプ ラスミンを阻害することを特徴とする前記請求項のいずれかに記載の物質。 5、フィブリン/フィブリノーゲンを溶解することを特徴とする請求項1〜3 のいずれかに記載の物質。 6、ヒト細胞でヒト免疫不全ウイルス(HIV)の複製を阻害することを特徴 とする請求項1〜3のいずれかに記載の物質。 7、抗菌性を有することを特徴とする請求項1〜3のいずれかに記載の物質。 8、治療薬として用いることを特徴とする前記請求項のいずれかに記載の物質 。 9、請求項1〜7のいずれかに記載の物質と、適当な賦形剤とを一緒に含んで なることを特徴とする薬学的組成物。 10、真性糖尿病、血液凝固障害、好中球機能疾患、リウマチ性関節炎、HIV 感染、または他の免疫学的または炎症状疾患の治療のための医薬を製造するのに 請求項1〜7のいずれかに記載の物質を使用。 11、請求項3に記載のタンパク質状またはポリペプチド様物質の少なくとも一 部をコードすることを特徴とする核酸分子。 12、少な〈とも下記の配列の一部、またはそれらと70%のホモロジーを有す る配列を含んでなることを特徴とする請求項11記載の核酸分子: (ここで、R=A/G,N=A/C/G/T,Y=C/T,D=A/G/T) 。 13、請求項11または12記載の核酸と、適当な発現制御因子とを一緒に含ん でなることを特徴とする発現ベクター。 14、請求項13記載の発現ベクターと発現機構とを含んでなることを特徴とす る請求項3に記載の物質の少なくとも一部を発現するための発現系。 15、前記発現系は、組換え宿主細胞であることを特徴とする請求項14記載の 発現系。 16、請求項1〜7のいずれかに記載の物質を特異的に認識することを特徴とす る抗体。 17、請求項1〜7のいずれかに記載の物質の少なくともエピトープを模倣する ことを特徴とする抗イディオタイプの抗体。 18、請求項1〜7のいずれかに記載の物質の少なくとも1つの活性を模倣する ことを特徴とする抗イディオタイプの抗体。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94117053 | 1994-10-28 | ||
DE94117053.2 | 1995-03-14 | ||
EP95103637 | 1995-03-14 | ||
DE95103637.5 | 1995-03-14 | ||
PCT/EP1995/004223 WO1996013585A1 (en) | 1994-10-28 | 1995-10-27 | A novel family of protease inhibitors, and other biologic active substances |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10509589A true JPH10509589A (ja) | 1998-09-22 |
JP4278175B2 JP4278175B2 (ja) | 2009-06-10 |
Family
ID=26135896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51431496A Expired - Fee Related JP4278175B2 (ja) | 1994-10-28 | 1995-10-27 | プロテアーゼ阻害剤および他の生物活性物質の新しい系 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6239106B1 (ja) |
EP (1) | EP0789764B1 (ja) |
JP (1) | JP4278175B2 (ja) |
AT (1) | ATE211765T1 (ja) |
AU (1) | AU3870195A (ja) |
CA (1) | CA2203827A1 (ja) |
DE (1) | DE69524971T2 (ja) |
DK (1) | DK0789764T3 (ja) |
ES (1) | ES2171563T3 (ja) |
PT (1) | PT789764E (ja) |
WO (1) | WO1996013585A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002539788A (ja) * | 1999-03-18 | 2002-11-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 血小板接着の阻止用タンパク質 |
JP2020531586A (ja) * | 2017-08-27 | 2020-11-05 | アンタイ−ヴァイラル テクノロジーズ, エルエルシー | 合成リジンアナログ及び模倣物の抗ウイルス用途のための方法及び組成物 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2235394A1 (en) | 1995-11-13 | 1997-05-22 | Gerard Voerman | Anti-viral isolates obtainable from leeches |
AUPO427596A0 (en) * | 1996-12-20 | 1997-01-23 | Cooperative Research Centre For Tropical Plant Pathology | Anti-microbial protein |
EP0875564A1 (en) * | 1997-05-02 | 1998-11-04 | Gerard Voerman | Biologically active extract from the leech 'Limnatis nilotica' |
FR2763944B1 (fr) * | 1997-06-03 | 2000-12-15 | Centre Nat Rech Scient | Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases |
US6232287B1 (en) * | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
KR20160054475A (ko) * | 2013-08-05 | 2016-05-16 | 제라드 뵈르만 | 흡연의 해로운 영향을 감소시키는 신규의 수단 |
EP3193910A1 (en) * | 2014-08-05 | 2017-07-26 | Réunion Therapeutics B.V. | Mutants of leech derived neutrophil elastase inhibitors and uses thereof |
CN105646702B (zh) * | 2016-04-13 | 2019-03-01 | 中国科学院昆明动物研究所 | 菲牛蛭Kazal型胰蛋白酶抑制剂Bdellin-HM及其编码基因和应用 |
US11262125B2 (en) * | 2018-01-02 | 2022-03-01 | Praxair Technology, Inc. | System and method for flexible recovery of argon from a cryogenic air separation unit |
WO2022232516A1 (en) * | 2021-04-30 | 2022-11-03 | The Regents Of The University Of California | Cartilage treatment for use in eyelid reconstruction |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL86857A (en) * | 1988-06-24 | 1994-04-12 | Yissum Res Dev Co | Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same |
US5824641A (en) * | 1993-04-09 | 1998-10-20 | Bio-Technology General Corp | Method of treating of preventing influenza |
-
1995
- 1995-10-27 WO PCT/EP1995/004223 patent/WO1996013585A1/en active IP Right Grant
- 1995-10-27 CA CA002203827A patent/CA2203827A1/en not_active Abandoned
- 1995-10-27 JP JP51431496A patent/JP4278175B2/ja not_active Expired - Fee Related
- 1995-10-27 ES ES95937853T patent/ES2171563T3/es not_active Expired - Lifetime
- 1995-10-27 US US08/836,686 patent/US6239106B1/en not_active Expired - Lifetime
- 1995-10-27 DE DE69524971T patent/DE69524971T2/de not_active Expired - Lifetime
- 1995-10-27 DK DK95937853T patent/DK0789764T3/da active
- 1995-10-27 PT PT95937853T patent/PT789764E/pt unknown
- 1995-10-27 EP EP95937853A patent/EP0789764B1/en not_active Expired - Lifetime
- 1995-10-27 AT AT95937853T patent/ATE211765T1/de active
- 1995-10-27 AU AU38701/95A patent/AU3870195A/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002539788A (ja) * | 1999-03-18 | 2002-11-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 血小板接着の阻止用タンパク質 |
JP4805461B2 (ja) * | 1999-03-18 | 2011-11-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血小板接着の阻止用タンパク質 |
JP2020531586A (ja) * | 2017-08-27 | 2020-11-05 | アンタイ−ヴァイラル テクノロジーズ, エルエルシー | 合成リジンアナログ及び模倣物の抗ウイルス用途のための方法及び組成物 |
Also Published As
Publication number | Publication date |
---|---|
US6239106B1 (en) | 2001-05-29 |
CA2203827A1 (en) | 1996-05-09 |
DE69524971D1 (de) | 2002-02-14 |
JP4278175B2 (ja) | 2009-06-10 |
DE69524971T2 (de) | 2002-08-29 |
AU3870195A (en) | 1996-05-23 |
WO1996013585A1 (en) | 1996-05-09 |
DK0789764T3 (da) | 2002-04-22 |
ES2171563T3 (es) | 2002-09-16 |
EP0789764B1 (en) | 2002-01-09 |
EP0789764A1 (en) | 1997-08-20 |
ATE211765T1 (de) | 2002-01-15 |
PT789764E (pt) | 2002-06-28 |
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