JPH10501149A - 食物不耐性/アレルギーを確認する診断方法及び該方法実施時に用いる装置 - Google Patents
食物不耐性/アレルギーを確認する診断方法及び該方法実施時に用いる装置Info
- Publication number
- JPH10501149A JPH10501149A JP8500742A JP50074296A JPH10501149A JP H10501149 A JPH10501149 A JP H10501149A JP 8500742 A JP8500742 A JP 8500742A JP 50074296 A JP50074296 A JP 50074296A JP H10501149 A JPH10501149 A JP H10501149A
- Authority
- JP
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- Prior art keywords
- allergen
- large intestine
- perfusion
- marker
- inflatable
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0035—Vaccination diagnosis other than by injuring the skin, e.g. allergy test patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0061—Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.アレルギーの疑いが有る患者の大腸粘膜を疑わしいアレルギーの原因とされ るアレルゲンで経直腸反応誘発すること、前記患者の大腸から試料を経直腸採取 すること、及び採取した試料を分析することを含むアレルギー診断方法であって 、 (a)試料を大腸の内腔から採取すること、 (b)試料中の炎症マーカーを測定すること、及び (c)マーカー量の増大(放出量増大)を、前記患者が当該アレルゲンに対して アレルギーであることの指標と看做すこと を特徴とする方法。 2.アッセイするマーカーが好中球、好酸球、肥満細胞/好塩基球に由来し、ま たはサイトカイン、プロスタグランジン、もしくはアルブミンなどの血漿タンパ ク質であることを特徴とする請求項1に記載の方法。 3.アッセイするマーカーがミエロペルオキシダーゼ、好酸球塩基性タンパク質 、ヒスタミン、及び/またはサイトカイン(例えばIL−6及び/またはIL− 8)またはプロスタグランジン(例えばPGE2)であることを特徴と する請求項1または2に記載の方法。 4.大腸の一部のみを反応誘発することを特徴とする請求項1から3のいずれか 1項に記載の方法。 5.試料採取を大腸へ経直腸挿入する装置を用いて行ない、前記装置は、放出さ れたマーカーの収集を可能にし、場合によっては大腸の灌流、及び/または大腸 粘膜の一部へのアレルゲンの接触実現も可能にする手段を含むことを特徴とする 請求項1から4のいずれか1項に記載の方法。 6.(a)前記装置が大腸の全体または一部の灌流を可能にし、かつ放出された マーカーの収集を可能にする手段を含むこと、及び (b)前記装置を大腸内に適用し、大腸の一部をまずアレルゲン非含有緩衝液で 灌流し、装置を取り出し、反応誘発用の水性アレルゲン組成物を大腸内に適用し 、前記アレルゲン組成物を大腸から除去し、前記装置を大腸内に再度適用し、か つ大腸の反応誘発部分をアレルゲン非含有緩衝液で灌流する(2回目の灌流)こ とによって試料を採取し、前記諸段階において少なくとも2回目の灌流に用いた 灌流溶液を炎症マーカーに関して分析するべく回収することを特徴とする請求項 5に記載の方法。 7.(a)前記装置が放出されたマーカーの収集、大腸の灌流、及び大脳粘膜の 一部へのアレルゲンの接触実現のための手段を含むこと、及び (b)前記装置を大腸内に適用し、最初に大腸の一部をアレルゲン非含有緩衝液 で灌流し、同じ大腸部分に、大腸での反応誘発用の水性アレルゲン組成物で2回 目の灌流を行ない、かつ最後に同じ大腸部分にアレルゲン非含有緩衝液で3回目 の灌流を行なうことによって試料を採取し、前記諸段階において少なくとも3回 目の灌流に用いた灌流溶液を炎症マーカーに関して分析するべく回収すること を特徴とする請求項5に記載の方法。 8.灌流液を最初の灌流操作と最後の灌流操作とから別個の試料として回収して 炎症マーカーに関して分析し、その際同じマーカーについて最後の灌流操作から 得た灌流液中の濃度が最初の灌流操作から得た灌流液中の濃度より高いことを、 灌流を受けた患者が用いた反応誘発アレルゲンに対して不耐性/アレルギーであ ることの指標と看做すことを特徴とする請求項6または7に記載の方法。 9.前記装置が膨張可能部分を有し、この部分は該部分の各々の側で開口する中 心チャネルと、装置を大腸内に経直 腸適用した時に膨張可能部分の外壁が大腸、好ましくは直腸の粘膜と直接接触す るように膨張部分の膨張を制御することを可能にするチャネルとを囲繞し、膨張 可能部分の外側を規定する面上には拡散性アレルゲンが存在し、場合によっては 炎症マーカーの受容体も存在することを特徴とする請求項5に記載の方法。 10.アレルゲンが膨張可能部分の外側面において幾つかの部分面上に存在し、 炎症マーカーの受容体は膨張可能部分の外側面において前記以外の部分面上に存 在することを特徴とする請求項9に記載の方法。 11.直腸へ経直腸挿入する装置であって、膨張可能部分を有し、この部分は該 部分の各々の側で開口する中心チャネルと、装置を直腸内に適用した時に膨張可 能部分の外壁が直腸の粘膜と直接接触するように膨張部分の膨張を制御すること を可能にする分離チャネルとを囲繞し、膨張可能部分の外側を規定する面上には 拡散性アレルゲンが存在し、場合によっては炎症マーカーの受容体も存在するこ とを特徴とする装置。 12.アレルゲンが動物及び植物タンパク質またはその部分加水分解アレルゲン フラグメント、例えばグリアジンな どのグルテン、乳タンパク質などの牛タンパク質、大豆タンパク質等の中から選 択されることを特徴とする請求項11に記載の装置。 13.受容体が、好中球由来、好酸球由来、肥満細胞/好塩基球由来の炎症マー カー、またはサイトカイン(例えばIL−6及びIL−8)及び血漿タンパク質 などのマーカーの中から選択された物質の受容体であることを特徴とする請求項 11または12に記載の装置。 14.受容体がミエロペルオキシダーゼ、好酸球塩基性タンパク質、ヒスタミン 、サイトカイン(IL−6またはIL−8など)、PGE2などのプロスタグラ ンジン、またはアルブミンなどの血漿タンパク質の受容体であることを特徴とす る請求項10または11に記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9401883-5 | 1994-06-01 | ||
SE9401883A SE9401883L (sv) | 1994-06-01 | 1994-06-01 | Sätt vid diagnosticering av födoämnesintolerans/allergi samt instrument för diagnostiseringen |
PCT/SE1995/000602 WO1995032668A1 (en) | 1994-06-01 | 1995-05-26 | A diagnostic method for establishing food intolerance/allergy, and an instrument for use when carrying out the method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10501149A true JPH10501149A (ja) | 1998-02-03 |
JP3640966B2 JP3640966B2 (ja) | 2005-04-20 |
Family
ID=20394198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50074296A Expired - Fee Related JP3640966B2 (ja) | 1994-06-01 | 1995-05-26 | 食物不耐性/アレルギーを確認する診断方法及び該方法実施時に用いる装置 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5983899A (ja) |
EP (1) | EP0762849B1 (ja) |
JP (1) | JP3640966B2 (ja) |
AT (1) | ATE279146T1 (ja) |
AU (1) | AU689594B2 (ja) |
CA (1) | CA2191768C (ja) |
DE (1) | DE69533648T8 (ja) |
ES (1) | ES2232823T3 (ja) |
SE (1) | SE9401883L (ja) |
WO (1) | WO1995032668A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003512122A (ja) * | 1999-10-26 | 2003-04-02 | アリメンタ ダイアグナスティクス エイビー | 腸内試料採取用装置およびその使用 |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511425B1 (en) | 1997-05-30 | 2003-01-28 | Aerocrine Ab | Method for the diagnosis of food intolerance |
US6576429B1 (en) | 1999-10-26 | 2003-06-10 | Alimenta Diagnostics Ab | Apparatus for intestinal sampling and use thereof |
EP1255992A1 (en) * | 1999-11-16 | 2002-11-13 | Aerocrine AB | Method for use in the diagnosis of food allergies and/or food intolerances |
DE10110838C2 (de) * | 2001-03-06 | 2003-04-03 | Mlu Halle Wittenberg | Verfahren zur Diagnostik von Allergien, Pseudoallergien und Intoleranzen |
EP1552790A1 (de) * | 2004-01-07 | 2005-07-13 | Heiko Dr. Schwertner | Vorrichtung an der Mundschleimhaut zur Analyse von biochemischen Prozessen oder Molekülen |
US10080481B2 (en) * | 2005-02-10 | 2018-09-25 | G.I. View Ltd. | Advancement techniques for gastrointestinal tool with guiding element |
US20090039181A1 (en) * | 2006-04-12 | 2009-02-12 | Auer Jr John | Cleaning Attachment for Water Hose |
WO2008149364A2 (en) * | 2007-06-07 | 2008-12-11 | Sarah Brenner | Methods for diagnosing hypersensitivity reactions |
DE112009003237A5 (de) * | 2008-09-08 | 2012-07-05 | Ogeno Gmbh | Biopsie-instrument zur anreicherung von probenmaterial |
WO2010127144A1 (en) * | 2009-04-29 | 2010-11-04 | Muniyappa Pravin K | Device and method for the diagnosis of gastrointestinal allergy |
WO2019226361A1 (en) * | 2018-05-25 | 2019-11-28 | Ramji Anant | Methods for testing for food allergies and allergens in foods |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3616684A (en) * | 1983-11-10 | 1985-06-03 | Ventrex Laboratories Inc. | Multiple allergen-bearing matrixes useful for qualitative allergy screening |
IT1206532B (it) * | 1985-10-15 | 1989-04-27 | Marcucci Francesco | Metodo allergodiagnostico mucosale e relativo dispositivo per il rilievo in vivo delle ige specifiche e totali |
SE465017B (sv) * | 1989-11-24 | 1991-07-15 | Lars Knutson | Anordning foer segmentell perfusion/aspiration av grovtarmen |
-
1994
- 1994-06-01 SE SE9401883A patent/SE9401883L/ not_active Application Discontinuation
-
1995
- 1995-05-26 CA CA002191768A patent/CA2191768C/en not_active Expired - Fee Related
- 1995-05-26 DE DE69533648T patent/DE69533648T8/de not_active Expired - Fee Related
- 1995-05-26 ES ES95921209T patent/ES2232823T3/es not_active Expired - Lifetime
- 1995-05-26 EP EP95921209A patent/EP0762849B1/en not_active Expired - Lifetime
- 1995-05-26 AT AT95921209T patent/ATE279146T1/de not_active IP Right Cessation
- 1995-05-26 US US08/750,107 patent/US5983899A/en not_active Expired - Lifetime
- 1995-05-26 AU AU26345/95A patent/AU689594B2/en not_active Ceased
- 1995-05-26 JP JP50074296A patent/JP3640966B2/ja not_active Expired - Fee Related
- 1995-05-26 WO PCT/SE1995/000602 patent/WO1995032668A1/en active IP Right Grant
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003512122A (ja) * | 1999-10-26 | 2003-04-02 | アリメンタ ダイアグナスティクス エイビー | 腸内試料採取用装置およびその使用 |
JP4810039B2 (ja) * | 1999-10-26 | 2011-11-09 | アリメンタ メディカル エイビー | 腸内試料採取用装置およびその使用 |
Also Published As
Publication number | Publication date |
---|---|
JP3640966B2 (ja) | 2005-04-20 |
SE9401883L (sv) | 1995-12-02 |
ES2232823T3 (es) | 2005-06-01 |
DE69533648D1 (de) | 2004-11-18 |
DE69533648T2 (de) | 2006-02-23 |
CA2191768C (en) | 2006-01-03 |
SE9401883D0 (sv) | 1994-06-01 |
AU689594B2 (en) | 1998-04-02 |
CA2191768A1 (en) | 1995-12-07 |
AU2634595A (en) | 1995-12-21 |
EP0762849B1 (en) | 2004-10-13 |
EP0762849A1 (en) | 1997-03-19 |
ATE279146T1 (de) | 2004-10-15 |
US5983899A (en) | 1999-11-16 |
DE69533648T8 (de) | 2006-04-27 |
WO1995032668A1 (en) | 1995-12-07 |
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