JPH09509325A - 単離チロシナーゼ由来ペプチド抗原とその利用方法 - Google Patents
単離チロシナーゼ由来ペプチド抗原とその利用方法Info
- Publication number
- JPH09509325A JPH09509325A JP7522390A JP52239095A JPH09509325A JP H09509325 A JPH09509325 A JP H09509325A JP 7522390 A JP7522390 A JP 7522390A JP 52239095 A JP52239095 A JP 52239095A JP H09509325 A JPH09509325 A JP H09509325A
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. MHC分子と、配列認識番号(SEQ ID NO):4,配列認識番号 (SEQ ID NO):7及び配列認識番号(SEQ ID NO):8とか らなるグループから選択されるチロシナーゼ由来ペプチドとの複合体に対して特 異的な治療薬によって治療対象体を同定する方法であって、以下の工程を有する 方法、 (i)対象体からの異常細胞サンプルを、前記複合体に対して特定的な細胞 溶解T細胞に接触させる工程、及び (ii)前記異常細胞サンプルの少なくとも一部分の溶解を、前記治療の対 象体の同定として判断する工程。 2. 請求項1の方法であって、前記MHC分子はHLA−A2である。 3. 請求項1の方法であって、前記MHC分子はHLA−B44である。 4. 細胞異常を有する対象体を治療する方法であって、前記対象体に、MHC 分子と、配列認識番号(SEQ ID NO):4,配列認識番号(SEQ I D NO):7及び配列認識番号(SEQ ID NO): 8とからなるグループから選択されるチロシナーゼ由来ペプチドとの複合体をそ の表面に提示する細胞に対する細胞傷害性T細胞反応を活性化する薬剤を、その 表面に前記複合体を提示する異常細胞に対する反応を活性化するのに十分な量投 与する工程を有する方法。 5. 請求項3の方法であって、前記MHC分子はHLA−A2である。 6. 請求項4の方法であって、前記MHC分子はHLA−B44である。 7. 請求項4の方法であって、前記薬剤は、ヒトチロシナーゼをコードするベ クターを有する。 8. 請求項7の方法であって、前記薬剤は、更に、HLA−A2をコードする 第2ベクターを有する。 9. 請求項7の方法であって、前記薬剤は、更に、HLA−B44をコードす る第2ベクターを有する。 10.請求項7の方法であって、前記ベクターも、HLA−A2をコードする。 11.請求項7の方法であって、前記ベクターも、HLA−B44をコードする 。 12.請求項4の方法であって、前記薬剤は、前記複合体をその表面に提示する 非増殖性細胞のサンプルである。 13.細胞異常を治療する方法であって、異常細胞表面上におけるMHC分子と 、配列認識番号(SEQ ID NO):4,配列認識番号(SEQ ID N O):7及び配列認識番号(SEQ ID NO):8とからなるグループから 選択されるチロシナーゼ由来ペプチドとの複合体の提示によって特徴付けられる 細胞異常を有する対象体に、前記複合体に対して特異的な細胞傷害性T細胞を前 記異常細胞の溶解に十分な量投与する工程を有する方法。 14.請求項13の方法であって、前記MHC分子はHLA−2Aである。 15.請求項13の方法であって、前記MHC分子はHLA−B44である。 16.請求項13の方法であって、前記細胞傷害性T細胞は自己由来細胞である 。 17.HLA−A2からなるグループから選択されたMHC分子と、配列認識番 号(SEQ ID NO):4,配列認識番号(SEQ ID NO):7及び 配列認識番号(SEQ ID NO):8とからなるグループから選択されるチ ロシナーゼ由来ペプチドとの複合体に対して特異的な単離細胞傷害性T細胞。 18.HLA−A2と配列認識番号(SEQ ID NO):4との複合体に対して特異的な、請求項17の単離細胞傷害性T細胞 。 19.HLA−B44と配列認識番号(SEQ ID NO):7との複合体に 対して特異的な、請求項17の単離細胞傷害性T細胞。 20.HLA−B44と配列認識番号(SEQ ID NO):8との複合体に 対して特異的な、請求項17の単離細胞傷害性T細胞。 21.その表面に、MHC分子と、配列認識番号(SEQ ID NO):4, 配列認識番号(SEQ ID NO):7及び配列認識番号(SEQ ID N O):8とからなるグループから選択されるチロシナーゼ由来ペプチドとの複合 体を提示する異常細胞を同定する方法であって、異常細胞のサンプルを前記複合 体に対して特異的な細胞傷害性T細胞に接触させる工程と、前記異常細胞の溶解 を、前記複合体を提示する細胞の同定として判定する工程を有する方法。 22.請求項21の方法であって、前記MHC分子はHLA−A2である。 23.請求項21の方法であって、前記MHC分子はHLA−B44である。 24.配列認識番号(SEQ ID NO):4,配列 認識番号(SEQ ID NO):7及び配列認識番号(SEQ ID NO) :8とからなるグループから選択される単離ペプチド。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US08/203,054 | 1994-02-28 | ||
US08/203,054 US5530096A (en) | 1992-12-22 | 1994-02-28 | Isolated, tyrosinase derived peptides and uses thereof |
US08/233,305 | 1994-04-26 | ||
US08/233,305 US5519117A (en) | 1992-12-22 | 1994-04-26 | Isolated, tyrosinase derived peptides and uses thereof |
PCT/US1995/001990 WO1995023234A1 (en) | 1994-02-28 | 1995-02-16 | Isolated, tyrosinase derived peptides and uses thereof |
Publications (2)
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JPH09509325A true JPH09509325A (ja) | 1997-09-22 |
JP3721437B2 JP3721437B2 (ja) | 2005-11-30 |
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JP52239095A Expired - Lifetime JP3721437B2 (ja) | 1994-02-28 | 1995-02-16 | 単離チロシナーゼ由来ペプチド抗原とその利用方法 |
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US (2) | US5519117A (ja) |
EP (1) | EP0750679A4 (ja) |
JP (1) | JP3721437B2 (ja) |
CN (1) | CN1169966C (ja) |
AU (1) | AU677766B2 (ja) |
CA (1) | CA2184175C (ja) |
FI (1) | FI963334A0 (ja) |
HK (1) | HK1001404A1 (ja) |
NO (1) | NO963487L (ja) |
NZ (1) | NZ282528A (ja) |
WO (1) | WO1995023234A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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US7252829B1 (en) | 1998-06-17 | 2007-08-07 | Idm Pharma, Inc. | HLA binding peptides and their uses |
US20020168374A1 (en) * | 1992-08-07 | 2002-11-14 | Ralph T. Kubo | Hla binding peptides and their uses |
ES2172287T4 (es) | 1992-12-22 | 2003-04-16 | Ludwig Inst Cancer Res | Metodos de deteccion y tratamiento de individuos con celulas anormales que expresan los antigenos peptidicos hla-a2/tirosinasa. |
US5851523A (en) * | 1994-03-24 | 1998-12-22 | Ludwig Institute For Cancer Research. | Isolated, peptides derived from MAGE tumor rejection antigen precursors which complex with HLA-A2 molecules and uses thereof |
US5997870A (en) * | 1994-06-03 | 1999-12-07 | Ludwig Institute For Cancer Research | Isolated peptides which bind to HLA-B44 Molecules |
US5589334A (en) * | 1994-06-03 | 1996-12-31 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecule which codes for a tumor rejection antigen precursor which is processed to an antigen presented by HLA-B44, and uses thereof |
US6951917B1 (en) | 1995-09-26 | 2005-10-04 | The United States Of America As Represented By The Department Of Health And Human Services | MHC-class II restricted melanoma antigens and their use in therapeutic methods |
US7501501B2 (en) | 1995-09-26 | 2009-03-10 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | MHC-Class II restricted melanoma antigens and their use in therapeutic methods |
US6096313A (en) * | 1996-02-09 | 2000-08-01 | Ludwig Institute For Cancer Research | Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant |
US6680191B1 (en) | 1997-04-25 | 2004-01-20 | Ludwig Institute For Cancer | Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof |
US6667037B1 (en) * | 1998-10-09 | 2003-12-23 | Ludwig Institute For Cancer Research | Isolated peptides which bind to HLA-B35 molecules, larger peptides which contain these, nucleic acid molecules encoding peptides, and uses thereof |
AU1013601A (en) | 1999-10-22 | 2001-05-08 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
DE60238864D1 (de) * | 2001-11-07 | 2011-02-17 | Mankind Corp | Für epitope von antigenen kodierende expressionsvektoren und verfahren zu deren konzeption |
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US4898814A (en) * | 1986-10-06 | 1990-02-06 | Donald Guthrie Foundation For Medical Research, Inc. | A cDNA clone for human tyrosinase |
ES2172287T4 (es) * | 1992-12-22 | 2003-04-16 | Ludwig Inst Cancer Res | Metodos de deteccion y tratamiento de individuos con celulas anormales que expresan los antigenos peptidicos hla-a2/tirosinasa. |
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- 1994-04-26 US US08/233,305 patent/US5519117A/en not_active Expired - Lifetime
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- 1995-02-16 WO PCT/US1995/001990 patent/WO1995023234A1/en active Application Filing
- 1995-02-16 EP EP19950912563 patent/EP0750679A4/en not_active Withdrawn
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Publication number | Publication date |
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NO963487D0 (no) | 1996-08-22 |
NZ282528A (en) | 1998-05-27 |
JP3721437B2 (ja) | 2005-11-30 |
AU677766B2 (en) | 1997-05-01 |
CN1169966C (zh) | 2004-10-06 |
AU1966895A (en) | 1995-09-11 |
US5843687A (en) | 1998-12-01 |
HK1001404A1 (en) | 1998-06-19 |
US5519117A (en) | 1996-05-21 |
EP0750679A4 (en) | 1997-06-11 |
FI963334A (fi) | 1996-08-27 |
CA2184175C (en) | 2007-04-17 |
CA2184175A1 (en) | 1995-08-31 |
EP0750679A1 (en) | 1997-01-02 |
FI963334A0 (fi) | 1996-08-27 |
WO1995023234A1 (en) | 1995-08-31 |
CN1154144A (zh) | 1997-07-09 |
NO963487L (no) | 1996-08-28 |
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