JPH09502161A - 補足された及び補足されていない組織シーラント、その製造法及び使用法 - Google Patents
補足された及び補足されていない組織シーラント、その製造法及び使用法Info
- Publication number
- JPH09502161A JPH09502161A JP6520353A JP52035394A JPH09502161A JP H09502161 A JPH09502161 A JP H09502161A JP 6520353 A JP6520353 A JP 6520353A JP 52035394 A JP52035394 A JP 52035394A JP H09502161 A JPH09502161 A JP H09502161A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- drug
- tissue sealant
- supplemented
- fibrin glue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0042—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.組織シーラントおよび薬物とからなることを特徴とする組成物。 2.充実肥厚皮膚の傷治療を抑制しない請求項1の組成物。 3.該組織シーラントがフィブリン膠である請求項1または2の組成物。 4.組織シーラントおよび薬物とからなることを特徴とする薬物の局所放出を促 進する組成物。 5.該薬物が固体である請求項5の組成物。 6.該固体が該薬物の水難溶性形である請求項5の組成物。 7.該薬物が抗生物質である請求項4、5または6の組成物。 8.該薬物がテトラサイクリン遊離塩基である請求項4、5、6または7の組成 物。 9.該抗生物質がテトラサイクリン塩酸塩である請求項7の組成物。 10.該抗生物質がシプロフロキサシン塩酸塩である請求項7の組成物。 11.該薬物が抗増殖剤である請求項4の組成物。 12.該薬物が5−フルオロウラシルである請求項4、5または11の組成物。 13.該組織シーラントがフィブリン膠である請求項4、5、6または11の組 成物。 14.該組織シーラントがフィブリン膠である請求項7の組成物。 15.該組織シーラントがフィブリン膠である請求項8の組成物。 16.該組織シーラントがフィブリン膠である請求項9の組成物。 17.該組織シーラントがフィブリン膠である請求項10の組成物。 18.該組織シーラントがフィブリン膠である請求項12の組成物。 19.組織シーラントおよび薬物からなる組成物を組織に適用することを特徴と する薬物を組織へ局所放出する方法。 20.該組成物が請求項4、5、6または11のいずれかの組成物である請求項 19の方法。 21.該組成物が請求項7の組成物である請求項19の方法。 22.該組成物が請求項8の組成物である請求項19の方法。 23.該組成物が請求項9の組成物である請求項19の方法。 24.該組成物が請求項10の組成物である請求項19の方法。 25.該組成物が請求項12の組成物である請求項19の方法。 26.該組成物が請求項13の組成物である請求項19の方法。 27.該組成物が請求項14の組成物である請求項19の方法。 28.該組成物が請求項15の組成物である請求項19の方法。 29.該組成物が請求項16の組成物である請求項19の方法。 30.該組成物が請求項17の組成物である請求項19の方法。 31.該組成物が請求項18の組成物である請求項19の方法。 32.組織シーラントおよびその寿命をさらに延長するのに有効な量の補薬を含 む、延長された寿命を有する補薬添加組織シーラントからなる組成物。 33.該寿命がインビトロで延長される請求項32の組成物。 34.該補薬が固体である請求項32の組成物。 35.該固体が該薬物の水難溶性形である請求項34の組成物。 36.該補薬がテトラサイクリン遊離塩基である請求項32、33、34または 35の組成物。 37.該補薬がシプロフロキサシン塩酸塩である請求項32、33、34または 35の組成物。 38.該組織シーラントがフィブリン膠である請求項32、33、34または3 5の組成物。 39.該組織シーラントがフィブリン膠である請求項36の組成物。 40.該組織シーラントがフィブリン膠である請求項37の組成物。 41.組織シーラントを含む自給式組織シーラント傷用医療材料。 42.成長因子をさらに含む請求項41の傷用医療材料。 43.該成長因子が線維芽細胞成長因子である請求項41の傷用医療材料。 44.薬物をさらに含む請求項41の傷用医療材料。 45.該薬物が抗生物質である請求項44の傷用医療材料。 46.該薬物が鎮痛剤である請求項44の傷用医療材料。 47.該組織シーラントがフィブリン膠である請求項41、42、43、44、 45または46の傷用医療材料。 48.薬物を補充した組織シーラントの製造法。 49.該組織シーラント(TS)が固定する前に該TSと薬物を混合する請求項 48の方法。 50.該薬物が固体である請求項48または49の方法。 51.該固体が該薬物の水難溶性形である請求項50の方法。 52.該薬物がテトラサイクリン遊離塩基である請求項48、49、50または 51の方法。 53.該薬物がシプロフロキサシン塩酸塩である請求項48、49、50または 51の方法。 54.該薬物が5−フルオロウラシルである請求項48、49、50または51 の方法。 55.該組織シーラントがフィブリン膠である請求項48または49の方法。 56.該組織シーラントがフィブリン膠である請求項50の方法。 57.該組織シーラントがフィブリン膠である請求項51の方法。 58.該組織シーラントがフィブリン膠である請求項52の方法。 59.該組織シーラントがフィブリン膠である請求項53の方法。 60.該組織シーラントがフィブリン膠である請求項54の方法。 61.その混合物を固定する前に該薬物をフィブリノーゲン濃厚物、トロンビン および塩化カルシウムと混合する請求項55の方法。 62.該組織シーラントを該薬物を含有する溶液に浸漬する請求項48の方法。 63.組織シーラントおよび薬物からなる組成物を生体物質に適用することを特 徴とする生体物質の表面を被覆する方法。 64.該薬物が抗生物質である請求項63の方法。 65.該組成物がさらに細胞を含む請求項63の方法。 66.該細胞が内皮細胞、骨芽細胞または線維芽細胞である請求項65の方法。 67.該生体物質が整形外科用具または人工血管である請求項63の方法。 68.該組織シーラントがフィブリン膠である請求項63、64、65、66ま たは67の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US3116493A | 1993-03-12 | 1993-03-12 | |
US08/031,164 | 1993-03-12 | ||
PCT/US1994/002708 WO1994020133A1 (en) | 1993-03-12 | 1994-03-14 | Supplemented and unsupplemented tissue sealants, methods of their production and use |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2006178637A Division JP2006297130A (ja) | 1993-03-12 | 2006-06-28 | 補足された及び補足されていない組織シーラント、その製造法及び使用法 |
Publications (1)
Publication Number | Publication Date |
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JPH09502161A true JPH09502161A (ja) | 1997-03-04 |
Family
ID=21857957
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6520353A Withdrawn JPH09502161A (ja) | 1993-03-12 | 1994-03-14 | 補足された及び補足されていない組織シーラント、その製造法及び使用法 |
JP2006178637A Pending JP2006297130A (ja) | 1993-03-12 | 2006-06-28 | 補足された及び補足されていない組織シーラント、その製造法及び使用法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006178637A Pending JP2006297130A (ja) | 1993-03-12 | 2006-06-28 | 補足された及び補足されていない組織シーラント、その製造法及び使用法 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0696201B2 (ja) |
JP (2) | JPH09502161A (ja) |
AT (1) | ATE271882T1 (ja) |
AU (1) | AU696691C (ja) |
CA (1) | CA2158134C (ja) |
DE (1) | DE69433920T2 (ja) |
ES (1) | ES2225828T3 (ja) |
WO (1) | WO1994020133A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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AU1432292A (en) * | 1991-02-07 | 1992-09-07 | Lawrence Samuel Bass | Drug delivery composition and method of using the same |
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1994
- 1994-03-14 CA CA2158134A patent/CA2158134C/en not_active Expired - Fee Related
- 1994-03-14 EP EP94910927A patent/EP0696201B2/en not_active Expired - Lifetime
- 1994-03-14 JP JP6520353A patent/JPH09502161A/ja not_active Withdrawn
- 1994-03-14 WO PCT/US1994/002708 patent/WO1994020133A1/en active IP Right Grant
- 1994-03-14 AT AT94910927T patent/ATE271882T1/de not_active IP Right Cessation
- 1994-03-14 DE DE69433920T patent/DE69433920T2/de not_active Expired - Lifetime
- 1994-03-14 ES ES94910927T patent/ES2225828T3/es not_active Expired - Lifetime
- 1994-03-14 AU AU63648/94A patent/AU696691C/en not_active Ceased
-
2006
- 2006-06-28 JP JP2006178637A patent/JP2006297130A/ja active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009131649A (ja) * | 1997-03-20 | 2009-06-18 | Stryker Corp | 骨の修復のための骨形成デバイスおよびその使用 |
JP2012161635A (ja) * | 1997-03-20 | 2012-08-30 | Stryker Corp | 骨の修復のための骨形成デバイスおよびその使用 |
JP2003500172A (ja) * | 1999-06-01 | 2003-01-07 | ブリストル−マイヤーズ スクイブ カンパニー | フィブリンポリマー構造体 |
Also Published As
Publication number | Publication date |
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AU696691C (en) | 2003-09-18 |
EP0696201B1 (en) | 2004-07-28 |
EP0696201A1 (en) | 1996-02-14 |
CA2158134C (en) | 2010-05-04 |
DE69433920D1 (de) | 2004-09-02 |
EP0696201A4 (en) | 1996-06-26 |
WO1994020133A1 (en) | 1994-09-15 |
ATE271882T1 (de) | 2004-08-15 |
JP2006297130A (ja) | 2006-11-02 |
EP0696201B2 (en) | 2012-09-19 |
DE69433920T2 (de) | 2005-06-02 |
ES2225828T3 (es) | 2005-03-16 |
AU6364894A (en) | 1994-09-26 |
AU696691B2 (en) | 1998-09-17 |
CA2158134A1 (en) | 1994-09-15 |
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