JPH0665087A - Antipruritic for external use - Google Patents
Antipruritic for external useInfo
- Publication number
- JPH0665087A JPH0665087A JP4215296A JP21529692A JPH0665087A JP H0665087 A JPH0665087 A JP H0665087A JP 4215296 A JP4215296 A JP 4215296A JP 21529692 A JP21529692 A JP 21529692A JP H0665087 A JPH0665087 A JP H0665087A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- alcohol
- water
- dried
- antipruritic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は生薬抽出物等を有効成分
とする外用止痒剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antipruritic agent for external use containing a crude drug extract or the like as an active ingredient.
【０００２】[0002]
【従来の技術】従来から生薬抽出物が種々の薬効を有す
ることが知られている。その中で、茵陳蒿はキク科のカ
ハラヨモギの若い茎葉を乾燥したものであり、古くから
東洋医学では、内服して、胆汁分泌増加作用、肝臓細胞
の再生促進作用、利尿作用、殺菌作用および降血圧作用
を有することが知られており、黄胆、肝炎、水分代謝異
常および高血圧の改善等に頻用されてきた生薬である。
成分としてはクマリン化合物であるスコパロン、β−ピ
ネン、カピロンおよびカピリン等を含む精油類、クロロ
ゲン酸、カフェー酸、脂肪酸、多糖類およびタンニン質
などの存在が知られている。2. Description of the Related Art It has been known that crude drug extracts have various medicinal effects. Among them, 茵 蒿 is a dried young stem and leaf of Asteraceae Kahala mugwort, which has long been taken in oriental medicine to increase bile secretion, promote liver cell regeneration, diuretic, bactericidal and It is known to have a hypotensive effect, and is a crude drug that has been frequently used for improving yellow gall, hepatitis, water metabolism abnormality, hypertension and the like.
As components, it is known that essential oils including coumarin compounds such as scoparone, β-pinene, capilone and capilin, chlorogenic acid, caffeic acid, fatty acids, polysaccharides and tannins are present.
【０００３】米糠多糖類は、米糠中に含まれる多糖類で
あり水に良く溶け、アルコール、エーテルおよびベンゼ
ンに不溶の淡褐色〜白色の粉末である。米糠の荒れ肌改
善および保水作用は本多糖類が大きく寄与している。こ
れについては、特開昭64−66106号公報「化粧料」に詳
記されている。また、上記特開昭64−66106号公報には
米糠多糖類の抽出方法も記載されている。Rice bran polysaccharide is a polysaccharide contained in rice bran, which is a light brown to white powder which is well soluble in water and insoluble in alcohol, ether and benzene. This polysaccharide contributes greatly to the improvement of the rough skin and water retention of rice bran. This is described in detail in JP-A-64-66106, "Cosmetic". Further, Japanese Patent Laid-Open No. 64-66106 also describes a method for extracting rice bran polysaccharide.
【０００４】鯉魚油は、その組成脂肪酸としてリノレン
酸、リノール酸、イコサペンタエン酸（ＥＰＡ）、ドコ
サヘキサエン酸（ＤＨＡ）などのフリーラジカルを抑制
する抗酸化作用をもつ不飽和脂肪酸が多く、皮膚細胞の
損傷の改善に寄与するものと考えられている。Carp fish oil contains a large amount of unsaturated fatty acids, such as linolenic acid, linoleic acid, icosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which have antioxidative action as free fatty acids, and damages skin cells. It is believed to contribute to the improvement of
【０００５】[0005]
【発明が解決しようとする課題】現在、アトピー性皮膚
炎、老人性皮膚掻痒症等の皮膚の痒みによって愁訴をう
ったえる患者が激増しており、副作用のない適確な止痒
剤の開発が望まれている。At present, the number of patients who have complaints due to itching of the skin such as atopic dermatitis and pruritus senile is increasing rapidly, and development of a proper antipruritic drug without side effects is desired. It is rare.
【０００６】[0006]
【課題を解決するための手段】痒みの原因の１つとし
て、皮膚表皮の保水性が失われ、皮膚が乾燥して外温変
化が刺激として鋭敏に感じられることが挙げられる。特
に老人性掻痒症の痒みの大半は皮膚乾燥によってもたら
されるといわれている。本発明者らは、アルコール可溶
部を除去して製した茵陳蒿水性エキスが強い保水性を有
することを見いだした。Means for Solving the Problems One of the causes of itch is that water retention of the epidermis of the skin is lost, the skin is dried, and a change in external temperature is sensibly sensed as a stimulus. It is said that most of the pruritus in senile pruritus is caused by dry skin. The inventors of the present invention have found out that the water-soluble linseed liquor extract produced by removing the alcohol-soluble portion has strong water retention.
【０００７】また、茵陳蒿のアルコール可溶部除去水性
エキス、米糠多糖類、鯉より分離した鯉魚油、及びハッ
カより得られるｌ−メントールを一定割合に配合した外
用剤がすぐれた止痒作用を示すことを見出し、さらに老
化により皮脂や汗の分泌が衰え、皮脂欠乏症や乾燥肌と
なり、寒気や冷気の刺激を鋭敏に受け易くなって生ずる
老人性皮膚掻痒症に対しては、茵陳蒿のアルコール可溶
部除去水性エキスのみ配合した外用剤で止痒効果のある
ことを見いだした。[0007] Further, an external preparation containing a certain proportion of an aqueous extract for removing the alcohol-soluble part of Acacia catechu, rice bran polysaccharide, carp fish oil separated from carp, and l-menthol obtained from peppermint has an excellent antipruritic effect. It is found that the secretion of sebum and sweat decreases due to aging, resulting in sebum deficiency and dry skin, and senile cutaneous pruritus caused by acute sensitivity to cold and cold air stimuli. It was found that the external preparation containing only the alcohol-soluble part-removing aqueous extract of (1) has an antipruritic effect.
【０００８】米糠多糖類を皮膚の掻痒治癒に用いるのは
本発明が最初であり、鯉魚油を掻痒止めの外用剤に用い
るのも本発明が最初である。本発明によれば、茵陳蒿の
アルコール可溶部除去水性エキスを有効成分とする外用
止痒剤が提供される。また、本発明によれば、茵陳蒿の
アルコール可溶部除去水性エキスを0.01〜5.0重量％、
望ましくは0.1〜2.0重量％配合し、米糠多糖類を0.01〜
3.0重量％、望ましくは0.1〜2.0重量％配合し、鯉魚油
を0.005〜3.0重量％、望ましくは0.1〜2.0重量％配合
し、ｌ−メントールを0.005〜2.0重量％、望ましくは0.
01〜1.0重量％配合する外用止痒剤が提供される。The present invention is the first time that rice bran polysaccharide is used for healing pruritus of the skin, and that the first time that carp fish oil is used as an external preparation for itching prevention. ADVANTAGE OF THE INVENTION According to this invention, the antipruritic agent for external use which uses the alcohol-soluble part removal aqueous extract of Boehmella radix as an active ingredient is provided. Further, according to the present invention, 0.01-5.0% by weight of the alcohol-soluble part-removing aqueous extract of Amaranthus linden,
Desirably, 0.1 to 2.0% by weight is added, and rice bran polysaccharide is added to 0.01 to
3.0 wt%, preferably 0.1-2.0 wt%, carp fish oil 0.005-3.0 wt%, preferably 0.1-2.0 wt%, l-menthol 0.005-2.0 wt%, preferably 0.
An antipruritic agent for external use is provided which is blended in an amount of 01 to 1.0% by weight.
【０００９】本発明の外用止痒剤は常法に従って、軟膏
剤、硬膏剤、液剤（酒精剤、チンキ剤、ローション剤等
を含む）、湿布剤（パップ剤、パスター剤）、塗布剤、
噴霧剤、散布剤、リニメント剤（塗擦剤）、クリーム
剤、乳剤、溶湯剤等の剤形とすることができる。用いる
賦形剤等の他の成分は当該分野で公知のものでよく、一
回の投与もしくは使用量に必要な本発明の物質を含むよ
うに製剤化するのが望ましい。The external antipruritic agent of the present invention is, according to a conventional method, an ointment, a plaster, a liquid (including an alcoholic beverage, a tincture, a lotion, etc.), a poultice (a patch, a paste), a coating agent,
It may be in the form of a spray, a spray, a liniment (rubbing agent), a cream, an emulsion, a melt, or the like. Other components such as an excipient to be used may be known in the art, and it is desirable to formulate them so as to contain the substance of the present invention required for single administration or dose.
【００１０】本発明に使用される茵陳蒿のアルコール可
溶部除去水性エキスは、以下の方法で製造することがで
きる。細切した茵陳蒿に水を加え、熱抽出を繰り返して
濾過し、その濾液を50°以下で減圧濃縮し、その濃縮液
を噴霧乾燥することによって茵陳蒿乾燥エキスを得る。
得られる茵陳蒿乾燥エキスは褐色の粉末で、わずかにに
おいがあり味は苦い性状を有する。The alcoholic soluble portion-removing aqueous extract of Amaranthus chinensis used in the present invention can be produced by the following method. Water is added to the finely chopped Amaranthus chinensis, hot extraction is repeated and filtered, the filtrate is concentrated under reduced pressure at 50 ° or lower, and the concentrated liquid is spray-dried to obtain a dried Amaranthus lindenum extract.
The dried extract of Amaranthus chinensis is a brown powder, has a slight odor, and has a bitter taste.
【００１１】この茵陳蒿乾燥エキスを水に溶解し、ｎ−
ブタノールを加えて攪拌後静置して分離した下層の水層
を分取する。この水層に更にｎ−ブタノールを加えて同
操作を繰り返し、アルコール可溶部分を除去した後、水
層部分を噴霧乾燥して茵陳蒿のアルコール可溶部除去水
性エキスを得る。また、茵陳蒿のアルコール可溶部除去
水性エキスは、茵陳蒿乾燥エキスを水に溶解して、エタ
ノール中に攪拌しながら少量ずつ注入し、折出する沈殿
を濾取した後、乾燥することによっても得ることが出来
る。[0011] This dried extract of Amaranthus chinensis was dissolved in water and n-
Butanol is added, and the mixture is stirred and then left to stand to separate the lower aqueous layer. The same operation is repeated by further adding n-butanol to this aqueous layer to remove the alcohol-soluble portion, and then the aqueous layer portion is spray-dried to obtain the alcohol-soluble portion-removed aqueous extract of Amaranthus chinensis. In addition, the alcohol-soluble part-removing aqueous extract of Amaranthus chinensis is prepared by dissolving a dried extract of Amaranthus chinensis in water, injecting it little by little into ethanol with stirring, filtering the resulting precipitate, and then drying. It can also be obtained by
【００１２】こうして得られた茵陳蒿のアルコール可溶
部除去水性エキスは、淡褐色の粉末で水に可溶、メタノ
ールやエタノールなどのアルコールおよびアセトンに溶
けにくく、ベンゼン、エーテルおよびクロロホルムなど
に不溶である。上記エキスの水溶液は硫酸銅、酢酸銅な
どの水溶液を加えると多量の沈殿を生ずる。また、フェ
ノール・硫酸法、アンスロン・硫酸法、クロモトロプ酸
・硫酸法およびカルバゾール・硫酸法においていずれも
陽性を示し、多糖類が多量含まれていることを確認して
いる。The thus obtained water-soluble extract for removing the alcohol-soluble portion of Amaranthus chinensis is a light brown powder which is soluble in water, hardly soluble in alcohol such as methanol and ethanol and acetone, and insoluble in benzene, ether and chloroform. Is. An aqueous solution of the above extract causes a large amount of precipitation when an aqueous solution of copper sulfate, copper acetate or the like is added. In addition, the phenol / sulfuric acid method, the anthrone / sulfuric acid method, the chromotropic acid / sulfuric acid method and the carbazole / sulfuric acid method all showed positive results, confirming that they contained a large amount of polysaccharides.
【００１３】本発明で使用される鯉魚油については、鯉
魚を水あるいは低濃度のエタノールで熱抽出して濾過し
た後、分離した鯉魚の油脂分を採取することによって製
造することができる。 こうして得られた鯉魚油は特有
の臭気を有する淡褐色の液である。次に本発明では、米
糠多糖類としては、特開昭64−66106号公報に記載の方
法に従って抽出したものを使用し、ｌ−メントールとし
ては、日本薬局方ｌ−メントールを使用することができ
る。The carp fish oil used in the present invention can be produced by hot-extracting carp fish with water or low-concentration ethanol, filtering and then collecting the separated oil and fat of carp fish. The carp fish oil thus obtained is a light brown liquid having a peculiar odor. Next, in the present invention, as the rice bran polysaccharide, one extracted according to the method described in JP-A No. 64-66106 can be used, and as l-menthol, Japanese Pharmacopoeia l-menthol can be used. .
【００１４】[0014]
製造例１．（茵陳蒿のアルコール可溶部除去水性エキス
の製造） 茵陳蒿６kgを細切し、水20ｌを加え、２時間煮沸抽出し
た。この操作を２回繰り返して濾過し、その濾液を50℃
以下で10ｌになるまで減圧濃縮した。その濃縮液を噴霧
乾燥により乾燥して茵陳蒿乾燥エキス1.05kgを得た（収
量17.5％）。本品は褐色の粉末でわずかににおいがあ
り、味は苦い性状を有していた。この茵陳蒿乾燥エキス
500ｇを水３ｌに溶解し、ｎ−ブタノール３ｌを加えて
よく攪拌し、静置して分離した下層の水層を分取した。
この水層に更にｎ−ブタノール３ｌを加えて同操作を繰
り返し、アルコール可溶部分を除去した。水層部分を噴
霧乾燥に付し260ｇの茵陳蒿のアルコール可溶部除去水
性エキスを得た（生薬より収量8.66％）。Production Example 1. (Production of Alcohol-Soluble Part-Removing Aqueous Extract of Amaranthus flavum) 6 kg of Amaranthus flavum was cut into small pieces, 20 l of water was added, and the mixture was boiled and extracted for 2 hours. Repeat this operation twice to filter, and filter the filtrate at 50 ℃.
It was concentrated under reduced pressure until the volume became 10 l. The concentrated liquid was dried by spray drying to obtain 1.05 kg of dried linseed extract (yield 17.5%). This product was a brown powder with a slight odor and had a bitter taste. This dried linseed extract
500 g was dissolved in 3 liters of water, 3 liters of n-butanol was added, well stirred, and left to stand to separate the lower aqueous layer.
3 l of n-butanol was further added to this aqueous layer and the same operation was repeated to remove the alcohol-soluble portion. The water layer portion was subjected to spray drying to obtain 260 g of an alcohol-soluble portion-removed aqueous extract of Amaranthus chinensis (yield 8.66% from crude drug).
【００１５】また、茵陳蒿乾燥エキス500ｇを水2.5ｌに
溶解し、エタノール25ｌ中に攪拌しながら少量づつ注入
した。折出する沈殿を濾取して乾燥することにより215
ｇ（収量7.17％）の茵陳蒿のアルコール可溶部除去水性
エキスを得た。得られた茵陳蒿のアルコール可溶部除去
水性エキスは、淡褐色の粉末で水に可溶、メタノール、
エタノールおよびアセトンに溶けにくく、ベンゼン、エ
ーテルおよびクロロホルムに不溶であった。本品の水溶
液に硫酸銅、酢酸銅などの水溶液を加えると多量の沈殿
を生じた。また、フェノール・硫酸法、アンスロン・硫
酸法、クロモトロプ酸・硫酸法、カルバゾール・硫酸法
においていずれも陽性反応を示し、多糖類が多量含まれ
ていることを確認した。Further, 500 g of the dried extract of Amaranthus chinensis was dissolved in 2.5 l of water and poured into 25 l of ethanol little by little while stirring. 215
Thus, g (yield: 7.17%) of an aqueous extract from which the alcohol-soluble portion was removed was obtained. The alcohol-soluble part-removing aqueous extract of Amaranthus chinensis obtained is a light brown powder soluble in water, methanol,
It was insoluble in ethanol and acetone and insoluble in benzene, ether and chloroform. A large amount of precipitate was produced when an aqueous solution of copper sulfate, copper acetate, etc. was added to the aqueous solution of this product. In addition, the phenol / sulfuric acid method, the anthuron / sulfuric acid method, the chromotropic acid / sulfuric acid method, and the carbazole / sulfuric acid method all showed a positive reaction, confirming that a large amount of polysaccharide was contained.
【００１６】製造例２．（鯉魚油の製造方法） ブツ切りにした黒鯉1.5kgに、防腐と塩折の目的で15％
しょ糖水溶液４ｌを加え、還流冷却器を付して約８時間
加熱し、一昼夜放置して、上部に分離した油分を採取
し、圧搾濾過して鯉魚油15g（収量３％）を得た。こう
して得られた鯉魚油は特有の臭気を有する淡褐色の液
で、次の如き組成を有した。Manufacturing Example 2. (Method of producing carp fish oil) 1.5kg of chopped black carp is 15% for the purpose of preservation and salt folding.
4 l of a sucrose aqueous solution was added, the mixture was heated with a reflux condenser for about 8 hours, left to stand for a whole day and night, and the oil separated at the top was collected and squeezed and filtered to obtain 15 g of carp fish oil (yield 3%). The carp fish oil thus obtained was a light brown liquid having a peculiar odor and had the following composition.
【００１７】 酸価 1.7 ケン化価 191.8 ヨウ素価 114.6 不ケン化物(％) 1.7 又、脂肪酸ガスクロマトグラフィーで分析すると、次の
如き組成を有した。Acid value 1.7 Saponification value 191.8 Iodine value 114.6 Unsaponifiable matter (%) 1.7 Further, when analyzed by fatty acid gas chromatography, it had the following composition.
【００１８】分析法 ａ）メチルエステルの調整 基準油脂分析試験法２・４・10−71によりケン化し、不
ケン化物を除去後、 脂肪酸とし規準油脂分析試験
法２・４・20−71Iによりメチルエステル化した。Analytical method a) Preparation of methyl ester After saponification according to standard oil / fat analysis test method 2.4 / 10-71 and removal of unsaponifiable matter, it is converted to fatty acid and methyl according to standard oil / fat analysis test method 2.4 / 20-71I. Esterified.
【００１９】ｂ）ガスクロマトグラフの条件 カラム：２ｍ×３mm：20％ＤＥＧＳ クロモソルブ ＷＡＷ 60〜80メッシュ 温 度；注入口250℃； カラム 210℃ 検出器；ＦＩＤB) Gas chromatograph conditions Column: 2 m x 3 mm: 20% DEGS Chromosolv WAW 60-80 mesh Temperature; Inlet 250 ° C; Column 210 ° C Detector; FID
【００２０】[0020]
【表１】 [Table 1]
【００２１】保水試験１ 製造例１の方法により製造された茵陳蒿のアルコール可
溶部除去水性エキスを用いて、その保水効果を、通常老
人性掻痒症を改善する外用薬や化粧品に保水剤として頻
用されている尿素の保水効果と比較した。 （１）実施方法 茵陳蒿のアルコール可溶部除去水性エキスの５％水溶液
および尿素の５％水溶液を作成し、コントロールとして
は水のみを用い、この中にそれぞれヒトの足より剥離し
た角層を厚さ0.5mm、直径10mmの錠剤にプレスしたもの
を15分間浸漬した。そして1被検体試料当り角質錠は５
個を使用した。次にそれぞれの角層を取り出し、20℃で
93％の相対湿度下に放置し、５日後の角質100mg当りの
残存水分保持量を測定し、1試料当り５個の平均値を算
出し、各試料の保水性の比較を行った。結果を表２に表
す。Water Retention Test 1 Using the water-soluble extract for removing the alcohol-soluble portion of Amaranthus chinensis produced by the method of Production Example 1, its water-retaining effect is usually applied to external medicines and cosmetics for improving senile pruritus. The water retention effect of urea, which is frequently used as (1) Method of Implementation A 5% aqueous solution of an alcohol-soluble part-removing aqueous extract and a 5% aqueous solution of urea of Acacia catechu were prepared, and only water was used as a control, in which the stratum corneum exfoliated from the human foot. Tablets having a thickness of 0.5 mm and a diameter of 10 mm were pressed and soaked for 15 minutes. And there are 5 keratin tablets per sample.
Used pieces. Next, remove each stratum corneum and at 20 ℃
The sample was allowed to stand under a relative humidity of 93%, the residual water retention amount per 100 mg of keratin after 5 days was measured, and an average value of 5 samples was calculated to compare the water retention of each sample. The results are shown in Table 2.
【００２２】[0022]
【表２】 上記の結果より茵陳蒿のアルコール可溶部除去水性エキ
スはコントロールに比し水分保持量がはるかに高く、保
水作用をもつことは明らかであり、その強さは従来保水
剤として繁用されてきた尿素と同等の効力をもつものと
考えられる。しかも尿素のように、基剤中で分解し、変
色、悪臭をもたらすことのない利点を有する。[Table 2] From the above results, it is clear that the water-soluble extract that removes the alcohol-soluble portion of Amaranthus chinensis has a much higher water retention capacity than the control and has a water retention effect, and its strength has been conventionally used as a water retention agent. It is considered to have the same potency as urea. Moreover, unlike urea, it has the advantage that it does not decompose in the base material and does not cause discoloration or odor.
【００２３】 製剤例１（軟膏） 茵陳蒿のアルコール可溶部除去水性エキス 0.5％ 米糠多糖類 0.3％ 鯉魚油 0.4％ ｌ−メントール 0.2％ 日本薬局方親水軟膏 98.8％ 日本薬局方親水軟膏を加熱溶融し、これに所定量の茵陳
蒿のアルコール可溶部除去水性エキス、米糠多糖類、ｌ
−メントールの微粉末および鯉魚油をよくかきまぜなが
ら加え、軟膏が固化するまで攪拌を続けることによって
製する。Formulation Example 1 (Ointment) Alcohol-soluble portion-removing aqueous extract of Amaranthus linden 0.5% Rice bran polysaccharide 0.3% Carp fish oil 0.4% 1-menthol 0.2% Japanese Pharmacopoeia hydrophilic ointment 98.8% Japanese Pharmacopoeia hydrophilic ointment heated Melt and add a predetermined amount of water-soluble extract for removing alcohol-soluble part of Amaranthus flavum, rice bran polysaccharide, l
-Menthol fine powder and carp fish oil are added with good agitation, and stirring is continued until the ointment solidifies.
【００２４】 製剤例２（ローション液剤） 茵陳蒿のアルコール可溶部除去水性エキス 0.5％ 米糠多糖類 0.3％ 鯉魚油 0.005％ ｌ−メントール 0.012％ エタノール 15.0％ 蒸留水 84.183％ 所定量のｌ−メントールおよび鯉魚油を所定量のエタノ
ールに溶解し、それを所定量の茵陳蒿のアルコール可溶
部除去水性エキスおよび米糠多糖類を溶解した蒸留水の
中にはげしく攪拌しながら加えることによって製する。Formulation Example 2 (lotion solution) Alcohol-soluble part-removing aqueous extract of Amaranthus linden 0.5% Rice bran polysaccharide 0.3% Carp fish oil 0.005% 1-menthol 0.012% Ethanol 15.0% Distilled water 84.183% Predetermined amount of 1-menthol And carp fish oil are dissolved in a predetermined amount of ethanol, and the solution is added to distilled water in which a predetermined amount of the water-soluble extract for removing the alcohol-soluble portion and the rice bran polysaccharide are dissolved with vigorous stirring.
【００２５】 製剤例３（軟膏剤） 茵陳蒿のアルコール可溶部除去水性エキス 1.0％ 米糠多糖類 0.3％ 鯉魚油 0.3％ ｌ−メントール 0.2％ 日本薬局方親水軟膏 98.2％Formulation Example 3 (Ointment) Alcohol-soluble part-removing aqueous extract of Amaranthus linden 1.0% Rice bran polysaccharide 0.3% Carp fish oil 0.3% l-menthol 0.2% Japanese Pharmacopoeia hydrophilic ointment 98.2%
【００２６】臨床試験１ （１）対象および実施方法 アトピー性皮膚炎と診断されたアレルギー患者中、アレ
ルギー改善の漢方薬を服用し、外用に非ステロイド系消
炎剤（アンダークリーム）もしくは抗真菌剤（エンペシ
ドクリーム）を混合塗布しても痒みの止まらない重症の
小児および成人89名に、毎日就寝前および有症時に掻痒
部に製剤例３の軟膏を５週間連続塗布し、止痒効果を検
討した。 （２）効果の判定方法 各症状ごとに、下記に示す4段階の評価基準を作り、試
験前の症状と試験終了後の症状を比較して、３段階以上
改善効果のあったものを著効、２段階改善効果のあった
ものを有効、１段階改善効果のあったものをやや有効、
不変のものを無効、悪化したものを悪化として判定し
た。Clinical trial 1 (1) Subjects and method of administration Among allergic patients diagnosed with atopic dermatitis, Chinese herbs for allergy improvement were taken, and non-steroidal anti-inflammatory drug (under cream) or antifungal agent (empeside) was applied externally. The ointment of Formulation Example 3 was continuously applied for 5 weeks to the pruritus area before going to bed and at the time of illness to 89 severely ill children and adults whose itching did not stop even after mixed application of cream), and the antipruritic effect was examined. (2) How to judge the effect For each symptom, make the following four-step evaluation criteria, compare the symptom before the test and the symptom after the test, and the one with an improvement effect of 3 or more is markedly effective. Those with a two-step improvement effect are effective, those with a one-step improvement effect are slightly effective,
Invariant was judged as invalid, and deteriorated as bad.
【００２７】 ４：絶えず強い掻痒感があり痒さで夜中も目がさめる ３：掻痒感が強く寝つきにくい ２：掻痒感はあるが寝つきはよい １：掻痒感が全くない （３）治療効果4: There is always a strong itching sensation and itching wakes up during the night. 3: Itching is strong and it is difficult to fall asleep. 2: Itching is good but sleeping is good. 1: There is no itching (3) Therapeutic effect
【００２８】[0028]
【表３】 表３に示されているように被験者89名中、著効８例（９
％）、有効17例（19％）、やや有効37例（42％）を示
し、これらを合して62例（70％）の患者に有効であっ
た。投薬対象の被験者がアレルギー治療の漢方薬を内服
し、非ステロイド系消炎剤もしくは抗真菌剤を塗布した
後でも効果が得られず、まだ寝られないという強い掻痒
をもつ重症の患者であることを考えると、70％に達する
止痒効果は高い治療効果を示すものといえる。[Table 3] As shown in Table 3, out of 89 subjects, 8 excellent responses (9
%), Effective 17 cases (19%), and moderately effective case 37 (42%), which were effective in 62 cases (70%). Consider that the subject to be treated is a severely ill patient with strong pruritus that cannot take any effect even after taking a Chinese herbal medicine for allergy treatment and applying a non-steroidal anti-inflammatory drug or an antifungal drug, and still cannot sleep. Therefore, it can be said that the antipruritic effect reaching 70% shows a high therapeutic effect.
【００２９】臨床試験２ （１）対象及び方法 老人性皮膚掻痒症と診断された患者中、絶えず強い掻痒
感があり、痒さで夜中も目がさめる重症の患者20名につ
き、茵陳蒿のアルコール可溶部除去水性エキスを日本薬
局方親水軟膏に３％配合して製造した、３％茵陳蒿のア
ルコール可溶部除去水性エキス配合親水軟膏を毎日就寝
前及び有症時に掻痒部に使用して、４週間連続塗布し、
止痒効果を検討した。Clinical Study 2 (1) Subjects and Methods Among the patients diagnosed with pruritus senile senile, 20 of the severely ill patients who have a persistently strong itching sensation and awaken with itching even in the middle of the night. 3% of the Japanese Pharmacopoeia hydrophilic ointment containing 3% aqueous alcohol extract for removing alcohol soluble parts was used for pruritus every day before bedtime and when having symptoms. Then, apply continuously for 4 weeks,
The antipruritic effect was examined.
【００３０】（２）効果の判定方法 臨床試験１と同様の４段階評価基準および判定方法に従
って、使用前の症状と試験終了後の症状とを比較した。 （３）治療効果(2) Judgment Method of Effect According to the same four-stage evaluation criteria and judgment method as in the clinical test 1, the symptoms before use and the symptoms after the test were compared. (3) Treatment effect
【００３１】[0031]
【表４】 表４に示されているように老人性掻痒症の被験者20名
中、著効2例（10％)、有効４例（20％）、やや有効5例
（25％）を示し、これらを合して重症の老人性皮膚掻痒
に対して11例（55％）の患者に有効であった。この結果
は、茵陳蒿のアルコール可溶部除去水性エキスが老人性
掻痒症の改善に明らかに有効であることを示している。[Table 4] As shown in Table 4, out of 20 subjects with pruritus senilis, excellent response was obtained in 2 cases (10%), effective in 4 cases (20%), and slightly effective in 5 cases (25%). It was effective in 11 (55%) patients with severe pruritus senile. This result shows that the alcohol-soluble part-removing aqueous extract of Amaranthus chinensis is obviously effective in improving senile pruritus.
Claims (2)
溶部除去水性エキスを有効成分として含有することを特
徴とする外用止痒剤。1. An antipruritic agent for external use, which comprises an alcohol-soluble part-removing aqueous extract of Chinese mackerel as an active ingredient.
ス0.01〜5.0重量％、米糠多糖類0.01〜3.0重量％、鯉魚
油0.005〜3.0重量％およびｌ−メントール0.005〜2.0重
量％を有効成分として含有することを特徴とする外用止
痒剤。2. An active ingredient comprising 0.01 to 5.0% by weight of an alcohol-soluble part-removing aqueous extract of Amaranthus chinensis, 0.01 to 3.0% by weight of rice bran polysaccharide, 0.005 to 3.0% by weight of carp fish oil and 0.005 to 2.0% by weight of l-menthol. An antipruritic agent for external use characterized by being contained as.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21529692A JP3442093B2 (en) | 1992-08-12 | 1992-08-12 | Topical antipruritic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21529692A JP3442093B2 (en) | 1992-08-12 | 1992-08-12 | Topical antipruritic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0665087A true JPH0665087A (en) | 1994-03-08 |
| JP3442093B2 JP3442093B2 (en) | 2003-09-02 |
Family
ID=16669976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21529692A Expired - Lifetime JP3442093B2 (en) | 1992-08-12 | 1992-08-12 | Topical antipruritic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3442093B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0813875A2 (en) * | 1996-06-19 | 1997-12-29 | Institute For Advanced Skin Research Inc. | Inhibition of abnormal accumulation of extracellular matrices |
| KR100377262B1 (en) * | 2000-11-06 | 2003-03-26 | 애경산업(주) | Cosmetic composition fot atopic skin containing artemisia extract |
| EP2042167A1 (en) * | 2007-09-26 | 2009-04-01 | Aisa Therapeutics | Use of a monoterpene to induce tissue repair |
| JP5561365B2 (en) * | 2010-08-17 | 2014-07-30 | 有限会社 健康百二十才 | Long-lasting antipruritic skin preparation |
| CN109897118A (en) * | 2019-03-06 | 2019-06-18 | 武汉轻工大学 | The preparation method and application of the rice bran polysaccharide iron of fluorescent marker |
-
1992
- 1992-08-12 JP JP21529692A patent/JP3442093B2/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0813875A2 (en) * | 1996-06-19 | 1997-12-29 | Institute For Advanced Skin Research Inc. | Inhibition of abnormal accumulation of extracellular matrices |
| EP0813875A3 (en) * | 1996-06-19 | 1998-12-16 | Institute For Advanced Skin Research Inc. | Inhibition of abnormal accumulation of extracellular matrices |
| US6068845A (en) * | 1996-06-19 | 2000-05-30 | Institute For Advanced Skin Research Inc. | Inhibition of abnormal accumulation of extra-cellular matrices |
| KR100377262B1 (en) * | 2000-11-06 | 2003-03-26 | 애경산업(주) | Cosmetic composition fot atopic skin containing artemisia extract |
| EP2042167A1 (en) * | 2007-09-26 | 2009-04-01 | Aisa Therapeutics | Use of a monoterpene to induce tissue repair |
| WO2009040420A3 (en) * | 2007-09-26 | 2009-06-25 | Aisa Therapeutics | Use of a monoterpene to increase tissue repair |
| JP2010540497A (en) * | 2007-09-26 | 2010-12-24 | エイザ・セラピューティクス | Use of monoterpenes to increase tissue repair |
| JP5561365B2 (en) * | 2010-08-17 | 2014-07-30 | 有限会社 健康百二十才 | Long-lasting antipruritic skin preparation |
| CN109897118A (en) * | 2019-03-06 | 2019-06-18 | 武汉轻工大学 | The preparation method and application of the rice bran polysaccharide iron of fluorescent marker |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3442093B2 (en) | 2003-09-02 |
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