JPH06504930A - 神経の治療および再生に使用するための生物分解性および生物吸収性ガイドチャンネル - Google Patents
神経の治療および再生に使用するための生物分解性および生物吸収性ガイドチャンネルInfo
- Publication number
- JPH06504930A JPH06504930A JP4503965A JP50396592A JPH06504930A JP H06504930 A JPH06504930 A JP H06504930A JP 4503965 A JP4503965 A JP 4503965A JP 50396592 A JP50396592 A JP 50396592A JP H06504930 A JPH06504930 A JP H06504930A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- ester
- medical
- alcohol
- medical device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/1128—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (24)
- 1.損傷を受けた神経組織の治療に使用するための医療用具であって、(a)生 物適合性および生物吸収性の水不溶性ヒアルロン酸エステルからなるマトリック ス; (b)該マトリックス中に埋め込まれる生物適合性および生物吸収性の水不溶性 ヒアルロン酸エステルからなる糸;および(c)損傷を受けた神経組織の治療に 活性を有する活性因子;からなる管状の生物適合性および生物吸収性複合体から なる医療用具。
- 2.ヒアルロン酸エステルがヒアルロン酸と薬理学的に不活性なアルコールとの 全または部分エステルである請求項1に記載の医療用具。
- 3.アルコールが脂肪族、アリール脂肪族、環式脂肪族または複素環式アルコー ルである請求項2に記載の医療用具。
- 4.脂肪族アルコールがC1−12脂肪族アルコールである請求項3に記載の医 療用具。
- 5.エステルがヒアルロン酸の全エステルである請求項1〜4のいずれかに記載 の医療用具。
- 6.エステルがヒアルロン酸の部分エステルである請求項1〜4のいずれかに記 載の医療用具。
- 7.脂肪族アルコールがベンジルアルコールである請求項2に記載の医療用具。
- 8.ヒアルロン酸エステルがベンジルアルコールで75%エステル化されたヒア ルロン酸エステルである請求項1に記載の医療用具。
- 9.活性因子が、神経成長因子、毛様体神経栄養因子、脳由来の神経栄養因子、 ニューロトロピン−3、ガンダリオシド、ガンダリオシド誘導体、およびこれら の混合物からなる群から選ばれる一員である請求項1〜8のいずれかに記載の医 療用具。
- 10.活性因子と糸がマトリックス中に同時押出しされる請求項9に記載の医療 用具。
- 11.最低150デニールの値、最低0.4g/デニールの破断点引張強さ、お よび最低2%の伸びを有する請求項1〜10のいずれかに記載の医療用具。
- 12.約4〜25mg/cmの重量を有する請求項1〜11のいずれかに記載の 医療用具。
- 13.80〜1000μmの厚みを有する請求項1〜12のいずれかに記載の医 療用具。
- 14.複合体が少なくとも2層のコイル化された糸からなる請求項1〜13のい ずれかに記載の医療用具。
- 15.コイル化された糸の密度が少なくとも3コイル/cm2である請求項14 に記載の医療用具。
- 16.マトリックスと糸の織り込み管からなる請求項1〜15のいずれかに記載 の医療用具。
- 17.織り込み管が生物分解性かつ不溶性のヒアルロン酸エステル中に埋め込ま れている請求項16に記載の医療用具。
- 18.損傷を受けた神経の治療のための、請求項1〜16のいずれかに記載の医 療用具の使用。
- 19.神経組織の再生を増強、促進または刺激するための、請求項1〜16のい ずれかに記載の医療用具の使用。
- 20.生物適合性および生物吸収性の水不溶性ヒアルロン酸エステルからなるマ トリックスおよび糸であって、該糸が該マトリックス中に埋め込まれた管状の生 物適合性および生物吸収性複合体内に損傷を受けた神経を確保することからなる 神経組織の治療方法。
- 21.ヒアルロン酸エステルがヒアルロン酸と薬理学的に不活性なアルコールと の全または部分エステルである請求項20に記載の方法。
- 22.アルコールがC1−12脂肪族アルコールである請求項21に記載の方法 。
- 23.アルコールがベンジルアルコールである請求項21に記載の方法。
- 24.生物適合性および生物吸収性の水不溶性ヒアルロン酸エステルからなる糸 およびマトリックスであって、糸分配器に機能的に結合させた回転円筒鋳型を用 いて、該糸を該マトリックス中に埋め込んで巻取ることからなる医療用具の製造 方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000032A/91 | 1991-02-11 | ||
ITPD910032A IT1247157B (it) | 1991-02-11 | 1991-02-11 | Canali di guida biodegradabili e bioassorbibili da impiegare per la rigenerazione nervosa. |
PCT/EP1992/000285 WO1992013579A1 (en) | 1991-02-11 | 1992-02-10 | Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH06504930A true JPH06504930A (ja) | 1994-06-09 |
Family
ID=11389458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4503965A Ceased JPH06504930A (ja) | 1991-02-11 | 1992-02-10 | 神経の治療および再生に使用するための生物分解性および生物吸収性ガイドチャンネル |
Country Status (12)
Country | Link |
---|---|
US (1) | US5735863A (ja) |
EP (1) | EP0571415B1 (ja) |
JP (1) | JPH06504930A (ja) |
AT (1) | ATE125158T1 (ja) |
AU (1) | AU1189792A (ja) |
CA (1) | CA2100792C (ja) |
DE (1) | DE69203596T2 (ja) |
DK (1) | DK0571415T3 (ja) |
ES (1) | ES2077397T3 (ja) |
GR (1) | GR3017764T3 (ja) |
IT (1) | IT1247157B (ja) |
WO (1) | WO1992013579A1 (ja) |
Cited By (3)
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JP2002320630A (ja) * | 2001-04-26 | 2002-11-05 | Nipro Corp | 生体組織または器官再生用器具 |
JP2004073221A (ja) * | 2002-08-09 | 2004-03-11 | Nipro Corp | 生分解性筒状体およびそれを用いた生体組織または器官再生器具 |
JP2012501391A (ja) * | 2008-09-02 | 2012-01-19 | タウトナ グループ エルピー | ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用 |
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IT1254170B (it) * | 1991-12-18 | 1995-09-11 | Mini Ricerca Scient Tecnolog | Membrane composite per la rigenerazione guidata di tessuti |
IT1259141B (it) * | 1992-08-03 | 1996-03-11 | Fidia Spa | Canali di guida biodegradabili e bioriassorbibili da impiegare per la riparazione tissutale come adiuvante in interventi chirurgici |
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-
1991
- 1991-02-11 IT ITPD910032A patent/IT1247157B/it active IP Right Grant
-
1992
- 1992-02-10 WO PCT/EP1992/000285 patent/WO1992013579A1/en active IP Right Grant
- 1992-02-10 JP JP4503965A patent/JPH06504930A/ja not_active Ceased
- 1992-02-10 CA CA002100792A patent/CA2100792C/en not_active Expired - Lifetime
- 1992-02-10 AT AT92903786T patent/ATE125158T1/de active
- 1992-02-10 DK DK92903786.9T patent/DK0571415T3/da active
- 1992-02-10 US US08/104,025 patent/US5735863A/en not_active Expired - Lifetime
- 1992-02-10 ES ES92903786T patent/ES2077397T3/es not_active Expired - Lifetime
- 1992-02-10 DE DE69203596T patent/DE69203596T2/de not_active Expired - Lifetime
- 1992-02-10 AU AU11897/92A patent/AU1189792A/en not_active Abandoned
- 1992-02-10 EP EP92903786A patent/EP0571415B1/en not_active Expired - Lifetime
-
1995
- 1995-10-18 GR GR950402865T patent/GR3017764T3/el unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002320630A (ja) * | 2001-04-26 | 2002-11-05 | Nipro Corp | 生体組織または器官再生用器具 |
JP2004073221A (ja) * | 2002-08-09 | 2004-03-11 | Nipro Corp | 生分解性筒状体およびそれを用いた生体組織または器官再生器具 |
JP4581318B2 (ja) * | 2002-08-09 | 2010-11-17 | ニプロ株式会社 | 生分解性筒状体およびそれを用いた生体組織または器官再生器具 |
JP2012501391A (ja) * | 2008-09-02 | 2012-01-19 | タウトナ グループ エルピー | ヒアルロン酸および/またはその誘導体の糸、その作製方法、ならびにその使用 |
Also Published As
Publication number | Publication date |
---|---|
AU1189792A (en) | 1992-09-07 |
CA2100792A1 (en) | 1992-08-12 |
ES2077397T3 (es) | 1995-11-16 |
WO1992013579A1 (en) | 1992-08-20 |
DE69203596D1 (de) | 1995-08-24 |
GR3017764T3 (en) | 1996-01-31 |
DK0571415T3 (da) | 1995-12-04 |
US5735863A (en) | 1998-04-07 |
EP0571415A1 (en) | 1993-12-01 |
EP0571415B1 (en) | 1995-07-19 |
ITPD910032A0 (it) | 1991-02-11 |
ATE125158T1 (de) | 1995-08-15 |
DE69203596T2 (de) | 1996-03-21 |
CA2100792C (en) | 2004-06-29 |
ITPD910032A1 (it) | 1992-08-11 |
IT1247157B (it) | 1994-12-12 |
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