JPH05501568A - 抗マラリア性組成物 - Google Patents
抗マラリア性組成物Info
- Publication number
- JPH05501568A JPH05501568A JP3510033A JP51003391A JPH05501568A JP H05501568 A JPH05501568 A JP H05501568A JP 3510033 A JP3510033 A JP 3510033A JP 51003391 A JP51003391 A JP 51003391A JP H05501568 A JPH05501568 A JP H05501568A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- combination
- effective amount
- artemether
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (11)
- 1.マラリアに対する活性成分の相乗作用に適する医薬組成物であって、相乗的 有効量の次式の化合物:▲数式、化学式、表等があります▼(I)と、相乗的有 効量の少なくとも1種類の次式の化合物の▲数式、化学式、表等があります▼( II)(式中;R及びR1は共に酸素を示すか、又はR及びR1の一方が独立し てヒドロキシ、C1−C6−アルコキシ、C1−C6−アルケニルオキシ、C1 −C5−アルカノイルオキシ、カルボキシ−C1−C6−アルカノイルオキシ、 シクロヘキサンカルボニルオキシ、ベンゾイルオキシもしくはナフトイルオキシ を示し、そして他方が水素を示す)、及びそれらの医薬品として受け入れられる 塩を含んでなる組成物。
- 2.請求項1に記載の医薬組成物であって、相乗的に有効量のベンフルメトール (I)を、前記の式IIに含まれるアルテミシニン、ジヒドロアルテミシニン、 アルテエテル、アルテメテル及びアルテスネートより成る群から選ばれる少なく とも1種類の相乗的に有効量の化合物と組合せて含んで成る組成物。
- 3.請求項1に記載の医薬組成物であって、相乗的に有効量のベンフルメトール (I)を相乗的に有効量のアルテメテル(II)と組合せて含んで成る組成物。
- 4.マラリアに対する活性成分の相乗作用のために適する医薬組成物であって、 相乗的に有効量のベンフルメトール(I)を相乗的に有効量のアルテメテル(I I)と組合せて含んで成る組成物。
- 5.請求項1に記載の医薬組成物であって、1から10重量部のベンフルメトー ル(I)を、1重量部の式(II)の化合物と組合せて含んで成る組成物。
- 6.請求項1に記載の医薬組成物であって、3から7重量部のベンフルメトール (I)を、1重量部の式(II)の化合物と組合せて含んで成る組成物。
- 7.請求項4に記載の医薬組成物であって、1重量部のベンフルメトール(I) を、5から6重量部のアルテメテル(II)と組合せて含んで成る組成物。
- 8.請求項5又は6に記載の医薬組成物であって、1重量部のベンフルメトール (I)を、5から6重量部のアルテメテル(II)と組合せて含んで成る組成物 。
- 9.マラリアに対する活性成分の相乗作用に適する医薬組成物の調製方法であっ て、相乗的に有効量の請求項1に記載の化合物(I)を、相乗的に有効量の少な くとも1種類の前記の式(II)の化合物又はその医薬品として受け入れられて いる塩と混合し、そして該活性成分の組合せを医薬品として受け入れられている 添加剤の任意的な添加のもとで適当な投与形態に製剤化せしめることを含んで成 る方法。
- 10.ヒト又は動物の体の治療のために利用される、請求項1に記載の医薬組成 物。
- 11.患者に有効量の請求項1に記載の医薬組成物を投与することを含んで成る 、マラリアの治療方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN90106722A CN1058717A (zh) | 1990-08-08 | 1990-08-08 | 抗疟新药—复方蒿甲醚及其制备方法 |
CN91102575.8 | 1991-04-24 | ||
CN90106722.9 | 1991-04-24 | ||
CN91102575A CN1085527C (zh) | 1990-08-08 | 1991-04-24 | 增效复方抗疟药本芴醇的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05501568A true JPH05501568A (ja) | 1993-03-25 |
JP2562857B2 JP2562857B2 (ja) | 1996-12-11 |
Family
ID=25742651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3510033A Expired - Lifetime JP2562857B2 (ja) | 1990-08-08 | 1991-06-05 | 抗マラリア性組成物 |
Country Status (27)
Country | Link |
---|---|
US (1) | US5677331A (ja) |
EP (1) | EP0500823B1 (ja) |
JP (1) | JP2562857B2 (ja) |
KR (1) | KR100221689B1 (ja) |
CN (2) | CN1058717A (ja) |
AP (1) | AP231A (ja) |
AT (1) | ATE135209T1 (ja) |
AU (1) | AU642747B2 (ja) |
CA (1) | CA2065285C (ja) |
DE (2) | DE10199038I2 (ja) |
DK (1) | DK0500823T3 (ja) |
EG (1) | EG19905A (ja) |
ES (1) | ES2084168T3 (ja) |
FI (1) | FI921491A0 (ja) |
GR (1) | GR3019313T3 (ja) |
HK (1) | HK1000312A1 (ja) |
HU (1) | HU227345B1 (ja) |
IE (1) | IE72095B1 (ja) |
IL (1) | IL98463A (ja) |
LU (1) | LU90844I2 (ja) |
MA (1) | MA22176A1 (ja) |
NL (1) | NL300048I2 (ja) |
NZ (1) | NZ238477A (ja) |
PT (1) | PT97945B (ja) |
SA (1) | SA91120263B1 (ja) |
WO (1) | WO1992002217A1 (ja) |
ZA (1) | ZA914490B (ja) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637594A (en) * | 1991-04-11 | 1997-06-10 | Ciba Geigy Corporation | Antimalarial synergistic compositions containing benflumetol |
NZ246606A (en) * | 1992-02-07 | 1995-09-26 | Ciba Geigy Ag | Antimalarial compostions containing a synergistic combination of benflumetol and quinine or a derivative thereof |
WO1995027964A1 (en) * | 1994-04-12 | 1995-10-19 | Qualcomm Incorporated | Method and apparatus for freight transportation using a satellite navigation system |
US5657088A (en) * | 1995-12-22 | 1997-08-12 | Cirrus Logic, Inc. | System and method for extracting caption teletext information from a video signal |
US6136847A (en) * | 1996-12-02 | 2000-10-24 | Johns Hopkins University | Water-soluble trioxanes as potent and safe antimalarial agents |
CH692321A5 (de) | 1997-11-03 | 2002-05-15 | Mepha Ag | Pharmazeutisch wirksame Zusammensetzung, welche eine gegen Malariaparasiten wirksame Substanz enthält. |
CO5040050A1 (es) * | 1998-06-25 | 2001-05-29 | Novartis Ag | Compuestos de 2-amino-1-(9-arilmetilidina-2,7-dicloro-9h- fluoren-4-ilo)-etanoles n-sustituidos, procedimientos para su obtencion y preparados farmaceuticos que los contienen . |
IN191696B (ja) * | 1999-02-12 | 2003-12-20 | Council Scient Ind Res | |
WO2001074353A1 (en) * | 2000-03-31 | 2001-10-11 | Council Of Scientific And Industrial Research | A synergistic anti-malarial formulation |
EP1329452A1 (en) * | 2000-10-20 | 2003-07-23 | Ajinomoto Co., Inc. | Medicinal compositions, dose and method for treating malaria |
US7842719B2 (en) * | 2002-10-31 | 2010-11-30 | Kemin Foods, L.C. | Use of endoperoxides for the treatment of infections caused by flaviviridae, including hepatitis C, bovine viral diarrhea and classical swine fever virus |
WO2004075817A2 (en) * | 2003-02-26 | 2004-09-10 | Vrije Universiteit Brussel | Suspendable pharmaceutical composition |
AP2006003557A0 (en) * | 2003-09-04 | 2006-04-30 | Cipla Ltd | Antimalarial compositions and process thereof. |
US20110206636A1 (en) * | 2003-09-16 | 2011-08-25 | Kemin Foods, LLC | Use of Endoperoxides for the Treatment of Infections Caused by Flaviviridae, Including Hepatitis C, Bovine Viral Diarrhea and Classical Swine Fever Virus |
WO2007017646A2 (en) * | 2005-08-05 | 2007-02-15 | Cipla Limited | Anti-malarial composition comprising artesunate and lumefantrine |
WO2007036947A1 (en) * | 2005-09-30 | 2007-04-05 | Ipca Laboratories Limited | Delayed release anti-malarial composition |
CN101478965A (zh) * | 2006-06-26 | 2009-07-08 | 兰贝克赛实验室有限公司 | 蒿甲醚和本芴醇的高剂量口服药物组合物 |
CN100463669C (zh) * | 2006-08-31 | 2009-02-25 | 广州市医药工业研究所 | 复方蒿甲醚自乳化剂 |
WO2008098586A1 (en) * | 2007-02-13 | 2008-08-21 | Dafra Pharma N.V. | Pharmaceutical carrier composition and pharmaceutical composition |
CH700941B1 (de) * | 2007-12-04 | 2010-11-15 | Mepha Ag | Pharmazeutische Zusammensetzung zur Behandlung von Malaria. |
FR2926993B1 (fr) * | 2008-02-06 | 2011-03-11 | Sanofi Aventis | Association entre un sel de bis-thiazolium ou l'un de ses precurseurs et l'artemisinine ou l'un de ses derives pour le traitement du paludisme |
WO2010004573A1 (en) * | 2008-07-07 | 2010-01-14 | Ipca Laboratories Limited | Synergistic antimalarial pharmaceutical composition |
EP2830433B1 (en) * | 2012-03-30 | 2018-11-21 | Südzucker AG | Improved rolling compound powders for applying on the surface of chewing gum core materials |
CN103251584A (zh) * | 2013-05-09 | 2013-08-21 | 西安力邦制药有限公司 | 注射用蒿甲醚/本芴醇复方脂肪乳的制备及其在疟疾治疗中的应用 |
WO2015140709A1 (en) * | 2014-03-19 | 2015-09-24 | Novartis Ag | Solid pharmaceutical dosage forms |
KR20190139291A (ko) | 2017-04-24 | 2019-12-17 | 노파르티스 아게 | 2-아미노-l-(2-(4-플루오로페닐)-3-(4-플루오로페닐아미노)-8,8-디메틸-5,6-디하이드로이미다조[1,2-a]피라진-7(8h)-일)에타논 및 이의 조합물의 치료 요법 |
CN113599382B (zh) * | 2021-08-20 | 2023-01-03 | 兰州大学 | 喹啉类衍生物在制备治疗糖尿病及其并发症药物中的应用 |
CN116747218B (zh) * | 2023-08-21 | 2023-10-31 | 山东省中医药研究院 | 百秋李醇、百秋李醇复合抗疟组合物及制备抗疟原虫药物中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN85100978A (zh) * | 1985-04-01 | 1986-08-13 | 中医研究院中药研究所 | 还原青蒿素的生产工艺 |
CN85100781B (zh) * | 1985-04-01 | 1988-07-06 | 广西壮族自治区桂林制药厂 | 抗疟药物青蒿酯的制备方法 |
CN87101346A (zh) * | 1987-06-09 | 1988-03-09 | 山东省中医药研究所 | 青蒿素提取工艺 |
EP0362810B1 (en) * | 1988-10-07 | 1993-05-05 | Hoechst Aktiengesellschaft | Antimalarial compositions using quinidine, artemisinine and its derivatives |
CN1029680C (zh) * | 1988-11-10 | 1995-09-06 | 军事医学科学院微生物流行病研究所 | 抗疟新药苯芴醇的合成新工艺 |
-
1990
- 1990-08-08 CN CN90106722A patent/CN1058717A/zh not_active Withdrawn
-
1991
- 1991-04-24 CN CN91102575A patent/CN1085527C/zh not_active Expired - Lifetime
- 1991-06-05 AT AT91911449T patent/ATE135209T1/de not_active IP Right Cessation
- 1991-06-05 JP JP3510033A patent/JP2562857B2/ja not_active Expired - Lifetime
- 1991-06-05 WO PCT/EP1991/001033 patent/WO1992002217A1/en active IP Right Grant
- 1991-06-05 EP EP91911449A patent/EP0500823B1/en not_active Expired - Lifetime
- 1991-06-05 DE DE2001199038 patent/DE10199038I2/de active Active
- 1991-06-05 DE DE69117922T patent/DE69117922T2/de not_active Expired - Lifetime
- 1991-06-05 CA CA002065285A patent/CA2065285C/en not_active Expired - Lifetime
- 1991-06-05 HU HU9201528A patent/HU227345B1/hu unknown
- 1991-06-05 AU AU79549/91A patent/AU642747B2/en not_active Expired
- 1991-06-05 DK DK91911449.6T patent/DK0500823T3/da active
- 1991-06-05 KR KR1019920700800A patent/KR100221689B1/ko not_active IP Right Cessation
- 1991-06-05 ES ES91911449T patent/ES2084168T3/es not_active Expired - Lifetime
- 1991-06-10 MA MA22451A patent/MA22176A1/fr unknown
- 1991-06-11 NZ NZ238477A patent/NZ238477A/xx not_active IP Right Cessation
- 1991-06-11 EG EG35991A patent/EG19905A/xx active
- 1991-06-12 PT PT97945A patent/PT97945B/pt not_active IP Right Cessation
- 1991-06-12 AP APAP/P/1991/000275A patent/AP231A/en active
- 1991-06-12 ZA ZA914490A patent/ZA914490B/xx unknown
- 1991-06-12 IE IE198991A patent/IE72095B1/en not_active IP Right Cessation
- 1991-06-12 IL IL9846391A patent/IL98463A/en not_active IP Right Cessation
- 1991-12-10 SA SA91120263A patent/SA91120263B1/ar unknown
-
1992
- 1992-04-03 FI FI921491A patent/FI921491A0/fi unknown
-
1994
- 1994-03-23 US US08/216,440 patent/US5677331A/en not_active Expired - Lifetime
-
1996
- 1996-03-14 GR GR960400492T patent/GR3019313T3/el unknown
-
1997
- 1997-09-29 HK HK97101870A patent/HK1000312A1/xx not_active IP Right Cessation
-
2001
- 2001-07-19 NL NL300048C patent/NL300048I2/nl unknown
- 2001-07-19 LU LU90844C patent/LU90844I2/fr unknown
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