JPH05163135A - Beautifying cosmetic composition - Google Patents
Beautifying cosmetic compositionInfo
- Publication number
- JPH05163135A JPH05163135A JP3360926A JP36092691A JPH05163135A JP H05163135 A JPH05163135 A JP H05163135A JP 3360926 A JP3360926 A JP 3360926A JP 36092691 A JP36092691 A JP 36092691A JP H05163135 A JPH05163135 A JP H05163135A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- whitening
- cosmetic composition
- beautifying
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、優れた美白効果を有す
る美白用化粧料組成物に関し、さらに詳細には、特にシ
ミ、ソバカス等の予防又は治療に有効であって、優れた
美白効果を示すと共に、安定性および皮膚に対する高い
安全性を併せ持つ美白用化粧料組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition having an excellent whitening effect, and more specifically, it is particularly effective in preventing or treating spots, freckles and the like, and has an excellent whitening effect. The present invention relates to a whitening cosmetic composition having both stability and high safety to the skin.
【0002】[0002]
【従来の技術】従来から、シミ、ソバカス等の予防又は
治療を目的として、ハイドロキノンおよびその配糖体、
コウジ酸およびその誘導体、アスコルビン酸およびその
誘導体、チオール系化合物、種々の動植物抽出物等の物
質を美白成分として配合する美白用化粧料が提案されて
いる。2. Description of the Related Art Conventionally, hydroquinone and its glycoside, for the purpose of preventing or treating spots, freckles, etc.,
There has been proposed a whitening cosmetic composition containing substances such as kojic acid and its derivatives, ascorbic acid and its derivatives, thiol compounds, and various animal and plant extracts as a whitening component.
【0003】[0003]
【発明が解決しようとする課題】しかしこれら化粧料に
は、種々の問題点が残されており、実用性の面で問題が
あった。例えば、美白成分としてのハイドロキノンは安
全性に問題があり、また、ハイドロキノン配糖体、コウ
ジ酸およびその誘導体、アスコルビン酸およびその誘導
体等には、化粧料の配合成分とし使用するには極性が高
すぎるという問題点がある。However, various problems remain in these cosmetics, and there is a problem in terms of practicality. For example, hydroquinone as a whitening ingredient has a problem in safety, and hydroquinone glycosides, kojic acid and its derivatives, ascorbic acid and its derivatives, etc. have a high polarity for use as a blending ingredient of cosmetics. There is a problem that it is too much.
【0004】さらに、グルタチオン、システイン等のチ
オール系化合物は、配合後の安定性に問題が残ってお
り、また、その他の動植物抽出物、例えば胎盤エキス、
アロエエキス等の配合も知られてはいるが、その美白効
果が満足出来るものではなかった。Further, thiol compounds such as glutathione and cysteine still have problems in stability after compounding, and other animal and plant extracts such as placenta extract,
Aloe extract and other formulations are known, but their whitening effect was not satisfactory.
【0005】[0005]
【課題を解決するための手段】本発明者等は、優れた美
白効果を有する物質を見出すべく、マウスのB16メラ
ノーマ株を用いたメラニン生成抑制試験を指標に、種々
の食品素材について、スクリーニングを行った。その結
果、キクラゲ科キクラゲ(Auricuraria a
uricula−judae)の抽出物、アブラナ科ワ
サビ(Wasabia japonica)の抽出物、
ナス科トウガラシ(Capsicumannum)およ
びタデ科ソバ(Fagopyrumesculentu
m)の抽出成分が、メラニン生成を強く抑制すると共に
細胞毒性が極めて弱く、化粧料の美白成分として極めて
有効であることを見出した。[Means for Solving the Problems] In order to find a substance having an excellent whitening effect, the present inventors have screened various food materials with a melanin production inhibition test using a B16 melanoma strain of a mouse as an index. went. As a result, Asteraceae (Auricularia a)
uricula-judae) extract, extract of Wasabia japonica,
Capsicum capsicum and Capricorn buckwheat (Fagopyrum esculentu)
It was found that the extract component of m) strongly suppresses melanin production and has extremely weak cytotoxicity, and is extremely effective as a whitening component of cosmetics.
【0006】本発明は、上記知見に基づいて完成された
ものであり、上記抽出物の内、少なくとも一つを有効成
分として含有する美白化粧料組成物を提供するものであ
る。The present invention has been completed based on the above findings, and provides a whitening cosmetic composition containing at least one of the above extracts as an active ingredient.
【0007】本発明において、美白化粧料組成物とは、
シミ、ソバカス等の予防又は治療に有効な皮膚用化粧料
組成物を言い、医薬部外品としてのローション、乳液、
クリーム、パック剤、石鹸等の薬用化粧品および医薬品
としてのローション、乳液、クリーム、軟膏等の皮膚外
用剤を含むものである。In the present invention, the whitening cosmetic composition means
A skin cosmetic composition effective for the prevention or treatment of spots, freckles, etc., a lotion as a quasi drug, an emulsion,
It includes external cosmetics such as creams, packs, medicated cosmetics such as soaps and lotions as pharmaceuticals, emulsions, creams, ointments and the like.
【0008】本発明で用いた食品素材は、いずれも長い
歴史の間に食品素材として人類に受け入れられてきたも
のであり、少なくともその経口毒性の面では全く問題が
ない素材である。例えば、本発明で用いたキクラゲは、
担子菌類キクラゲ科に属する食用キノコであり、世界各
国で食用とされているが、特に中国では木耳と称し、中
華料理に不可欠の材料となっている。しかしながら、こ
のものが美白剤としての有効であるということは全く知
られていない。All of the food materials used in the present invention have been accepted by humanity as food materials over a long history and have no problem at least in terms of oral toxicity. For example, the mushrooms used in the present invention are
It is an edible mushroom belonging to the basidiomycete fungus family and is said to be edible in many countries around the world. In China, it is called a wood ear and is an essential ingredient for Chinese cuisine. However, it is completely unknown that this product is effective as a whitening agent.
【0009】本発明で用いたワサビは、その根茎を摺り
おろして、おろしワサビとして辛味料に使用する他に、
リュウマチや神経痛などの局所鎮痛剤として、おろしワ
サビを局所に貼付する民間薬としての用途も知られてい
るが、このものが美白剤としての有効であるということ
は全く知られていない。The horseradish used in the present invention is not only used as a grated horseradish but also as a spicy sauce by grazing the rhizome.
As a local analgesic for rheumatism and neuralgia, it is also known to be used as a folk medicine in which grated horseradish is applied locally, but it is not known at all to be effective as a whitening agent.
【0010】本発明で用いたトウガラシは、その果実を
乾燥して辛味料に使用する他、番椒として、皮膚刺激剤
および辛味性健胃剤としての用途が日本薬局方に記載さ
れ、また、民間薬として霜焼けの予防および治療薬とし
て使用されているが、このものが美白剤としての有効で
あるということは全く知られていない。The capsicum used in the present invention is used as a spicy substance after drying its fruit, and as peppercorn, its use as a skin stimulant and a pungency stomachic agent is described in the Japanese Pharmacopoeia, and it is also a folk medicine. It is used as a preventive and therapeutic agent for frost burning, but it is not known at all that it is effective as a whitening agent.
【0011】本発明で用いたソバは、その果実を食用に
する他、その乾燥茎葉からルチンを精製することが記載
されているが、このものが美白剤としての有効であると
いうことは全く知られていない。It is described that the buckwheat used in the present invention has its fruits edible and that rutin is purified from its dried foliage, but it is completely known that this is effective as a whitening agent. Has not been done.
【0012】これらの植物体等の原料から有効成分を抽
出する時に使用する溶媒は、有効成分が効果的に抽出さ
れる溶媒であれば特に限定されるものではないが、水ま
たはアセトン、メタノール、エタノール、プロパノール
等の低級アルコールのように水と混和する有機溶媒、も
しくはそれらの混液、酢酸エチル等を用いるのが好まし
い。The solvent used when extracting the active ingredient from these raw materials such as plants is not particularly limited as long as the active ingredient can be effectively extracted, but water or acetone, methanol, It is preferable to use an organic solvent miscible with water such as lower alcohols such as ethanol and propanol, a mixed solution thereof, ethyl acetate or the like.
【0013】これらの抽出物は、市販のキクラゲ、ワサ
ビ、トウガラシ、ソバの実等をそのまま溶媒で抽出して
得ることも出来るが、好ましくは、抽出効率を高めるた
めには、これらの原料を細かく裁断してから溶媒で抽出
することが望ましい。抽出は、細かく裁断した原料1g
に対して、5〜100ml、好ましくは10〜20ml
の溶媒を用い、1日から1か月間、好ましくは2〜5日
間、2〜4回に分けて室温で行うことが望ましい。ま
た、抽出物中の有効成分の濃度を高めるために、所望に
より、得られた抽出物を更に、濃縮、液液分配、吸着ク
ロマトグラフィー、順相もしくは逆相クロマトグラフィ
ー等の手段に付すことも可能である。These extracts can be obtained by directly extracting commercially available fungus, horseradish, capsicum, buckwheat, etc. with a solvent, but preferably, in order to enhance extraction efficiency, these raw materials are finely divided. It is desirable to cut and then extract with a solvent. Extraction is 1 g of finely chopped raw material
To 5 to 100 ml, preferably 10 to 20 ml
It is desirable to use the above solvent at room temperature for 1 to 1 month, preferably 2 to 5 days, in 2 to 4 times. Further, in order to increase the concentration of the active ingredient in the extract, the obtained extract may be further subjected to such means as concentration, liquid-liquid partitioning, adsorption chromatography, normal phase or reverse phase chromatography, if desired. It is possible.
【0014】本発明の美白化粧料組成物は、上記のよう
にして得られる抽出物と、化粧料に一般に用いられてい
る成分、例えば、油性成分、界面活性剤、紫外線吸収
剤、低級アルコール、防腐剤、殺菌剤、色剤、粉末、香
料、水溶性高分子、緩衝剤などをその剤形に合わせ、本
発明の効果を損なわない範囲で適宜配合することにより
調製される。The whitening cosmetic composition of the present invention comprises the extract obtained as described above and components generally used in cosmetics such as oily components, surfactants, ultraviolet absorbers, lower alcohols, Preservatives, bactericides, colorants, powders, fragrances, water-soluble polymers, buffers and the like are prepared according to the dosage form, and appropriately mixed within a range that does not impair the effects of the present invention.
【0015】本発明の美白化粧料組成物中の上記抽出物
の配合量は、メラニン生成抑制作用ならびに皮膚の角質
透過性等を考慮して定めることが好ましいが、一般には
上記抽出物を原材料換算で0.01〜50重量%、好ま
しくは、0.1〜20重量%程度とすれば良い。The amount of the above-mentioned extract compounded in the whitening cosmetic composition of the present invention is preferably determined in consideration of the melanin production inhibitory action, the skin keratin permeability, etc. It is 0.01 to 50% by weight, preferably 0.1 to 20% by weight.
【0016】[0016]
【作用】本発明の有効成分である、上記抽出物が、どの
ように作用して美白効果を示すのかは、未だ詳らかでは
ない。しかし、上記抽出物がマウスのB16メラノーマ
株を用いたメラニン生成抑制試験で、細胞毒性を示さず
にメラニン生成を強く抑制することからみて、チロシン
からメラニン生成までのいずれかのステップにおいて、
この反応を阻害するものであることが予想される。It is not yet known how the above-mentioned extract, which is the active ingredient of the present invention, acts to have a whitening effect. However, in view of the fact that the above extract strongly suppresses melanin production without showing cytotoxicity in a melanin production inhibition test using a mouse B16 melanoma strain, in any step from tyrosine to melanin production,
It is expected to inhibit this reaction.
【0017】次に実施例によって本発明をさらに詳細に
説明するが、本発明の範囲はこれらのみに限定されるも
のではない。Next, the present invention will be described in more detail by way of examples, but the scope of the present invention is not limited to these.
【0018】[0018]
実施例1 キクラゲ抽出物の調製 乾燥黒キクラゲ(日本産・食料品店より購入)10gを
細かく裁断し、エタノール200mlを加えて室温下、
48時間抽出した。抽出液を濾別し、残渣はさらにエタ
ノール200mlを加えて、同様に再抽出した。抽出液
を集めて減圧濃縮し、溶媒を留去した後、水5mlおよ
び酢酸エチル10mlを加え、これを分液ロートに移し
て激しく振とうした後静置して2層に分離し、上層の酢
酸エチル層を集めた。これを無水硫酸ナトリウムで乾燥
した後減圧濃縮し、抽出物260mgを得た。Example 1 Preparation of a fungus extract: 10 g of dried black fungus (purchased from a Japanese grocery store) was cut into small pieces, and 200 ml of ethanol was added thereto at room temperature.
Extracted for 48 hours. The extract was filtered off and the residue was re-extracted in the same manner by adding 200 ml of ethanol. The extracts were collected and concentrated under reduced pressure, the solvent was distilled off, 5 ml of water and 10 ml of ethyl acetate were added, and the mixture was transferred to a separatory funnel, shaken vigorously, and left standing to separate into two layers. The ethyl acetate layer was collected. This was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain 260 mg of an extract.
【0019】実施例2 キクラゲ抽出物の調整 ワサビ根茎(青果商より購入)20gをすり器ですり卸
し、実施例1と同様にエタノール抽出、酢酸エチル転溶
の後減圧濃縮し、抽出物140mgを得た。[0019] grated in Example 2 adjusted wasabi rhizome (purchased from Seika quotient) of wood ear extract sliding unit of 20g, ethanol extract as in Example 1, under reduced pressure followed by concentration of ethyl acetate redissolution, the extract 140mg Obtained.
【0020】実施例3 トウガラシ抽出物の調製 青唐がらし(食料品店より購入)20gを細かく裁断
し、実施例1と同様にエタノール抽出、酢酸エチル転溶
の後減圧濃縮し、抽出物170mgを得た。Example 3 Preparation of capsicum extract 20 g of red chili pepper (purchased from a grocery store) was finely chopped, extracted with ethanol in the same manner as in Example 1, transferred to ethyl acetate and concentrated under reduced pressure to obtain 170 mg of extract. It was
【0021】実施例4 ソバ抽出物の調製 半ゆでにして殻を除去したソバの実(そば米、食料品店
より購入)10gをコーヒーミルを用いて細かく破砕し
た後、50%エタノール100mlを加えて室温下、4
8時間抽出した。抽出液を濾別し、残渣はさらに50%
エタノール100mlを加えて、同様に再抽出した。抽
出液を集めて減圧濃縮し、溶媒を留去した後、実施例1
と同様に酢酸エチル転溶の後減圧濃縮し、抽出物310
mgを得た。Example 4 Preparation of buckwheat extract 10 g of buckwheat seeds (buckwheat rice, purchased from a grocery store) from which half-boiled shells were removed were finely crushed using a coffee mill, and 100 ml of 50% ethanol was added. At room temperature, 4
Extracted for 8 hours. The extract is filtered off and the residue is 50%
100 ml of ethanol was added and re-extracted in the same manner. The extracts were collected, concentrated under reduced pressure, and the solvent was distilled off.
In the same manner as in Example 1, the extract was dissolved in ethyl acetate and then concentrated under reduced pressure to extract 310
mg was obtained.
【0022】実施例5 メラニン生成抑制試験 メラニン生成抑制試験はマウスのメラノーマ細胞を用い
て、次の様に行った。先ず、1×105個のB16メラ
ノーマ細胞を、10%(v/v)牛胎児血清を含むイー
グル最少栄養培地5mlを入れた直径60mmのシャー
レに播種し、5%(v/v)炭酸ガスに調整した炭酸ガ
スインキュベーターで37℃で24時間培養した。次い
でこのシャーレにエタノールに溶解した試料を50μl
添加した。同条件でさらに5日間培養した後、トリプシ
ン処理により細胞を回収し、その白色化度を肉眼で評価
し、同時に、細胞塊体積の変化を肉眼で判定し、細胞毒
性の指標とした。Example 5 Melanin production inhibition test The melanin production inhibition test was carried out as follows using mouse melanoma cells. First, 1 × 10 5 B16 melanoma cells were seeded in a petri dish having a diameter of 60 mm containing 5 ml of Eagle's minimal nutrient medium containing 10% (v / v) fetal bovine serum, and 5% (v / v) carbon dioxide gas was added. The cells were cultured at 37 ° C. for 24 hours in a carbon dioxide gas incubator adjusted to 1. Next, 50 μl of a sample dissolved in ethanol on this petri dish
Was added. After further culturing for 5 days under the same conditions, cells were collected by trypsin treatment, the degree of whitening was visually evaluated, and at the same time, the change in cell mass volume was visually evaluated and used as an index of cytotoxicity.
【0023】この測定法で、実施例1のキクラゲ抽出
物、実施例2のワサビ抽出物、実施例3のトウガラシ抽
出物および実施例4のソバ抽出物について、種々の濃度
でメラニン生成抑制を測定した。結果を第1表に示す。
本発明の抽出物はいずれも、細胞塊体積を減少させない
範囲で、実用化に充分な++(白色化度大)のメラニン
生成抑制効果を示した。このことは、本発明の抽出物
が、優れた美白効果と高い安全性を兼ね備えた、有用な
美白成分であることを示すものである。By this measuring method, inhibition of melanin production was measured at various concentrations for the fungus extract of Example 1, the horseradish extract of Example 2, the pepper extract of Example 3 and the buckwheat extract of Example 4. did. The results are shown in Table 1.
All of the extracts of the present invention showed a ++ (high degree of whitening) melanin production inhibitory effect sufficient for practical use within the range where the cell mass volume was not reduced. This indicates that the extract of the present invention is a useful whitening ingredient having both an excellent whitening effect and high safety.
【0024】[0024]
【表1】 [Table 1]
【0025】実施例6 美白クリームの製造 〔処方〕 A 実施例1の抽出物 0.05g 精製水 5.50g B 3−サクシニルオキシグリチルレチン酸 第二ナトリウム 0.05g C スクワラン 10.00g ミリスチン酸オクチルドデシル 8.00g マイクロクリスタリンワックス 4.00g ベヘニルアルコール 3.00g 親油型モノステアリン酸グリセリン 2.50g モノステアリン酸ポリオキシエチレン ソルビタン(20E.O.) 2.50g D 1,3−ブチレングリコール 10.00g パラオキシ安息香酸メチル 0.10g 精製水 54.00g E 香料 0.30gExample 6 Production of Whitening Cream [Formulation] A Extract of Example 1 0.05 g Purified water 5.50 g B 3-Succinyloxyglycyrrhetinic acid dibasic sodium 0.05 g C Squalane 10.00 g Octyldodecyl myristate 8.00 g Microcrystalline wax 4.00 g Behenyl alcohol 3.00 g Lipophilic glyceryl monostearate 2.50 g Polyoxyethylene sorbitan monostearate (20 EO) 2.50 g D 1,3-butylene glycol 10.00 g Paraoxy Methyl benzoate 0.10 g Purified water 54.00 g E Fragrance 0.30 g
【0026】〔製法〕80〜85℃に加熱したDにBを
加え、これに80〜85℃に加熱溶解したCをホモミキ
サーで攪拌しながら加え、均一に乳化した。これを室温
で徐々に約50℃に冷却し、EおよびAを加えた。さら
に攪拌を続けながら室温まで冷却し、美白クリームを製
造した。このようにして製造した美白クリームは、美白
効果に優れたものであった。[Production Method] B was added to D heated to 80 to 85 ° C., and C which was heated and dissolved at 80 to 85 ° C. was added thereto with stirring with a homomixer to uniformly emulsify. It was gradually cooled to about 50 ° C. at room temperature and E and A were added. The whitening cream was manufactured by further cooling to room temperature while continuing stirring. The whitening cream thus produced had an excellent whitening effect.
【0027】実施例7 美白クリームの製造 実施例6の〔処方〕A に代えて、 と処方し、実施例6と同様に美白クリームを製造した。Example 7 Production of Whitening Cream Instead of [Formulation] A in Example 6, Then, a whitening cream was produced in the same manner as in Example 6.
【0028】実施例8 カーマインローションの製造 Example 8 Production of Carmine Lotion
【0028】〔製法〕Dの約60gをAに加え、ホモミ
キサーで均一に分散させて粉体分散液を作製した。これ
にBの溶液およびCを加え、さらにDの残部を加え、さ
らにホモミキサーで均一に分散させてカーマインローシ
ョンを製造した。このようにして製造したカーマインロ
ーションは、ほてり感を鎮め、美白効果に優れたもので
あった。[Production Method] About 60 g of D was added to A and uniformly dispersed with a homomixer to prepare a powder dispersion. A solution of B and C were added to this, the rest of D was added, and the mixture was uniformly dispersed with a homomixer to produce a carmine lotion. The carmine lotion produced in this manner had a hot whitening effect and an excellent whitening effect.
【0029】実施例9 美白軟膏の製造 Example 9 Production of whitening ointment
【0030】〔製法〕マクロゴール4000およびマク
ロゴール400を水浴上で65℃に加温して溶解し、均
一に混合してマクロゴール軟膏基剤を製造した。これに
Bの溶液を練合して美白軟膏を製造した。このようにし
て製造した美白軟膏は、ほてり感を鎮め、美白効果に優
れたものであった。[Manufacturing Method] Macrogol 4000 and Macrogol 400 were heated to 65 ° C. in a water bath to dissolve, and uniformly mixed to prepare a Macrogol ointment base. The solution of B was kneaded with this to produce a whitening ointment. The whitening ointment thus produced had a hot whitening effect and was excellent in whitening effect.
【0031】[0031]
【発明の効果】キクラゲ科キクラゲの抽出物、アブラナ
科ワサビの抽出物、ナス科トウガラシおよびタデ科ソバ
の抽出物は、細胞毒性を示すことなくメラニン生成を著
しく抑制する。従って、本発明の、これらの抽出物ある
いはその精製物の内、少なくとも一つを含有する美白用
化粧料組成物は、安全で美白効果が高いものである。EFFECTS OF THE INVENTION Extracts of the genus Asteraceae, the extract of Brassicaceae, the horseradish, the extracts of Capsicum angustifolia and the buckwheat buckwheat significantly suppress melanin production without showing cytotoxicity. Therefore, the whitening cosmetic composition of the present invention containing at least one of these extracts or purified products thereof is safe and has a high whitening effect.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 FI 技術表示箇所 A61K 35/84 ADA A 7180−4C (72)発明者 浅見 純生 大阪府三島郡島本町若山台1丁目1番1号 サントリー株式会社基礎研究所内─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 5 Identification number Reference number within the agency FI Technical indication location A61K 35/84 ADA A 7180-4C (72) Inventor Junsei Asami 1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka Prefecture 1-1-1 Suntory Ltd. Basic Research Center
Claims (1)
ワサビの抽出物、ナス科トウガラシの抽出物およびタデ
科ソバの抽出物の内、少なくとも一つを有効成分として
含有することを特徴とする美白用化粧料組成物。1. A whitening product comprising at least one of an extract of Chrysomelidae, an extract of Brassicaceae, a horseradish, an extract of Capsicum, and a buckwheat buckwheat as an active ingredient. Cosmetic composition.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3360926A JPH05163135A (en) | 1991-12-16 | 1991-12-16 | Beautifying cosmetic composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3360926A JPH05163135A (en) | 1991-12-16 | 1991-12-16 | Beautifying cosmetic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH05163135A true JPH05163135A (en) | 1993-06-29 |
Family
ID=18471487
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3360926A Pending JPH05163135A (en) | 1991-12-16 | 1991-12-16 | Beautifying cosmetic composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH05163135A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0717845A (en) * | 1993-06-30 | 1995-01-20 | Sansho Seiyaku Co Ltd | Skin external preparation |
EP0919218A4 (en) * | 1997-03-19 | 2000-08-02 | Shiseido Co Ltd | Dermatologic preparations for beautifying |
WO2002058664A1 (en) * | 2001-01-26 | 2002-08-01 | Lmd | Use of an isothiocyanate, a thiocyanate or a mixture thereof as depigmenting agent |
JP2004107284A (en) * | 2002-09-20 | 2004-04-08 | Naris Cosmetics Co Ltd | Cosmetic |
JP2005075769A (en) * | 2003-08-29 | 2005-03-24 | Eiyo Kogaku Kenkyusho:Kk | Pack agent for make-up |
JP2007137768A (en) * | 2005-11-14 | 2007-06-07 | Eikoudou:Kk | Skin or hair cosmetic |
JP2011195519A (en) * | 2010-03-19 | 2011-10-06 | Maruzen Pharmaceut Co Ltd | Melanin production inhibitor, glutathione production promoter, hyaluronic acid production promoter and involucrin production promoter, and skin cosmetic |
JP2017125117A (en) * | 2016-01-13 | 2017-07-20 | 金印株式会社 | Antioxidant |
WO2018212147A1 (en) | 2017-05-15 | 2018-11-22 | 江崎グリコ株式会社 | Skin dullness eliminating agent, and skin barrier function maintaining or improving agent |
KR20190014435A (en) * | 2017-08-02 | 2019-02-12 | 부경대학교 산학협력단 | Method for producing buckwheat sprout with increased rutin contents |
WO2021084665A1 (en) * | 2019-10-30 | 2021-05-06 | 株式会社 資生堂 | Platelet-derived growth factor (pdgf)-bb production promoter, stem cell stabilizer containing this, and skin anti-aging agent containing these |
-
1991
- 1991-12-16 JP JP3360926A patent/JPH05163135A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0717845A (en) * | 1993-06-30 | 1995-01-20 | Sansho Seiyaku Co Ltd | Skin external preparation |
EP0919218A4 (en) * | 1997-03-19 | 2000-08-02 | Shiseido Co Ltd | Dermatologic preparations for beautifying |
WO2002058664A1 (en) * | 2001-01-26 | 2002-08-01 | Lmd | Use of an isothiocyanate, a thiocyanate or a mixture thereof as depigmenting agent |
FR2820036A1 (en) * | 2001-01-26 | 2002-08-02 | L M D | USE OF ISOTHIOCYANATE, THIOCYANATE OR MIXTURE AS DEPIGMENTING |
JP2004107284A (en) * | 2002-09-20 | 2004-04-08 | Naris Cosmetics Co Ltd | Cosmetic |
JP2005075769A (en) * | 2003-08-29 | 2005-03-24 | Eiyo Kogaku Kenkyusho:Kk | Pack agent for make-up |
JP2007137768A (en) * | 2005-11-14 | 2007-06-07 | Eikoudou:Kk | Skin or hair cosmetic |
JP2011195519A (en) * | 2010-03-19 | 2011-10-06 | Maruzen Pharmaceut Co Ltd | Melanin production inhibitor, glutathione production promoter, hyaluronic acid production promoter and involucrin production promoter, and skin cosmetic |
JP2017125117A (en) * | 2016-01-13 | 2017-07-20 | 金印株式会社 | Antioxidant |
WO2018212147A1 (en) | 2017-05-15 | 2018-11-22 | 江崎グリコ株式会社 | Skin dullness eliminating agent, and skin barrier function maintaining or improving agent |
KR20190014435A (en) * | 2017-08-02 | 2019-02-12 | 부경대학교 산학협력단 | Method for producing buckwheat sprout with increased rutin contents |
WO2021084665A1 (en) * | 2019-10-30 | 2021-05-06 | 株式会社 資生堂 | Platelet-derived growth factor (pdgf)-bb production promoter, stem cell stabilizer containing this, and skin anti-aging agent containing these |
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