JPH07238011A - Skin-beautifying cosmetic composition - Google Patents
Skin-beautifying cosmetic compositionInfo
- Publication number
- JPH07238011A JPH07238011A JP6064313A JP6431394A JPH07238011A JP H07238011 A JPH07238011 A JP H07238011A JP 6064313 A JP6064313 A JP 6064313A JP 6431394 A JP6431394 A JP 6431394A JP H07238011 A JPH07238011 A JP H07238011A
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- extract
- cosmetic composition
- skin
- whitening
- beautifying
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、優れた美白効果を有す
る美白用化粧料組成物に関し、さらに詳細には、特にシ
ミ、ソバカス等の予防又は治療に有効であって、優れた
美白効果を示すと共に、安全で安定な美白用化粧料組成
物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition having an excellent whitening effect. More specifically, it is particularly effective in preventing or treating spots, freckles, etc., and has an excellent whitening effect. The present invention also relates to a safe and stable whitening cosmetic composition.
【０００２】[0002]
【従来の技術】従来から、シミ、ソバカス等の予防又は
治療を目的として、ハイドロキノン及びその配糖体、コ
ウジ酸及びその誘導体、アスコルビン酸及びその誘導
体、チオール系化合物、種々の動植物の抽出物等を美白
成分として配合する美白用化粧料が提案されている。2. Description of the Related Art Conventionally, hydroquinone and its glycosides, kojic acid and its derivatives, ascorbic acid and its derivatives, thiol compounds, extracts of various animals and plants, etc. for the purpose of preventing or treating spots, freckles, etc. A whitening cosmetic composition has been proposed in which is added as a whitening ingredient.
【０００３】[0003]
【発明が解決しようとする課題】しかしこれら化粧料に
は、種々の問題点が残されており、実用性の面で問題が
あった。例えば美白成分としてのハイドロキノンは安全
性に問題があり、また、ハイドロキノン配糖体、コウジ
酸及びその誘導体、アスコルビン酸及びその誘導体等に
は、化粧料の配合成分として使用するには極性が高すぎ
るという問題点がある。However, these cosmetics have various problems, and there is a problem in practical use. For example, hydroquinone as a whitening component has a safety problem, and the polarity of hydroquinone glycosides, kojic acid and its derivatives, ascorbic acid and its derivatives, etc. is too high to be used as a blending component of cosmetics. There is a problem.
【０００４】さらに、グルタチオン、システイン等のチ
オール系化合物は、配合後の安定性に問題が残ってお
り、また、動植物の抽出物、例えば胎盤エキス、アロエ
エキス等の配合も知られてはいるが、その美白効果は満
足出来るものではなかった。Further, thiol compounds such as glutathione and cysteine still have a problem in stability after compounding, and compounding of animal and plant extracts such as placenta extract and aloe extract is known. , Its whitening effect was not satisfactory.
【０００５】[0005]
【課題を解決するための手段】本発明者等は、優れた美
白効果を有する物質を見出すべく、マウスのＢ１６メラ
ノーマ株を用いたメラニン生成抑制試験を指標に、種々
の植物について、スクリーニングを行った。その結果、
生薬として知られるバリオスベルマム モンタナム、イ
ンドセンダン及びセイヨウヒルガオの各抽出物が、強い
メラニン生成抑制効果のあることを見い出し、又該抽出
物は細胞毒性が極めて弱く、化粧料の美白成分として極
めて有効であることを見い出し、本発明を完成した。[Means for Solving the Problems] In order to find a substance having an excellent whitening effect, the present inventors screened various plants using a melanin production suppression test using a mouse B16 melanoma strain as an index. It was as a result,
It was found that each extract of Barrios verumum montanum, neem, and bindweed, which is known as a crude drug, has a strong melanin production inhibitory effect, and the extract has extremely weak cytotoxicity and is extremely effective as a whitening ingredient of cosmetics. Therefore, the present invention has been completed.
【０００６】即ち、本発明はバリオスペルマム モンタ
ナム、インドセンダン及びセイヨウヒルガオから選ばれ
る１種または２種以上の植物の抽出物を配合することを
特徴とする美白用化粧料組成物を提供するものである。That is, the present invention provides a whitening cosmetic composition comprising an extract of one or more kinds of plants selected from Variospermum montanam, neem, and bindweed. Is.
【０００７】本発明において、美白用化粧料組成物と
は、シミ、ソバカス等の予防又は治療に有効な皮膚用化
粧料組成物を言い、医薬部外品としてのローション、乳
液、クリーム、パック剤、石鹸等の薬用化粧品及び医薬
品としてのローション、乳液、クリーム、軟膏等の皮膚
外用剤を含むものである。In the present invention, the whitening cosmetic composition refers to a skin cosmetic composition which is effective in preventing or treating spots, freckles and the like, and is a quasi-drug lotion, emulsion, cream, pack. , External lotions such as soaps and other medicated cosmetics and pharmaceuticals such as lotions, emulsions, creams and ointments.
【０００８】本発明で用いた植物は、いずれも生薬とし
て長い歴史の間人類に受け入れられてきたものであり、
毒性の面では問題がない素材である。All of the plants used in the present invention have been accepted by human beings for a long history as crude drugs,
It is a material with no toxicity issues.
【０００９】本発明で用いたバリオスベルマム モンタ
ナム（Ｂａｌｉｏｓｐｅｒｍｕｍｍｏｎｔａｎｕｍ、植
物名；ＤＡＮＴＩ）は、トウダイグサ科の植物で、解
熱、解毒薬等として使用されてきた。インドセンダン
（Ｍｅｌｉａ ａｚａｄｉｒａｃｈｔａ、植物名；ＮＥ
ＥＭ） は、センダン科の植物で、整腸薬、鎮痛薬等と
して使用されてきた。また、セイヨウヒルガオ（Ｃｏｎ
ｖｏｌｖｕｌｕｓ ａｒｖｅｎｓｉｓ、植物名；ＢＨＡ
ＤＲＡＢＡＬＡ）は、ヒルガオ科の植物で、かゆみ止
め、止痛等の効能がある。しかし、これらのものが美白
剤として有効であるということは全く知られていない。The Baliospermum montanum (plant name: DANTI) used in the present invention is a plant of the Euphorbiaceae family, and has been used as an antipyretic drug and an antidote. Neem (Melia azadirachta, plant name; NE
EM) is a plant of the family Sacanthidae and has been used as an intestinal medicine, an analgesic, and the like. In addition, Convolvulus vulgaris (Con
volvulus arvensis, plant name; BHA
DRABALA) is a plant of the Convolvulaceae family, and has effects such as itching and pain relief. However, it is completely unknown that these substances are effective as a whitening agent.
【００１０】本発明において使用する植物の抽出物は、
植物を水系又は有機系溶媒を用いて抽出することにより
得られるものである。植物から抽出物を得る時に使用す
る溶媒は、有効成分が効果的に抽出される溶媒であれば
特に限定されるものではないが、水、アセトン、又はメ
タノール、エタノール、プロパノール等の低級アルコー
ル、もしくはそれらの混液、酢酸エチル等を用いるのが
好ましい。The plant extract used in the present invention is
It is obtained by extracting the plant with an aqueous or organic solvent. The solvent used when obtaining the extract from the plant is not particularly limited as long as it is a solvent in which the active ingredient is effectively extracted, but water, acetone, or a lower alcohol such as methanol, ethanol or propanol, or It is preferable to use a mixed solution thereof, ethyl acetate or the like.
【００１１】抽出に際しては、市販（インド産、インド
生薬商より入手可能）の前記植物をそのまま溶媒で抽出
して得ることもできるが、抽出効率を高めるためには、
これらの原料を細かく裁断してから溶媒で抽出すること
が望ましい。抽出は、細かく裁断した原料１ｇに対し
て、５〜１００ｍｌ、好ましくは１０〜２０ｍｌの溶媒
を用い、１日から１か月間、好ましくは２〜５日間、２
〜４回に分けて室温で行うことが望ましい。At the time of extraction, the above-mentioned plant (commercially available from India, available from Indian crude drug dealer) can be directly extracted with a solvent, but in order to improve the extraction efficiency,
It is desirable that these raw materials be finely cut and then extracted with a solvent. The extraction is performed using 5 to 100 ml, preferably 10 to 20 ml of solvent per 1 g of the finely cut raw material, for 1 day to 1 month, preferably 2 to 5 days, 2
It is desirable to perform the treatment at room temperature in four times.
【００１２】また、抽出物中の有効成分の濃度を高める
ために、所望により、得られた抽出物を更に、濃縮、液
液分配、吸着クロマトグラフィー、順相もしくは逆相ク
ロマトグラフィー等の手段に付すことも可能である。Further, in order to increase the concentration of the active ingredient in the extract, the obtained extract is further subjected to means such as concentration, liquid-liquid partitioning, adsorption chromatography, normal phase or reverse phase chromatography, if desired. It is also possible to attach.
【００１３】本発明の美白用化粧料組成物は、上記のよ
うにして得られる抽出物を単独、あるいは混合させて使
用することができる。また、化粧料に一般に用いられて
いる成分、例えば、油性成分、界面活性剤、紫外線吸収
剤、低級アルコール、防腐剤、殺菌剤、色剤、粉末、香
料、水溶性高分子、緩衝剤などをその剤形に合わせ、本
発明の効果を損なわない範囲で適宜配合することにより
調製される。In the whitening cosmetic composition of the present invention, the extract obtained as described above can be used alone or in a mixture. In addition, components commonly used in cosmetics, for example, oily components, surfactants, ultraviolet absorbers, lower alcohols, preservatives, bactericides, coloring agents, powders, fragrances, water-soluble polymers, buffers, etc. It is prepared by appropriately blending it according to its dosage form and within a range that does not impair the effects of the present invention.
【００１４】本発明の美白用化粧料組成物中の上記抽出
物の配合量は、メラニン生成抑制作用ならびに皮膚の角
質透過性等を考慮して定めることが好ましいが、一般的
には上記抽出物を原材料換算で０．０１〜５０重量％、
好ましくは、０．１〜２０重量％程度とすれば良い。The blending amount of the above extract in the whitening cosmetic composition of the present invention is preferably determined in consideration of the melanin production inhibitory action and the skin keratin permeability, but generally the above extract is used. 0.01 to 50% by weight in terms of raw materials,
Preferably, it is about 0.1 to 20% by weight.
【００１５】[0015]
【作用】本発明の有効成分である上記抽出物が、どのよ
うに作用して美白効果を示すのかは、未だ明らかではな
い。しかし、上記抽出物がマウスのＢ１６メラノーマ株
を用いたメラニン生成抑制試験で、細胞毒性を示さずに
メラニン生成を強く抑制することからみて、チロシンか
らメラニン生成までのいずれかのステップにおいて、こ
の反応を阻害するものであることが予想される。It is not yet clear how the above-mentioned extract, which is the active ingredient of the present invention, acts to have a whitening effect. However, in the melanogenesis inhibition test using the mouse B16 melanoma strain, the above-mentioned extract strongly inhibits melanin production without showing cytotoxicity, and therefore, in any step from tyrosine to melanin production, this reaction It is expected that the
【００１６】次に実施例によって本発明をさらに詳細に
説明する。Next, the present invention will be described in more detail by way of examples.
実施例１バリオスペルマム モンタナム抽出物の調整 バリオスペルマム モンタナム１００ｇ（インド生薬商
より入手）を細かく裁断し、５０％エタノール１０００
ｍｌを加えて室温下、４８時間抽出した。濾過により固
形物を除いた後、抽出液を集めて減圧濃縮により溶液を
留去し、抽出物５．７ｇを得た。Example 1 Preparation of Barriospermum Montanum Extract 100g of Barriospermum Montanum (obtained from Indian crude drug dealer) was finely cut into 1000% 50% ethanol.
After adding ml, the mixture was extracted at room temperature for 48 hours. After removing the solid matter by filtration, the extracts were collected and concentrated under reduced pressure to remove the solution by distillation to obtain 5.7 g of an extract.
【００１７】実施例２インドセンダン抽出物の調製 インドセンダン１０ｇ（インド生薬商より入手）を細か
く裁断し、９０％エタノール１００ｍｌを加えて室温
下、３日間抽出した。濾過により不溶物を取り除いた
後、ロータリーエバポレーターを用いて溶媒を完全に除
いた。これに２００ｍｌの水と２００ｍｌのヘキサンを
加えよく振りまぜた後、分液ロート中で静置し、上層
（ヘキサン層）と下層（水層）を回収した。上層を減圧
濃縮により溶液を留去し、抽出物０．５６ｇを得た。こ
れをヘキサン画分と称する。また、下層から残存してい
るヘキサンを完全に取り除いた後、２００ｍｌの酢酸エ
チルを加えよく振りまぜたのち、分液ロート中で静置
し、上層（酢酸エチル層）を回収した。同様に、上層を
減圧濃縮により溶液を留去し、抽出物０．７６ｇを得
た。これを酢酸エチル画分と称する。Example 2 Preparation of neem extract 10 g neem (obtained from Indian crude drug dealer) was finely cut, 100 ml of 90% ethanol was added, and the mixture was extracted at room temperature for 3 days. After removing the insoluble matter by filtration, the solvent was completely removed using a rotary evaporator. 200 ml of water and 200 ml of hexane were added thereto, and the mixture was shaken well and then allowed to stand in a separating funnel to collect an upper layer (hexane layer) and a lower layer (aqueous layer). The solution was distilled off by concentrating the upper layer under reduced pressure to obtain 0.56 g of an extract. This is called a hexane fraction. Further, after completely removing the hexane remaining from the lower layer, 200 ml of ethyl acetate was added, and the mixture was shaken well and then allowed to stand in a separating funnel to recover the upper layer (ethyl acetate layer). Similarly, the upper layer was concentrated under reduced pressure to remove the solution by distillation to obtain 0.76 g of an extract. This is called the ethyl acetate fraction.
【００１８】実施例３セイヨウヒルガオ抽出物の調製 セイヨウヒルガオ１００ｇ（インド生薬商より入手）を
細かく裁断し、実施例１と同様にエタノールで抽出し、
抽出物３．０ｇを得た。Example 3 Preparation of Bindweed Bindweed extract 100 g of Bindweed Bindweed (obtained from Indian Herb Pharmacy) was finely cut and extracted with ethanol in the same manner as in Example 1,
3.0 g of extract was obtained.
【００１９】実施例４メラニン生成抑制試験 メラニン生成抑制試験はマウスのメラノーマ細胞を用い
て、次の様に行った。先ず、１×１０５個のＢ１６メラ
ノーマ細胞を、１０％（Ｖ／Ｖ）牛胎児血清を含むイー
グル最少栄養培地５ｍｌを入れた直径６０ｍｍのシャー
レに播種し、５％（Ｖ／Ｖ）炭酸ガスに調整した炭酸ガ
スインキュベーターで３７℃２４時間培養した。次いで
このシャーレに５０％エタノールに溶解した試料を５０
μｌ添加した。同条件でさらに５日間培養した後、トリ
プシン処理により細胞を回収し、その白色化度を肉眼で
評価し、同時に、細胞塊体積の変化を肉眼で判定し、細
胞毒性の指標とした。Example 4 Melanin Production Inhibition Test The melanin production inhibition test was carried out as follows using mouse melanoma cells. First, 1 × 10 5 B16 melanoma cells were seeded in a petri dish having a diameter of 60 mm containing 5 ml of Eagle's minimal nutrient medium containing 10% (V / V) fetal bovine serum, and 5% (V / V) carbon dioxide gas was added. The cells were cultured at 37 ° C. for 24 hours in a carbon dioxide incubator adjusted to 1. Next, a 50% ethanol-dissolved sample was added to this petri dish.
μl was added. After further culturing for 5 days under the same conditions, cells were collected by trypsin treatment, the degree of whitening thereof was visually evaluated, and at the same time, the change in cell mass volume was visually evaluated and used as an index of cytotoxicity.
【００２０】この測定方法で、実施例１、実施例２及び
実施例３の各植物抽出物について、メラニン生成抑制を
測定した。また、従来から美白成分として用いられてい
るアルブチンについても同様に測定した。結果を第１表
に示す。また、細胞毒性についても第１表に示す。本発
明の抽出物は、いずれもアルブチンよりも低濃度で実用
化に充分なメラニン生成抑制効果を示した。また、本発
明の抽出物を室温で３ヵ月間保存後、再度メラニン生成
抑制及び細胞毒性を評価したが、同様な結果が得られ
た。これらの結果は、本発明の抽出物が、優れた美白効
果と安全性及び安定性を兼ね備えた、有用な美白成分で
あることを示すものである。By this measuring method, the melanin production inhibition was measured for each of the plant extracts of Example 1, Example 2 and Example 3. Further, arbutin, which has been conventionally used as a whitening ingredient, was also measured in the same manner. The results are shown in Table 1. The cytotoxicity is also shown in Table 1. All of the extracts of the present invention showed a sufficient melanin production inhibitory effect for practical use at a concentration lower than that of arbutin. Further, the extract of the present invention was stored at room temperature for 3 months and then evaluated for melanin production inhibition and cytotoxicity again, but similar results were obtained. These results show that the extract of the present invention is a useful whitening ingredient having both excellent whitening effect, safety and stability.
【００２１】[0021]
【表１】 [Table 1]
【００２２】実施例５美白クリームの製造（１） 〔処方〕 Ａ 実施例１の抽出物 ０．０５ｇ 精製水 ５．５０ｇ Ｂ ３−サクシニルオキシグリチルレチン酸 第二ナトリウム ０．０５ｇ Ｃ スクワラン １０．００ｇ ミリスチン酸オクチルドデシル ８．００ｇ マイクロクリスタリンワックス ４．００ｇ ベヘニルアルコール ３．００ｇ 親油型モノステアリン酸グリセリン ２．５０ｇ モノステアリン酸ポリオキシエチレン ソルビタン（２０Ｅ．Ｏ．） ２．５０ｇ Ｄ １，３−プチレングリコール １０．００ｇ パラオキシ安息香酸メチル ０．１０ｇ 精製水 ５４．００ｇ Ｅ 香料 ０．３０ｇExample 5 Production of whitening cream (1) [Formulation] A Extract of Example 1 0.05 g Purified water 5.50 g B 3-Succinyloxyglycyrrhetinic acid secondary sodium 0.05 g C Squalane 10.00 g Myristin Octyldodecyl acid 8.00 g Microcrystalline wax 4.00 g Behenyl alcohol 3.00 g Lipophilic glyceryl monostearate 2.50 g Polyoxyethylene sorbitan monostearate (20 EO) 2.50 g D 1,3-Putylene glycol 10.00 g Methyl paraoxybenzoate 0.10 g Purified water 54.00 g E Fragrance 0.30 g
【００２３】〔製法〕８０〜８５℃に加熱したＤにＢを
加え、これに８０〜８５℃に加熱溶解したＣをホモミキ
サーで撹拌しながら加え、均一に乳化した。これを室温
で徐々に約５０℃に冷却し、Ｅ及びＡを加えた。さらに
撹拌を続けながら室温まで冷却し、美白クリームを製造
した。このようにして製造したクリームは、美白効果に
優れたものであった。[Manufacturing Method] B was added to D heated to 80 to 85 ° C., and C melted by heating at 80 to 85 ° C. was added thereto with stirring with a homomixer to uniformly emulsify. It was gradually cooled to about 50 ° C. at room temperature and E and A were added. The whitening cream was manufactured by further cooling to room temperature while continuing stirring. The cream thus produced had an excellent whitening effect.
【００２４】実施例６美白クリームの製造（２） 実施例５の〔処方〕Ａに代えて、 Ａ 実施例２のヘキサン画分 ０．２５ｇ 精製水 ５．３０ｇ と処方し、実施例５と同様に美白クリームを製造した。Example 6 Production of whitening cream (2) [Formulation] A in Example 5 was replaced with A, hexane fraction of Example 2, 0.25 g, purified water, 5.30 g, and the same procedure as in Example 5. Manufactured whitening cream.
【００２５】実施例７カーマインローションの製造 〔処方〕 Ａ 酸化亜鉛 １．３０ｇ 無水ケイ酸 １．１０ｇ タルク ２．００ｇ ベンガラ ０．０１ｇ ポリオキシエチレンステアリン酸 アミド（４Ｅ．Ｏ．） ０．０５ｇ Ｂ 実施例１の抽出物 ０．０５ｇ エタノール ５．５５ｇ Ｃ 濃グリセリン ３．００ｇ カンフル ０．１０ｇ パラオキシ安息香酸メチル ０．０５ｇ 香料 ０．０５ｇ Ｄ 精製水 ８６．７４ｇExample 7 Preparation of Carmine Lotion [Formulation] A zinc oxide 1.30 g silicic anhydride 1.10 g talc 2.00 g red iron oxide 0.01 g polyoxyethylene stearic acid amide (4 EO) 0.05 g B Extract of Example 1 0.05 g Ethanol 5.55 g C Concentrated glycerin 3.00 g Camphor 0.10 g Methyl paraoxybenzoate 0.05 g Perfume 0.05 g D Purified water 86.74 g
【００２６】〔製法〕Ｄの約６０ｇをＡに加え、ホモミ
キサーで均一に分散させて粉体分散液を作製した。これ
にＢの溶液及びＣを加え、さらにＤの残部を加え、さら
にホモミキサーで均一に分散させてカーマインローショ
ンを製造した。このようにして製造したカーマインロー
ションは、ほてり感を鎮め、美白効果に優れたものであ
った。[Production Method] About 60 g of D was added to A and uniformly dispersed with a homomixer to prepare a powder dispersion. A solution of B and C were added thereto, the rest of D was added, and the mixture was uniformly dispersed with a homomixer to produce a carmine lotion. The carmine lotion thus produced had a hot whitening effect and was excellent in whitening effect.
【００２７】実施例８美白軟膏の製造 〔処方〕 Ａ マクロゴール４０００ ４７．５０ｇ マクロゴール４００ ４７．５０ｇ Ｂ 実施例２の酢酸エチル画分 ０．１５ｇ 実施例３の抽出物 ０．１０ｇ 精製水 ４．７５ｇExample 8 Production of whitening ointment [formulation] A Macrogol 4000 47.50 g Macrogol 400 47.50 g B Ethyl acetate fraction of Example 2 0.15 g Extract of Example 3 0.10 g Purified water 4 .75 g
【００２８】〔製法〕マクロゴール４０００及びマクロ
ゴール４００を水浴上で６５℃に加温して溶解し、均一
に混合してマクロゴール軟膏基剤を製造した。これにＢ
の溶液を練合して美白軟膏を製造した。このようにして
製造した美白軟膏は、美白効果に優れたものであった。[Manufacturing Method] Macrogol 4000 and Macrogol 400 were heated to 65 ° C. in a water bath to be dissolved and uniformly mixed to prepare a Macrogol ointment base. B to this
The solution was mixed to produce a whitening ointment. The whitening ointment thus produced was excellent in whitening effect.
【００２９】[0029]
【発明の効果】バリオスペルマム モンタナム、インド
センダン及びセイヨウヒルガオの各抽出物は、細胞毒性
を示すことなくメラニン生成を著しく抑制する。従っ
て、本発明のこれらの植物の抽出物を１種又は２種以上
配合する美白用化粧料組成物は、安全で美白効果が高い
ものである。EFFECTS OF THE INVENTION Each of the extracts of Variospermum montanam, neem, and bindweed significantly suppresses melanin production without showing cytotoxicity. Therefore, the whitening cosmetic composition containing one or more of the plant extracts of the present invention is safe and has a high whitening effect.
Claims (1)
タナム（Ｂａｌｉｏｓｐｅｒｍｕｍｍｏｎｔａｎｕ
ｍ）、センダン科のインドセンダン（Ｍｅｌｉａ ａｚ
ａｄｉｒａｃｈｔａ）及びヒルガオ科のセイヨウヒルガ
オ（Ｃｏｎｖｏｌｖｕｌｕｓａｒｖｅｎｓｉｓ）から選
ばれる１種又は２種以上の植物の抽出物を配合すること
を特徴とする美白用化粧料組成物。1. A Variospermum Montanum of the Euphorbiaceae family.
m), Neem (Melia az) from the genus Meliaceae
adilachta) and an extract of one or more kinds of plants selected from Convolvulus arvensis of the family Convolvulaceae, and a whitening cosmetic composition comprising the same.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6064313A JPH07238011A (en) | 1994-02-24 | 1994-02-24 | Skin-beautifying cosmetic composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6064313A JPH07238011A (en) | 1994-02-24 | 1994-02-24 | Skin-beautifying cosmetic composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07238011A true JPH07238011A (en) | 1995-09-12 |
Family
ID=13254632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6064313A Pending JPH07238011A (en) | 1994-02-24 | 1994-02-24 | Skin-beautifying cosmetic composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07238011A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2818140A1 (en) * | 2000-12-14 | 2002-06-21 | Sederma Sa | Cosmetic use of Convolvulus tricolor extracts to increase skin hydration and prevent skin aging and wrinkles |
| KR100482695B1 (en) * | 2002-05-13 | 2005-04-13 | 주식회사 태평양 | Composition for skin whitening containing extract from Melia azedarach or β-carboline alkaloids |
| JP2006327988A (en) * | 2005-05-26 | 2006-12-07 | Ichimaru Pharcos Co Ltd | Whitening agent and skin care preparation for whitening |
| JP2010195732A (en) * | 2009-02-26 | 2010-09-09 | Kao Corp | Dopa oxidase activity inhibitor, beautifying agent and skin care preparation for external use |
| JP2011105666A (en) * | 2009-11-19 | 2011-06-02 | Kao Corp | Dopa oxidase activity inhibitor and whitening agent |
| US9445987B2 (en) | 2009-10-05 | 2016-09-20 | Kao Corporation | Ceramide production enhancer and moisturizer |
| CN110433114A (en) * | 2019-08-16 | 2019-11-12 | 湖南科技学院 | The plant extracts inhibited tyrosinase activity and its application |
-
1994
- 1994-02-24 JP JP6064313A patent/JPH07238011A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2818140A1 (en) * | 2000-12-14 | 2002-06-21 | Sederma Sa | Cosmetic use of Convolvulus tricolor extracts to increase skin hydration and prevent skin aging and wrinkles |
| KR100482695B1 (en) * | 2002-05-13 | 2005-04-13 | 주식회사 태평양 | Composition for skin whitening containing extract from Melia azedarach or β-carboline alkaloids |
| JP2006327988A (en) * | 2005-05-26 | 2006-12-07 | Ichimaru Pharcos Co Ltd | Whitening agent and skin care preparation for whitening |
| JP2010195732A (en) * | 2009-02-26 | 2010-09-09 | Kao Corp | Dopa oxidase activity inhibitor, beautifying agent and skin care preparation for external use |
| US9445987B2 (en) | 2009-10-05 | 2016-09-20 | Kao Corporation | Ceramide production enhancer and moisturizer |
| US9682029B2 (en) | 2009-10-05 | 2017-06-20 | Kao Corporation | Ceramide production enhancer and moisturizer |
| JP2011105666A (en) * | 2009-11-19 | 2011-06-02 | Kao Corp | Dopa oxidase activity inhibitor and whitening agent |
| CN110433114A (en) * | 2019-08-16 | 2019-11-12 | 湖南科技学院 | The plant extracts inhibited tyrosinase activity and its application |
| CN110433114B (en) * | 2019-08-16 | 2022-03-22 | 湖南科技学院 | Plant extract for inhibiting tyrosinase activity and application thereof |
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