JPH0490757A - Adhesive dressing - Google Patents
Adhesive dressingInfo
- Publication number
- JPH0490757A JPH0490757A JP20499890A JP20499890A JPH0490757A JP H0490757 A JPH0490757 A JP H0490757A JP 20499890 A JP20499890 A JP 20499890A JP 20499890 A JP20499890 A JP 20499890A JP H0490757 A JPH0490757 A JP H0490757A
- Authority
- JP
- Japan
- Prior art keywords
- porous
- membrane
- polyolefin membrane
- film
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000853 adhesive Substances 0.000 title claims abstract description 34
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 34
- 229920000098 polyolefin Polymers 0.000 claims abstract description 45
- 229910052751 metal Inorganic materials 0.000 claims abstract description 22
- 239000002184 metal Substances 0.000 claims abstract description 22
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 10
- 239000011148 porous material Substances 0.000 claims abstract description 8
- 230000035699 permeability Effects 0.000 claims abstract description 7
- 239000012528 membrane Substances 0.000 claims description 75
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 16
- 241000894006 Bacteria Species 0.000 abstract description 9
- 208000015181 infectious disease Diseases 0.000 abstract description 6
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 abstract description 5
- 238000010559 graft polymerization reaction Methods 0.000 abstract description 5
- 238000010030 laminating Methods 0.000 abstract description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract description 2
- 208000005422 Foreign-Body reaction Diseases 0.000 abstract description 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 206010052428 Wound Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- -1 n- propyl Chemical group 0.000 description 23
- 239000004743 Polypropylene Substances 0.000 description 19
- 229920001155 polypropylene Polymers 0.000 description 19
- 239000010410 layer Substances 0.000 description 14
- 239000002033 PVDF binder Substances 0.000 description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 6
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 229910052709 silver Inorganic materials 0.000 description 6
- 239000004332 silver Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 229940057995 liquid paraffin Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 239000008188 pellet Substances 0.000 description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
- 238000004544 sputter deposition Methods 0.000 description 3
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000003522 acrylic cement Substances 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000003484 crystal nucleating agent Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920006264 polyurethane film Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000001771 vacuum deposition Methods 0.000 description 2
- UJPMYEOUBPIPHQ-UHFFFAOYSA-N 1,1,1-trifluoroethane Chemical compound CC(F)(F)F UJPMYEOUBPIPHQ-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920006370 Kynar Polymers 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010884 ion-beam technique Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は、手術後の縫合部、傷の手当などに使用され、
空気や水蒸気は透過するが、水分や細菌の侵入を防ぐこ
とができる外科用ドレッシングに関する。[Detailed Description of the Invention] [Industrial Application Field] The present invention is used for sutures after surgery, wound care, etc.
It relates to a surgical dressing that is permeable to air and water vapor but prevents the ingress of moisture and bacteria.
手術後の縫合部や傷の手当等に使用する創傷用ドレッシ
ング材は、簡単に操作することができ、患者が入浴した
りシャワーを浴びたりした場合に交換する必要がなく、
傷口への感染を防止することが必要である。Wound dressings used for post-surgical sutures and wound dressings are easy to manipulate and do not need to be changed when the patient takes a bath or shower.
It is necessary to prevent infection of the wound.
従来はガーゼ、脱脂綿が用いられていたが、滲出液をす
みやかに吸収するために、創傷面が脱水症状になり乾燥
してしまい、その結果癲皮ができる。この際にガーゼが
創面に固着して離れにくく、剥す際に患者に苦痛を与え
てしまい、出血等を伴うものである。また滲出液がガー
ゼを通して表面に出てくると、細菌が傷に侵入する可能
性が考えられる。Conventionally, gauze and absorbent cotton have been used, but because they absorb exudate quickly, the wound surface becomes dehydrated and dry, resulting in the formation of scabs. At this time, the gauze adheres to the wound surface and is difficult to remove, causing pain to the patient when it is removed and causing bleeding. Additionally, if exudate comes to the surface through the gauze, bacteria may enter the wound.
これに代わるものとして、吸湿性パッドと非粘着性多孔
フィルムからなるスポンジ状バ、ソドと防水性絆創膏を
組み合わせたドレッシングＣＡｉｒｓｔｒｉｐ■、 Ｓ
ｍｆｔｈ ＆ Ｎｅｐｈｅｗ Ｌｉｍ１ｔｅｄ）や高水
蒸気透過性を有するポリウレタンフィルムと接着剤層か
らなる接着性ドレッシング（Ｏｐ −５ｉｔｅ■Ｓｍ１
ｔｈ ｌ Ｎｅｐｈｅｗ Ｌｉｍ１ｔｅｄ： Ｂｉｏｃ
ｌｕｓｉｖｅ（８１，Ｊｏｈｎｓｏｎ ＆Ｊｏｈｎｓｏ
ｎ＋ Ｔｅｇａｄｅｒｍ’３Ｍ）などが市販されている
。As an alternative to this, there are dressings such as CAirstrip, which is a combination of a sponge-like bandage made of a hygroscopic pad and a non-adhesive porous film, and a waterproof bandage.
mfth & Nephew Lim1ted) and adhesive dressing (Op-5ite Sm1) consisting of a polyurethane film with high water vapor permeability and an adhesive layer.
th l Nephew Lim1ted: Bioc
lusive (81, Johnson & Johnson
n+ Tegaderm'3M) and the like are commercially available.
しかしながらこれらのうち吸湿性のパッド等を使用して
いるドレッシングでは多層構造から構成され、かさ高く
なることから脇から水分や細菌等が侵入してくる可能性
が考えられる。また高水蒸気透過性を有するポリウレタ
ンフィルムは原料として医療グレードになると汎用の材
料ではなく、高価である等の問題がある。However, among these dressings that use hygroscopic pads, etc., they have a multilayer structure and are bulky, so there is a possibility that moisture, bacteria, etc. may enter from the armpits. Furthermore, when a polyurethane film having high water vapor permeability is used as a medical grade raw material, it is not a general-purpose material and has problems such as being expensive.
一方、特開昭５８−１５５８５４号公報に見られたよう
に、多孔質フィルムからなる創傷被覆材かあるが、手術
後の縫合部に適用した場合、粘着部分が存在しない為、
皮膚との密着性に問題があり、感染することが予想され
る。On the other hand, as seen in JP-A-58-155854, there is a wound dressing made of porous film, but when applied to the sutured area after surgery, it does not have an adhesive part.
There is a problem with adhesion to the skin, and infection is expected.
また創傷面や傷口の縫合部では感染が起こりやすい為、
抗菌剤を含有したクリーム基剤を使用して感染防止を行
っている。しかし抗菌剤をガーゼに練り込んだ場合、滲
出液とともにガーゼ包帯に約５７％が染み込み、創面に
は約２１％しか到達しない。またクリーム基剤では毎日
のように創傷面に塗り込むなど操作上面倒である。In addition, infection is likely to occur on the wound surface and the sutured part of the wound.
A cream base containing antibacterial agents is used to prevent infection. However, when an antibacterial agent is kneaded into gauze, about 57% of the agent soaks into the gauze bandage along with exudate, and only about 21% reaches the wound surface. In addition, cream-based products are cumbersome to use, as they have to be applied to the wound surface every day.
このような点から、一般に接着性ドレ・ソシングとして
は、■）操作性がよいこと、２）使用時までに滅菌され
ていること、３）全面接着が可能であること、４）創面
に固着しないこと、５）原料が容易に入手でき、製造が
容易でかつ安価であること等の要件を満たすことが望ま
れるか、未だこれらの条件を満たすドレッシングは得ら
れていないのが現状である。From these points of view, adhesive dressings generally have the following characteristics: ■) have good operability, 2) be sterilized before use, 3) be able to adhere to the entire surface, and 4) adhere to the wound surface. 5) It is desired that raw materials be easily available, production is easy, and inexpensive, etc. However, at present, dressings that meet these conditions have not yet been obtained.
上記目的は下記の構成を有する接着性ドレッシングによ
って達成される。The above object is achieved by an adhesive dressing having the following configuration.
（１）多孔質ポリオレフィン膜もしくは多孔質ノ＼ロゲ
ン化ポリオレフィン膜からなる層、接着剤からなる層お
よび弾性を付与した多孔質ポリオレフィン膜もしくは多
孔質ノ＼ロゲン化ポリオレフィン膜からなる層を順次積
層してなり、上記各層のいずれかの層に抗菌性を有する
金属を蒸着させてなる接着性ドレッシング。(1) A layer consisting of a porous polyolefin membrane or a porous \logenated polyolefin membrane, a layer consisting of an adhesive, and a layer consisting of a porous polyolefin membrane or a porous \logenated polyolefin membrane with elasticity are laminated in sequence. An adhesive dressing comprising a metal having antibacterial properties deposited on any one of the above layers.
（２）弾性多孔質膜がアクリル酸メチル、エチル、ｎ−
プロピル、１ｓｏ−プロピル、ｎ−ブチルまたは１ｓｏ
−ブチルでグラフト重合した多孔質ポリオレフィン膜で
ある１項に記載の接着性ドレッシング。(2) The elastic porous membrane is made of methyl acrylate, ethyl acrylate, n-
propyl, 1so-propyl, n-butyl or 1so
- Adhesive dressing according to item 1, which is a porous polyolefin membrane grafted with butyl.
（３）多孔質ポリオレフィン膜あるいは弾性多孔質膜の
平均孔径が０．０１〜１．０μｍである１または２項の
いずれかの項に記載の接着性Ｆルッノング。(3) The adhesive F-lunnong according to any one of items 1 and 2, wherein the porous polyolefin membrane or the elastic porous membrane has an average pore diameter of 0.01 to 1.0 μm.
（４） 多孔質ポリオレフィン膜ある０は弾性多孔質
膜の水蒸気透過率が２００〜５０００ Ｋ ／イ・２４
ｈｒである１乃至３項のいずｎかの項に記載の接着性ド
レッシング。(4) Porous polyolefin membrane 0 is an elastic porous membrane whose water vapor permeability is 200 to 5000 K/I・24
The adhesive dressing according to any one of items 1 to 3, which is hr.
（５）多孔質ポリオレフィン膜もしくはノ＼ロゲン化ポ
リオレフィン膜からなる層がそれら゛に親水性ポリマー
を化学的に結合させた親水性多孔質ポリオレフィン膜層
である１乃至４項のいずれかの項に記載の接着性ドレッ
シング。(5) In any one of items 1 to 4, the layer consisting of a porous polyolefin membrane or a halogenated polyolefin membrane is a hydrophilic porous polyolefin membrane layer in which a hydrophilic polymer is chemically bonded to the porous polyolefin membrane. Adhesive dressing as described.
（６）多孔質ポリオレフィン膜もしくは多孔質／％ロゲ
ン化ポリオレフィン膜からなる層が、他の層の面積より
小さいことを特徴とする１乃至５項のいずれかの項に記
載の接着性ドレッシング。(6) The adhesive dressing according to any one of items 1 to 5, characterized in that the layer consisting of a porous polyolefin membrane or a porous/% rogenated polyolefin membrane has a smaller area than the other layers.
本発明の接着性ドレッシングは、上記のように多孔質ポ
リオレフィン膜もしくは多孔質ハロゲン化ポリオレフィ
ン膜からなる層、接着剤からなる層および弾性を付与し
た多孔質ポリオレフィン膜もしくは多孔質ハロゲン化ポ
リオレフィン膜からなる層を順次積層してなり、上記各
層のいずれかの層に抗菌性を得する金属を蒸着させてな
る。As described above, the adhesive dressing of the present invention consists of a layer consisting of a porous polyolefin membrane or porous halogenated polyolefin membrane, a layer consisting of an adhesive, and a porous polyolefin membrane or porous halogenated polyolefin membrane imparted with elasticity. It is made up of layers laminated one after another, and a metal that provides antibacterial properties is deposited on one of the layers.
本発明に用いられている多孔質膜は、多孔質のものであ
れば、特に限定されないが、汎用で低価格な面を考慮に
入れると、好ましくはポリオレフィンあるいは一部ハロ
ゲン化されたポリオレフィンが望ましい。好ましい例と
しては、ポリエチレン、ポリプロピレン、ポリフッ化ビ
ニリデン、ポリ塩素化ポリエチレンなどがあげられる。The porous membrane used in the present invention is not particularly limited as long as it is porous, but polyolefin or partially halogenated polyolefin is preferable in consideration of general purpose and low cost. . Preferred examples include polyethylene, polypropylene, polyvinylidene fluoride, polychlorinated polyethylene, and the like.
本発明の多孔質ポリオレフィン膜もしくは多孔質ハロゲ
ン化ポリオレフィン膜は、上記ポリオレフィンもしくは
ハロゲン化ポリオレフィンにメトキシエチルアクリレー
トあるいはＮ−ジメチルアクリルアミドをグラフト重合
させて親水性とするのが望ましい。特にポリメトキシエ
チルアクリレートは生体適合性に優れており、生体組織
と接触しても異物反応が少ないという利点を有している
。The porous polyolefin membrane or porous halogenated polyolefin membrane of the present invention is preferably made hydrophilic by graft polymerizing methoxyethyl acrylate or N-dimethylacrylamide to the polyolefin or halogenated polyolefin. In particular, polymethoxyethyl acrylate has excellent biocompatibility and has the advantage of causing little foreign body reaction even when it comes into contact with living tissue.
上記多孔質ポリオレフィン膜は接着性ドレッシングとし
て使用するには、孔径０，０１〜１．０庫、水蒸気透過
率２００〜５０００ｇ／ｒｒｒ・２４ｈｒの範囲内にあ
るものがよい。In order to use the porous polyolefin membrane as an adhesive dressing, it is preferable to have a pore diameter of 0.01 to 1.0 and a water vapor permeability of 200 to 5000 g/rrr.24 hr.
本発明に使用される金属は銀、銅又は亜鉛等であるか、
抗菌性の点から銀が好ましい。また膜表面に存在させる
金属は２種類以上であっても良いし、酸化物、塩の状態
であっても良い。そして多孔質膜に存在させる金属の量
については、特に限定されないか、コスト面、溶出金属
による２次汚染等から、膜表面に存在させる金属は、膜
表面のＸ線光電子スペクトルによる金属原子／炭素原子
比が０．０２〜５．０の範囲内にあるものが良い。すな
わち、金属原子／炭素原子が５．０を越えると、膜表面
での金属存在比が過剰となり、抗菌性を有するものの、
孔径が付着した金属により縮小化して膜本来の水蒸気透
過性が失われてしまう。又、過剰に金属が付着してこの
金属が薄膜化してしまうと、孔が閉塞されたり、金属層
が衝撃等で剥離するばかりか、非経済的である。逆に金
属原子／炭素原子比が０，０２以下であると、安定した
抗菌性が失われる戊がある。The metal used in the present invention is silver, copper, zinc, etc.
Silver is preferred from the viewpoint of antibacterial properties. Further, two or more types of metals may be present on the film surface, or they may be in the form of oxides or salts. The amount of metal present in the porous membrane is not particularly limited, or due to costs, secondary contamination due to eluted metal, etc., the metal present on the membrane surface is determined by metal atoms/carbon It is preferable that the atomic ratio is within the range of 0.02 to 5.0. In other words, when the metal atom/carbon atom ratio exceeds 5.0, the metal abundance ratio on the film surface becomes excessive, and although it has antibacterial properties,
The pore size is reduced by the attached metal and the membrane's inherent water vapor permeability is lost. Furthermore, if an excessive amount of metal adheres and the metal becomes thin, the pores may become clogged, the metal layer may peel off due to impact, etc., and this is uneconomical. Conversely, if the metal atom/carbon atom ratio is less than 0.02, stable antibacterial properties may be lost.
多孔質ポリオレフィン膜もしくは多孔質ハロゲン化ポリ
オレフィン膜からなる層が接着剤層より面積か小さい場
合は、上記ポリオレフィン膜の外側で接着剤が皮膚に直
接接するので、接着性ドレッシングがしっかりと固定さ
れる。If the layer consisting of a porous polyolefin membrane or a porous halogenated polyolefin membrane is smaller in area than the adhesive layer, the adhesive dressing will be securely fixed because the adhesive will be in direct contact with the skin on the outside of the polyolefin membrane.
〔作 用〕
本発明の接着性ドレッシングは例えば次のようにして製
造される。[Function] The adhesive dressing of the present invention is manufactured, for example, as follows.
まず、ポリプロピレン粉末に所定量の流動パラフィン及
び結晶核形成剤を加えて溶融混練しペレット化する。こ
のベレットを１５０〜２００℃で溶融し、Ｔダイ付押出
機により押出し、冷却固定化液中に導き冷却固定化して
フィルムにし、該フィルム中の不純物を流動パラフィン
で抽出し、１３５℃程度の空気中で約２分間熱処理を行
い、ポリプロピレン膜の多孔質膜を得る。該膜にメトキ
シエチルアクリレートをプラズマ開始表面グラフト重合
し、親水化処理したポリプロピレン膜の多孔質膜を得る
。この膜の湿潤下での表面の潤滑性を表１に示した。First, a predetermined amount of liquid paraffin and a crystal nucleating agent are added to polypropylene powder, and the mixture is melt-kneaded and pelletized. This pellet is melted at 150 to 200°C, extruded using an extruder equipped with a T-die, introduced into a cooling fixing liquid, cooled and fixed to form a film, and impurities in the film are extracted with liquid paraffin. A heat treatment is performed for about 2 minutes in a polypropylene film to obtain a porous polypropylene film. Plasma-initiated surface graft polymerization of methoxyethyl acrylate is performed on the membrane to obtain a porous polypropylene membrane subjected to hydrophilic treatment. Table 1 shows the surface lubricity of this film under wet conditions.
表 】 創傷被覆材の表面潤滑性
材料表面の湿潤下での表面潤滑性の度合を、平均摩擦係
数（摩擦抵抗）と摩擦係数の変動（いわゆるざらざら感
）より求めることができる。[Table] Surface Lubricity of Wound Dressing Material The degree of surface lubricity of a material surface under wet conditions can be determined from the average coefficient of friction (frictional resistance) and variation in the coefficient of friction (so-called roughness).
未処理のポリプロピレン膜では平均摩擦係数と摩擦係数
の変動が高い値を示すのに対して、メトキシエチルアク
リレートで親水化処理を施すと低い値を示し、湿潤下で
非常にざらつき感が低く、ぬるぬるとした水和状態とな
る。While the untreated polypropylene film shows high average friction coefficient and friction coefficient variation, the hydrophilic treatment with methoxyethyl acrylate shows low values, resulting in very low roughness and slimy feeling under wet conditions. It becomes a hydrated state.
一方弾性ポリブロビレン製の多孔質膜を得るには、ポリ
プロピレン膜の多孔質膜にアクリル酸エチルをプラズマ
開始表面グラフト重合する。この膜は処理前のポリプロ
ピレン製の多孔質膜と比較して、強度が１４８倍、伸度
１０倍以上であった。次にこの弾性多孔質膜を真空蒸着
用のペルジャー内に収容し、ペルジャー内を減圧し、所
定時間銀を真空蒸着する。尚、膜表面に金属を存在させ
る方法は、他にスパッタリング法、イオンビーム法等が
あるが特に限定されない。On the other hand, to obtain a porous membrane made of elastic polypropylene, ethyl acrylate is subjected to plasma-initiated surface graft polymerization onto a porous polypropylene membrane. This membrane had 148 times the strength and 10 times the elongation of the polypropylene porous membrane before treatment. Next, this elastic porous membrane is placed in a Pel jar for vacuum deposition, the pressure inside the Pel jar is reduced, and silver is vacuum deposited for a predetermined period of time. Note that the method for making metal present on the film surface is not particularly limited, although there are other methods such as sputtering method and ion beam method.
上記で得られた金属が膜に蒸着した弾性多孔質膜上に、
アクリル系の接着剤を精密被覆用具（アプリケーター）
を用いて塗布する。この接着剤を塗布した弾性ポリプロ
ピレン製の多孔質膜と金属を蒸着させた親水性ポリプロ
ピレン製の多孔質膜をラミネートすることにより、本発
明の接着性ドレッシングが作成される。On the elastic porous membrane on which the metal obtained above was deposited,
Acrylic adhesive precision coating tool (applicator)
Apply using. The adhesive dressing of the present invention is produced by laminating a porous membrane made of elastic polypropylene coated with this adhesive and a porous membrane made of hydrophilic polypropylene coated with metal.
本発明の接着性ドレッシングは、手や足の関節等の屈伸
する箇所に適用することができ、空気や水蒸気は透過す
るが、水分や細菌の侵入を防ぐことができ、患者が入浴
したりシャワーを浴びたりする場合に交換する必要がな
い。The adhesive dressing of the present invention can be applied to areas that bend and stretch, such as the joints of the hands and feet, and is permeable to air and water vapor, but prevents moisture and bacteria from entering, allowing the patient to take a bath or shower. There is no need to replace it when showering.
以下、実施例をあげて本発明をさらに具体的に説明する
。Hereinafter, the present invention will be explained in more detail with reference to Examples.
［１）
多孔質膜の作製（１）
メルトフローインデックスが３０及び０．３のポリプロ
ピレン混合物（混合重量比１００ ： ４０）１００重
量部当り、４００重量部の流動パラフィン（平均分子量
３２４）及び０．３重量部の結晶核形成剤としての１．
３，２．４−ビス（ｐ−エチルベンジリデン）ソルビト
ールを二輪型押出機により溶融混練し、ベレット化した
。このベレットを上記二軸型押出機を用いて１５０〜２
００℃で溶融し、スリット幅０．６關のＴダイより空気
中に押出しフィルム状にし、このフィルム状物をＴダイ
直下に置かれたガイドローラーによって冷却固定化液中
に導き冷却固定化した後巻取る。この巻取ったフィルム
状物を一定寸法に切断し、縦横両方向を固定し、１．１
．２− ）リクロロー１．２．２− トリフルオロエタ
ン中にｌＯ分間計４回浸漬して、フィルム物中の流動パ
ラフィンの抽出を行う。次いで１３５℃の空気中で２分
間熱処理を行って、孔径０．Ｂ−１膜厚１４０ｔｌｎの
ポリプロピレン製多孔質膜を得た。[1) Preparation of porous membrane (1) Per 100 parts by weight of a polypropylene mixture with a melt flow index of 30 and 0.3 (mixing weight ratio 100:40), 400 parts by weight of liquid paraffin (average molecular weight 324) and 0.3 parts by weight were added. 1.3 parts by weight as a crystal nucleating agent.
3,2.4-bis(p-ethylbenzylidene) sorbitol was melt-kneaded using a two-wheeled extruder and formed into pellets. This pellet was heated to 150 to 2
It was melted at 00°C and extruded into a film through a T-die with a slit width of 0.6 degrees in the air, and this film-like material was introduced into a cooling fixing liquid by a guide roller placed directly below the T-die, where it was cooled and fixed. Rewind later. This rolled-up film-like material is cut into a certain size, fixed both vertically and horizontally, and 1.1
．． 2-) Rechloro 1.2.2- Extract the liquid paraffin in the film by immersing it in trifluoroethane for 10 minutes a total of 4 times. Next, heat treatment was performed in air at 135°C for 2 minutes to reduce the pore size to 0. B-1 A polypropylene porous membrane having a thickness of 140 tln was obtained.
多孔質膜の作製（２）
ポリフッ化ビニリデン粉末（三菱油化■製Ｋｙｎａｒ
Ｋ３０Ｌ） １８玉量部をアセトン７３．８重量部及び
ジメチルホルムアミド８．２玉量部に溶解してなる溶液
を、ポリエチレンテレフタレートフィルム上にキャスト
した後、１．１．２− トリクロロトリフルオロエタン
洛中に５分間浸漬し、乾燥して平均孔径０．４５ｍ、膜
厚１３５虜のポリフッ化ビニリデン多孔質膜を得た。Preparation of porous membrane (2) Polyvinylidene fluoride powder (Kynar manufactured by Mitsubishi Yuka)
A solution prepared by dissolving 18 parts by weight of K30L) in 73.8 parts by weight of acetone and 8.2 parts by weight of dimethylformamide was cast onto a polyethylene terephthalate film, and then 1.1.2-trichlorotrifluoroethane was added. The membrane was immersed in water for 5 minutes and dried to obtain a polyvinylidene fluoride porous membrane with an average pore diameter of 0.45 m and a film thickness of 135 mm.
弾性多孔質膜の作製（３）
上記で得られたポリプロピレン製多孔質膜あるいはポリ
フッ化ビニリデン多孔質膜にアクリル酸エチルをプラズ
マ開始表面グラフト重合し、弾性を付与したポリプロピ
レン製多孔質膜あるいはポリフッ化ビニリデン製多孔質
膜を得た。Preparation of elastic porous membrane (3) Plasma-initiated surface graft polymerization of ethyl acrylate is performed on the polypropylene porous membrane or polyvinylidene fluoride porous membrane obtained above to impart elasticity to the polypropylene porous membrane or polyvinylidene fluoride porous membrane. A porous membrane made of vinylidene was obtained.
親水性多孔質膜の作製（４）
上記で得られたポリプロピレン製の多孔質膜あるいはフ
ッ化ビニリデン製の多孔質膜にメトキシエチルアクリレ
ートをプラズマ開始表面グラフト重合し親水化したポリ
プロピレン製多孔質膜あるいはポリフッ化ビニリデン製
多孔質膜を得た。Preparation of a hydrophilic porous membrane (4) A porous polypropylene membrane made hydrophilic by plasma-initiated surface graft polymerization of methoxyethyl acrylate on the polypropylene porous membrane or vinylidene fluoride porous membrane obtained above, or A porous membrane made of polyvinylidene fluoride was obtained.
［７〕 銀蒸着した多孔質膜の作製 上記の多孔質膜に銀をスパッタリング蒸着する。[7] Preparation of porous membrane with silver vapor deposition Silver is deposited on the porous film by sputtering.
このスパッタリングは、まず多孔質膜を真空蒸着用のペ
ルジャーに設置し、１Ｏ−５Ｔｏｒｒにまず減圧した後
、シャーターを開いて多孔質膜に所定時間銀をスパッタ
リング蒸着した。In this sputtering, the porous film was first placed in a Pel jar for vacuum deposition, the pressure was first reduced to 10-5 Torr, the shutter was opened, and silver was sputter-deposited on the porous film for a predetermined period of time.
（１１１Ｆ）
接着性ドレッシングの作製
上記で得られた弾性多孔質膜上に、アクリル系の接着剤
を精密被覆用具（アプリケーター）を用いて塗布し製膜
した。この接着剤を塗布した弾性ポリプロピレン製の多
孔質膜と金属を蒸着させた親水性ポリプロピレン製の多
孔質膜をラミネートすることにより接着性ドレッシング
が得られた。(111F) Preparation of adhesive dressing On the elastic porous membrane obtained above, an acrylic adhesive was applied using a precision coating tool (applicator) to form a film. An adhesive dressing was obtained by laminating a porous membrane made of elastic polypropylene coated with this adhesive and a porous membrane made of hydrophilic polypropylene coated with metal.
抗菌性の評価
Ｍｕｌｌｅｒ−ＨｉｌＬｏｎ Ａｇａｒ （Ｄｉ［′ｃ
ｏ社製）をオートクレーブにかけた後５０℃に保ち、２
０ｍ１ずつシャーレに分注し、１時間室温に放置し固め
た。菌は平板で培養した後、トリス緩衝液中に各種の菌
を懸濁して菌液とし、培地上に綿棒で３回ずつ全体に塗
布した。上記の方法で調製した試料を直径８ｍ１ｍに切
りぬき、菌を塗布した培地上に置き、３７℃で１８時間
培養した。結果を表１に示した。Antibacterial evaluation Muller-HilLon Agar (Di['c
(manufactured by company o) was autoclaved and kept at 50℃,
0ml each was dispensed into petri dishes and left to solidify at room temperature for 1 hour. After culturing the bacteria on a flat plate, each type of bacteria was suspended in Tris buffer to obtain a bacterial solution, which was applied to the entire surface of the medium three times using a cotton swab. The sample prepared by the above method was cut out to a diameter of 8 ml, placed on a culture medium coated with bacteria, and cultured at 37° C. for 18 hours. The results are shown in Table 1.
以上述へたように、本発明は弾性を付与した多孔質膜と
親水処理した多孔質膜とが接着剤を介したドレッシング
であり、更に抗菌性のある金属を蒸着させて抗菌性を付
与することを特徴としており、空気や水蒸気は透過する
が、水分や細菌の侵入を防ぐことができ、更に患者か入
浴したりシャワーを浴びたりする場合にドレッシングを
交換する必要がなく、傷口への感染を防止することがで
きる。As described above, the present invention is a dressing in which a porous membrane imparted with elasticity and a porous membrane subjected to hydrophilic treatment are interposed with an adhesive, and a metal having antibacterial properties is further vapor-deposited to impart antibacterial properties. It is characterized by the fact that it allows air and water vapor to pass through, but prevents moisture and bacteria from entering, and there is no need to change the dressing when the patient takes a bath or shower, preventing infection of the wound. can be prevented.
・・金属粒子・・Metal particles
Claims (5)
化ポリオレフィン膜からなる層、接着剤からなる層およ
び弾性を付与した多孔質ポリオレフィン膜もしくは多孔
質ハロゲン化ポリオレフィン膜からなる層を順次積層し
てなり、上記各層のいずれかの層に抗菌性を有する金属
を蒸着させてなる接着性ドレッシング。(1) A layer consisting of a porous polyolefin membrane or porous halogenated polyolefin membrane, a layer consisting of an adhesive, and a layer consisting of a porous polyolefin membrane or porous halogenated polyolefin membrane imparted with elasticity are laminated in sequence, and the above-mentioned An adhesive dressing in which a metal with antibacterial properties is deposited on one of the layers.
平均孔径が０．０１〜１．０μｍである請求項１に記載
の接着性ドレッシング。(2) The adhesive dressing according to claim 1, wherein the porous polyolefin membrane or the elastic porous membrane has an average pore diameter of 0.01 to 1.0 μm.
水蒸気透過率が２００〜５０００ｇ／ｍ＾２・２４ｈｒ
である請求項１または２に記載の接着性ドレッシング。(3) The water vapor permeability of the porous polyolefin membrane or elastic porous membrane is 200 to 5000g/m^2・24hr
The adhesive dressing according to claim 1 or 2.
オレフィン膜からなる層がそれらに親水性ポリマーを化
学的に結合させた親水性多孔質ポリオレフィン膜層であ
る請求項１乃至３のいずれかの項に記載の接着性ドレッ
シング。(4) The layer comprising the porous polyolefin membrane or the halogenated polyolefin membrane is a hydrophilic porous polyolefin membrane layer having a hydrophilic polymer chemically bonded thereto. Adhesive dressing.
化ポリオレフィン膜からなる層が、他の層の面積より小
さいことを特徴とする請求項１乃至４のいずれかの項に
記載の接着性ドレッシング。(5) The adhesive dressing according to any one of claims 1 to 4, wherein the layer consisting of a porous polyolefin membrane or a porous halogenated polyolefin membrane has a smaller area than the other layers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499890A JP2892790B2 (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499890A JP2892790B2 (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0490757A true JPH0490757A (en) | 1992-03-24 |
| JP2892790B2 JP2892790B2 (en) | 1999-05-17 |
Family
ID=16499764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20499890A Expired - Lifetime JP2892790B2 (en) | 1990-08-03 | 1990-08-03 | Adhesive dressing |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2892790B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10314203A (en) * | 1997-05-16 | 1998-12-02 | Kyowa:Kk | Skin protective material |
| WO2003034962A1 (en) * | 2001-10-17 | 2003-05-01 | Noritake Co.,Limited | External affected area protective material |
-
1990
- 1990-08-03 JP JP20499890A patent/JP2892790B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10314203A (en) * | 1997-05-16 | 1998-12-02 | Kyowa:Kk | Skin protective material |
| WO2003034962A1 (en) * | 2001-10-17 | 2003-05-01 | Noritake Co.,Limited | External affected area protective material |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2892790B2 (en) | 1999-05-17 |
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