JP2896210B2 - Wound dressing - Google Patents
Wound dressingInfo
- Publication number
- JP2896210B2 JP2896210B2 JP20499690A JP20499690A JP2896210B2 JP 2896210 B2 JP2896210 B2 JP 2896210B2 JP 20499690 A JP20499690 A JP 20499690A JP 20499690 A JP20499690 A JP 20499690A JP 2896210 B2 JP2896210 B2 JP 2896210B2
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- JP
- Japan
- Prior art keywords
- wound
- film
- porous
- wound dressing
- metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、創傷被覆材に関するものである。詳しく述
べると、本発明は創傷、熱傷等による皮膚欠損受傷の
際、該皮膚欠損部位に適用され、該皮膚欠損部位と接す
る面を水和潤滑状態にして、表面再生を促進する創傷被
覆材に関する。Description: TECHNICAL FIELD The present invention relates to a wound dressing. More specifically, the present invention relates to a wound dressing that is applied to a skin defect site when a skin defect is caused by a wound or burn, and that makes the surface in contact with the skin defect site a hydrated lubricating state to promote surface regeneration. .
外傷性の皮膚創傷および採皮創等の創傷および疾患に
伴う創部に対する創傷治療方法としては、大別して創傷
部を乾燥状態に保ち、痂皮を形成させて治癒を行う、い
わゆるdry dressingと、適度の湿潤環境をつくり、速や
かな表皮細胞の遊走を行うwet dressingとが知られてお
り、後者は創傷の治癒も速やかであり、創傷部表面の乾
燥壊死が少なく、創面の保護効果も有することなどが知
られている。As wound treatment methods for wounds such as traumatic skin wounds and cutaneous wounds and wounds associated with diseases, the so-called dry dressing, which roughly divides the wound into a dry state, forms a scab to heal, and moderates Wet dressing is known to create a moist environment and quickly migrate epidermal cells.The latter has a rapid wound healing, has less dry necrosis on the wound surface, has a protective effect on the wound surface, etc. It has been known.
しかし、wet dressingの一方法であるサージカルドレ
ープを用いる方法では、浸出液の貯留が多く創面に再吸
収されるおそれがあり、また感染の危険も大きく、接着
剤が直接創面と接するため、創傷治癒に有害と思われる
問題点があることが指摘されている。また、創面から剥
がれやすいこともあり、創面と接する部分に小さな突起
を付けたものもあるが、逆に除去困難という欠点を有す
るなどの問題点があった。However, in the method using surgical drape, which is one method of wet dressing, there is a large possibility that the exudate is stored in the wound surface and the wound surface may be reabsorbed, and the risk of infection is large. It has been pointed out that there are problems that are considered harmful. In addition, there is a case where a small projection is provided on a portion in contact with the wound surface because it may be easily peeled off from the wound surface.
これらの問題点を解決するため近年では被覆材の創傷
部と接触する部位にコラーゲン、キチン、フィブリン等
の生体高分子を用いるもの、あるいはゴム系の素材中に
保湿成分を分散させ密着・非癒着・高含水状態の確保な
どを図ったもの、さらには本発明者らが以前提案した創
傷部に接触する部位の少なくとも一部が撥水性物質によ
り被覆された生体適合性のヒドロゲル形成性の支持層
（例えば、カルボキシメチルセルロース、アルギン酸塩
系、ヒアルロン酸塩系、ポリ（メタ）アクリル酸塩系）
と、該支持層の創傷部に接触する部位とは反対側に形成
された水分透過調節層とからなる創傷被覆材（特開昭62
-183760号公報）等があり、一定の成果をおさめてい
る。In order to solve these problems, in recent years, materials that use biopolymers such as collagen, chitin, fibrin, etc., or rubber-based materials have been dispersed in moisturizing components in areas where they come into contact with wounds, and adherence / non-adhesion has occurred. -A biocompatible hydrogel-forming support layer in which at least a part of a site that comes into contact with a wound previously proposed by the present inventors is coated with a water-repellent substance, in order to ensure a high water content. (For example, carboxymethylcellulose, alginate, hyaluronate, poly (meth) acrylate)
A wound dressing comprising a support layer and a moisture permeation control layer formed on the side opposite to the site in contact with the wound (see JP-A-62
-183760), etc., and have achieved certain results.
一方、dry dressingとして多孔質高分子膜があるが、
この場合dressingが創面に固着してしまい剥す際に出血
を伴う為、最近では創面と接触する部位には非粘着性多
孔フィルム（Melolin ,Smith ＆ Nephew Limited）を
使用したドレッシングが市販されている。 On the other hand, there is a porous polymer membrane as dry dressing,
In this case, the dressing sticks to the wound surface and bleeds when peeling off
In recent years, non-adhesive materials have often
Perforated film (Melolin , Smith & Nephew Limited)
The used dressing is commercially available.
また創傷面や傷口の縫合部では感染が起こりやすい
為、抗菌剤を含有したクリーム基剤を使用して感染防止
を行っている。しかし、抗菌剤をガーゼに練り込んだ場
合、滲出液とともにガーゼ包帯に約57％が染み込み、創
面に約21％しか到達しない。またクリーム基剤では毎日
のように創傷面に塗り込むなど操作上面倒である。Infection is likely to occur at the wound surface or at the suturing area of the wound. Therefore, infection is prevented using a cream base containing an antibacterial agent. However, when the antibacterial agent is kneaded into the gauze, about 57% of the gauze bandage is soaked together with the exudate, and only about 21% reaches the wound surface. In addition, with a cream base, the operation surface is inconvenient, such as applying it to the wound surface every day.
上記従来の被覆材もある程度の効果は有しているが、
創傷部と接触する部分の生体適合性を有する基剤層の形
成に用いられている材料が、分解、脱落しやすく、創傷
被覆材としての使用時における物性に問題があり、さら
に、その分解、離脱物が異物として認識されることがあ
り、創傷部の治癒を遅延させる危険性があった。また、
支持層の創傷部に接触する部位とは反対側に形成される
水分透過調節層は、適度な水分透過能と細菌侵入阻止能
を有していることが必要とされるが、この両者の性質を
満足させる材料は、かなり限定されるものであった。Although the above-mentioned conventional coating material also has some effects,
The material used to form the biocompatible base layer in the area that comes into contact with the wound is easily decomposed and easily dropped off, and there is a problem with the physical properties when used as a wound dressing. The detachment may be recognized as a foreign substance, and there is a risk of delaying the healing of the wound. Also,
The moisture permeation control layer formed on the side of the support layer opposite to the part in contact with the wound needs to have an appropriate water permeability and an ability to prevent bacterial invasion. The materials satisfying the above were considerably limited.
そこで、本発明は創面への良好な密着性を有し、創傷
部と接触しても容易に分解、離脱することがなく、創傷
部の治癒、特に表皮再生が促進され、創傷部の早期の治
癒を行うことができ、また多孔質ポリオレフィン膜が水
蒸気透過性を兼ね備えた創傷被覆材を提供することを目
的とする。Therefore, the present invention has good adhesion to the wound surface, does not easily decompose and detach even when it comes into contact with the wound, and promotes the healing of the wound, particularly the regeneration of the epidermis, An object of the present invention is to provide a wound dressing capable of healing and having a porous polyolefin membrane having water vapor permeability.
また広範囲熱傷やIII度熱傷では感染が起こりやすい
為、抗菌剤を含有したクリーム基剤を使用して感染防止
を行っている。しかし、このうち滲出液とともにガーゼ
包帯に約57％が染み込み、創傷面には約21％しか到達し
ない。また、クリーム基剤では毎日のように創傷面に塗
り込むなど操作上面倒である。この膜に抗菌性のある金
属を蒸着させれば、外部からの感染防止のみならず、創
面が細菌により汚染されている場合にも適応することが
できる。Infection is likely to occur with widespread burns and third-degree burns, so infections are prevented using cream bases containing antimicrobial agents. However, of these, about 57% permeate the gauze bandage with the exudate and reach only about 21% at the wound surface. In addition, in the case of a cream base, the operation surface is inconvenient, such as being applied to the wound surface every day. If an antibacterial metal is deposited on this film, it can be applied not only to prevent infection from the outside but also to the case where the wound surface is contaminated with bacteria.
上記目的は下記の構成を有する創傷被覆材によって達
成される。The above object is achieved by a wound dressing having the following configuration.
１）多孔質ポリオレフィン膜あるいは多孔質ハロゲン化
ポリオレフィン膜の一方の表面に親水性ポリマーを化学
的に結合させ、親水性ポリマーを結合させた面に抗菌性
を有する金属を蒸着させてなることを特徴とする創傷被
覆材。1) A hydrophilic polymer is chemically bonded to one surface of a porous polyolefin film or a porous halogenated polyolefin film, and an antibacterial metal is deposited on the surface to which the hydrophilic polymer is bonded. Wound dressing material.
２）多孔質ポリオレフィン膜の平均孔径が0.01〜1.0μ
ｍである１項に記載の創傷被覆材。2) The average pore size of the porous polyolefin membrane is 0.01 to 1.0μ
2. The wound dressing according to item 1, which is m.
３）多孔質ポリオレフィン膜の水蒸気透過率が200〜500
0mg/m2・24hrである１項または２項に記載の創傷被覆
材。3) The water vapor permeability of the porous polyolefin membrane is 200 to 500
Item 3. The wound dressing according to item 1 or 2, which has a dose of 0 mg / m 2 · 24 hr.
本発明の創傷被覆材は、上記のように多孔質ポリオレ
フィン膜あるいは多孔質ハロゲン化ポリオレフィン膜に
親水性ポリマーを化学的に結合させたものからなり、皮
膚欠損部位に接する面を水和潤滑状態にして、表皮再生
を促進することができる。The wound dressing of the present invention comprises a porous polyolefin membrane or a porous halogenated polyolefin membrane chemically bonded with a hydrophilic polymer as described above, and the surface in contact with the skin defect site is hydrated and lubricated. Thus, epidermal regeneration can be promoted.
本発明に用いられる膜は多孔質ポリオレフィン膜ある
いは多孔質ハロゲン化ポリオレフィン膜であり、汎用で
低価格な面を考慮すると、ポリエチレン、ポリプロピレ
ン、ポリフッ化ビニリデン、ポリ塩化ビニリデン、塩素
化ポリエチレンなどが好ましい。多孔質ポリオレフィン
膜あるいは多孔質ハロゲン化ポリオレフィン膜に結合さ
せる親水性ポリマーとしてはメトキシエチルアクリレー
トあるいはＮ−ジメチルアクリルアミドがあげられ、こ
れらを上記ポリオレフィン膜にグラフト重合させること
により化学的に結合させるポリメトキシエチルアクリレ
ートは生体適合性に優れており、生体組織と接触しても
異物反応が少ないという利点を有する。得られた被覆材
は、孔径0.01〜1.0μｍ、水蒸気透過率200〜5000mg/m2
・24hrの範囲内にあるものがよい。The film used in the present invention is a porous polyolefin film or a porous halogenated polyolefin film. In view of general and low cost, polyethylene, polypropylene, polyvinylidene fluoride, polyvinylidene chloride, chlorinated polyethylene and the like are preferable. Examples of the hydrophilic polymer to be bonded to the porous polyolefin film or the porous halogenated polyolefin film include methoxyethyl acrylate or N-dimethylacrylamide, and polymethoxyethyl which is chemically bonded to the above-mentioned polyolefin film by graft polymerization. Acrylate is excellent in biocompatibility and has the advantage that there is little foreign body reaction even when it comes into contact with living tissue. The obtained coating material has a pore size of 0.01 to 1.0 μm and a water vapor transmission rate of 200 to 5000 mg / m 2.
・ It is better to be within 24 hours.
本発明において抗菌剤として使用される金属は銀、銅
又は亜鉛等であるが、抗菌性の点から銀が好ましい。ま
た膜表面に存在させる金属は２種類以上であっても良い
し、金属単体、酸化物または塩の状態であってもよい。
そして多孔質膜に存在させる金属の量については、特に
限定されないが、コスト面、溶出金属による２次汚染等
から、膜表面に存在させる金属は膜表面のＸ線光電子ス
ペクトルによる金属原子／炭素原子の存在比が0.02〜5.
0の範囲内にあるものが良い。金属原子／炭素原子が5.0
を越えると、膜表面での金属存在比が過剰となり、抗菌
性を有するものの、孔径が付着した金属により、縮小化
して膜本来の水蒸気透過性が失われてしまう。又、過剰
に金属が付着してこの金属が薄膜化してしまうと、孔が
閉塞されたり、金属層が衝撃等で剥離するばかりか、非
経済的である。逆に金属原子／炭素原子比が0.02以下で
あると、安定した抗菌性が失われる虞がある。The metal used as the antibacterial agent in the present invention is silver, copper, zinc, or the like, but silver is preferable from the viewpoint of antibacterial properties. Further, two or more kinds of metals may be present on the surface of the film, or a metal alone, an oxide or a salt may be used.
The amount of the metal present on the porous film is not particularly limited, but the metal present on the film surface is determined by the metal atom / carbon atom based on the X-ray photoelectron spectrum of the film surface because of cost, secondary contamination by the eluted metal, and the like. The abundance of 0.02 to 5.
A value within the range of 0 is good. 5.0 metal atoms / carbon atoms
If it exceeds, the metal content ratio on the membrane surface becomes excessive, and although it has antibacterial properties, the metal having pore diameters is reduced to lose the original water vapor permeability of the membrane. Further, if the metal is excessively attached and the metal is thinned, not only is the hole closed or the metal layer is peeled off by impact or the like, but it is uneconomical. Conversely, if the metal atom / carbon atom ratio is 0.02 or less, stable antibacterial properties may be lost.
本発明の創傷被覆材は例えば次のようにして製造され
る。まず、ポリプロピレン粉末に所定量の流動パラフィ
ン及び結晶核形成剤を加えて溶融混練しペレット化す
る。このペレットを150〜200℃で溶融し、Ｔダイ付押出
機により押出し、冷却固定化液中に導き冷却固定化して
フィルムにし、該フィルム中の流動パラフィンの抽出を
行い、135℃程度の空気中で約２分間熱処理を行い、ポ
リプロピレン製の多孔質膜を得る。該膜にメトキシエチ
ルアクリレートをプラズマ開始表面グラフト重合し、親
水化処理したポリプロピレン製の多孔質膜を得る。この
膜の湿潤下での表面の潤滑性を表１に示した。The wound dressing of the present invention is manufactured, for example, as follows. First, a predetermined amount of liquid paraffin and a crystal nucleating agent are added to polypropylene powder, melt-kneaded, and pelletized. The pellets are melted at 150 to 200 ° C., extruded by an extruder equipped with a T-die, guided into a cooling and fixing solution, cooled and fixed to form a film, and liquid paraffin in the film is extracted. For about 2 minutes to obtain a porous film made of polypropylene. The film is subjected to plasma-induced surface graft polymerization of methoxyethyl acrylate to obtain a hydrophilic porous polypropylene film. Table 1 shows the lubricity of this film under wet conditions.
材料表面の湿潤下での表面潤滑性の度合を、平均摩擦
係数（摩擦抵抗）と摩擦係数の変動（いわゆるざらざら
感）より求めることができる。 The degree of surface lubricity under the wet condition of the material surface can be determined from the average friction coefficient (friction resistance) and the fluctuation of the friction coefficient (so-called rough feeling).
未処理のポリプロピレン膜では平均摩擦係数と摩擦係
数の変動が高い値を示すのに対して、メトキシエチルア
クリレートで親水化処理を施すと、低い値を示し、湿潤
下で非常にざらつき感が低く、ぬるぬるとした水和状態
となる。In an untreated polypropylene film, the average coefficient of friction and the coefficient of friction show high values, whereas when subjected to a hydrophilization treatment with methoxyethyl acrylate, the values show a low value, and the feeling of roughness under wet conditions is very low, It becomes a slimy hydrated state.
次にこの多孔質膜を真空蒸着用のベルジャー内に収容
し、ベルジャー内を減圧し、所定時間銀を真空蒸着す
る。尚、膜表面に金属を存在させる方法は、他にスパッ
タリング法、イオンビーム法等があり、特に限定されな
い。Next, the porous film is housed in a bell jar for vacuum evaporation, the inside of the bell jar is depressurized, and silver is vacuum evaporated for a predetermined time. In addition, as a method for causing a metal to exist on the film surface, there are other methods such as a sputtering method and an ion beam method, and are not particularly limited.
上記で得られた金属が膜に蒸着した多孔質膜上に、ア
クリル系の接着剤を精密被覆用具（アプリケーター）を
用いて塗布させることにより、本発明の創傷被覆材が作
成される。The wound dressing material of the present invention is prepared by applying an acrylic adhesive using a precision coating tool (applicator) on the porous film on which the metal obtained above is deposited on the film.
本発明の創傷被覆材は、膜表面に金属を存在させたの
で、この金属による抗菌作用によって、細菌の増殖が抑
制される。In the wound dressing of the present invention, since a metal is present on the membrane surface, the antibacterial action of the metal suppresses the growth of bacteria.
以下、実施例を示して本発明をさらに具体的に説明す
る。Hereinafter, the present invention will be described more specifically with reference to examples.
実施例１ メルトフローインデックスが30及び0.3のポリプロピ
レン混合物（混合重量比100:40）100重量部当り、400重
量部の流動パラフィン（平均分子量324）及び0.3重量部
の結晶核形成剤としての1,3,2,4−ビス（ｐ−エチルベ
ンジリデン）ソルビトールを二軸型押出機により溶融混
練し、ペレット化した。このペレットを上記二軸型押出
機を用いて150〜200℃で溶融し、スリット0.6mmのＴダ
イより空気中に押出しフィルム状にし、このフィルム状
物をＴダイ直下に置かれたガイドローラーによって冷却
固定化液中に導き冷却固定化した後巻取る。この巻取っ
たフィルム状物を一定寸法に切断し、縦横両方向に固定
し、1,1,2−トリクロロ−1,2,2−トリフルオロエタン中
に10分間計４回浸漬して、フィルム状物中の流動パラフ
ィンの抽出を行う。次いで135℃の空気中で２分間熱処
理を行って、孔径0.6μｍ、膜厚140μのポリプロピレン
製多孔質膜を得た。Example 1 400 parts by weight of liquid paraffin (average molecular weight 324) and 0.3 part by weight of 1, as a crystal nucleating agent per 100 parts by weight of a polypropylene mixture having a melt flow index of 30 and 0.3 (mixing ratio by weight of 100: 40). 3,2,4-bis (p-ethylbenzylidene) sorbitol was melt-kneaded with a twin-screw extruder and pelletized. The pellets are melted at 150 to 200 ° C. using the above twin screw extruder, extruded into air from a T-die having a slit of 0.6 mm to form a film, and the film is guided by a guide roller placed immediately below the T-die. It is guided into a cooling fixing solution, cooled and fixed, and then wound up. This rolled film is cut into a fixed size, fixed in both the vertical and horizontal directions, and immersed in 1,1,2-trichloro-1,2,2-trifluoroethane four times in total for 10 minutes. Extraction of liquid paraffin in the material. Next, heat treatment was performed in air at 135 ° C. for 2 minutes to obtain a polypropylene porous film having a pore diameter of 0.6 μm and a thickness of 140 μm.
この膜にN,N−ジメチルアクリルアミドをプラズマ開
始表面グラフト重合し親水化したポリプロピレン膜を得
た。N, N-dimethylacrylamide was plasma-initiated on the membrane and graft-polymerized onto the membrane to obtain a hydrophilic polypropylene membrane.
実施例２ ポリフッ化ビニリデン粉末（三菱油化（株）製Kynar
K301）18重量部をアセトン73.8重量部及びジメチルホル
ムアミド8.2重量部に溶解してなる溶液を、ポリエチレ
ンテレフタレートフィルム上にキャストした後、1,1,2
−トリフルオロエタン浴中に５分間浸漬し、乾燥して平
均孔径0.45μｍ、膜厚135μｍのポリフッ化ビニリデン
多孔質膜を得た。この膜にN,N−ジメチルアクリルアミ
ドをプラズマ開始表面グラフト重合し親水化したポリフ
ッ化ビニリデン膜を得た。Example 2 Polyvinylidene fluoride powder (Kynar manufactured by Mitsubishi Yuka Co., Ltd.)
K301) A solution prepared by dissolving 18 parts by weight of 73.8 parts by weight of acetone and 8.2 parts by weight of dimethylformamide was cast on a polyethylene terephthalate film, and then cast into a 1,1,2
-Dipped in a trifluoroethane bath for 5 minutes and dried to obtain a polyvinylidene fluoride porous membrane having an average pore diameter of 0.45 µm and a film thickness of 135 µm. N, N-dimethylacrylamide was plasma-initiated on this film by plasma graft polymerization to obtain a hydrophilic polyvinylidene fluoride film.
実施例３ 実施例１で得られた多孔質膜に銀をスパッタリング蒸
着する。このスパッタリング蒸着は、まず多孔質膜を真
空蒸着用のベルジャーに設置し、10-5Torrにまず減圧し
た後、シャーターを開いて多孔質膜に所定時間銀をスパ
ッタリング蒸着した。Example 3 Silver was sputter-deposited on the porous film obtained in Example 1. In this sputtering deposition, first, the porous film was set on a bell jar for vacuum deposition, the pressure was first reduced to 10 −5 Torr, then the shutter was opened and silver was deposited on the porous film by sputtering for a predetermined time.
試験例１ ［抗菌性の評価］ Muller-Hilton Agar（Difco社製）をオートクレーブ
にかけた後50℃に保ち、20mlずつシャーレに分注し、１
時間室温に放置し固めた。菌は平板で培養した後、トリ
ス緩衝液中に各種の菌を懸濁して菌液とし、培地上に綿
棒で３回ずつ全体に塗布した。実施例３の方法で調製し
た試料を直径8mmに切りぬき、菌を塗布した培地上に置
き、37℃で18時間培養した。結果を表１に示した。Test Example 1 [Evaluation of antibacterial property] Muller-Hilton Agar (manufactured by Difco) was autoclaved, kept at 50 ° C, and dispensed into petri dishes in 20 ml portions.
It was left at room temperature for an hour to harden. After culturing the bacteria on a plate, various bacteria were suspended in a Tris buffer to form a bacterial solution, and the whole was applied to the medium three times with a cotton swab. The sample prepared by the method of Example 3 was cut out to a diameter of 8 mm, placed on a medium coated with bacteria, and cultured at 37 ° C. for 18 hours. The results are shown in Table 1.
試験例２ 実施例３の方法で調製した本発明の創傷被覆材と、多
孔質ポリプロピレン膜に銀を蒸着させた親水性ポリマー
を有しない創傷被覆材について、試験例１と同様の方法
で抗菌性の評価を行なった。結果を表２に示す。 Test Example 2 The wound dressing material of the present invention prepared by the method of Example 3 and the wound dressing material having no hydrophilic polymer obtained by evaporating silver on a porous polypropylene film were subjected to antibacterial activity in the same manner as in Test Example 1. Was evaluated. Table 2 shows the results.
〔発明の効果〕 本発明の創傷被覆材は熱傷、採皮創および皮膚剥削
傷、外傷性皮膚欠損創等の疾患ないし、創傷による患部
に適用された際に、適当な水蒸気透過性と創面との接触
面を水和潤滑状態にして、創面に密着し表皮再生を促進
することができ、特に抗菌性を付与した金属を保持させ
ることによって、傷口への感染を防止することができ
る。 [Effect of the Invention] The wound dressing of the present invention has a suitable water vapor permeability and wound surface when applied to a disease such as a burn, a cut wound and a skin abrasion wound, a traumatic skin defect wound, or an affected area by a wound. The contact surface can be hydrated and lubricated to adhere to the wound surface and promote regeneration of the epidermis. In particular, by holding a metal having antibacterial properties, infection to the wound can be prevented.
親水性ポリマーと抗菌性金属を被覆材表面で共存させ
た場合は、親水性ポリマーを共存させないときと比較し
て殺菌能力が向上する。これは、被覆材表面に導入され
た親水性ポリマーが、水分により膨潤して構造がルーズ
になることにより、金属イオンの脱離、拡散が促進され
るため、抗菌性が向上するものと推定される。When the hydrophilic polymer and the antibacterial metal are allowed to coexist on the surface of the coating material, the sterilizing ability is improved as compared with when the hydrophilic polymer is not coexisted. This is presumed to be due to the fact that the hydrophilic polymer introduced on the surface of the coating material swells due to moisture and the structure becomes loose, thereby promoting desorption and diffusion of metal ions, thereby improving antibacterial properties. You.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 片倉 健男 神奈川県足柄上郡中井町井ノ口1500番地 テルモ株式会社内 (72)発明者 高橋 晃 神奈川県足柄上郡中井町井ノ口1500番地 テルモ株式会社内 (56)参考文献 特開 昭61−106640（ＪＰ，Ａ) 特開 昭59−205959（ＪＰ，Ａ) 特開 昭60−72557（ＪＰ，Ａ) (58)調査した分野(Int.Cl.6，ＤＢ名) A61L 15/00 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Takeo Katakura 1500 Inoguchi, Nakai-machi, Ashigara-kami, Kanagawa Prefecture Inside Terumo Corporation (72) Inventor Akira Takahashi 1500 Inokachi, Nakai-machi, Ashigara-gun, Kanagawa Prefecture 1500 Terumo Corporation (56) References JP-A-61-106640 (JP, A) JP-A-59-205959 (JP, A) JP-A-60-72557 (JP, A) (58) Fields investigated (Int. Cl. 6 , DB name) A61L 15/00
Claims (3)
ロゲン化ポリオレフィン膜の一方の表面に親水性ポリマ
ーを化学的に結合させ、親水性ポリマーを結合させた面
に抗菌性を有する金属を蒸着させてなることを特徴とす
る創傷被覆材。1. A method in which a hydrophilic polymer is chemically bonded to one surface of a porous polyolefin film or a porous halogenated polyolefin film, and an antibacterial metal is deposited on the surface to which the hydrophilic polymer is bonded. A wound dressing characterized by the above.
〜1.0μｍである請求項１に記載の創傷被覆材。2. A porous polyolefin membrane having an average pore size of 0.01
The wound dressing according to claim 1, which has a thickness of from 1.0 to 1.0 µm.
200〜5000mg/m2・24hrである請求項１または２に記載の
創傷被覆材。3. The water vapor transmission rate of the porous polyolefin membrane is
The wound dressing according to claim 1, wherein the amount is 200 to 5000 mg / m 2 · 24 hr.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499690A JP2896210B2 (en) | 1990-08-03 | 1990-08-03 | Wound dressing |
| AU81524/91A AU640507B2 (en) | 1990-08-03 | 1991-07-31 | Wound-covering materials |
| EP19910402183 EP0470007B1 (en) | 1990-08-03 | 1991-08-02 | Wound-covering materials |
| DE1991608136 DE69108136T2 (en) | 1990-08-03 | 1991-08-02 | Wound covering material. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20499690A JP2896210B2 (en) | 1990-08-03 | 1990-08-03 | Wound dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0490764A JPH0490764A (en) | 1992-03-24 |
| JP2896210B2 true JP2896210B2 (en) | 1999-05-31 |
Family
ID=16499736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP20499690A Expired - Lifetime JP2896210B2 (en) | 1990-08-03 | 1990-08-03 | Wound dressing |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2896210B2 (en) |
| AU (1) | AU640507B2 (en) |
-
1990
- 1990-08-03 JP JP20499690A patent/JP2896210B2/en not_active Expired - Lifetime
-
1991
- 1991-07-31 AU AU81524/91A patent/AU640507B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0490764A (en) | 1992-03-24 |
| AU8152491A (en) | 1992-02-06 |
| AU640507B2 (en) | 1993-08-26 |
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