JPH043505B2 - - Google Patents

Info

Publication number: JPH043505B2
Authority: JP; Japan
Prior art keywords: time; electrical signal; partial thromboplastin; plasma; value
Prior art date: 1983-09-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP58167351A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6058555A (ja

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-09

Filing date

1983-09-09

Publication date

1992-01-23

1983-09-09 Application filed filed Critical

1983-09-09 Priority to JP16735183A priority Critical patent/JPS6058555A/ja

1985-04-04 Publication of JPS6058555A publication Critical patent/JPS6058555A/ja

1992-01-23 Publication of JPH043505B2 publication Critical patent/JPH043505B2/ja

Status Granted legal-status Critical Current

Links

108010000499 Thromboplastin Proteins 0.000 claims description 27
102000002262 Thromboplastin Human genes 0.000 claims description 27
239000003153 chemical reaction reagent Substances 0.000 claims description 27
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims description 25
108010049003 Fibrinogen Proteins 0.000 claims description 23
102000008946 Fibrinogen Human genes 0.000 claims description 23
229940012952 fibrinogen Drugs 0.000 claims description 23
230000015271 coagulation Effects 0.000 claims description 19
238000005345 coagulation Methods 0.000 claims description 19
108010094028 Prothrombin Proteins 0.000 claims description 18
102100027378 Prothrombin Human genes 0.000 claims description 18
229940039716 prothrombin Drugs 0.000 claims description 18
230000008859 change Effects 0.000 claims description 15
238000000034 method Methods 0.000 claims description 15
230000023555 blood coagulation Effects 0.000 claims description 14
230000008569 process Effects 0.000 claims description 7
238000003756 stirring Methods 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 6
230000001678 irradiating effect Effects 0.000 claims description 3
239000000203 mixture Substances 0.000 claims description 3
230000004913 activation Effects 0.000 claims 1
238000005259 measurement Methods 0.000 description 12
238000012360 testing method Methods 0.000 description 9
238000006243 chemical reaction Methods 0.000 description 4
230000000694 effects Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
206010053567 Coagulopathies Diseases 0.000 description 2
102000009123 Fibrin Human genes 0.000 description 2
108010073385 Fibrin Proteins 0.000 description 2
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
208000032843 Hemorrhage Diseases 0.000 description 2
108090000190 Thrombin Proteins 0.000 description 2
230000000740 bleeding effect Effects 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
238000011088 calibration curve Methods 0.000 description 2
230000035602 clotting Effects 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000010586 diagram Methods 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
229950003499 fibrin Drugs 0.000 description 2
239000012086 standard solution Substances 0.000 description 2
229960004072 thrombin Drugs 0.000 description 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000013013 elastic material Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000006870 function Effects 0.000 description 1
208000031169 hemorrhagic disease Diseases 0.000 description 1
238000007689 inspection Methods 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

JP16735183A 1983-09-09 1983-09-09 血液凝固測定方法および測定装置 Granted JPS6058555A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP16735183A JPS6058555A (ja)	1983-09-09	1983-09-09	血液凝固測定方法および測定装置

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP16735183A JPS6058555A (ja)	1983-09-09	1983-09-09	血液凝固測定方法および測定装置

Publications (2)

Publication Number	Publication Date
JPS6058555A JPS6058555A (ja)	1985-04-04
JPH043505B2 true JPH043505B2 (de)	1992-01-23

Family

ID=15848113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP16735183A Granted JPS6058555A (ja)	1983-09-09	1983-09-09	血液凝固測定方法および測定装置

Country Status (1)

Country	Link
JP (1)	JPS6058555A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2610434B2 (ja) *	1987-06-05	1997-05-14	株式会社京都第一科学	血液凝固能測定方法
JP2994557B2 (ja)	1994-09-02	1999-12-27	株式会社アズウェル	フィブリノゲン測定方法およびその測定試薬
JP4858092B2 (ja)	2006-11-07	2012-01-18	アイシン精機株式会社	車両用ステップ装置
JP4957523B2 (ja) *	2007-11-22	2012-06-20	アイシン精機株式会社	車両用ステップ装置
JP5312835B2 (ja) *	2008-03-31	2013-10-09	シスメックス株式会社	血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム
JP5312834B2 (ja) *	2008-03-31	2013-10-09	シスメックス株式会社	血液凝固分析装置、血液凝固分析方法、及び、コンピュータプログラム
WO2009122993A1 (ja)	2008-03-31	2009-10-08	シスメックス株式会社	血液凝固分析装置、血液凝固分析方法、及びコンピュータプログラム
JP7191613B2 (ja) *	2018-09-26	2022-12-19	キヤノンメディカルシステムズ株式会社	血液凝固分析装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5467496A (en) *	1977-11-09	1979-05-30	Itoman Kk	Device for measuring solidification of blood plasma
JPS5469497A (en) *	1977-11-12	1979-06-04	Kyoto Daiichi Kagaku Kk	Method and device for measuring blood solidification time
JPS56129843A (en) *	1980-02-16	1981-10-12	Compur Electronic Gmbh	Photometric method of and apparatus for measuring progress of reaction
JPS56140240A (en) *	1980-04-04	1981-11-02	Hitachi Ltd	Photometer for blood coagulation measurement
JPS5730954A (en) *	1980-08-01	1982-02-19	Hitachi Ltd	Measuring device for blood coagulation

1983
- 1983-09-09 JP JP16735183A patent/JPS6058555A/ja active Granted

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5467496A (en) *	1977-11-09	1979-05-30	Itoman Kk	Device for measuring solidification of blood plasma
JPS5469497A (en) *	1977-11-12	1979-06-04	Kyoto Daiichi Kagaku Kk	Method and device for measuring blood solidification time
JPS56129843A (en) *	1980-02-16	1981-10-12	Compur Electronic Gmbh	Photometric method of and apparatus for measuring progress of reaction
JPS56140240A (en) *	1980-04-04	1981-11-02	Hitachi Ltd	Photometer for blood coagulation measurement
JPS5730954A (en) *	1980-08-01	1982-02-19	Hitachi Ltd	Measuring device for blood coagulation

Also Published As

Publication number	Publication date
JPS6058555A (ja)	1985-04-04

Publication	Publication Date	Title
US4252536A (en)	1981-02-24	Method and system for measuring blood coagulation time
US4047890A (en)	1977-09-13	Method and apparatus for determining deficiencies in enzymatic reactors particularly clotting factor levels in blood plasmas
US6069011A (en)	2000-05-30	Method for determining the application of a sample fluid on an analyte strip using first and second derivatives
US20060035298A1 (en)	2006-02-16	System and method for determining a coagulation parameter
JPH08502590A (ja)	1996-03-19	差込可能メモリーキーを伴うバイオセンシングメータ
US5156974A (en)	1992-10-20	Method for determining the fibrinogen level of a blood sample
JPH043505B2 (de)	1992-01-23
JP5029638B2 (ja)	2012-09-19	血液凝固分析装置
JP6692361B2 (ja)	2020-05-13	自動分析装置、自動分析システム及び自動分析方法
CN104854459A (zh)	2015-08-19	自动分析装置
US7817255B2 (en)	2010-10-19	Apparatus with a combination of a point light source and a single lens
Karon et al.	2008	Accuracy of capillary whole blood international normalized ratio on the CoaguChek S, CoaguChek XS, and i-STAT 1 point-of-care analyzers
US4454752A (en)	1984-06-19	Test circuit for use in coagulation instrument
KR101205098B1 (ko)	2012-11-26	엘이디 컬러 센서를 이용한 자동 중화 적정 장치 및 방법
JPH0334592B2 (de)	1991-05-23
JP2610434B2 (ja)	1997-05-14	血液凝固能測定方法
JPH10123140A (ja)	1998-05-15	血液凝固測定装置
CN111272678A (zh)	2020-06-12	一种样本检测方法、凝血分析仪及存储介质
EP0010526B1 (de)	1983-08-03	Verfahren und Vorrichtung zur Untersuchung der Blutkoagulation oder der Aggregation von Blutplättchen
US20040219680A1 (en)	2004-11-04	Method and apparatus for determining anticoagulant therapy factors
JPS58172537A (ja)	1983-10-11	光散乱測定装置
CA1062501A (en)	1979-09-18	Method and apparatus for determining deficiencies in enzymatic reactions particularly clotting factor levels in blood plasma
TW201113522A (en)	2011-04-16	Microchip blood analyzer
JPS6168539A (ja)	1986-04-08	生化学測定装置
JPH04318463A (ja)	1992-11-10	血液凝固時間の測定方法