JPH0386172A - Method and device for coating living body - Google Patents
Method and device for coating living bodyInfo
- Publication number
- JPH0386172A JPH0386172A JP1223181A JP22318189A JPH0386172A JP H0386172 A JPH0386172 A JP H0386172A JP 1223181 A JP1223181 A JP 1223181A JP 22318189 A JP22318189 A JP 22318189A JP H0386172 A JPH0386172 A JP H0386172A
- Authority
- JP
- Japan
- Prior art keywords
- coating
- temperature
- living body
- solution
- temp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 40
- 239000011248 coating agent Substances 0.000 title claims abstract description 33
- 238000000034 method Methods 0.000 title claims description 13
- 102000008186 Collagen Human genes 0.000 claims abstract description 10
- 108010035532 Collagen Proteins 0.000 claims abstract description 10
- 238000005507 spraying Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 16
- 239000000499 gel Substances 0.000 claims description 14
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 7
- 230000036760 body temperature Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 abstract description 4
- 108010010803 Gelatin Proteins 0.000 abstract description 3
- 229920000159 gelatin Polymers 0.000 abstract description 3
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- 235000019322 gelatine Nutrition 0.000 abstract description 3
- 235000011852 gelatine desserts Nutrition 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 238000003756 stirring Methods 0.000 abstract description 2
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000002861 polymer material Substances 0.000 abstract 1
- 239000008279 sol Substances 0.000 description 13
- 230000006870 function Effects 0.000 description 8
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- 241001465754 Metazoa Species 0.000 description 4
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- 208000035415 Reinfection Diseases 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
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- 238000011282 treatment Methods 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- 238000003860 storage Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
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- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
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- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 235000012255 calcium oxide Nutrition 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
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Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明は生体温以上の温度でゲル化する高分子物質溶液
の加熱ゾルにより人、動物、植物を被覆する方法および
その装置に関するもので、医療。[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a method and apparatus for coating humans, animals, and plants with a heated sol of a polymeric substance solution that gels at a temperature higher than body temperature. medical care.
美容その他の分野に広く利用できる。It can be widely used in beauty and other fields.
合成樹脂、綿１紙、シリコンなどを材料とした単層また
は多層の被覆材が目的、対象、症状に応じて使用されて
来た。Single-layer or multi-layer dressings made of synthetic resin, cotton paper, silicone, etc. have been used depending on the purpose, target, and symptoms.
熱傷、外傷１手術後の皮膚欠損部などに対する治療用被
覆材として、豚皮、グルプリン膜、コラーゲン膜などの
ほか、ナイロン、シリコン、コラーゲンなどの複合構造
材、キチン不織布などが開発使用されている。In addition to pig skin, glupurin membranes, and collagen membranes, composite structural materials such as nylon, silicone, and collagen, and chitin nonwoven fabrics have been developed and used as therapeutic dressings for skin defects after burns and trauma 1 surgery. .
従来の被覆方法には次のような欠点があり、現在はとん
ど解決されていないのが実状である。Conventional coating methods have the following drawbacks, which have not been resolved at present.
（１）はとんどすべての被覆がフィルムやシートによっ
て行われているために、密着性が悪く、特に円曲部や凹
凸部の多い広範囲な生体表面への被覆が不完全になり、
再感染の恐れも増加し、治療、回復が後れる。In (1), almost all the coating is done with films or sheets, so the adhesion is poor, and the coverage is incomplete, especially over a wide range of biological surfaces with many curved parts and uneven parts.
The risk of reinfection also increases, delaying treatment and recovery.
（２）多くの被覆材が単機能であるために、併用するか
多層構造の被覆材を使用すると、構成材の効果が相互に
相殺され、全体としての効果や効率が低下するばかりで
なく、生体表面の機能が阻害される。(2) Since many covering materials have a single function, when used in combination or with multilayered covering materials, the effects of the constituent materials not only cancel each other out, but also reduce the overall effectiveness and efficiency. Functions of biological surfaces are inhibited.
発明者は多年研究の結果、生体温以上の温度でゲル化す
る高分子物質溶液を加熱ゾルとして、生体表面に噴霧ま
たは塗布することにより、前記の問題点を完全に解決す
ることを見出し、本発明を完成した。As a result of many years of research, the inventor discovered that the above-mentioned problems could be completely solved by spraying or applying a heated sol to the surface of a living body using a solution of a polymeric substance that gels at a temperature higher than the body temperature. Completed the invention.
生体錫以上の温度でゲル化する高分子物質溶液を加熱ゾ
ルとして、生体表面に噴ａｔたは塗布すると、
（１）フィルムやシートと異シ、表面に極めてよく密着
し、円曲部や凹凸部の広い表面でも、迅速、確実、容易
に均一な被覆を行うことができる。When a solution of a polymeric substance that gels at a temperature higher than that of living tin is heated as a sol and is sprayed or applied onto the surface of a living body, (1) it adheres extremely well to the surface, unlike a film or sheet, and forms curved parts and irregularities. Even large surfaces can be uniformly coated quickly, reliably, and easily.
（２）生成した安定皮膜は表面に密着していて、水釦よ
び熱の吸収、放出を自動的に行い、単層でありながら多
機能的であるため、皮膚の機能を阻害せず、その機能と
連動して効率よく被覆の目的を達することができる。(2) The generated stable film adheres to the surface and automatically absorbs and releases water and heat. Although it is a single layer, it is multifunctional, so it does not inhibit skin functions and In conjunction with the function, the purpose of the coating can be achieved efficiently.
本発明に釦いて、生体＠（人では３７℃）以上の温度で
ゲル化する高分子物質を使用する理由は、噴霧または塗
布で表面に付着した加熱ゾルの溶液が、直後にゲル化に
より固定化しないと流れてしまう恐れがあること、更に
本発明の多機能性安定皮膜がゾル→ゲル→水分蒸発→安
定皮膜の経過により始めて形成されることによる。実用
的なゲル化温度は３８〜４５℃程度でちり、これ以上高
い場合には被覆温度は更に高くなり、皮膚に対する熱障
害の恐れが生ずる。The reason for using a polymer substance that gels at a temperature higher than that of a living body (37°C for humans) in the present invention is that the heated sol solution that adheres to the surface by spraying or coating is immediately fixed by gelation. This is because the multifunctional stable film of the present invention is formed only through the process of sol → gel → water evaporation → stable film. The practical gelling temperature is about 38 to 45°C, and if it is higher than this, the coating temperature will be even higher and there is a risk of thermal damage to the skin.
ゲル化する高分子物質溶液は高分子物質の種類。The polymer substance solution that gels is a type of polymer substance.
と組合せ、濃度（加水量）、共存物質などの条件により
選択調整される。It is selected and adjusted depending on conditions such as concentration (amount of water added) and coexisting substances.
本発明に使用される高分子物質としては、コラーゲン蛋
白質（コラーゲン、ゼラチンなど）、乳蛋白質（カゼイ
ンなど）、大豆蛋白質などの天然蛋白質、澱粉、ペクチ
ン、グルコマンナン、 寒天。The polymeric substances used in the present invention include collagen proteins (collagen, gelatin, etc.), milk proteins (casein, etc.), natural proteins such as soybean proteins, starch, pectin, glucomannan, and agar.
カラギーナンなどの天然多糖質その他の天然高分子物質
とその誘導体のほか、ポリビニルアルコール、ポリアク
リル酸ナトリウム、ポリアミノ酸などの親水性合成高分
子化合物が、例示の如何に拘らず、生体温以上のみ度で
ゲルを作る溶液の調製が可能であり、安全性、生体適合
性のある範囲内で、目的、対象、症状に応じて使用可能
である。In addition to natural polysaccharides such as carrageenan, other natural polymer substances, and their derivatives, hydrophilic synthetic polymer compounds such as polyvinyl alcohol, sodium polyacrylate, and polyamino acids, regardless of the examples, may be used at temperatures above the body temperature. It is possible to prepare a gel-forming solution, and it can be used depending on the purpose, subject, and symptom within a safe and biocompatible range.
これら使用可能な高分子物質の中で、コラーゲン蛋白質
は人や動物に対して抗原性や変異原性がほとんど無く、
生分解性（埋没時）や創傷、熱傷の治療作用があるなど
、本発明の生体被覆方法が最も適した材料である。また
カラギーナン、寒天などの多糖質はコラーゲン蛋白質と
は異り、動物系ではないが、人や動物、植物に対する生
体適合性が高く、特に酸性側で安定性が高い特徴があり
、貴重な材質である。Among these polymeric substances that can be used, collagen protein has almost no antigenicity or mutagenicity to humans or animals.
The biocovering method of the present invention is the most suitable material because it is biodegradable (when buried) and has a therapeutic effect on wounds and burns. In addition, unlike collagen proteins, polysaccharides such as agar are not animal-based, but they are highly biocompatible with humans, animals, and plants, and are particularly stable on the acidic side, making them valuable materials. be.
主材としての高分子物質と＼もに、皮膜形成性。Both the polymeric material and the main material have film-forming properties.
柔軟性、保湿性などの改質材、各種の有効成分を目的、
用途により適宜併用する。医療分野では消炎剤、鎮痛剤
、抗菌剤１組織再生促進剤など、また美容分野では保湿
剤、栄養剤などがある。For the purpose of improving flexibility, moisture retention, etc., and various active ingredients,
Use in combination as appropriate depending on the purpose. In the medical field, there are anti-inflammatory agents, analgesics, antibacterial agents, tissue regeneration promoters, etc., and in the beauty field, there are moisturizers, nutritional agents, etc.
本発明の生体被覆方法を行うには、使用する高分子物質
に所要量の水を加えて膨潤させた後、５０〜９０℃に加
熱し、透明になる迄攪拌溶解する。To perform the biological coating method of the present invention, a required amount of water is added to the polymeric substance to be used to swell it, and then heated to 50 to 90°C and stirred and dissolved until it becomes transparent.
このようにして得られた溶液ゾルを４０〜５０℃で皮膚
に噴霧または塗布する。噴霧または塗布のいずれを選ぶ
かについては、通常目的とする安定皮膜が薄い場合には
、粘度即ち濃度の低い溶液ゾルを噴霧し、皮膜が厚い場
合には高粘度、高濃度の溶液ゾルを塗布するが、噴霧ま
たは塗布の回数、対象面積、凹凸の程度、使い易さなど
から可能な範囲で任意に選択される。The solution-sol thus obtained is sprayed or applied to the skin at 40-50°C. When it comes to choosing between spraying and coating, usually if the desired stable film is thin, a solution sol with low viscosity or concentration is sprayed, and if the film is thick, a solution sol with high viscosity or concentration is applied. However, it is arbitrarily selected within a possible range based on the number of times of spraying or coating, target area, degree of unevenness, ease of use, etc.
噴霧または塗布後、０〜２分程度でゲル化固定され、厚
さ２０〜２００μの含水皮膜となり、外気の湿度、高分
子物質の種類、濃度、膜の厚さなどにより異るが、通常
３０分〜５時間程度で水分蒸発が進み、厚さ５〜Ｚｏｏ
μ、水分１０〜２０に程度の安定皮膜が形成される。After spraying or application, it gels and fixes in about 0 to 2 minutes, forming a water-containing film with a thickness of 20 to 200 μm. Although it varies depending on the humidity of the outside air, the type and concentration of the polymer substance, and the thickness of the film, it is usually 30 μm in thickness. Moisture evaporation progresses in about 5 minutes to 5 hours, and the thickness
A stable film with a moisture content of 10 to 20 μm is formed.
一度ゲル化した高分子物質溶液を使用して被覆する場合
、通常融解温度は凝固温度より高いので、ゲル化温度よ
り１０℃以上高い温度で加熱融解ゾルとする。しかしこ
の温度では皮膚に対して熱感または熱傷を与えるので、
噴霧では４５〜５０℃。When coating using a polymeric material solution that has been gelled, the melting temperature is usually higher than the solidification temperature, so the solution is heated and melted into a sol at a temperature 10° C. or more higher than the gelling temperature. However, this temperature causes a sensation of heat or burns to the skin.
45-50℃ for spraying.
塗布では４０〜４５℃程度に降温後被覆する。In coating, the temperature is lowered to about 40 to 45°C before coating.
製造保管後ゲル化した内容物を使用する実際の場合には
、次のような主として（１）業務用または（２）家庭用
いずれかの装置を使用することが有効で不可欠である。In the actual case of using the gelled contents after manufacture and storage, it is effective and essential to use equipment that is primarily either (1) commercial or (2) household.
（１）内容物選択のための溶液容器の交換が可能であり
、融解（５０〜９０℃）および被＆（４０〜５０℃）の
二段階に定温加熱可能な機能を有する生体被覆装置。こ
の装置は医療、美容など主として業務用に適している。(1) A biological coating device that allows exchange of solution containers for content selection and has the function of being able to heat at a constant temperature in two stages: melting (50 to 90°C) and heating (40 to 50°C). This device is mainly suitable for commercial purposes such as medical and beauty treatments.
（二段階定温被覆装置）図により二段階定温被覆装置の
一例を説明する。(Two-stage constant-temperature coating device) An example of a two-stage constant-temperature coating device will be explained with reference to the drawings.
この装置は、塗布用口と取替可能な噴霧口（２）が接続
挿入された交換可能な溶液容器（３）を内蔵した本体（
１）と保温キャップ（４）から構成されている。本体（
１）と保温キャップ（４）の内側には、面体ヒーター（
５）を付設し、内容溶液を融解温度（５０〜９０℃）と
被覆温度（４０〜５０℃）の二段階に定温設定できるよ
うになっている。溶液容器（３）は溶液の種類１組成に
よって交換使用する。保存ゲル化した溶液容器（３）を
セットし加熱すると、内容液は融解ゾルになる迄昇温せ
ず、５０℃以上の内容溶液に固有な融解温度に達すると
、センサー（６）に感知され、加熱ヒーター（５）が切
れて降温し、次に４０〜５０℃の設定温度に保持される
。噴霧または塗布のための加圧は、内蔵されたミニコン
プレッサー（７）による加圧空気が送。This device consists of a main body (3) with a built-in replaceable solution container (3) into which an application port and a replaceable spray port (2) are connected and inserted.
1) and a thermal cap (4). Main body (
There is a facepiece heater (
5), so that the temperature of the content solution can be set at two constant temperatures: melting temperature (50-90°C) and coating temperature (40-50°C). The solution container (3) is used interchangeably depending on the type and composition of the solution. When the stored gelled solution container (3) is set and heated, the temperature of the content does not rise until it becomes a molten sol, and when it reaches the melting temperature specific to the content solution of 50°C or higher, it is detected by the sensor (6). , the heating heater (5) is turned off to lower the temperature, and then the set temperature is maintained at 40 to 50°C. Pressurization for spraying or application is supplied by pressurized air from a built-in mini compressor (7).
入管（８）を通して、溶液容器（３）カよび噴霧口（２
）へ圧送される。二段階定温と加圧のためのミニコンプ
レッサー（７）の駆動を調整する調節器（９）を本体の
内または外に設置する。Through the entry pipe (8), insert the solution container (3) and the spray nozzle (2).
). A regulator (9) for controlling the drive of a mini-compressor (7) for two-stage constant temperature and pressurization is installed inside or outside the main body.
（２）美容など主として家庭用に使用する簡易生体被覆
装置で、■化学反応利用発熱材の内Ｒまたはマイクロ波
によるゲルの加熱融解機能と本体材質および■使用適温
指示材を具備した装置である。(2) It is a simple biological coating device mainly used for household purposes such as beauty care, and is equipped with ■ a heat-melting function for gel using chemical reaction exothermic materials or microwaves, main body material, and ■ suitable temperature indicator for use. .
本装置は通常の噴霧または塗布装置（加圧ガス充填また
は手動加圧）の外側を、還元鉄や生石灰など発熱材の膚
や粉末で取巻き、酸素およびまたは水との反応によって
発熱する構造とするか、または発熱材を全く使用するこ
となくマイクロ波での加熱に耐え得る材質とする。更に
これらの加熱方式による内容物の加熱融解後、降温して
使用適温を示すための指温材を表面に貼布する。指温材
には、数字（例えば４５℃）１着色２色の変化、絵の出
現などの表示方法がある。これらの加熱方式と使用適温
表示により、安全、安価な使い捨ての商品として、家庭
用などに広く使用できる。This device has a structure in which the outside of a normal spray or applicator (filled with pressurized gas or manually pressurized) is surrounded by skin or powder of a heat-generating material such as reduced iron or quicklime, which generates heat by reaction with oxygen and/or water. Alternatively, the material should be made of a material that can withstand microwave heating without using any heat generating material. Furthermore, after the contents are heated and melted by these heating methods, a finger temperature material is attached to the surface to lower the temperature and indicate the appropriate temperature for use. There are several display methods for the finger temperature material, such as a number (for example, 45°C), a change in one color and two colors, and the appearance of a picture. With these heating methods and appropriate temperature indications, they can be used widely for household purposes as safe, inexpensive, and disposable products.
以上のように本発明は、生体温以上の温度でゲル化する
高分子物質溶液の加熱融解ゾルを、生体に噴霧または塗
布することにより、従来の方法では得られなかった密着
した皮膜を均一、確実、容易に行うことが出来、被覆の
目的を完全に達する被覆力法トよびその装置に関する。As described above, the present invention sprays or applies a heated molten sol of a polymeric material solution that gels at a temperature higher than the body temperature to a living body, thereby creating a uniform, close-fitting film that cannot be obtained with conventional methods. The present invention relates to a coating force method that can be carried out reliably, easily, and completely achieves the purpose of coating, and an apparatus therefor.
本発明生体被覆方法では、生体温以上の温度でゲル化す
る高分子物質溶液を加熱ゾルとして噴霧または塗布する
ので、表面に極めてよく密着し、円曲部や凹凸部の広い
表面でも、迅速、確実、容易に均一な被覆を行うことが
できる。先ず含水皮膜が生成し、この皮膜（水分５０〜
９０％）ゾルはゲル化し、水分蒸発によって、安定皮膜
（水分１０〜２０％）が形成される。この特異な経過か
ら最終皮膜が形成されるために、従来の方法では全く得
られなかった密着性と柔軟性のある安定皮膜となる。In the biological coating method of the present invention, a polymer substance solution that gels at a temperature higher than the biological body temperature is sprayed or applied as a heated sol, so it adheres extremely well to the surface and can be quickly coated even on curved or uneven surfaces. Uniform coating can be achieved reliably and easily. First, a water-containing film is formed, and this film (moisture 50~
(90%) the sol gels and a stable film (10-20% water) is formed by water evaporation. Because the final film is formed through this unique process, it becomes a stable film with adhesion and flexibility that could not be obtained using conventional methods.
この皮膜は１０〜２０％の平衝水分に収斂し、外接する
気体、液体いずれの水分または熱を吸収、放出するため
に、皮膚の水分蒸泄、透湿１体＠調節などの機能と連動
し、皮膚の機能を妨げることはほとんどない。This film converges to an equilibrium moisture content of 10 to 20%, and works in conjunction with the skin's functions such as moisture evaporation and moisture permeability @ regulation in order to absorb and release moisture or heat from any surrounding gas or liquid. However, it rarely interferes with skin function.
またこの安定皮膜は単層でありながら多機能であるため
に、被覆の効果や効率が極めて優れている。Moreover, since this stable coating is multifunctional even though it is a single layer, the coating effect and efficiency are extremely excellent.
実施例 Ｌ
精製コラーゲン蛋白質（ゼラチン） ９０ ｔ、グリセ
リン１０ｔを水４００ｆ中に加え、３０分間膨潤させた
後、攪拌しながら６０〜７０℃に加熱溶解した。気泡を
除いた透明液を本発明の二段階定温加熱被覆装置に入れ
、４８℃で上腕部に噴霧した。１０秒後にゲル化固定さ
れ、３時間後に厚さ２０μ、水分１８％の安定皮膜を形
成した。この皮膜は皮膚に極めてよく密着し、柔軟性が
あり、違和感が全くなく、皮膚の機能に連動した＼め、
２４時間後も異常が認められなかった。Example L 90 t of purified collagen protein (gelatin) and 10 t of glycerin were added to 400 f of water, allowed to swell for 30 minutes, and then heated and dissolved at 60 to 70° C. with stirring. The clear liquid from which air bubbles were removed was placed in a two-stage constant-temperature coating device of the present invention and sprayed onto the upper arm at 48°C. After 10 seconds, the gel was fixed, and after 3 hours, a stable film with a thickness of 20 μm and a moisture content of 18% was formed. This film adheres extremely well to the skin, is flexible, does not cause any discomfort, and is linked to the skin's functions.
No abnormality was observed even after 24 hours.
比較例 Ｌ
市販被覆用プラスチックフィルムを実施例１と同様上腕
部に貼布した。その結果密着性が悪く、シワが生じ、２
４時間後には貼布面にムレとカスミが生じ、周辺部に赤
い発疹が出来た。皮膚の機能が明らかに妨げられていた
。Comparative Example L A commercially available plastic film for covering was applied to the upper arm in the same manner as in Example 1. As a result, adhesion is poor, wrinkles occur, and
After 4 hours, stuffiness and smear appeared on the applied surface, and a red rash appeared in the surrounding area. Skin function was clearly disturbed.
実施例 ２
実施例１の保存液と装置を使用して、５５℃で溶解後、
４５℃で胸部から腋の下への広範囲な浅達度バ度の熱傷
に噴霧した。繰返し噴霧した＼め、厚さ４０μの安定皮
膜となった。全面に密着した均一な被覆を迅速容易に行
うことが出来た。その結果、体液の原理が防止され、皮
膜が剥離せず、１０日後には表皮の再生が認められ、順
調に回復した。Example 2 Using the storage solution and apparatus of Example 1, after dissolution at 55°C,
It was sprayed at 45°C on a wide shallow degree burn from the chest to the armpit. After repeated spraying, a stable film with a thickness of 40μ was obtained. A uniform coating that adhered to the entire surface could be quickly and easily applied. As a result, the body fluid principle was prevented, the film did not peel off, and 10 days later, epidermal regeneration was observed, and the patient made a smooth recovery.
比較例 ２
実施例２と類似の症状の患者に対し、フィブリン膜を使
用して被覆した。大判（１２ｍＸ２４α）ではシワが出
来、小判（６Ｃ１ｌＸ １０ｃｍ）では手間と無駄が生
じ、再感染を含めて回復が大巾に後れ、２１日以上を要
した。Comparative Example 2 A patient with symptoms similar to those in Example 2 was coated with a fibrin membrane. The large size (12m x 24α) caused wrinkles, and the small size (6C11 x 10cm) caused trouble and waste, and recovery, including reinfection, was significantly delayed and took more than 21 days.
実施例 ＆ 精製カラギーナン（カッパータイＴｆ）１０Ｆ。Example & Purified carrageenan (Kappa Thai Tf) 10F.
グリセリン１ｔを水１８９ｆ中に分散させ、８０℃に加
熱溶解した後、二段階定温被覆装置に入れ、４２℃で下
腿部の創傷に塗布した。３０秒後にゲル化固定し、厚さ
１０μ、水分１５％の安定皮膜が３時間後に形成された
。止血も完全で２０時間後も違和感は全くなく回復は順
調であった。1 t of glycerin was dispersed in 189 f of water, heated and dissolved at 80°C, placed in a two-stage constant temperature coating device, and applied to the wound on the lower leg at 42°C. The gel was fixed after 30 seconds, and a stable film with a thickness of 10 μm and a moisture content of 15% was formed after 3 hours. The bleeding was completely stopped, and the patient did not feel any discomfort even after 20 hours, and the recovery was smooth.
比較例 ＆
実施例３と類似の症状に対し、リバノールガーゼを当て
、プラスティックフィルム釦よび包帯テ被覆した。血液
吸収性が悪く、実施例３に比較して傷の回復に約２倍の
日数を要した。Comparative Example & Symptoms similar to those in Example 3 were treated with ribanol gauze and covered with a plastic film button and bandage. Blood absorption was poor, and it took approximately twice as many days for wound recovery as compared to Example 3.
実施例 ↓
実施例１と同様のコラーゲン蛋白質５３ｔ、グリセリン
６ｆ、ヒアルロン酸１ｆを水１４０２に分散した後、６
５℃に加熱透明に溶解した。この溶液を本発明の簡易生
体被覆装置に入れて２日間保存した。酸素と湿度を防ぐ
ための包装を破り、還元鉄を酸素および水に接触発熱さ
せた。５５℃で融解した後、指示温度４５℃に降温した
時に顔面に塗布した。３０分後に弾力のあるフィルムと
して剥離出来、皮膚に柔軟性としっとりとしたしなやか
さを与えることが出来た。Example ↓ After dispersing 53t of collagen protein, 6f of glycerin, and 1f of hyaluronic acid in water 1402 as in Example 1,
The mixture was heated to 5°C to become transparently dissolved. This solution was placed in the simple biological coating device of the present invention and stored for 2 days. The packaging to prevent oxygen and humidity was broken, and reduced iron was exposed to oxygen and water to generate heat. After melting at 55°C, it was applied to the face when the temperature had fallen to the indicated temperature of 45°C. After 30 minutes, it could be peeled off as an elastic film, giving the skin flexibility, moisture, and suppleness.
本発明の生体被覆方法とその装置を実施することにより
、次のような多くの効果を挙げることが出来る。By implementing the biological covering method and device of the present invention, many effects such as those described below can be achieved.
（１１従来の被覆方法では得られなかった密着性が優れ
、円曲部や凹凸部の多い生体表面への被覆が完全に行わ
れ、その結果、再感染の恐れがなくなり、治療９回復が
早くなった。(11) Excellent adhesion that could not be obtained with conventional coating methods, and complete coverage of biological surfaces with many curved and uneven parts.As a result, there is no risk of reinfection, and treatment 9. Faster recovery. became.
（２）本発明の皮膜が単層でありながら多機能であるた
め、被覆の効果や効率が改善され、生体表面の機能を阻
害せずに被覆が出来るようになった。(2) Since the film of the present invention is multifunctional even though it is a single layer, the effect and efficiency of the coating is improved, and the coating can be performed without inhibiting the functions of the biological surface.
（３）生体被覆装置を使用することにより、本発明の方
法を実施することが容易となり、業務用、家庭用いずれ
の用途に対しても実用化が促進される。(3) By using a biological coating device, it becomes easy to implement the method of the present invention, and its practical application is promoted for both commercial and home use.
（４）医療、美容、農業、畜産その他の分野で広い応用
が期待され、経済的、社会的に大きく貢献出来る。(4) It is expected to have a wide range of applications in medical, beauty, agriculture, livestock, and other fields, and can make significant economic and social contributions.
図は二段階定温被覆装置の一例を示す縦断面図。
１：本体 ２：噴霧口
３：溶液容器 ４：保温キャップ５：面体ヒ
ーター ６：センサー７°ミニコンプレツサー
８：送入管
９：調節器 １０：電源The figure is a longitudinal sectional view showing an example of a two-stage constant temperature coating device. 1: Main body 2: Spray nozzle 3: Solution container 4: Heat insulation cap 5: Face heater 6: Sensor 7° mini compressor
8: Feed pipe 9: Regulator 10: Power supply
Claims (1)
熱ゾルとして、生体表面に噴霧または塗布する生体被覆
方法。 ２ 高分子物質がコラーゲン蛋白質である特許請求の範
囲第１項記載の生体被覆方法。 ３ 高分子物質が多糖質である特許請求の範囲第１項記
載の生体被覆方法。 ４ 内容物選択のための交換可能な溶液容器と、融解な
らびに被覆（噴霧または塗布）の二段階定温加熱できる
機能とを内蔵する特許請求の範囲第１項、第２項または
第３項記載の生体被覆方法に使用する装置。 ５ （１）化学反応利用発熱材の内蔵またはマイクロ波によ
り加熱融解する機能と構造に対し、 （２）使用適温指示材を付設する特許請求の範囲第１項
、第２項または第３項記載の生体被覆方法に使用する装
置。[Scope of Claims] 1. A method for coating a living body in which a solution of a polymeric substance that gels at a temperature higher than the body temperature is sprayed or applied as a heated sol onto the surface of a living body. 2. The biological coating method according to claim 1, wherein the polymeric substance is collagen protein. 3. The biological coating method according to claim 1, wherein the polymeric substance is a polysaccharide. 4. The solution according to claim 1, 2 or 3, which has a built-in exchangeable solution container for content selection and a two-step constant temperature heating function of melting and coating (spraying or coating). Equipment used in biocoating methods. 5 (1) Regarding the function and structure of a built-in exothermic material using a chemical reaction or heating and melting by microwaves, (2) Claims 1, 2, or 3 include an appropriate temperature indicating material for use. Equipment used in the biological coating method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1223181A JPH0386172A (en) | 1989-08-31 | 1989-08-31 | Method and device for coating living body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1223181A JPH0386172A (en) | 1989-08-31 | 1989-08-31 | Method and device for coating living body |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0386172A true JPH0386172A (en) | 1991-04-11 |
Family
ID=16794076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1223181A Pending JPH0386172A (en) | 1989-08-31 | 1989-08-31 | Method and device for coating living body |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0386172A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995007719A1 (en) * | 1993-09-16 | 1995-03-23 | Sunao Kubota | Wound covering material and wound covering composition |
| JP2005230064A (en) * | 2004-02-17 | 2005-09-02 | Sato Gijutsu Kenkyusho:Kk | Sealing agent for forming wound protective film and aerosol tube for jetting the sealing agent |
-
1989
- 1989-08-31 JP JP1223181A patent/JPH0386172A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995007719A1 (en) * | 1993-09-16 | 1995-03-23 | Sunao Kubota | Wound covering material and wound covering composition |
| JP2005230064A (en) * | 2004-02-17 | 2005-09-02 | Sato Gijutsu Kenkyusho:Kk | Sealing agent for forming wound protective film and aerosol tube for jetting the sealing agent |
| JP4671322B2 (en) * | 2004-02-17 | 2011-04-13 | 有限会社佐藤技術研究所 | Sealant for forming wound protective film |
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