JPH03264522A - Bandage for application in oral cavity - Google Patents
Bandage for application in oral cavityInfo
- Publication number
- JPH03264522A JPH03264522A JP6208690A JP6208690A JPH03264522A JP H03264522 A JPH03264522 A JP H03264522A JP 6208690 A JP6208690 A JP 6208690A JP 6208690 A JP6208690 A JP 6208690A JP H03264522 A JPH03264522 A JP H03264522A
- Authority
- JP
- Japan
- Prior art keywords
- bandage
- oral cavity
- chitosan
- photosensitive resin
- mucous membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000214 mouth Anatomy 0.000 title claims abstract description 15
- 239000011347 resin Substances 0.000 claims abstract description 30
- 229920005989 resin Polymers 0.000 claims abstract description 30
- 229920001661 Chitosan Polymers 0.000 claims abstract description 29
- 229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 20
- 239000000853 adhesive Substances 0.000 claims description 31
- 230000001070 adhesive effect Effects 0.000 claims description 31
- 210000004400 mucous membrane Anatomy 0.000 abstract description 12
- 229920000642 polymer Polymers 0.000 abstract description 7
- 230000002378 acidificating effect Effects 0.000 abstract description 5
- 229920001577 copolymer Polymers 0.000 abstract description 5
- 239000003814 drug Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract description 4
- 229920002845 Poly(methacrylic acid) Polymers 0.000 abstract description 2
- 230000000840 anti-viral effect Effects 0.000 abstract description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 125000000542 sulfonic acid group Chemical group 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 4
- 241001082241 Lythrum hyssopifolia Species 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 210000002200 mouth mucosa Anatomy 0.000 description 11
- 239000000178 monomer Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 8
- -1 softeners Substances 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 239000003999 initiator Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 description 5
- 239000005020 polyethylene terephthalate Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 230000007937 eating Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000003505 polymerization initiator Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VNQXSTWCDUXYEZ-UHFFFAOYSA-N 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione Chemical compound C1CC2(C)C(=O)C(=O)C1C2(C)C VNQXSTWCDUXYEZ-UHFFFAOYSA-N 0.000 description 2
- UZKWTJUDCOPSNM-UHFFFAOYSA-N 1-ethenoxybutane Chemical compound CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 2
- FJPGAMCQJNLTJC-UHFFFAOYSA-N 2,3-Heptanedione Chemical compound CCCCC(=O)C(C)=O FJPGAMCQJNLTJC-UHFFFAOYSA-N 0.000 description 2
- VVBLNCFGVYUYGU-UHFFFAOYSA-N 4,4'-Bis(dimethylamino)benzophenone Chemical compound C1=CC(N(C)C)=CC=C1C(=O)C1=CC=C(N(C)C)C=C1 VVBLNCFGVYUYGU-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 229930006711 bornane-2,3-dione Natural products 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 239000011256 inorganic filler Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000012766 organic filler Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 229920001567 vinyl ester resin Polymers 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 229920003067 (meth)acrylic acid ester copolymer Polymers 0.000 description 1
- 150000000181 1,2-naphthoquinones Chemical class 0.000 description 1
- LOZBSNNVCOJWGN-UHFFFAOYSA-N 1-benzylanthracene-9,10-dione Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3C(=O)C2=C1CC1=CC=CC=C1 LOZBSNNVCOJWGN-UHFFFAOYSA-N 0.000 description 1
- CTXUTPWZJZHRJC-UHFFFAOYSA-N 1-ethenylpyrrole Chemical compound C=CN1C=CC=C1 CTXUTPWZJZHRJC-UHFFFAOYSA-N 0.000 description 1
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- OOOCMOATXUFYQW-UHFFFAOYSA-N 4-methyl-2-methylidenepentanamide Chemical compound CC(C)CC(=C)C(N)=O OOOCMOATXUFYQW-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 description 1
- 244000250129 Trigonella foenum graecum Species 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 229920006221 acetate fiber Polymers 0.000 description 1
- 229920001284 acidic polysaccharide Polymers 0.000 description 1
- 150000004805 acidic polysaccharides Chemical class 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- JZMPIUODFXBXSC-UHFFFAOYSA-N ethyl carbamate;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)C=C.CCOC(N)=O JZMPIUODFXBXSC-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- PBZROIMXDZTJDF-UHFFFAOYSA-N hepta-1,6-dien-4-one Chemical compound C=CCC(=O)CC=C PBZROIMXDZTJDF-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- XBDAKYZJVVYINU-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-(2-methylprop-2-enoyloxy)ethyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CC(=C)C(=O)OCCOC(=O)C(C)=C XBDAKYZJVVYINU-UHFFFAOYSA-N 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003232 mucoadhesive effect Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical class C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 1
- TZMFJUDUGYTVRY-UHFFFAOYSA-N pentane-2,3-dione Chemical compound CCC(=O)C(C)=O TZMFJUDUGYTVRY-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- ARJOQCYCJMAIFR-UHFFFAOYSA-N prop-2-enoyl prop-2-enoate Chemical compound C=CC(=O)OC(=O)C=C ARJOQCYCJMAIFR-UHFFFAOYSA-N 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 125000003011 styrenyl group Chemical class [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- FUSUHKVFWTUUBE-UHFFFAOYSA-N vinyl methyl ketone Natural products CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、口腔内の損傷部や疾患部を保護するための、
あるいは口腔粘膜を介して薬物を吸収させるための口腔
内貼付用バンデージに関する。Detailed Description of the Invention (Industrial Application Field) The present invention provides a method for protecting damaged and diseased areas in the oral cavity.
Alternatively, the present invention relates to an intraoral bandage for absorbing a drug through the oral mucosa.
（従来の技術）
口腔内の損傷部や疾患部の保護を目的として、あるいは
口腔粘膜を介して所定の薬効成分を体内に吸収させるこ
とを目的として、口腔内貼付用バンデージが調製されて
いる。口腔内貼付用バンデージは、湿潤した口腔内粘膜
に貼付することが可能で、かつ唾液の分泌や飲食などに
より容易に剥離しないことが必要とされる。口腔内貼付
用バンデージとしては、例えば、特公昭５Ｂ−７６０５
号公報には、ヒドロキシプロピルセルロースとアクリル
酸（共）重合体またはその塩とを含む組成の口腔内貼付
用バンデージが開示されている。特開昭５９−１８６９
１３号公報には、ゼラチンまたは寒天、グルテン、カル
ボキシビニルポリマー及び酢酸ビニル又はガム類を含む
組成の口腔内貼付用バンデージが開示されている。特開
昭６０２１５６２２号公報には、ポリビニルピロリドン
、ポリビニルアルコール、ポリエチレングリコール、ア
ルギン酸またはその塩、無水マレイン酸−メチルビニル
エーテル共重合体、及びアクリル酸（共）重合体を含む
組成の口腔内貼付用バンデージが開示されている。特開
昭６０−１４２９２７号公報にはキトサンまたはキトサ
ン誘導体を含む組成の口腔内貼付用バンデージが開示さ
れている。特開昭６１−２４９４７３号公報には、ポリ
カルボン酸、ポリ無水カルボン酸及び酢酸ビニル共重合
体を含む組成の口腔内貼付用バンデージが開示されてい
る。(Prior Art) Bandages for intraoral application have been prepared for the purpose of protecting damaged or diseased areas in the oral cavity or for the purpose of absorbing certain medicinal ingredients into the body through the oral mucosa. Bandages for intraoral application are required to be able to be applied to moist oral mucosa and not to be easily peeled off due to saliva secretion, eating and drinking, etc. As a bandage for intraoral application, for example, Japanese Patent Publication No. 5B-7605
The publication discloses a bandage for intraoral application having a composition containing hydroxypropyl cellulose and an acrylic acid (co)polymer or a salt thereof. Japanese Patent Publication No. 59-1869
No. 13 discloses a bandage for intraoral application having a composition containing gelatin or agar, gluten, carboxyvinyl polymer, and vinyl acetate or gums. JP-A-60215622 discloses a bandage for intraoral application having a composition containing polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, alginic acid or its salt, maleic anhydride-methyl vinyl ether copolymer, and acrylic acid (co)polymer. is disclosed. JP-A-60-142927 discloses a bandage for intraoral application having a composition containing chitosan or a chitosan derivative. JP-A-61-249473 discloses a bandage for intraoral application having a composition containing polycarboxylic acid, polycarboxylic anhydride, and vinyl acetate copolymer.
上記各公報のバンデージは、いずれも親水性ポリマーを
主成分とする基剤層を有している。このような親水性ポ
リマーは、口腔内において唾液などの少量の水分が付与
されると粘着性を有するようになり、口腔粘膜に付着す
る。しかし、親水性ポリマーは、唾液や飲食による過剰
の水分により膨潤し崩壊し易い。このような耐水性の欠
如を補うために、上記各公報においては、いずれも親水
性ポリマーに加えて水不溶性または水難溶性のポリマ〜
が基剤中に含有されている。しかし、水不溶（難溶）性
ポリマーが存在するため、耐水性は向上するが、粘膜貼
付性基剤の粘膜への付着性が低下するという欠点がある
。The bandages disclosed in each of the above-mentioned publications all have a base layer containing a hydrophilic polymer as a main component. Such hydrophilic polymers become sticky when a small amount of water such as saliva is added to them in the oral cavity, and adhere to the oral mucosa. However, hydrophilic polymers tend to swell and disintegrate due to excess water from saliva or eating and drinking. In order to compensate for this lack of water resistance, the above publications all use water-insoluble or poorly water-soluble polymers in addition to hydrophilic polymers.
is contained in the base. However, since the water-insoluble (poorly soluble) polymer is present, although the water resistance is improved, there is a drawback that the adhesion of the mucosal adhesive base to the mucous membrane is reduced.
また、粘膜貼付性基剤及び耐水性のある粘膜非貼付性基
剤からなる２層構造のバンデージも提案されている。し
かし、粘膜非貼付性基剤に耐水性を付与するためにはこ
の基剤の主成分は疎水性である必要があり、この為に粘
膜貼付性基剤との親和性が欠如しており、含水時に貼付
性基剤から非貼付性基剤が剥離し易くなるという欠点が
ある。Furthermore, a bandage with a two-layer structure consisting of a mucosal adhesive base and a water-resistant non-mucosal adhesive base has also been proposed. However, in order to impart water resistance to a non-mucosal adhesive base, the main component of this base must be hydrophobic, and for this reason, it lacks compatibility with mucosal adhesive bases. There is a drawback that the non-stick base tends to peel off from the sticky base when it contains water.
また、貼付後もバンデージが柔らかすぎるため、飲食や
会話による物理的な影響を受は易く、バンデージが粘膜
から剥離し易いという欠点がある。Furthermore, since the bandage is too soft even after application, it is susceptible to physical effects from eating, drinking, and talking, and has the disadvantage that the bandage is easily peeled off from the mucous membrane.
このように、口腔粘膜への付着性が良好であり、かつ、
充分な耐水性を有する口腔内貼付用バンデージは得られ
ていないのが現状である。In this way, it has good adhesion to the oral mucosa, and
At present, a bandage for intraoral application with sufficient water resistance has not been obtained.
（発明が解決しようとする課題）
本発明は、上記の欠点を解決するものであり、その目的
とするところは、口腔内粘膜に対して、十分な付着性を
有し、かつ耐水性及び形状保持性に優れた口腔内貼付用
バンデージを提供することにある。(Problems to be Solved by the Invention) The present invention solves the above-mentioned drawbacks, and its purpose is to have sufficient adhesion to the oral mucosa, water resistance, and shape. An object of the present invention is to provide a bandage for intraoral application with excellent retention properties.
（課題を解決するための手段〉
本発明者らは、上記の欠点を解決するべく鋭意研究し、
親水性ポリマー及び非溶解状態のキトサンもしくはその
誘導体を含有する粘膜貼付性基剤層の片面に、感光性樹
脂層を設けることにより解決できることを発見し、本発
明に到達したもので４〜
ある。(Means for Solving the Problems) The present inventors have conducted extensive research to solve the above drawbacks, and
We have discovered that the problem can be solved by providing a photosensitive resin layer on one side of a mucosal adhesive base layer containing a hydrophilic polymer and undissolved chitosan or its derivative, and have arrived at the present invention.
すなわち、本発明の口腔内貼付用バンデージは、親水性
ポリマー及び非溶解状態のキトサンもしくはその誘導体
を含有する粘膜貼付性基剤層の片面に、感光性樹脂層が
設けられており、口腔内に貼付するのに必要な柔軟性を
有するものであり、そのことにより上記目的が達成され
る。That is, the bandage for intraoral application of the present invention has a photosensitive resin layer provided on one side of a mucosal adhesive base layer containing a hydrophilic polymer and undissolved chitosan or a derivative thereof, so that it can be applied to the oral cavity. It has the necessary flexibility for application, thereby achieving the above objective.
該粘膜貼付性基剤層に含有される親水性ポリマーは、カ
ルボキシル基、水酸基、スルホン酸残基などの酸性基を
有するポリマーである。これらのポリマーは、水に可溶
であり、かつ水と混合し得る溶媒（例えば、アルコール
類、アセトン、アセトニトリルなどの高極性溶媒）の少
なくとも一種に可溶である。このようなポリマーの例と
しては、ポリ（メタ）アクリル酸、ポリ（メタ）アクリ
ル酸無水物、無水マレイン酸（共）重合体などが挙げら
れる。これらのポリマーは、従来の技術の項で記載した
ように、少量の水分を吸収して強力な付着力を有するよ
うになる。The hydrophilic polymer contained in the mucous membrane adhesive base layer is a polymer having acidic groups such as carboxyl groups, hydroxyl groups, and sulfonic acid residues. These polymers are soluble in water and at least one type of solvent that is miscible with water (for example, highly polar solvents such as alcohols, acetone, and acetonitrile). Examples of such polymers include poly(meth)acrylic acid, poly(meth)acrylic anhydride, maleic anhydride (co)polymer, and the like. These polymers absorb small amounts of moisture and become highly adhesive, as described in the prior art section.
本発明に用いられるキトサンは、キチン（β１．４−ポ
リ−Ｎ−アセチルグルコサミン）の脱アセチル化物であ
り、β−１，４−ポリゲルコサごン構造で主としてなり
、遊離のアミノ基を有する。本発明においては、このキ
トサンおよびその誘導体（キチン、キトサンの塩および
キトサンの誘導体を包含する）が用いられている（以下
、キトサンおよびその誘導体を「キトサンｊとして示す
）。このような「キトサン」は、粘膜貼付性基剤中に非
溶解状態で存在する。例えば、粒子状あるいは短繊維状
とするのが好適である。粒子状である場合には、１００
メツシユを通過するような粒子とすることが好ましい。Chitosan used in the present invention is a deacetylated product of chitin (β1,4-poly-N-acetylglucosamine), mainly has a β-1,4-polygelcosagon structure, and has a free amino group. In the present invention, this chitosan and its derivatives (including chitin, chitosan salts, and chitosan derivatives) are used (hereinafter, chitosan and its derivatives will be referred to as "chitosan j").Such "chitosan" exists in an undissolved state in the mucosal adhesive base. For example, it is preferable to use it in the form of particles or short fibers. If it is particulate, 100
Preferably, the particles are such that they can pass through the mesh.
また、短繊維の場合は、繊維径が１０ＩＩｍ以下、繊維
長が１ｍｍ以下であることが好ましい。この「キトサン
」と、上記親水性ポリマーとは、重量比で５ノ９５〜７
０／３０の割合で混合される。親水性ポリマーが過剰で
あり「キトサン」が過少であると、得られるバンデージ
の耐水性に劣る。逆に親水性ポリマーが過少であり、「
キトサン」が過剰であると、バンデージの口腔粘膜への
付着性に劣る。Moreover, in the case of short fibers, it is preferable that the fiber diameter is 10 IIm or less and the fiber length is 1 mm or less. This "chitosan" and the above-mentioned hydrophilic polymer have a weight ratio of 5:95 to 7.
Mixed at a ratio of 0/30. If the hydrophilic polymer is too much and the chitosan is too little, the resulting bandage will have poor water resistance. On the other hand, there is too little hydrophilic polymer,
If the amount of "chitosan" is excessive, the adhesion of the bandage to the oral mucosa will be poor.
−
−
粘膜貼付性基剤中には、さらに、酸性基を有する水溶性
化合物が含有されても良い。このような化合物は、通常
、分子内にカルボキシル基を有する水溶性化合物であり
、その例としては、シュウ酸、フマル酸などのジカルボ
ン酸；アルギン酸、ヒアルロン酸、コンドロイチン硫酸
などの酸性多糖類あるいはその塩；および（メタ）アク
リル酸（共）重合体の塩が挙げられる。- - The mucosal adhesive base may further contain a water-soluble compound having an acidic group. Such compounds are usually water-soluble compounds having a carboxyl group in the molecule; examples include dicarboxylic acids such as oxalic acid and fumaric acid; acidic polysaccharides such as alginic acid, hyaluronic acid, and chondroitin sulfate; and salts of (meth)acrylic acid (co)polymers.
粘膜貼付性基剤中には、この他に、必要に応して薬物や
各種添加剤が含有され得る。添加剤には例えば、薬物の
吸収促進剤、抗菌剤、軟化剤、界面活性剤、架橋剤、中
和・緩衝剤、有機あるいは無機の増量剤、香料、着色料
、着味料などがある。In addition to the above, drugs and various additives may be contained in the mucosal adhesive base as required. Examples of additives include drug absorption enhancers, antibacterial agents, softeners, surfactants, crosslinking agents, neutralizing/buffering agents, organic or inorganic fillers, fragrances, colorants, and flavorings.
本発明に使用される感光性樹脂層は、一般に反応モノマ
ー、光重合開始剤、熱安定剤等をバインダー樹脂中に分
散させた複合材料から成る。また、必要に応して、可塑
剤及び無機・有機フィラーを含有しても良い。この感光
性樹脂層の性能としては、可視または紫外光を照射する
前は粘膜貼付性基剤同様柔軟な性状で、照射後は硬化し
て透湿性の低い、形状を保持する物性を示す必要がある
。The photosensitive resin layer used in the present invention is generally made of a composite material in which a reactive monomer, a photopolymerization initiator, a heat stabilizer, etc. are dispersed in a binder resin. Furthermore, if necessary, a plasticizer and an inorganic/organic filler may be contained. The performance of this photosensitive resin layer is that before it is irradiated with visible or ultraviolet light, it is flexible like a mucosal adhesive base, and after irradiation, it hardens and exhibits physical properties that allow it to maintain its shape with low moisture permeability. be.
反応性モノマーとしては、エチレン性２重結合を少なく
とも１個有する付加重合可能な化合物、例えば、α−シ
アノアクリル酸、（メタ）アクリル酸、ウレタン（メタ
）アクリル酸、クトロン酸もしくはマレイン酸等の酸と
１価または２価アルコールとのエステル類、さらに、Ｎ
−イソブチルアクリルアミドのような（メタ）アクリル
アごド類、酢酸ビニルのようなカルボン酸のビニルエス
テル類、ブチルビニルエーテルのようなビニルエーテル
類、Ｎ−ビニルピロリドンのようなモノＮ−ビニル化合
物、スチレン誘導体などが挙げられる。特に、１官能性
、多官能性の（メタ）アクリル酸エステル類および、ウ
レタン（メタ）アクリル酸エステル類が好適である。Reactive monomers include addition-polymerizable compounds having at least one ethylenic double bond, such as α-cyanoacrylic acid, (meth)acrylic acid, urethane (meth)acrylic acid, ctronic acid, or maleic acid. Esters of acids and monohydric or dihydric alcohols, and N
- (Meth)acrylates such as isobutylacrylamide, vinyl esters of carboxylic acids such as vinyl acetate, vinyl ethers such as butyl vinyl ether, mono-N-vinyl compounds such as N-vinylpyrrolidone, styrene derivatives, etc. can be mentioned. Particularly suitable are monofunctional and polyfunctional (meth)acrylic esters and urethane (meth)acrylic esters.
光重合開始剤としては、活性光線により上記重合性単量
体を活性化し、重合を開始させる性質を有するものであ
れば良く、一般に光増感剤が用いられる。光増感剤は、
その吸収スペクトルの波長により、紫外光重合開始剤、
可視光重合開始剤に分類される。紫外光重合開始剤とし
ては、ヘンジインメチルエーテル、ベンズアルデヒド、
ベンゾフェノン、ミヒラーケトン、ベンジルアンスラキ
ノン等が挙げられる。可視光重合開始剤としては、ジア
セチル、ベンジル、２．３−ペンタジオン等の鎖状のα
−ジケトン化合物、カンファーキノン、ゼシクロ （２
，２，１）ヘプタン−２，３−ジオンの様な脂環式のα
−ジケトン化合物、α、βナフトキノン等の多核牛ノン
類が挙げられる。光源の装置の価格および光線の人体に
対する安全性において、特に、可視光重合開始剤が好適
であり、アくン等と併用して用いられる。Any photopolymerization initiator may be used as long as it has the property of activating the polymerizable monomer with actinic rays to initiate polymerization, and a photosensitizer is generally used. The photosensitizer is
Depending on the wavelength of its absorption spectrum, ultraviolet photopolymerization initiators,
Classified as a visible light polymerization initiator. As the ultraviolet photopolymerization initiator, hengeine methyl ether, benzaldehyde,
Examples include benzophenone, Michler's ketone, and benzyl anthraquinone. As a visible light polymerization initiator, chain α such as diacetyl, benzyl, 2,3-pentadione, etc.
-diketone compounds, camphorquinone, zecyclo (2
,2,1) Alicyclic α such as heptane-2,3-dione
- Diketone compounds, polynuclear bovine nons such as α and β naphthoquinones are mentioned. In view of the cost of the light source device and the safety of the light rays to the human body, visible light polymerization initiators are particularly preferred, and are used in combination with Akun and the like.
バインダー樹脂としては、α、β−不飽和エチレン系単
量体を構成単位とする高分子物質が用いられるが、この
α、β−不飽和エチレン系単量体としては、例えば、ス
チレン等のスチレン類；ビニルナフタレン類；エチレン
等のα−オレフィン類；塩化ビニル等のハロゲン化ビニ
ル類；酢酸ビニル等のビニルエステル類；アクリル酸メ
チル等のアクリル酸エステル類；アクリロニトリル等の
（メタ）アクリル酸誘導体；ビニルメチルエーテル等の
ビニルエーテル頻；ビニルメチルケトン等のビニルケト
ン類；Ｎ−ビニルピロール等のＮビニル化合物等が挙げ
られる。As the binder resin, a polymer substance having α,β-unsaturated ethylenic monomer as a constituent unit is used. α-olefins such as ethylene; vinyl halides such as vinyl chloride; vinyl esters such as vinyl acetate; acrylic acid esters such as methyl acrylate; (meth)acrylic acid derivatives such as acrylonitrile vinyl ethers such as vinyl methyl ether; vinyl ketones such as vinyl methyl ketone; and N-vinyl compounds such as N-vinylpyrrole.
本発明において、必要に応じて、ラジカル反応を良好に
進める目的あるいは、反応性モノマー等のマスキングの
目的で、感光性樹脂層上に光透過性の保護フィルムを設
けてもよい。感光性樹脂層上に設けられる光透過性保護
フィルムとしては、光透過性及び柔軟性が要求され、必
要に応じて酸素不透過性等が要求される。たとえば、ポ
リ酢酸ビニル、ポリエチレン、ポリエチレンテレフタレ
ート、ポリ塩化ビニル、（メタ）アクリル酸エステル共
重合体などが挙げられる。該保護フィルムの厚みは、１
〜１００μｍが好ましく、より好ましくは５〜５０μｍ
である。In the present invention, a light-transmissive protective film may be provided on the photosensitive resin layer, if necessary, for the purpose of favorably advancing the radical reaction or for the purpose of masking reactive monomers and the like. The light transmitting protective film provided on the photosensitive resin layer is required to have light transmittance and flexibility, and if necessary, oxygen impermeability. Examples include polyvinyl acetate, polyethylene, polyethylene terephthalate, polyvinyl chloride, (meth)acrylic acid ester copolymer, and the like. The thickness of the protective film is 1
~100μm is preferable, more preferably 5~50μm
It is.
本発明の口腔内貼付用バンデージは、例えば、次のよう
にして調製される。粘膜貼付性基剤層は、上記親水性ポ
リマーおよび必要に応して薬物や添加剤をエタノールな
どの有機溶媒に均一に溶解も０
しくは分散させ、これに「キトサン」を加えて混合し、
該「キトサン」を均一に分散させる。この混合物を剥離
シートに流延し、乾燥することによりフィルム化して得
られる。また、上記各成分を混練し、得られた混練物を
押し出し又はプレス等によりフィルム化してもよい。こ
の粘膜貼付性基剤層の厚みは、１０〜５０００μｍが好
ましく、より好ましくは２０〜５００μｍである。The bandage for intraoral application of the present invention is prepared, for example, as follows. The mucosal adhesive base layer is prepared by uniformly dissolving or dispersing the hydrophilic polymer and, if necessary, drugs and additives in an organic solvent such as ethanol, and adding and mixing "chitosan" thereto.
The "chitosan" is uniformly dispersed. This mixture is cast onto a release sheet and dried to form a film. Alternatively, the above components may be kneaded and the resulting kneaded product may be formed into a film by extrusion, pressing, or the like. The thickness of this mucosal adhesive base layer is preferably 10 to 5000 μm, more preferably 20 to 500 μm.
感光性樹脂層は、前記感光性樹脂成分からなるペースト
状物を剥離シートで挟み込み、プレスして得られる。ま
た、上記感光性樹脂成分を有機溶媒に均一に溶解または
分散し、これを剥離シートまたは光透過性保護フィルム
上に流延し、乾燥することにより得られる。感光性樹脂
層の厚みは、５〜１０００μｍが好ましく、より好まし
くは１０〜５００μｍである。The photosensitive resin layer is obtained by sandwiching a paste-like material made of the photosensitive resin component between release sheets and pressing. It can also be obtained by uniformly dissolving or dispersing the photosensitive resin component in an organic solvent, casting the solution onto a release sheet or a light-transmitting protective film, and drying it. The thickness of the photosensitive resin layer is preferably 5 to 1000 μm, more preferably 10 to 500 μm.
このようにして得られた粘膜貼付性基剤層及び感光性樹
脂層を圧着プレスして、該口腔貼付用バンデージが得ら
れる。また、感光性樹脂層の上に、粘膜貼付性基剤の溶
液を流延・乾燥して積層する、あるいは、粘膜貼付性基
剤の上に、感光性樹脂の溶液を流延・乾燥して積層する
ことによっても得られる。The thus obtained mucosal adhesive base layer and photosensitive resin layer are pressure-pressed to obtain the oral cavity adhesive bandage. Alternatively, a solution of a mucosal adhesive base may be cast and dried on the photosensitive resin layer, or a photosensitive resin solution may be cast and dried on the mucosal adhesive base. It can also be obtained by laminating.
（作用）
該バンデージの粘膜貼付性基剤は、親水性高分子により
少量の水を吸収することにより、強力な粘膜付着力を発
現する。また、貼付後、粘膜及び外部からの水分により
、基剤中に含有される「キトサン」と親水性ポリマーの
酸性基とが相互作用を起こし、その結果、親水性ポリマ
ーが水に対して不溶化し、弾性体を形成・維持すること
により、口腔内の損傷部や疾患部の被覆・保護効果が高
い。(Function) The mucosal adhesive base of the bandage exhibits strong mucoadhesive force by absorbing a small amount of water using a hydrophilic polymer. In addition, after application, the "chitosan" contained in the base material interacts with the acidic groups of the hydrophilic polymer due to moisture from the mucous membrane and the outside, and as a result, the hydrophilic polymer becomes insoluble in water. By forming and maintaining an elastic body, it is highly effective in covering and protecting damaged and diseased areas in the oral cavity.
この相互作用については明らかでないが、「キトサン」
のアミノ基と親水性ポリマーの酸性基、例えば、カルボ
キシル基とのイオン結合あるいは水素結合による、「キ
トサンｊと親水性ポリマーとの結合に起因すると考えら
れる。基剤中に酸性基を有する水溶性化合物がさらに存
在する場合には、このような作用が増強される。このよ
うに、貼付性、耐水性、及び形状保持性に優れた粘膜貼
付性１
２
基剤であることから、単独の使用でも長時間にわたり口
腔内粘膜表面に貼付することが可能となる。Although this interaction is not clear, "chitosan"
This is thought to be due to the bond between Chitosan J and the hydrophilic polymer, which is caused by ionic bonding or hydrogen bonding between the amino group of the chitosan and the acidic group of the hydrophilic polymer, such as the carboxyl group. When the compound is further present, such effects are enhanced.Thus, since it is a mucosal adhesive base with excellent adhesiveness, water resistance, and shape retention, it is difficult to use it alone. However, it can be applied to the oral mucosal surface for a long period of time.
また、粘膜貼付性基剤に含有される「キトサン」により
抗菌・抗ウイルス効果及び創傷治癒促進効果も期待され
る。Furthermore, the "chitosan" contained in the mucosal adhesive base is expected to have antibacterial and antiviral effects and wound healing promoting effects.
さらに該粘膜貼付性基剤が粘膜に付着後、光照射を行い
感光性樹脂が硬化することにより単位時間当たりの粘膜
貼付性基剤の水分の吸収量が減少し、かつ貼付時の形状
を保持することにより、口腔内の物理的な影響を受けに
くくすることから、粘膜貼付性基剤単独と比較して耐水
性・耐久性に優れ、より長時間安定に付着することが可
能となる。Furthermore, after the mucosal adhesive base adheres to the mucous membrane, it is irradiated with light and the photosensitive resin is cured, thereby reducing the amount of moisture absorbed by the mucosal adhesive base per unit time and maintaining the shape when applied. By doing so, it is less susceptible to physical influences in the oral cavity, so it has superior water resistance and durability compared to a mucosal adhesive base alone, and can be stably adhered for a longer period of time.
また、このバンデージは、貼付時は柔軟なシート状であ
るため、口腔粘膜表面に貼付したときに違和感を与える
ことがない。Furthermore, since this bandage is in a flexible sheet form when applied, it does not give a sense of discomfort when applied to the oral mucosal surface.
（実施例） 以下に本発明を実施例につき説明する。(Example) The invention will be explained below with reference to examples.
ポリアクリル酸（親水性高分子）１５重量部をエタノー
ル８０重量部に均一に溶解させた。この溶液中に短繊維
キトサン酢酸塩（繊維径１μｍ ：繊維長５００μｍ）
５重量部を混合し、均一な分散液を調製した。この溶液
を表面シリコーン処理したポリエチレンテレフタレート
（ＰＥＴ）フィルム上に流延・乾燥し、厚み６０μｍ
のフィルム状粘膜貼付性基剤層（１）を得た。15 parts by weight of polyacrylic acid (hydrophilic polymer) was uniformly dissolved in 80 parts by weight of ethanol. In this solution, short fiber chitosan acetate (fiber diameter 1 μm: fiber length 500 μm) was added.
5 parts by weight were mixed to prepare a uniform dispersion. This solution was cast onto a polyethylene terephthalate (PET) film whose surface had been treated with silicone and dried to a thickness of 60 μm.
A film-like mucosal adhesive base layer (1) was obtained.
別に感光性樹脂として、下記の組成（数字は部数を示す
）
・ メチルメタクリレート−エチレングリコールジメタ
クリレート（９７：３） ３ ５の共重合体（粒
径５μｍ） ［１τイングー樹脂］・ ポリメタク
ーハト酸メチル（肚−１００，０００）
２ ０［バインダー 樹脂コ
・ メタク１ハレ酸メチル
４２［反応性モノマー］
・ エチレングリコールジメタクリレート
３［反応性モノマ
ー］
・ カンファーキノン
０．２［光重合開始剤］
３
４
・ シェラノー１シアミン
０．５
［光重合開始助剤］
により、ペースト状物を得た。Separately, as a photosensitive resin, the following composition (numbers indicate parts): Methyl methacrylate-ethylene glycol dimethacrylate (97:3) 3 5 copolymer (particle size 5 μm) [1τ Ingu resin] Polymethyl methacrylate (肚-100,000)
2 0 [Binder Resin Co-Methyl Methyl Halate
42 [Reactive monomer] ・Ethylene glycol dimethacrylate
3 [Reactive monomer] Camphorquinone
0.2 [Photopolymerization initiator] 3 4 ・Sheranow 1 Cyamine 0.5 [Photopolymerization initiation aid] A paste-like material was obtained.
このペーストを表面シリコーン処理ＰＥＴで挟み、１０
０ ｋｇ／ｃｗｔでプレスして、厚み４０ｕｍのフィル
ム状感光性樹脂層（ＩＩ）を得た。This paste was sandwiched between PET surfaces treated with silicone, and
A film-like photosensitive resin layer (II) having a thickness of 40 um was obtained by pressing at 0 kg/cwt.
以上のようにして得られたＩと■を１００ｋｇ／ｃｉで
圧着プレスして厚み９０μｍの柔軟な口腔内貼付用バン
デージを得た。I and ■ obtained as above were pressed together at 100 kg/ci to obtain a flexible bandage for intraoral application with a thickness of 90 μm.
（Ｂ）バンデージの性能評価
再生豚皮を４０ｍｍφに打ち抜き、ステンレス板（４０
Ｘ４０ｍｍ）に両面テープで固定する。(B) Performance evaluation of bandage Punch out recycled pork skin into a 40 mm diameter stainless steel plate (40 mm diameter).
x40mm) with double-sided tape.
（Ａ）項で得られたバンデージを１０ｍｍφに打ち抜き
、この豚皮上に貼付し、有効波長領域４００〜５００ｎ
ｍのハロゲンランプ（５００Ｗ）を使用し、可視光を１
分間照射して、感光性樹脂を硬化した。このステンレス
板を蒸留水４００＋ｎ／！の入った日本薬局方「溶出試
験」 （第２法）の試験器に入れ、１１００ｒｐでパド
ルを回転させながら６時間放置した。６時間後の付着状
態を観察した結果、バンデージの周囲はわずかに膨潤・
溶解しているものの、再生豚皮に十分付着しており、剥
離するのに抵抗を示し、バンデージは一体化して剥離し
た。The bandage obtained in section (A) was punched out to a size of 10 mmφ and pasted on the pig skin, and the effective wavelength range was 400 to 500 nm.
m halogen lamp (500W) and visible light
The photosensitive resin was cured by irradiation for a minute. Distilled water 400+n/! The sample was placed in a Japanese Pharmacopoeia ``Dissolution Test'' (Method 2) tester containing 1,100 rpm and left for 6 hours while rotating the paddle at 1100 rpm. As a result of observing the adhesion state after 6 hours, the area around the bandage was slightly swollen.
Although it was dissolved, it adhered well to the regenerated pigskin and showed resistance to peeling, and the bandage was peeled off as a unit.
北敦藁ユ
（Ａ）口腔内貼付用バンデージの調製
キトサン塩を使用しなかった以外は、実施例１と同様に
してフィルム状粘膜貼付性基剤層を得、これに感光性樹
脂層も設けないものをロ腔内貼付用ハ゛ンデージとした
。Preparation of Bandage for Intraoral Application of Kitaatsuwarayu (A) A film-like base layer for application to mucous membranes was obtained in the same manner as in Example 1, except that chitosan salt was not used, and a photosensitive resin layer was also provided on this. The one without was used as a hindage for intracavity application.
（Ｂ）バンデージの性能評価
比較例１の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in section (A) of Comparative Example 1, performance evaluation was performed in the same manner as in section (B) of Example 1.
バンデージは、１時間後には膨潤し、蒸留水中に溶解し
た。The bandage swelled after 1 hour and dissolved in distilled water.
丈搭量１
（Ａ）口腔内貼付用バンデージの調製
親水性ポリマーとして、ポリアクリル酸１０重量部を用
い、これとポリビニルピロリドン５重量５
６
部、およびプレドニゾロンＯ３１重量部をエタノール１
８０重量部に均一に溶解させた。これに２００メツシユ
のキトサン２０重量部を均一に分散させた。この溶液を
表面シリコーン処理したＰＥＴフィルム上に流延・乾燥
して厚み４０μｍのフィルム状粘膜貼付性基剤層（Ｉｎ
）を得た。Length weight 1 (A) Preparation of bandage for intraoral application 10 parts by weight of polyacrylic acid was used as the hydrophilic polymer, and 5 6 parts by weight of polyvinylpyrrolidone and 31 parts by weight of prednisolone O were mixed with 1 part by weight of ethanol.
It was uniformly dissolved in 80 parts by weight. 20 parts by weight of 200 meshes of chitosan were uniformly dispersed therein. This solution was cast onto a PET film whose surface had been treated with silicone and dried to form a 40 μm thick film-like mucosal adhesive base layer (In
) was obtained.
別に感光性樹脂として、下記の組成（数字は部数を示す
）
・ ポリメタクリ１シ酸メチル（肚−２００，０００）
４ Ｂ［バインダー
樹月旨］
・ メタクリル酸メチ１シ
４０［反応性モノマー］
・ トリメチロールプロパントリフクリレート
２［反応性モノマー
］
・ ウレタンジアクリレート（新中村化学 Ｕ−２００
） １ ０［反応性モノマー］
・ カシファーキノン
０・ ２［光重合開始剤］
・ ジェタノールアミン
０．５［光重合開始助剤］
により、ペースト状物を得た。Separately, as a photosensitive resin, the following composition (the number indicates the number of parts) - Polymethyl methacrylic acid monosaccharide (肚-200,000)
4 B [Binder
・Methi 1 methacrylate
40 [Reactive monomer] - Trimethylolpropane trifacrylate
2 [Reactive monomer] Urethane diacrylate (Shin Nakamura Chemical U-200
) 1 0 [Reactive monomer] ・Casiferquinone
0. 2 [Photopolymerization initiator] Jetanolamine
0.5 [Photopolymerization initiation aid] A paste-like material was obtained.
このペーストを４０μｍのニスメゾイカ■（積水化学製
；無可塑剤軟質ポリ塩化ビニル）と表面シリコーン処理
ＰＥＴ’？’挟み１００ ｋｇ／ｃＴＩＩＴニブレスし
て、厚み１４０μｍの柔軟なニスメゾイカＶラミネート
・フィルム状感光性樹脂層（ＩＶ）を得た。以上のよう
にして得られた■と■を１００ｋｇ／ ｃ＋ｆｌで圧着
プレスして厚み１６０μｍの柔軟な口腔内貼付用バンデ
ージを得た。This paste was mixed with 40 μm of Nismezoica ■ (manufactured by Sekisui Chemical; plasticizer-free soft polyvinyl chloride) and surface-treated PET'? A flexible Nismezoica V laminate film-like photosensitive resin layer (IV) having a thickness of 140 μm was obtained by nibbling at 100 kg/cTIIT. The materials (1) and (2) obtained as described above were pressed at 100 kg/c+fl to obtain a flexible bandage for intraoral application with a thickness of 160 μm.
（Ｂ）バンデージの性能評価
実施例２の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in Section (A) of Example 2, performance evaluation was performed in the same manner as in Section (B) of Example 1.
バンデージの周囲はわずかに膨潤・白化しているも、の
の、再生豚皮に十分付着しており、剥離するのに抵抗を
示し、バンデージは一体化して剥離した。Although the area around the bandage was slightly swollen and whitened, it was sufficiently adhered to the regenerated pig skin and showed resistance to peeling, and the bandage was peeled off as a unit.
また、バンデージを２０ｍｍφに打ち抜いたものを５人
のボランティアの口腔粘膜に貼付し、有効波長領域４０
０〜５００ｎｍのハロゲンランプ７
（５００Ｗ）を使用し、可視光を１分間照射して、感光
性樹脂を硬化した後、剥離時間を測定した結果、平均剥
離時間は、２０．３時間であった。In addition, bandages were punched out to a diameter of 20 mm and pasted on the oral mucosa of five volunteers.
After curing the photosensitive resin by irradiating it with visible light for 1 minute using a 0-500 nm halogen lamp 7 (500W), the peeling time was measured, and the average peeling time was 20.3 hours. .
止校樵１
（Ａ）口腔内貼付用バンデージの調製
２００メツシユのキトサンを使用しなかったこと以外は
、実施例２と同様にしてフィルム状粘膜貼付性基剤層を
得、これに感光性樹脂層も設けないものを口腔内貼付用
バンデージとした。1 (A) Preparation of bandage for intraoral application A film-like mucosal adhesive base layer was obtained in the same manner as in Example 2, except that 200 meshes of chitosan was not used, and a photosensitive resin was applied to this. A bandage without a layer was used for intraoral application.
（Ｂ）バンデージの性能評価
比較例２の（Ａ）項で得られたバンデージを用い、実施
例１ （Ｂ）項と同様にして性能評価を行った。(B) Performance evaluation of bandage Using the bandage obtained in section (A) of Comparative Example 2, performance evaluation was performed in the same manner as in section (B) of Example 1.
バンデージは、６時間後には全面膨潤・白化し、付着部
分については剥離するのに抵抗を示したが、実施例２と
比較してその抵抗は弱かった。また、ボランティアの口
腔粘膜における平均剥離時間は６．２時間であった。The entire surface of the bandage swelled and turned white after 6 hours, and the adhered portions showed resistance to peeling off, but this resistance was weaker than in Example 2. Moreover, the average peeling time on the oral mucosa of volunteers was 6.2 hours.
（発明の効果）
本発明によれば、このように、口腔内粘膜に対して優れ
た貼付性を示し、かつ耐水性・持久性に優れた口腔内貼
付用バンデージが提供される。このバンデージは柔軟な
シート状であるため貼付時に違和感を与えることがなく
、また、貼付後、粘膜貼付性基剤が粘膜からの水分を吸
水して弾性体を形成・維持することにより、口腔内の損
傷部や疾患部の被覆・保護効果が高くなる。さらに、貼
付後に感光性樹脂を硬化させることによって、貼付時の
形状を保持し、粘膜貼付性基剤への外部からの物理的な
影響を受けにくくすることから、長時間安定的に付着し
、粘膜の貼付部分を充分に保護する効果を有する。この
ようなバンデージは、長時間にわたり口腔粘膜表面に貼
付することが可能であり、例えば、口腔内の損傷部や疾
患部を充分に保護するバンデージとし、また、薬効成分
を経粘膜吸収させ、全身性作用・局所作用を発現させる
ための基剤として有用である。(Effects of the Invention) According to the present invention, an intraoral patch bandage that exhibits excellent adhesion to the oral mucosa and has excellent water resistance and durability is provided. This bandage is in the form of a flexible sheet, so it does not cause discomfort when applied, and after application, the mucosal adhesive base absorbs water from the mucous membrane to form and maintain an elastic body, allowing it to be used in the oral cavity. The effect of covering and protecting damaged and diseased areas is increased. Furthermore, by curing the photosensitive resin after application, it retains its shape at the time of application and makes the mucosal adhesive base less susceptible to external physical influences, allowing it to adhere stably for a long time. It has the effect of sufficiently protecting the mucous membrane area to which it is applied. Such bandages can be applied to the surface of the oral mucosa for a long period of time, and can be used to sufficiently protect damaged or diseased areas in the oral cavity, and can also absorb medicinal ingredients transmucosally, allowing them to be absorbed throughout the body. It is useful as a base for expressing sexual and local effects.
Claims (1)
その誘導体を含有する粘膜貼付性基剤層の片面に、感光
性樹脂層が設けられており、口腔内に貼付するのに必要
な柔軟性を有する、口腔内貼付用バンデージ。1. A photosensitive resin layer is provided on one side of the mucosal adhesive base layer containing a hydrophilic polymer and undissolved chitosan or its derivative, and has the flexibility necessary for application in the oral cavity. , bandage for intraoral application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2062086A JP2877422B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2062086A JP2877422B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03264522A true JPH03264522A (en) | 1991-11-25 |
| JP2877422B2 JP2877422B2 (en) | 1999-03-31 |
Family
ID=13189897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2062086A Expired - Fee Related JP2877422B2 (en) | 1990-03-13 | 1990-03-13 | Oral bandage |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2877422B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998055079A3 (en) * | 1997-06-06 | 1999-03-04 | Procter & Gamble | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| JP2011219391A (en) * | 2010-04-06 | 2011-11-04 | Lintec Corp | Sheet for peeling horny layer and method for peeling horny layer |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
-
1990
- 1990-03-13 JP JP2062086A patent/JP2877422B2/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998055079A3 (en) * | 1997-06-06 | 1999-03-04 | Procter & Gamble | A delivery system for an oral care substance using a strip of material having low flexural stiffness |
| USRE42126E1 (en) | 1999-07-02 | 2011-02-08 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
| US9554976B2 (en) | 2002-09-11 | 2017-01-31 | The Procter & Gamble Company | Tooth whitening product |
| US10493016B2 (en) | 2002-09-11 | 2019-12-03 | The Procter & Gamble Company | Tooth whitening product |
| JP2011219391A (en) * | 2010-04-06 | 2011-11-04 | Lintec Corp | Sheet for peeling horny layer and method for peeling horny layer |
| US10285915B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| US10285916B2 (en) | 2012-10-17 | 2019-05-14 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2877422B2 (en) | 1999-03-31 |
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