JPH0233690B2 - - Google Patents

Info

Publication number: JPH0233690B2
Authority: JP; Japan
Prior art keywords: hydrogen atom; formula; compound; carbon atoms; group
Prior art date: 1981-10-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP57184812A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5879924A (ja

Inventor

Kurisuteideisu Yani

Barutsuagi Fuerunando

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-22

Filing date

1982-10-22

Publication date

1990-07-30

1982-10-22 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1983-05-13 Publication of JPS5879924A publication Critical patent/JPS5879924A/ja

1990-07-30 Publication of JPH0233690B2 publication Critical patent/JPH0233690B2/ja

Status Granted legal-status Critical Current

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 5
150000003839 salts Chemical group 0.000 claims description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 4
150000001342 alkaline earth metals Chemical class 0.000 claims description 4
150000001412 amines Chemical class 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
125000003545 alkoxy group Chemical group 0.000 claims description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
150000001339 alkali metal compounds Chemical class 0.000 claims description 2
239000003699 antiulcer agent Substances 0.000 claims 1
150000001875 compounds Chemical class 0.000 description 21
241001465754 Metazoa Species 0.000 description 9
230000002496 gastric effect Effects 0.000 description 9
239000003814 drug Substances 0.000 description 7
241000700159 Rattus Species 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
238000000034 method Methods 0.000 description 6
239000000203 mixture Substances 0.000 description 6
-1 methoxy, ethoxy Chemical group 0.000 description 5
239000000546 pharmaceutical excipient Substances 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
208000025865 Ulcer Diseases 0.000 description 4
239000002775 capsule Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 4
230000000694 effects Effects 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
229910052783 alkali metal Inorganic materials 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
230000028327 secretion Effects 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
238000012360 testing method Methods 0.000 description 3
KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
206010020601 Hyperchlorhydria Diseases 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
238000005684 Liebig rearrangement reaction Methods 0.000 description 2
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
150000001340 alkali metals Chemical class 0.000 description 2
230000000767 anti-ulcer Effects 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
235000013305 food Nutrition 0.000 description 2
HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 2
239000008101 lactose Substances 0.000 description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
231100000397 ulcer Toxicity 0.000 description 2
230000036269 ulceration Effects 0.000 description 2
WACXXOUTJZQPTN-AATRIKPKSA-N (e)-4-(2-hydroxyphenyl)-4-oxobut-2-enoic acid Chemical compound OC(=O)\C=C\C(=O)C1=CC=CC=C1O WACXXOUTJZQPTN-AATRIKPKSA-N 0.000 description 1
WORYXBDHTBWLLL-VOTSOKGWSA-N (e)-4-(4-methoxyphenyl)-4-oxobut-2-enoic acid Chemical compound COC1=CC=C(C(=O)\C=C\C(O)=O)C=C1 WORYXBDHTBWLLL-VOTSOKGWSA-N 0.000 description 1
PLPDHGOODMBBGN-VOTSOKGWSA-N (e)-4-oxo-4-phenylbut-2-enoic acid Chemical class OC(=O)\C=C\C(=O)C1=CC=CC=C1 PLPDHGOODMBBGN-VOTSOKGWSA-N 0.000 description 1
229910002012 Aerosil® Inorganic materials 0.000 description 1
208000015877 Duodenal disease Diseases 0.000 description 1
208000012895 Gastric disease Diseases 0.000 description 1
208000007882 Gastritis Diseases 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
208000034991 Hiatal Hernia Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
208000007107 Stomach Ulcer Diseases 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
239000008135 aqueous vehicle Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229940110456 cocoa butter Drugs 0.000 description 1
235000019868 cocoa butter Nutrition 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000012024 dehydrating agents‎ Substances 0.000 description 1
125000005265 dialkylamine group Chemical group 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
WEHWNAOGRSTTBQ-UHFFFAOYSA-N dipropylamine Chemical compound CCCNCCC WEHWNAOGRSTTBQ-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000008298 dragée Substances 0.000 description 1
230000002183 duodenal effect Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
210000001156 gastric mucosa Anatomy 0.000 description 1
231100000029 gastro-duodenal ulcer Toxicity 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
239000008187 granular material Substances 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000003902 lesion Effects 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
210000001187 pylorus Anatomy 0.000 description 1
238000011002 quantification Methods 0.000 description 1
229940100486 rice starch Drugs 0.000 description 1
239000000523 sample Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000004448 titration Methods 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP57184812A 1981-10-22 1982-10-22 ４―フェニル―４―オキソ―２―ブテン酸の一置換誘導体よりなる薬剤 Granted JPS5879924A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR81-19832		1981-10-22
FR8119832A FR2515037A1 (fr)	1981-10-22	1981-10-22	A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant

Publications (2)

Publication Number	Publication Date
JPS5879924A JPS5879924A (ja)	1983-05-13
JPH0233690B2 true JPH0233690B2 (fr)	1990-07-30

Family

ID=9263283

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57184812A Granted JPS5879924A (ja)	1981-10-22	1982-10-22	４―フェニル―４―オキソ―２―ブテン酸の一置換誘導体よりなる薬剤

Country Status (12)

Country	Link
US (1)	US4454155A (fr)
JP (1)	JPS5879924A (fr)
BE (1)	BE894763A (fr)
CA (1)	CA1181341A (fr)
CH (1)	CH655657B (fr)
DE (1)	DE3239220A1 (fr)
FR (1)	FR2515037A1 (fr)
GB (1)	GB2111385B (fr)
IT (1)	IT1157231B (fr)
LU (1)	LU84427A1 (fr)
NL (1)	NL8204063A (fr)
SE (1)	SE455421B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1190340B (it) *	1986-06-06	1988-02-16	Roussel Maestretti Spa	Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
US6964379B2 (en) *	2003-04-07	2005-11-15	Crowley Joseph T	Exterior fire suppression system and method for installation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB588108A (en) *	1944-10-23	1947-05-14	Roche Products Ltd	Manufacture of bacteriostatic substances
US2532579A (en) *	1946-08-06	1950-12-05	Du Pont	Pest control compositions containing beta-acyl acrylates
US2562208A (en) *	1947-04-14	1951-07-31	Schering Corp	Fungistatic composition
DE1282644B (de) *	1962-09-08	1968-11-14	Hoechst Ag	Verfahren zur Herstellung von ungesaettigten ª€-Ketocarbonsaeureestern
GR37790B (el) *	1966-12-30	1969-07-15	F. Hoffmann - La Roche & Co. Aktiengesellschaft	Μεθοδος δια την παρασκευην παραγωγων του αρουλακρυλικου οξεος.
NL6717403A (fr) *	1966-12-30	1968-07-01
DE2047806A1 (en) *	1970-09-29	1972-04-06	Dr Karl Thomae GmbH, 7950 Biberach	3-aroyl-acrylic acids - pharmaceutical intermediates prepd from acetophenones and glyoxylic acid derivs
DE2103749A1 (en) *	1971-01-27	1972-08-10	Dr. Karl Thomae GmbH, 7951 Biberach	3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv)
DE2116293A1 (de) *	1971-04-02	1972-10-19	Cassella Farbwerke Mainkur Ag, 6000 Frankfurt	Ketonderivate und Verfahren zu ihrer Herstellung
US3753997A (en) *	1971-06-07	1973-08-21	A Ash	Trifluoromethly substituted-2,6-diphenyl-4-pyridyl carbinolamine antimalarials
BE788749A (fr) *	1971-09-13	1973-03-13	Takeda Chemical Industries Ltd	Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US4017517A (en) *	1971-09-13	1977-04-12	Takeda Chemical Industries, Ltd.	2-(Trisubstituted benzoyl)-propionic acid and a method for the production thereof
BE795893A (fr) *	1972-02-28	1973-06-18	Unicler	Derives de (methylene dioxy-3,4 phenyl)-1 dimethyl-4,4 pentene-1, leur preparation et leur application en therrapeutique
GB1392100A (en) *	1972-09-13	1975-04-23	Beecham Group Ltd	Insecticides
CH591415A5 (en) *	1972-09-13	1977-09-15	Takeda Chemical Industries Ltd	3-(Tri-substd. benzoyl) propionic acids - as relaxants or spasmolytics for the gall bladder
FR2270856B1 (fr) *	1974-01-17	1978-07-21	Screen
US3953463A (en) *	1974-03-06	1976-04-27	The United States Of America As Represented By The Secretary Of The Army	2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials
US3940404A (en) *	1974-03-06	1976-02-24	The United States Of America As Represented By The Secretary Of The Army	2-Substituted phenyl-6-trifluoromethyl-4-pyridyl-carbinolamines
FR2300551A2 (fr) *	1975-02-17	1976-09-10	Fabre Sa Pierre	Nouveaux
US4008323A (en) *	1974-03-25	1977-02-15	Pierre Fabre S.A.	Method of reducing cholesterol using certain aromatic keto acids
FR2379505A1 (fr) *	1977-02-04	1978-09-01	Screen	Nouveaux produits doues notamment de proprietes therapeutiques, leurs procedes de preparation, et medicaments a base de ces produits
JPS5536434A (en) *	1978-09-07	1980-03-14	Sankyo Co Ltd	4-phenyl-4-oxo-2-butenoic acid derivative and its preparation
FR2481118A1 (fr) *	1980-04-24	1981-10-30	Roussel Uclaf	Application a titre de medicaments de derives substitues de l'acide phenyl-4-oxo-2-butenoique
FR2504004A1 (fr) *	1981-04-17	1982-10-22	Roussel Uclaf	Application a titre de medicaments de derives d'acides phenyl aliphatique carboxyliques
FR2504127B1 (fr) *	1981-04-17	1985-07-19	Roussel Uclaf	Nouveaux derives d'acides phenyl aliphatique carboxyliques, procede pour leur preparation et leur application comme medicaments
IT1210582B (it) *	1981-10-22	1989-09-14	Roussel Maestretti Spa	Derivati di acido 4-fenil-4-ossobuten-2-oico dotati di proprieta'farmacologiche e composizioni farmaceutiche che li contengono
DE3228842A1 (de) *	1982-08-02	1984-02-02	Henkel Kgaa	Sebosuppressive kosmetische mittel, enthaltend aryloxobutensaeurederivate sowie neue aryloxobutensaeurederivate

1981
- 1981-10-22 FR FR8119832A patent/FR2515037A1/fr active Granted
1982
- 1982-10-11 SE SE8205767A patent/SE455421B/sv not_active IP Right Cessation
- 1982-10-20 US US06/435,623 patent/US4454155A/en not_active Expired - Fee Related
- 1982-10-21 LU LU84427A patent/LU84427A1/fr unknown
- 1982-10-21 IT IT49331/82A patent/IT1157231B/it active
- 1982-10-21 NL NL8204063A patent/NL8204063A/nl not_active Application Discontinuation
- 1982-10-21 BE BE0/209292A patent/BE894763A/fr not_active IP Right Cessation
- 1982-10-21 CH CH612982A patent/CH655657B/fr unknown
- 1982-10-21 CA CA000413906A patent/CA1181341A/fr not_active Expired
- 1982-10-22 GB GB08230212A patent/GB2111385B/en not_active Expired
- 1982-10-22 DE DE19823239220 patent/DE3239220A1/de active Granted
- 1982-10-22 JP JP57184812A patent/JPS5879924A/ja active Granted

Also Published As

Publication number	Publication date
CA1181341A (fr)	1985-01-22
US4454155A (en)	1984-06-12
GB2111385B (en)	1985-07-10
FR2515037A1 (fr)	1983-04-29
IT1157231B (it)	1987-02-11
IT8249331A0 (it)	1982-10-21
NL8204063A (nl)	1983-05-16
LU84427A1 (fr)	1983-06-13
SE455421B (sv)	1988-07-11
JPS5879924A (ja)	1983-05-13
CH655657B (fr)	1986-05-15
GB2111385A (en)	1983-07-06
DE3239220A1 (de)	1983-05-05
DE3239220C2 (fr)	1992-01-16
BE894763A (fr)	1983-04-21
SE8205767D0 (sv)	1982-10-11
SE8205767L (sv)	1983-04-23
FR2515037B1 (fr)	1984-08-17

Publication	Publication Date	Title
WO1991016338A1 (fr)	1991-10-31	Derive de glutathion a substitution-s-(acide gras inferieur)
JPH0227326B2 (fr)	1990-06-15
US4500731A (en)	1985-02-19	Derivatives of 4-phenyl-4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and therapeutic uses for them
US4450292A (en)	1984-05-22	Derivatives of phenyl aliphatic carboxylic acids, and use thereof in treating gastric and gastro-duodenal ailments
JPS6072843A (ja)	1985-04-24	４−フエニル−４−オキソ−２−ブテン酸の新誘導体、それらの製造法、薬剤としての使用及びそれらを含む組成物
JPH0233690B2 (fr)	1990-07-30
US4473583A (en)	1984-09-25	Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them
US4867737A (en)	1989-09-19	Derivatives of 4-phenyl-4-oxo-2-butenoic acid their preparation process, their use as medicaments and compositions containing them
JPH0227325B2 (fr)	1990-06-15
US4436752A (en)	1984-03-13	Treatment of gastric and gastro-duodenal disorders with derivatives of phenyl aliphatic carboxylic acids
JPS6052747B2 (ja)	1985-11-21	２−置換フエニル−５−アルキルチアゾリジン−４−オン、及び該化合物有効成分とする抗消化性潰瘍剤
JPS6299372A (ja)	1987-05-08	化合物
JPH0212938B2 (fr)	1990-03-30
US4156009A (en)	1979-05-22	Diazepine derivatives
US4486429A (en)	1984-12-04	Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
JPH0544470B2 (fr)	1993-07-06
JPS6310949B2 (fr)	1988-03-10
JPS625417B2 (fr)	1987-02-04
JPS6348263B2 (fr)	1988-09-28
JPS6140650B2 (fr)	1986-09-10
JPS6310700B2 (fr)	1988-03-08