JP7498551B2 - 抗炎症剤 - Google Patents
抗炎症剤 Download PDFInfo
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- JP7498551B2 JP7498551B2 JP2019174836A JP2019174836A JP7498551B2 JP 7498551 B2 JP7498551 B2 JP 7498551B2 JP 2019174836 A JP2019174836 A JP 2019174836A JP 2019174836 A JP2019174836 A JP 2019174836A JP 7498551 B2 JP7498551 B2 JP 7498551B2
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- inflammatory
- oil
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- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
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- SHWIJIJNPFXOFS-UHFFFAOYSA-N thiotaurine Chemical compound NCCS(O)(=O)=S SHWIJIJNPFXOFS-UHFFFAOYSA-N 0.000 description 1
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- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
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- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
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- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- 229930007850 β-damascenone Natural products 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
化合物1:一般式(1)において、R1が直鎖ヘキシル基である化合物
化合物2:一般式(1)において、R1がシクロヘキシル基である化合物
化合物1及び化合物2について、DNAマイクロアレイ解析により、生体中の抗炎症に関する遺伝子発現の抑制・促進作用の有無を評価した。具体的には、正常ヒト細胞を培地(HuMedia-KG2、倉敷紡績株式会社製)で24時間培養後、培地に化合物1を0.05質量%となる量で添加(試験例1)、又は化合物2を0.20質量%となる量で添加(試験例2)し、それぞれさらに24時間培養した。培養後の試験液をQIAzol Lysis Reagent(QIAGEN社製)に溶解させた後、精製RNAを回収し、RNA解析チップ(ジェノパール(登録商標)、三菱ケミカル株式会社製)を用いてDNAマイクロアレイを実施した。
IL1α:Homo sapiens interleukin 1, alpha
IL1β:Homo sapiens interleukin 1, beta
SERPIN1:Homo sapiens serpin family E member 1
IFNγ:Homo sapiens interferon gamma
NGF:Homo sapiens nerve growth factor
NGFR:Homo sapiens nerve growth factor receptor
Claims (3)
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2000119205A (ja) | 1998-10-09 | 2000-04-25 | Sakamoto Yakuhin Kogyo Co Ltd | グリセリルエーテル化合物の製造法 |
WO2019093481A1 (ja) | 2017-11-09 | 2019-05-16 | 北海道公立大学法人札幌医科大学 | 組織再生用医薬及びその製造方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS58134049A (ja) * | 1982-02-03 | 1983-08-10 | Kao Corp | グリセリルエ−テルの製造法 |
JPS6377833A (ja) * | 1986-09-19 | 1988-04-08 | Nippon Saafuakutanto Kogyo Kk | アルキルグリセリルエ−テルの製造法 |
FR2755852B1 (fr) * | 1996-11-15 | 1998-12-24 | Oreal | Utilisation d'un alkylether de glycerol dans une composition cosmetique et/ou dermatologique comme actif pour le traitement de la seborrhee et de l'acne |
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Patent Citations (2)
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JP2000119205A (ja) | 1998-10-09 | 2000-04-25 | Sakamoto Yakuhin Kogyo Co Ltd | グリセリルエーテル化合物の製造法 |
WO2019093481A1 (ja) | 2017-11-09 | 2019-05-16 | 北海道公立大学法人札幌医科大学 | 組織再生用医薬及びその製造方法 |
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