JP7410336B2 - ラクトバチルス・ガセリbnr17を含む更年期疾患治療用組成物 - Google Patents
ラクトバチルス・ガセリbnr17を含む更年期疾患治療用組成物 Download PDFInfo
- Publication number
- JP7410336B2 JP7410336B2 JP2022575673A JP2022575673A JP7410336B2 JP 7410336 B2 JP7410336 B2 JP 7410336B2 JP 2022575673 A JP2022575673 A JP 2022575673A JP 2022575673 A JP2022575673 A JP 2022575673A JP 7410336 B2 JP7410336 B2 JP 7410336B2
- Authority
- JP
- Japan
- Prior art keywords
- menopausal
- present
- composition
- bnr17
- lactobacillus gasseri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 48
- 241000186606 Lactobacillus gasseri Species 0.000 title claims description 33
- 208000017657 Menopausal disease Diseases 0.000 title claims description 19
- 235000013305 food Nutrition 0.000 claims description 35
- 206010027304 Menopausal symptoms Diseases 0.000 claims description 25
- 239000000284 extract Substances 0.000 claims description 23
- 230000000694 effects Effects 0.000 claims description 18
- 235000013376 functional food Nutrition 0.000 claims description 17
- 235000013399 edible fruits Nutrition 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 206010047791 Vulvovaginal dryness Diseases 0.000 claims description 13
- 239000004480 active ingredient Substances 0.000 claims description 13
- 208000001132 Osteoporosis Diseases 0.000 claims description 11
- 206010067371 Menopausal depression Diseases 0.000 claims description 10
- 244000046101 Sophora japonica Species 0.000 claims description 10
- 235000010586 Sophora japonica Nutrition 0.000 claims description 10
- 208000004454 Hyperalgesia Diseases 0.000 claims description 9
- 230000006872 improvement Effects 0.000 claims description 9
- 208000035154 Hyperesthesia Diseases 0.000 claims description 8
- 230000001747 exhibiting effect Effects 0.000 claims description 5
- 241000207199 Citrus Species 0.000 claims description 2
- 235000020971 citrus fruits Nutrition 0.000 claims description 2
- 239000008280 blood Substances 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 238000010171 animal model Methods 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 13
- 201000010099 disease Diseases 0.000 description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 13
- 241001465754 Metazoa Species 0.000 description 12
- 239000013642 negative control Substances 0.000 description 11
- 239000002702 enteric coating Substances 0.000 description 10
- 238000009505 enteric coating Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 230000037182 bone density Effects 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 239000013641 positive control Substances 0.000 description 9
- 230000002265 prevention Effects 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000008533 pain sensitivity Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 8
- 235000005911 diet Nutrition 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 210000002919 epithelial cell Anatomy 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 230000009245 menopause Effects 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000000529 probiotic effect Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 241000186660 Lactobacillus Species 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 229940039696 lactobacillus Drugs 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 102000055006 Calcitonin Human genes 0.000 description 5
- 108060001064 Calcitonin Proteins 0.000 description 5
- ZAHDXEIQWWLQQL-IHRRRGAJSA-N Deoxypyridinoline Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(O)=C(C[C@H](N)C([O-])=O)C(CC[C@H](N)C(O)=O)=C1 ZAHDXEIQWWLQQL-IHRRRGAJSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 102000004067 Osteocalcin Human genes 0.000 description 5
- 108090000573 Osteocalcin Proteins 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 5
- 229960004015 calcitonin Drugs 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 235000013373 food additive Nutrition 0.000 description 5
- 239000002778 food additive Substances 0.000 description 5
- 230000003780 keratinization Effects 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 239000006041 probiotic Substances 0.000 description 5
- 235000018291 probiotics Nutrition 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000002485 urinary effect Effects 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 description 4
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 229940076279 serotonin Drugs 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 235000013351 cheese Nutrition 0.000 description 3
- 235000015140 cultured milk Nutrition 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 235000020256 human milk Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000021109 kimchi Nutrition 0.000 description 3
- 235000012149 noodles Nutrition 0.000 description 3
- 238000009806 oophorectomy Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 235000015067 sauces Nutrition 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 239000004278 EU approved seasoning Substances 0.000 description 2
- 240000006570 Euonymus japonicus Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 244000294411 Mirabilis expansa Species 0.000 description 2
- 235000015429 Mirabilis expansa Nutrition 0.000 description 2
- 241000235395 Mucor Species 0.000 description 2
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 2
- 238000011887 Necropsy Methods 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 210000000702 aorta abdominal Anatomy 0.000 description 2
- 238000011888 autopsy Methods 0.000 description 2
- 235000013527 bean curd Nutrition 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000024279 bone resorption Effects 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000011194 food seasoning agent Nutrition 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 2
- 229960000907 methylthioninium chloride Drugs 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 235000013536 miso Nutrition 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 206010000050 Abdominal adhesions Diseases 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241000193749 Bacillus coagulans Species 0.000 description 1
- 241000194108 Bacillus licheniformis Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241000186715 Lactobacillus alimentarius Species 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241001134659 Lactobacillus curvatus Species 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 235000013967 Lactobacillus helveticus Nutrition 0.000 description 1
- 241001468157 Lactobacillus johnsonii Species 0.000 description 1
- 241000186604 Lactobacillus reuteri Species 0.000 description 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 1
- 241000186612 Lactobacillus sakei Species 0.000 description 1
- 241000194036 Lactococcus Species 0.000 description 1
- 241000192132 Leuconostoc Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 241000192001 Pediococcus Species 0.000 description 1
- 241000191998 Pediococcus acidilactici Species 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 241000235648 Pichia Species 0.000 description 1
- 241000186429 Propionibacterium Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000235527 Rhizopus Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N acrylic acid methyl ester Natural products COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000008452 baby food Nutrition 0.000 description 1
- 229940054340 bacillus coagulans Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 229940004120 bifidobacterium infantis Drugs 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 238000002306 biochemical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000010352 biotechnological method Methods 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000004097 bone metabolism Effects 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 235000012180 bread and bread product Nutrition 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000009164 estrogen replacement therapy Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 235000019985 fermented beverage Nutrition 0.000 description 1
- 235000021107 fermented food Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013332 fish product Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000020510 functional beverage Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229940054346 lactobacillus helveticus Drugs 0.000 description 1
- 229940001882 lactobacillus reuteri Drugs 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 238000010603 microCT Methods 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- -1 pH regulators Substances 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000020991 processed meat Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000020341 sensory perception of pain Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000013322 soy milk Nutrition 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 102000014898 transaminase activity proteins Human genes 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Alternative & Traditional Medicine (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Description
Claims (6)
- KCTC 10902BPとして寄託されたラクトバチルス・ガセリ(Lactobacillus gasseri)BNR17を有効成分として含有する更年期疾患治療用医薬組成物であって、
前記医薬組成物は、
(i)骨粗鬆症の改善;
(ii)更年期鬱病の緩和;
(iii)痛覚過敏症の改善;及び
(iv)膣乾燥症の改善;からなる群から選ばれるいずれか一つ以上の効果を発揮することを特徴とする、更年期疾患治療用医薬組成物。 - 前記組成物は、エンジュ抽出物をさらに含むことを特徴とする、請求項1に記載の更年期疾患治療用医薬組成物。
- 前記エンジュ抽出物は、エンジュ果実抽出物であることを特徴とする、請求項2に記載の更年期疾患治療用医薬組成物。
- KCTC 10902BPとして寄託されたラクトバチルス・ガセリ(Lactobacillus gasseri)BNR17を有効成分として含有する更年期症状の予防又は改善用機能性食品組成物であって、
前記食品組成物は、
(i)骨粗鬆症の改善;
(ii)更年期鬱病の緩和;
(iii)痛覚過敏症の改善;及び
(iv)膣乾燥症の改善;からなる群から選ばれるいずれか一つ以上の効果を発揮することを特徴とする、更年期症状の予防又は改善用機能性食品組成物。 - 前記組成物は、エンジュ抽出物をさらに含むことを特徴とする、請求項4に記載の更年期症状の予防又は改善用機能性食品組成物。
- 前記エンジュ抽出物は、エンジュ果実抽出物であることを特徴とする、請求項5に記載の更年期症状の予防又は改善用機能性食品組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20200019129 | 2020-02-17 | ||
KR10-2020-0019129 | 2020-02-17 | ||
PCT/KR2021/002034 WO2021167350A1 (ko) | 2020-02-17 | 2021-02-17 | 락토바실러스 가세리 bnr17을 포함하는 갱년기 질환 치료용 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023515275A JP2023515275A (ja) | 2023-04-12 |
JP7410336B2 true JP7410336B2 (ja) | 2024-01-09 |
Family
ID=77391458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022575673A Active JP7410336B2 (ja) | 2020-02-17 | 2021-02-17 | ラクトバチルス・ガセリbnr17を含む更年期疾患治療用組成物 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230124145A1 (ja) |
EP (1) | EP4108249A4 (ja) |
JP (1) | JP7410336B2 (ja) |
KR (2) | KR102558595B1 (ja) |
CN (1) | CN115087453A (ja) |
AU (1) | AU2021224434A1 (ja) |
CA (1) | CA3165082A1 (ja) |
WO (1) | WO2021167350A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102587940B1 (ko) | 2023-03-02 | 2023-10-11 | 주식회사 현대바이오랜드 | 에스트로겐 수용체 베타 특이적 활성화를 통한 여성 갱년기 증상의 예방 또는 치료 효능을 갖는 비피도박테리움 브레브 hdb7040 균주 |
CN116555129B (zh) * | 2023-07-11 | 2023-09-29 | 北京量化健康科技有限公司 | 格氏乳杆菌bdup、其应用及产品 |
CN117736960B (zh) * | 2024-02-21 | 2024-05-07 | 滨州医学院 | 一种小白链霉菌基因工程菌及其应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003252772A (ja) | 2002-03-04 | 2003-09-10 | Snow Brand Milk Prod Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
JP2007512320A (ja) | 2003-11-26 | 2007-05-17 | レックスジーンバイオテック・カンパニー・リミテッド | 槐角抽出物を有効成分として含有する更年期疾患の予防及び治療用組成物 |
WO2008016214A1 (en) | 2006-08-04 | 2008-02-07 | Bioneer Corporation | Lactic acid bacteria isolated from mother's milk with probiotic activity and inhibitory activity against body weight augmentation |
JP2009242431A (ja) | 2009-07-17 | 2009-10-22 | Snow Brand Milk Prod Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
WO2010038714A1 (ja) | 2008-09-30 | 2010-04-08 | 明治乳業株式会社 | 高いシュウ酸分解能を有する乳酸菌 |
JP2012180375A (ja) | 2012-06-15 | 2012-09-20 | Snow Brand Milk Products Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
JP2014055195A (ja) | 2013-12-26 | 2014-03-27 | Snow Brand Milk Products Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040038481A (ko) * | 2002-11-01 | 2004-05-08 | 주식회사 렉스진바이오텍 | 천연물로부터 분리된 이소플라본 함유 추출물을 포함하는건강보조식품 |
KR100943747B1 (ko) * | 2006-11-29 | 2010-02-23 | (주)바이오니아 | 락토바실러스 가세리 bnr17 균주를 포함하는 당뇨병예방 및 치료용 조성물 |
KR20110004603A (ko) * | 2009-07-08 | 2011-01-14 | (주)노바셀테크놀로지 | 폐경기 질환의 치료 또는 예방, 피부 노화 방지, 또는 피부 주름 개선용 회화나무 추출물 |
EP2428214A1 (en) * | 2010-09-14 | 2012-03-14 | HSO Health Care GmbH | Compositions for the vaginal and oral administration of lactobacillus and uses thereof |
WO2012073924A1 (ja) * | 2010-11-29 | 2012-06-07 | 株式会社明治 | 子宮内膜症の予防及び/又は改善剤及びこれを含んでなる飲食品組成物 |
KR101279852B1 (ko) * | 2011-06-29 | 2013-07-09 | 주식회사 쎌바이오텍 | 골다공증 예방 또는 치료용 조성물 |
KR102275268B1 (ko) * | 2016-05-26 | 2021-07-09 | 주식회사 엘지생활건강 | 갱년기 증상 또는 골다공증 개선용 조성물 |
KR101964841B1 (ko) * | 2017-03-07 | 2019-08-07 | 주식회사 엘지생활건강 | 여성 갱년기 증상 개선용 조성물 |
-
2021
- 2021-02-17 WO PCT/KR2021/002034 patent/WO2021167350A1/ko unknown
- 2021-02-17 CN CN202180013705.5A patent/CN115087453A/zh active Pending
- 2021-02-17 KR KR1020210021197A patent/KR102558595B1/ko active IP Right Grant
- 2021-02-17 AU AU2021224434A patent/AU2021224434A1/en active Pending
- 2021-02-17 US US17/759,872 patent/US20230124145A1/en active Pending
- 2021-02-17 EP EP21756799.9A patent/EP4108249A4/en active Pending
- 2021-02-17 CA CA3165082A patent/CA3165082A1/en active Pending
- 2021-02-17 JP JP2022575673A patent/JP7410336B2/ja active Active
-
2023
- 2023-07-05 KR KR1020230087003A patent/KR20230109598A/ko not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003252772A (ja) | 2002-03-04 | 2003-09-10 | Snow Brand Milk Prod Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
JP2007512320A (ja) | 2003-11-26 | 2007-05-17 | レックスジーンバイオテック・カンパニー・リミテッド | 槐角抽出物を有効成分として含有する更年期疾患の予防及び治療用組成物 |
WO2008016214A1 (en) | 2006-08-04 | 2008-02-07 | Bioneer Corporation | Lactic acid bacteria isolated from mother's milk with probiotic activity and inhibitory activity against body weight augmentation |
WO2010038714A1 (ja) | 2008-09-30 | 2010-04-08 | 明治乳業株式会社 | 高いシュウ酸分解能を有する乳酸菌 |
JP2009242431A (ja) | 2009-07-17 | 2009-10-22 | Snow Brand Milk Prod Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
JP2012180375A (ja) | 2012-06-15 | 2012-09-20 | Snow Brand Milk Products Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
JP2014055195A (ja) | 2013-12-26 | 2014-03-27 | Snow Brand Milk Products Co Ltd | 加齢に伴う代謝異常症の予防・改善・治療剤 |
Also Published As
Publication number | Publication date |
---|---|
WO2021167350A1 (ko) | 2021-08-26 |
KR20210104596A (ko) | 2021-08-25 |
EP4108249A4 (en) | 2024-02-07 |
CA3165082A1 (en) | 2021-08-26 |
CN115087453A (zh) | 2022-09-20 |
KR102558595B1 (ko) | 2023-07-25 |
US20230124145A1 (en) | 2023-04-20 |
KR20230109598A (ko) | 2023-07-20 |
AU2021224434A1 (en) | 2022-07-28 |
JP2023515275A (ja) | 2023-04-12 |
EP4108249A1 (en) | 2022-12-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7410336B2 (ja) | ラクトバチルス・ガセリbnr17を含む更年期疾患治療用組成物 | |
ES2640526T3 (es) | Agente para reducir grasa visceral | |
JP5954828B2 (ja) | 皮膚状態の改善用組成物 | |
TWI463986B (zh) | 胚芽乳酸桿菌cmu995菌株之新用途 | |
EP2440217B1 (en) | Nutrition for improving muscle strength in elderly | |
AU2007292786B2 (en) | Agent for accelerating the increase in and/or preventing the decrease in blood adiponectin level, and visceral fat accumulation inhibitor | |
US20190321420A1 (en) | Method and composition for preventing, treating or relieving bone diseases | |
KR20190118985A (ko) | 비만의 예방 또는 치료 효과를 가지는 신규 비피도박테리움 롱검 균주 또는 락토바실러스 람노서스 균주 및 이의 용도 | |
JP2022079551A (ja) | 筋線維化抑制用組成物 | |
JP2021527414A (ja) | ロイコノストック属菌株を含む腸機能改善用組成物 | |
CN112351693A (zh) | 用于抑制流感的重症化的抗流感病毒剂 | |
KR101545551B1 (ko) | 인슐린 저항성 개선 효능을 갖는 7종의 유산균 복합균주를 유효성분으로 함유하는 조성물 | |
KR102262765B1 (ko) | 목장 원유 유래 엑소좀을 포함하는 골밀도 강화 또는 골다공증 치료용 조성물 | |
Saleem et al. | Therapeutic potential of popular fermented dairy products and its benefits on human health | |
JP7383120B2 (ja) | 皮膚状態改善用組成物 | |
JP2023514808A (ja) | 抗酸化剤として使用するためのプロバイオティクス組成物 | |
JP2007126399A (ja) | グルタチオン増加用組成物 | |
JP2024517547A (ja) | L.ロイテリ(l.reuteri)のプレコンディショニング | |
JP2024517546A (ja) | 最終製剤中のgosプレコンディショニングl.ロイテリ(l.reuteri)及びgos | |
JP7344661B2 (ja) | 食品組成物の製造方法 | |
CN113116940A (zh) | 一种副干酪乳杆菌gmnl-346用于抗口腔癌之用途 | |
TWI568441B (zh) | 用於控制體重的羅伊氏乳桿菌gmnl-263組合物及其用途 | |
WO2021132453A1 (ja) | 毛細血管障害抑制剤、毛細血管障害改善剤、及び毛細血管新生促進剤 | |
KR20230045340A (ko) | 체지방을 감소시키거나 지방간 형성을 억제시키기 위한 열처리 락토바실러스 플란타룸 k8 조성물 | |
KR20230121587A (ko) | 엔테로코커스 패칼리스, 이의 배양액 또는 이의 사균체를 유효성분으로 포함하는 지방간 예방 또는 치료용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220826 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230620 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230914 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20231212 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20231221 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7410336 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |