JP7393026B2 - 経口組成物 - Google Patents
経口組成物 Download PDFInfo
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- JP7393026B2 JP7393026B2 JP2021201377A JP2021201377A JP7393026B2 JP 7393026 B2 JP7393026 B2 JP 7393026B2 JP 2021201377 A JP2021201377 A JP 2021201377A JP 2021201377 A JP2021201377 A JP 2021201377A JP 7393026 B2 JP7393026 B2 JP 7393026B2
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- present
- charcoal
- oral composition
- iron
- composition
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- 235000020824 obesity Nutrition 0.000 description 1
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- 239000006072 paste Substances 0.000 description 1
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- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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Landscapes
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Description
したがって、このような胆汁酸***効果を有する新たな組成物が求められている。
[1]炭及び鉄を含有することを特徴とする経口組成物。
[2]さらに、大麦若葉を含有することを特徴とする上記[1]に記載の経口組成物。
[3]胆汁酸の***のために用いられることを特徴とする上記[1]又は[2]に記載の経口組成物。
[4]脂肪の吸収抑制のために用いられることを特徴とする上記[1]~[3]のいずれかに記載の経口組成物。
[5]血中コレステロールの上昇抑制のために用いられることを特徴とする上記[1]~[4]のいずれかに記載の経口組成物。
[6]抗肥満(ダイエット)のために用いられることを特徴とする上記[1]~[5]のいずれかに記載の経口組成物。
すなわち、胆汁酸は腸で脂肪の吸収を促進するが、本発明の経口組成物は、腸で胆汁酸に吸着して胆汁酸を***するため、腸における脂肪吸収を抑制することができる。
すなわち、胆汁酸は、肝臓でコレステロールから異化されて生成され、腸において一部が体外へ***されるものの、多くは再吸収されて肝臓に戻るところ、本発明の経口組成物は、腸で胆汁酸に吸着して胆汁酸を***するため、腸から肝臓に戻る胆汁酸の量を低減することとなり、肝臓でのコレステロールから胆汁酸への生成を増加させ、血中コレステロールの上昇を抑制することができる。
(被験物質の調製)
各原料(炭、鉄、大麦若葉末)を表1に示すように配合し、比較例1~3、並びに実施例1及び2の被験物質を調製した。
37℃に温めた食後人工腸液(FeSSIF:100mM タウロコール酸ナトリウム 15mL、レシチン 284.3mg、1M 酢酸 14.4mL、1M 水酸化ナトリウム 10.1mL、1M 塩化ナトリウム 17.3mL、pH5.0)6mLに対して、被験物質を0.05%(W/V)濃度で加え、ボルテックスをした。その後、37℃恒温槽にて30分間100rpmで揺らしながら温めた。また、コントロールとして食後人工腸液6mLを37℃の恒温槽にて30分間100rpmで揺らしながら温めた。
総胆汁酸テストワコーを用いて、以下の方法でサンプル中の胆汁酸濃度を測定した。
下記成分からなる錠剤を製造した。得られた組成物は胆汁酸吸着作用が期待できるものであった。
鉄クロロフィル 0.0001%
大麦若葉末 0.04%
ビタミン 5%
二酸化ケイ素 6%
マルトース 55.5799%
還元麦芽糖 0.3%
ドロキシプロピルセルロース 15%
ステアリン酸カルシウム 3%
ヒドロキシプロピルメチルセルロース 15%
下記成分からなる顆粒剤を製造した。得られた組成物は胆汁酸吸着作用が期待できるものであった。
鉄クロロフィル 20%
大麦若葉末 2.25%
ステアリン酸カルシウム 1.5%
ドロマイト 6.25%
[製造例3](粉末飲料の製造)
下記成分からなる粉末飲料を製造した。得られた組成物は胆汁酸吸着作用が期待できるものであった。
鉄クロロフィル 0.16%
大麦若葉エキス末 1%
ビタミン 3%
還元麦芽糖 35.82%
難消化性デキストリン 60%
Claims (1)
- 炭と、鉄クロロフィリンナトリウム、クエン酸鉄及びピロリン酸鉄から選ばれる少なくとも1種の鉄と、を含有することを特徴とする抗肥満用経口組成物(ただし、以下の(1)~(3)の組成物を除く)。
(1)竹炭パウダーを含むレモネード
(2)緑茶並びに白炭及び/又は竹炭を含む動物飼料添加剤、並びに該添加剤を含む飼料
(3)キクラゲを含有する組成物
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