JP7369992B2 - 自律神経機能改善用の発酵乳 - Google Patents
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Description
(1)ラクトバチルス デルブルエッキー 亜種 ブルガリクスを含有し、無脂乳固形分を7.0%以上9.0%以下の範囲内で含み、100g/日以上120g/日以下の範囲内または100mL/日以上120mL/日以下の範囲内の量を1日2回、4週間以上継続して経口摂取させる、相対的交感神経活動指標(LF/HF)低減用の発酵乳。なお、ここで、「相対的交感神経活動指標(LF/HF)が有意に減少すること」とは、「自律神経機能の改善」を意味する。すなわち、本発明は、「ラクトバチルス デルブルエッキーを含有する自律神経機能の改善用の発酵乳」と言い換えることもできる。
生乳、脱脂粉乳、クリーム、液糖、ペクチン、砂糖、ステビアおよび香料を含む混合物Aにラクトバチルス デルブルエッキー 亜種 ブルガリクス OLL1073R-1(寄託番号:FERM BP-10741)およびストレプトコッカス サーモフィルス 1131をスターターとして添加して発酵させて、無脂乳固形分8.1%、乳脂肪分0.5%のドリンクタイプのヨーグルト(以下「試験飲料」と称する)を調製した。なお、この試験飲料は、調製後速やかに112mLずつ容器(印などのついていない無地のキャップ付きペットボトル)に充填された。なお、この試験飲料の栄養成分は、1本(112ml)当たり、エネルギー量76kcal、たんぱく質3.6g、脂質0.67g、炭水化物13.9g、糖類13.3gであった。
牛乳、脱脂粉乳、乳タンパク、液糖、ペクチン、砂糖、ステビア、乳酸および香料を含む混合物Bを殺菌処理して飲料(以下「プラセボ飲料」と称する)を調製した。なお、このプラセボ飲料は、調製後速やかに112mLずつ、試験飲料を充填した容器と同一の容器に充填された。なお、このプラセボ飲料の一般組成(無脂乳固形分、脂肪)、栄養成分(タンパク質、脂質、炭水化物、糖類)およびエネルギー量は、調製例1の試験飲料と同等であるが、本プラセボ飲料には乳酸菌が含まれていない。
大阪市立大学健康科学イノベーションセンターにボランティア登録している人らの中から30~60歳の健常者男女53名を対象として、無作為化、プラセボ対照二重盲検クロスオーバー比較試験を実施した(なお、上記53名を選定する際に、自律神経系の障害がある者(LF/HF≧10)の者は除外した。)。具体的には、以下の通りである。
文献1:Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur. Heart J., 7(3): 354-381 (1996)
文献2:特許第5491749号明細書
FERM BP-10740
Claims (6)
- ラクトバチルス デルブルエッキー 亜種 ブルガリクスを含有し、無脂乳固形分を7.0%以上9.0%以下の範囲内で含み、
100g/日以上120g/日以下の範囲内または100mL/日以上120mL/日以下の範囲内の量を1日2回、4週間以上継続して経口摂取させる、
相対的交感神経活動指標(LF/HF)低減用の発酵乳。 - ストレプトコッカス サーモフィルスをさらに含有する、請求項1に記載の相対的交感神経活動指標(LF/HF)低減用の発酵乳。
- 前記ラクトバチルス デルブルエッキー 亜種 ブルガリクスと前記ストレプトコッカス サーモフィルスとを用いて発酵される、請求項1または2に記載の相対的交感神経活動指標(LF/HF)低減用の発酵乳。
- 前記発酵乳はヨーグルトである、請求項1から3のいずれか1項に記載の相対的交感神経活動指標(LF/HF)低減用の発酵乳。
- 前記ラクトバチルス デルブルエッキー 亜種 ブルガリクスは、ラクトバチルス デルブルエッキー 亜種 ブルガリクス OLL1073R-1(FERM BP-10741)である
請求項1から4のいずれか1項に記載の相対的交感神経活動指標(LF/HF)低減用の発酵乳。 - ラクトバチルス デルブルエッキー 亜種 ブルガリクスを含有し、無脂乳固形分を7.0%以上9.0%以下の範囲内で含む発酵乳を、100g/日以上120g/日以下の範囲内または100mL/日以上120mL/日以下の範囲内の量で1日2回、4週間以上継続して経口摂取させる、
相対的交感神経活動指標(LF/HF)の低減方法(ヒトを治療する行為を除く。)。
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JP2019090381A JP7369992B2 (ja) | 2019-05-13 | 2019-05-13 | 自律神経機能改善用の発酵乳 |
US16/864,486 US20200360451A1 (en) | 2019-05-13 | 2020-05-01 | Fermented milk for improving autonomic function |
CN202010377019.3A CN111919887A (zh) | 2019-05-13 | 2020-05-07 | 用于改善***功能的发酵乳 |
US17/828,772 US20220288140A1 (en) | 2019-05-13 | 2022-05-31 | Fermented milk for improving autonomic nervous function |
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JP2005194259A (ja) | 2003-12-12 | 2005-07-21 | Meiji Milk Prod Co Ltd | Nk細胞活性化剤 |
JP2011126833A (ja) | 2009-12-18 | 2011-06-30 | Gekkeikan Sake Co Ltd | 自律神経調節剤 |
WO2014132982A1 (ja) | 2013-02-27 | 2014-09-04 | 株式会社明治 | ストレス軽減剤 |
WO2015133122A1 (ja) | 2014-03-04 | 2015-09-11 | カルピス株式会社 | 鎮静用の自律神経調整剤及び日周リズム改善剤 |
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KR20100016101A (ko) * | 2007-03-30 | 2010-02-12 | 산토리 홀딩스 가부시키가이샤 | 부교감 신경 활동 항진 작용을 갖는 의약 조성물 또는 음식물 |
JP5592640B2 (ja) * | 2009-11-30 | 2014-09-17 | アピ株式会社 | 乳酸菌発酵ローヤルゼリーを含有する抗ストレス剤、その製造方法、視床下部−下垂体−副腎皮質系の活動抑制剤、及び交感神経−副腎髄質系の活動抑制剤 |
JP5923238B2 (ja) * | 2010-07-07 | 2016-05-24 | アサヒグループホールディングス株式会社 | 迷走神経活性化剤 |
CN103221531B (zh) * | 2010-11-09 | 2018-03-16 | 朝日集团控股株式会社 | 具有高蛋白质水解活性的瑞士乳杆菌 |
JP5950993B2 (ja) * | 2014-12-25 | 2016-07-13 | アサヒグループホールディングス株式会社 | 迷走神経活性化剤 |
MX2018005745A (es) * | 2015-11-10 | 2018-09-17 | Mckenna Elizabeth | Control de niveles redox celulares. |
WO2017183595A1 (ja) * | 2016-04-20 | 2017-10-26 | 株式会社 明治 | 疲労感の改善用の発酵乳 |
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JP2005194259A (ja) | 2003-12-12 | 2005-07-21 | Meiji Milk Prod Co Ltd | Nk細胞活性化剤 |
JP2011126833A (ja) | 2009-12-18 | 2011-06-30 | Gekkeikan Sake Co Ltd | 自律神経調節剤 |
WO2014132982A1 (ja) | 2013-02-27 | 2014-09-04 | 株式会社明治 | ストレス軽減剤 |
WO2015133122A1 (ja) | 2014-03-04 | 2015-09-11 | カルピス株式会社 | 鎮静用の自律神経調整剤及び日周リズム改善剤 |
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OTOMI, Kaiho et al.,Effects of Yogurt Containing Lactobacillus gasseri OLL2716 on Autonomic Nerve Activities and Physiological Functions,Health,2015年,vol. 7,p. 397-405 |
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JP2020184906A (ja) | 2020-11-19 |
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US20200360451A1 (en) | 2020-11-19 |
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