JP7001777B2 - 直列形経鼻送達デバイス - Google Patents
直列形経鼻送達デバイス Download PDFInfo
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- JP7001777B2 JP7001777B2 JP2020139519A JP2020139519A JP7001777B2 JP 7001777 B2 JP7001777 B2 JP 7001777B2 JP 2020139519 A JP2020139519 A JP 2020139519A JP 2020139519 A JP2020139519 A JP 2020139519A JP 7001777 B2 JP7001777 B2 JP 7001777B2
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- propellant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Description
本出願は、参照によりその内容全体が本明細書に組み込まれている、2015年9月10日に出願した米国特許仮出願第62/216,789号の優先権を主張するものである。
基部、基部から放射状に延びるy字形接合器の第1の枝路、基部から放射状に延びるy字形接合器の第2の枝路、基部から放射状に延びるy字形接合器の第3の枝路、およびy字形接合器の内部用量装填チャネルを含むy字形接合器と、
y字形接合器の第1の枝路と流体連通している定量ポンプと、
y字形接合器の第2の枝路に結合する円錐形ばねと、
y字形接合器の第3の枝路と流体連通している用量チャンバと、
用量チャンバに結合するノズルと、
内部用量装填チャネルと用量チャンバとの間の拡散器と、
y字形接合器を取り囲むアクチュエータグリップと、
y字形接合器が内在するハウジングと
を備えるデバイス。
条項1乃至11のいずれか一項に記載のデバイス。
先端、アクチュエータ、および用量チャンバを含むハウジングであって、先端および用量チャンバはハウジング内で流体連通しているハウジングと、
先端の遠位部分に位置するノズルであって、化合物のための出口を提供し、複数のノズル開口部を含むノズルと、
用量チャンバと流体連通しているポンプであって、アクチュエータが作動したとき化合物を用量チャンバ内に移動させるためのポンプと
を備えるデバイス。
先端、アクチュエータ、および用量チャンバを含むハウジングであって、先端および用量チャンバはハウジングと流体連通しているハウジングと、
先端の遠位部分に位置するノズルであって、化合物のための出口を提供し、複数のノズル開口部を含むノズルと、
用量チャンバと流体連通しているポンプであって、アクチュエータが作動したとき化合物を用量チャンバ内に移動させるためのポンプと、
ハウジングと結合する推進剤キャニスタであって、アクチュエータによって作動される推進剤弁を有し、用量チャンバと流体連通している推進剤キャニスタと、
化合物をバイアルから用量チャンバ内に移動させるためのポンプに結合する化合物のバイアルと
を備え、
アクチュエータは、デバイスが作動したとき、化合物を用量チャンバ内に移動させるポンプを圧縮し、推進剤弁の作動が、化合物を押す推進剤を分散させて、化合物が複数のノズル開口部を通ってデバイスから出ることを実現するデバイス。
Claims (16)
- 化合物の鼻腔内送達のためのデバイスであって、
先端、化合物を収容するバイアル、及び、前記バイアルからくみ上げられた化合物を受け取るための用量チャンバを含むハウジングと、
作動により前記バイアルから化合物を移動させる定量ポンプと、
前記用量チャンバからの出口を提供するために前記用量チャンバと結合されたノズルと、
前記用量チャンバに結合され、推進剤キャニスタから推進剤を受け取るように構成された拡散器と、
前記推進剤キャニスタの一部を保持するように構成されたアクチュエータグリップと、
アクチュエータであって、前記ハウジングの圧縮時に前記バイアルからの化合物の放出を制御するとともに、化合物が前記用量チャンバから前記ノズルを出るときに、推進剤が化合物を同伴するように、作動の際に放出される化合物の大部分が前記用量チャンバに入った後、前記推進剤キャニスタからの推進剤の放出を制御するアクチュエータと、
を備えるデバイス。 - 前記定量ポンプを前記バイアルに固定するポンプ取付具をさらに備える請求項1に記載のデバイス。
- 前記定量ポンプに結合された逆止弁をさらに含む請求項1に記載のデバイス。
- 前記ハウジングに係合しているノーズコーンをさらに含む請求項1に記載のデバイス。
- 前記拡散器は環状である請求項1に記載のデバイス。
- 前記拡散器は多孔質材料である請求項1に記載のデバイス。
- 前記拡散器は前記用量チャンバの底を形成する請求項1に記載のデバイス。
- 化合物の鼻腔内送達のためのデバイスであって、
先端、及び、化合物を収容するバイアルから化合物を受け取るための用量チャンバを含むハウジングと、
前記用量チャンバからの出口を提供するために前記用量チャンバと結合されたノズルと、
作動により前記バイアルから化合物を移動させる定量ポンプと、
アクチュエータであって、前記ハウジングの圧縮時に前記バイアルからの化合物の放出を制御するとともに、化合物が前記用量チャンバから前記ノズルを出るときに、推進剤が化合物を同伴するように、作動の際に放出される化合物の大部分が前記用量チャンバに入った後、推進剤キャニスタからの推進剤の放出を制御するアクチュエータと、
を備えるデバイス。 - 前記推進剤キャニスタは、前記アクチュエータによって作動される推進剤弁を有し、前記推進剤キャニスタは、前記用量チャンバと流体連通している請求項8に記載のデバイス。
- 前記用量チャンバに結合され、推進剤キャニスタから推進剤を受け取るように構成された拡散器をさらに含む請求項8に記載のデバイス。
- 鼻腔の嗅覚領域への化合物の鼻腔内送達のためのデバイスであって、
先端、化合物を収容するバイアル、及び、前記バイアルからくみ上げられた化合物を受け取るための用量チャンバを含むハウジングと、
前記用量チャンバからの出口を提供するために前記用量チャンバと結合されたノズルと、
作動により前記バイアルから化合物を移動させる定量ポンプと、
推進剤を収容する推進剤キャニスタと、
アクチュエータであって、前記ハウジングの圧縮時に前記バイアルからの化合物の放出を制御するとともに、化合物が前記用量チャンバから前記ノズルを出るときに、推進剤が化合物を同伴するように、作動の際に放出される化合物の大部分が前記用量チャンバに入った後、前記推進剤キャニスタからの推進剤の放出を制御するアクチュエータと、
を備えるデバイス。 - 内部用量装填チャネルと、ばねと、をさらに含み、
前記拡散器が前記内部用量装填チャネルと前記用量チャンバとの間にある請求項1に記載のデバイス。 - 前記推進剤キャニスタは、前記アクチュエータによって作動される推進剤弁を有し、前記推進剤キャニスタは、前記用量チャンバと流体連通している請求項11に記載のデバイス。
- 拡散器をさらに備える請求項11に記載のデバイス。
- 内部用量装填チャネルをさらに含み、
前記拡散器は、前記内部用量装填チャネルの外壁と前記用量チャンバの内壁との間に着座される請求項14に記載のデバイス。 - 内部用量装填チャネルをさらに含み、
前記拡散器は、前記内部用量装填チャネルの外壁と前記用量チャンバの内壁との間に着座される請求項10に記載のデバイス。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562216789P | 2015-09-10 | 2015-09-10 | |
US62/216,789 | 2015-09-10 |
Related Parent Applications (1)
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JP2018513344A Division JP6753927B2 (ja) | 2015-09-10 | 2016-09-09 | 直列形経鼻送達デバイス |
Publications (2)
Publication Number | Publication Date |
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JP2020185475A JP2020185475A (ja) | 2020-11-19 |
JP7001777B2 true JP7001777B2 (ja) | 2022-02-10 |
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Application Number | Title | Priority Date | Filing Date |
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JP2018513344A Active JP6753927B2 (ja) | 2015-09-10 | 2016-09-09 | 直列形経鼻送達デバイス |
JP2020139519A Active JP7001777B2 (ja) | 2015-09-10 | 2020-08-20 | 直列形経鼻送達デバイス |
Family Applications Before (1)
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JP2018513344A Active JP6753927B2 (ja) | 2015-09-10 | 2016-09-09 | 直列形経鼻送達デバイス |
Country Status (14)
Country | Link |
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US (4) | US11266799B2 (ja) |
EP (1) | EP3341059B1 (ja) |
JP (2) | JP6753927B2 (ja) |
KR (1) | KR20180052662A (ja) |
CN (1) | CN108601916B (ja) |
AU (1) | AU2016321345B2 (ja) |
CA (1) | CA2998182A1 (ja) |
HK (1) | HK1252257A1 (ja) |
IL (1) | IL257845B (ja) |
MA (1) | MA42708A (ja) |
MX (1) | MX2018002895A (ja) |
NZ (1) | NZ741171A (ja) |
WO (1) | WO2017044897A1 (ja) |
ZA (1) | ZA201801543B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ741171A (en) | 2015-09-10 | 2022-01-28 | Impel Neuropharma Inc | In-line nasal delivery device |
FR3046553B1 (fr) * | 2016-01-07 | 2018-02-16 | Aptar France Sas | Ensemble de distribution nasale de produit fluide. |
AU2018334334B2 (en) | 2017-09-15 | 2024-06-13 | Shin Nippon Biomedical Laboratories, Ltd. | Medicine storage cartridge with nozzle, sprayer therefor, and powdered medicine dispensing device for nasal cavity |
EP3713626A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH INPUT INTERFACE |
JP7191099B2 (ja) * | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
EP3735244B1 (en) | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
EA202191856A1 (ru) | 2019-01-03 | 2021-09-02 | Импел Ньюрофарма, Инк. | Устройство для назальной доставки лекарственных средств |
US20230064327A1 (en) | 2020-01-22 | 2023-03-02 | Seelos Therapeutics, Inc. | Reducing side effects of nmda antagonists |
WO2022241214A1 (en) | 2021-05-14 | 2022-11-17 | Seelos Therapeutics, Inc. | Methods of using nmda receptor antagonists |
TW202310825A (zh) | 2021-05-14 | 2023-03-16 | 美商西羅斯醫療公司 | 減少nmda受體拮抗劑之副作用 |
KR20240045885A (ko) | 2022-09-30 | 2024-04-08 | 주식회사 이엠텍 | 비강 흡입기 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3704812A (en) | 1970-06-29 | 1972-12-05 | Ciba Geigy Corp | Multi-component dispenser and valve |
US3921857A (en) | 1973-11-29 | 1975-11-25 | Ciba Geigy Corp | Non-spitting liquid dispensing device |
WO2014179228A1 (en) | 2013-04-28 | 2014-11-06 | Impel Neuropharma Inc. | Medical unit dose container |
Family Cites Families (185)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB806284A (en) | 1955-11-14 | 1958-12-23 | Chi Ah Lai | A new or improved nasal inhaler |
US2933259A (en) | 1958-03-03 | 1960-04-19 | Jean F Raskin | Nozzle head |
NL297349A (ja) | 1962-08-31 | |||
US3425414A (en) | 1965-05-28 | 1969-02-04 | William J La Roche | Inhalant dispenser |
US3741443A (en) * | 1970-11-19 | 1973-06-26 | Ciba Geigy Corp | Dispensing system with propellant metering valve |
US3888253A (en) | 1972-08-04 | 1975-06-10 | Beecham Group Ltd | Device for administration of medicines |
FR2224175B1 (ja) | 1973-04-04 | 1978-04-14 | Isf Spa | |
US3982668A (en) | 1974-10-04 | 1976-09-28 | Ciba-Geigy Corporation | Aerosol dispenser for plurality of fluent materials |
CH588896A5 (ja) | 1973-10-31 | 1977-06-15 | Ciba Geigy Ag | |
US3971377A (en) | 1974-06-10 | 1976-07-27 | Alza Corporation | Medicament dispensing process for inhalation therapy |
US3908654A (en) | 1974-08-02 | 1975-09-30 | Rit Rech Ind Therapeut | Dispensing package for a dry biological and a liquid diluent |
ZA758010B (en) | 1975-11-14 | 1977-08-31 | Syntex Inc | Nasal spray adapter |
DE2750090A1 (de) | 1976-11-19 | 1978-06-01 | Sandoz Ag | Neue verabreichungsformen fuer organische verbindungen |
US4095596A (en) | 1976-11-26 | 1978-06-20 | Smithkline Corporation | Nasal inhaler |
US4227522A (en) | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
US4187985A (en) | 1978-12-08 | 1980-02-12 | The Continental Group, Inc. | Aerosol valve for barrier type packages |
BR8007911A (pt) | 1979-12-06 | 1981-06-16 | Glaxo Group Ltd | Inalador aperfeicoado |
US4412573A (en) | 1981-12-28 | 1983-11-01 | Baxter Travenol Laboratories, Inc. | Injection site |
WO1985002346A1 (en) | 1983-11-28 | 1985-06-06 | Vortran Corporation | Gas-powered nebulizer |
EP0162853A1 (en) | 1983-11-28 | 1985-12-04 | Vortran Corporation | Single inlet prepackaged inhaler |
WO1986001731A1 (en) | 1984-09-18 | 1986-03-27 | Vortran Corporation | All purpose nebulizer |
US4896832A (en) | 1987-09-07 | 1990-01-30 | Bespak Plc | Dispensing apparatus for metered quantities of pressurised fluid |
IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
NZ250988A (en) | 1990-06-14 | 1995-09-26 | Rhone Poulenc Rorer Ltd | Powder inhaler: swirling chamber with anti-static walls |
DE4038049C2 (de) | 1990-11-29 | 1994-12-01 | Anschuetz & Co Gmbh | Implantierbare Infusionspumpe |
US5331954A (en) | 1990-12-21 | 1994-07-26 | Novo Nordisk A/S | Device for nasal delivery of liquid medications |
IT1249600B (it) | 1991-02-21 | 1995-03-09 | Elettro Plastica Spa | Erogatore nasale di sostanze farmaceutiche nebulizzate |
US6681767B1 (en) | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
IT1250691B (it) | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
GB9125699D0 (en) | 1991-12-03 | 1992-01-29 | Glaxo Group Ltd | Device |
AU6428894A (en) | 1993-03-26 | 1994-10-24 | Franciscus W.H.M. Merkus | Pharmaceutical compositions for intranasal administration of dihydroergotamine, apomorphine and morphine |
BE1006872A6 (nl) | 1993-03-26 | 1995-01-10 | Merkus Franciscus W H M | Nasale farmaceutische preparaten met dihydroergotamine (dhe). |
GB9311892D0 (en) | 1993-06-09 | 1993-07-28 | Glaxo Wellcome Australia Ltd | Device |
US5349947A (en) | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
US5516006A (en) | 1993-07-30 | 1996-05-14 | Meshberg; Philip | Nasal dispenser |
US5398850A (en) | 1993-08-06 | 1995-03-21 | River Medical, Inc. | Gas delivery apparatus for infusion |
IT1266794B1 (it) | 1993-11-09 | 1997-01-21 | Faustino Ballini | Dispositivo a doccia micronizzata per il lavaggio delle cavita' nasali e limitrofe |
JP3911290B2 (ja) | 1994-05-13 | 2007-05-09 | アラダイム コーポレーション | エアゾールを含む麻酔用処方 |
US5435282A (en) | 1994-05-19 | 1995-07-25 | Habley Medical Technology Corporation | Nebulizer |
JP3372105B2 (ja) | 1994-05-26 | 2003-01-27 | 株式会社日立ユニシアオートモティブ | 吸入式投薬器 |
US5901703A (en) | 1995-02-06 | 1999-05-11 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
DE19518580A1 (de) | 1995-05-20 | 1996-11-21 | Thomas Ossinger | Lötbadtiegel |
JPH08322934A (ja) | 1995-05-29 | 1996-12-10 | Unisia Jecs Corp | 鼻腔用投薬器 |
DE19523516C1 (de) | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
US5823183A (en) | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
GB9516984D0 (en) | 1995-08-18 | 1995-10-18 | Pharmasol Ltd | Spray applicator |
IE77523B1 (en) | 1995-09-11 | 1997-12-17 | Elan Med Tech | Medicament delivery device |
US5711488A (en) | 1995-10-13 | 1998-01-27 | The Procter & Gamble Company | High pressure swirl atomizer |
US6678553B2 (en) | 1995-11-21 | 2004-01-13 | Intraabrain International Nv | Device for enhanced delivery of biologically active substances and compounds in an organism |
US5797390A (en) | 1996-03-06 | 1998-08-25 | Mcsoley; Thomas E. | Nasal inhaler having a directed spray pattern |
AUPN976496A0 (en) | 1996-05-10 | 1996-05-30 | Glaxo Wellcome Australia Ltd | Unit dose dispensing device |
US6595202B2 (en) | 1996-05-13 | 2003-07-22 | Universidad De Sevilla | Device and method for creating aerosols for drug delivery |
DE19622124A1 (de) | 1996-06-01 | 1997-12-04 | Alfred Von Schuckmann | Gerät zum Aufbringen von Flüssigkeiten |
WO1997048496A1 (en) | 1996-06-21 | 1997-12-24 | Hughes Technology Group L.L.C. | Micro-atomizing device |
US5906198A (en) | 1996-07-16 | 1999-05-25 | Flickinger; William J. | Nasal nebulizer |
US6410046B1 (en) | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
US7033598B2 (en) | 1996-11-19 | 2006-04-25 | Intrabrain International N.V. | Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal |
DE19704849B4 (de) | 1997-02-08 | 2011-02-17 | Ing. Erich Pfeiffer Gmbh | Austragvorrichtung für Medien |
IS4516A (is) | 1997-07-01 | 1999-01-02 | Gizurarson Sveinbjörn | Nýtt lyfjaform |
US6491940B1 (en) | 1999-01-27 | 2002-12-10 | Bruce H. Levin | Apparatus for administering composition for inhibiting cerebral neurovascular disorders and muscular headaches |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
GB9719775D0 (en) | 1997-09-18 | 1997-11-19 | Glaxo Group Ltd | Device |
US5954696A (en) | 1997-12-15 | 1999-09-21 | B. Braun Medical, Inc. | Pressure infusion pump |
US7335186B2 (en) | 1998-03-13 | 2008-02-26 | Alexander George Brian O'Neil | Patient controlled drug delivery device |
US6113078A (en) | 1998-03-18 | 2000-09-05 | Lytesyde, Llc | Fluid processing method |
US6062213A (en) | 1998-06-16 | 2000-05-16 | Fuisz Technologies Ltd. | Single unit dose inhalation therapy device |
ES2234266T3 (es) | 1998-07-24 | 2005-06-16 | Jago Research Ag | Formulaciones medicas para aerosoles. |
FR2782024B1 (fr) | 1998-08-04 | 2000-10-13 | Valois Sa | Tete de distribution et dispositif de distribution de produit fluide comportant une telle tete |
GB2345010B (en) | 1998-12-17 | 2002-12-31 | Electrosols Ltd | A delivery device |
US6294153B1 (en) | 1998-12-21 | 2001-09-25 | Generex Pharmaceuticals, Inc. | Aerosol pharmaceutical formulation for pulmonary and nasal delivery |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EP3124067A3 (en) | 1999-03-03 | 2017-05-24 | Optinose AS | Nasal delivery device |
GB0121568D0 (en) | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
GB0114272D0 (en) | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
CO5241299A1 (es) | 1999-03-17 | 2003-01-31 | Emsar Inc | Aparato y metodo para administrar una pulverizacion medicinal |
CA2368587A1 (en) | 1999-03-26 | 2000-10-05 | John R. Plachetka | High potency dihydroergotamine compositions |
DE19944209A1 (de) | 1999-09-15 | 2001-03-22 | Pfeiffer Erich Gmbh & Co Kg | Spender zum ggf. zerstäubten Ausbringen eines insbesondere flüssigen Mediums aus einem Behältnis |
DE60007593T2 (de) | 1999-10-14 | 2004-11-11 | Becton, Dickinson And Co. | Nasales Verabreichungsgerät mit Zerstäuberdüse |
US6382204B1 (en) | 1999-10-14 | 2002-05-07 | Becton Dickinson And Company | Drug delivery system including holder and drug container |
US6367471B1 (en) | 1999-11-01 | 2002-04-09 | Sheffield Pharmaceuticals, Inc. | Internal vortex mechanism for inhaler device |
US6810872B1 (en) | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
US6302101B1 (en) | 1999-12-14 | 2001-10-16 | Daniel Py | System and method for application of medicament into the nasal passage |
US6734162B2 (en) | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
US6540983B1 (en) | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
US6585957B1 (en) | 2000-01-25 | 2003-07-01 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
US6644305B2 (en) | 2000-04-14 | 2003-11-11 | Trudell Medical International | Nasal inhaler |
GB0015309D0 (en) | 2000-06-21 | 2000-08-16 | Djupesland Per G | Apparatus |
IT1317998B1 (it) | 2000-06-26 | 2003-07-21 | Medical Internat Licensing N V | Valvola erogatrice per spray nasale. |
IT1318646B1 (it) | 2000-07-26 | 2003-08-27 | Medical Internat Licensing N V | Ugello pr somministrazioni e lavaggi nasali. |
DE20122843U1 (de) | 2000-07-31 | 2008-06-26 | Nycomed Danmark Aps | Fentanyl Zusammensetzung zur nasalen Anwendung |
US6596740B2 (en) | 2000-10-24 | 2003-07-22 | Richard L. Jones | Nicotine mucosal spray |
US6644309B2 (en) | 2001-01-12 | 2003-11-11 | Becton, Dickinson And Company | Medicament respiratory delivery device and method |
ZA200306564B (en) | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
GB0109002D0 (en) | 2001-04-10 | 2001-05-30 | Glaxo Group Ltd | Dispenser |
GB0109001D0 (en) | 2001-04-10 | 2001-05-30 | Glaxo Group Ltd | Dispenser |
CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
US20030198669A1 (en) | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
EP1279404A1 (en) | 2001-07-26 | 2003-01-29 | Istituto Superiore di Sanità | Use of HIV-1 tat, fragments or derivatives thereof, to target or to activate antigen-presenting cells, to deliver cargo molecules for vaccination or to treat other diseases |
AU2002340083A1 (en) | 2001-09-28 | 2003-04-07 | Kurve Technology, Inc | Nasal nebulizer |
US20030091513A1 (en) | 2001-10-03 | 2003-05-15 | Mohsen Nahed M. | Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media |
GB2380410B (en) | 2001-10-05 | 2003-11-19 | Alchemy Healthcare Ltd | Apparatus for the nasal or oral delivery of a medicament |
US7021561B2 (en) | 2001-12-18 | 2006-04-04 | Becton, Dickinson And Company | Spray device and method |
GB0204829D0 (en) | 2002-03-01 | 2002-04-17 | Glaxo Group Ltd | A fluid dispensing device |
US7666876B2 (en) | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
GB0207422D0 (en) | 2002-03-28 | 2002-05-08 | Optinose As | Nasal devices |
GB0209494D0 (en) | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
WO2003093299A2 (en) | 2002-05-06 | 2003-11-13 | Thomas Jefferson University | Insulin-associated peptides with effects on cerebral health |
WO2003099359A1 (en) | 2002-05-09 | 2003-12-04 | Kurve Technology, Inc. | Particle dispersion chamber for nasal nebulizer |
US7220457B2 (en) | 2002-06-06 | 2007-05-22 | Anderson Steven R | Air atomizing assembly and method and system of applying an air atomized material |
US7338521B2 (en) * | 2002-06-13 | 2008-03-04 | World Heart, Inc. | Low profile inlet for an implantable blood pump |
GB0215270D0 (en) | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0215904D0 (en) | 2002-07-09 | 2002-08-21 | Team Holdings Uk Ltd | Drug delivery system and method |
GB0217198D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
FR2852928B1 (fr) * | 2003-03-24 | 2006-02-24 | Airlessystems | Distributeur de produit fluide. |
US20060147389A1 (en) | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
GB0309354D0 (en) | 2003-04-24 | 2003-06-04 | Glaxo Group Ltd | Nozzle for a nasal inhaler |
DE10321902A1 (de) | 2003-05-06 | 2004-12-09 | Ing. Erich Pfeiffer Gmbh | Austragvorrichtung für zumindest ein Medium |
GB0319119D0 (en) | 2003-08-14 | 2003-09-17 | Optinose As | Delivery devices |
GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
US8001963B2 (en) | 2003-09-05 | 2011-08-23 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersion chamber for nasal delivery of medicament to deep nasal cavity and paranasal sinuses |
AU2004272077A1 (en) | 2003-09-10 | 2005-03-24 | Map Pharmaceuticals, Inc. | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
US20070172517A1 (en) | 2003-09-17 | 2007-07-26 | Ben-Sasson Shmuel A | Compositions capable of facilitation penetration across a biological barrier |
GB0322284D0 (en) | 2003-09-23 | 2003-10-22 | Glaxo Group Ltd | Medicament dispenser |
US8109266B2 (en) | 2004-02-20 | 2012-02-07 | Pneumoflex Systems, Llc | Nebulizer having flow meter function |
WO2006039631A2 (en) | 2004-09-30 | 2006-04-13 | Centocor, Inc. | Methods and compositions for treating renal cell carcinoma related pathologies |
WO2006059340A1 (en) * | 2004-12-03 | 2006-06-08 | Aparna Thirumalai Anandampilla | A resonating (alerting) metered dose inhaler |
US7832394B2 (en) | 2004-12-22 | 2010-11-16 | Schechter Alan M | Apparatus for dispensing pressurized contents |
GB0503738D0 (en) | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
NZ562064A (en) | 2005-04-01 | 2011-03-31 | Intezyne Technologies Inc | Polymeric micelles for drug delivery |
GB0515592D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Nozzle for a nasal inhaler |
WO2007035913A2 (en) | 2005-09-21 | 2007-03-29 | Kurve Technology, Inc. | Medicament delivery control, monitoring, and reporting system and method |
MX2008006204A (es) | 2005-11-11 | 2008-10-17 | Aurogen Inc | Metodo para tratar por medio de la administracion de insulina la enfermedad o el trastorno del sistema nervioso central asociado con el encogimiento de tejido o atrofia. |
JP2009517184A (ja) | 2005-11-29 | 2009-04-30 | アルザ・コーポレーシヨン | 嗅覚部位に物質を送達するための鼻用送達装置 |
US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
US20070202051A1 (en) | 2006-02-10 | 2007-08-30 | Pari Gmbh | Aerosols for sinunasal drug delivery |
EP1988953B1 (en) | 2006-02-14 | 2017-07-19 | Optinose AS | Delivery device |
GB0604444D0 (en) | 2006-03-06 | 2006-04-12 | Optinose As | Nasal devices |
GB0605799D0 (en) | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
US7841338B2 (en) | 2006-04-13 | 2010-11-30 | Boehringer Ingelheim International Gmbh | Dispensing device |
GB2440316A (en) | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
CA2698137A1 (en) | 2006-08-30 | 2008-03-06 | Kurve Technology, Inc. | Aerosol generating and delivery device |
FR2908753B1 (fr) | 2006-11-16 | 2011-11-11 | Becton Dickinson France | Dispositif pour delivrer automatiquement des doses successives de produit |
WO2008067254A2 (en) | 2006-11-27 | 2008-06-05 | Abbott Respiratory Llc | Nasal drug delivery device and method |
GB0623732D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
GB0623728D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
PL2425820T3 (pl) | 2007-02-11 | 2015-08-31 | Map Pharmaceuticals Inc | Sposób terapeutycznego stosowania dhe w celu umożliwienia szybkiego złagodzenia migreny przy jednoczesnym zminimalizowaniu profilu działań niepożądanych |
US20100199984A1 (en) | 2007-04-02 | 2010-08-12 | Abbott Laboratories | Breath actuated nasal pump |
GB2448193A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
US8530463B2 (en) | 2007-05-07 | 2013-09-10 | Hale Biopharma Ventures Llc | Multimodal particulate formulations |
JP2011504163A (ja) | 2007-06-08 | 2011-02-03 | ヘルスパートナーズ リサーチ ファウンデーション | 中枢神経系への治療化合物の標的化を高めるための薬学的組成物および方法 |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
US20110053859A1 (en) | 2007-10-10 | 2011-03-03 | The U. S. Government Respresented by the Department of Veterans Affairs | Methods to reduce the effects of sleep deprivation |
WO2009061895A2 (en) * | 2007-11-06 | 2009-05-14 | 3M Innovative Properties Company | Medicinal inhalation devices and components thereof |
CA2713762C (en) | 2008-02-07 | 2016-10-18 | University Of Washington | Circumferential aerosol device |
CA2715302A1 (en) | 2008-02-15 | 2009-08-20 | Timothy Sean Immel | Aerosol therapy device with high frequency delivery |
US7875001B2 (en) * | 2008-02-25 | 2011-01-25 | Americo Michael Minotti | Multi medication nasal spray device and method |
US8517026B2 (en) | 2008-02-25 | 2013-08-27 | Adva Beck Amon | Nasal inserts |
NO329804B1 (no) | 2009-02-09 | 2010-12-20 | Fmc Kongsberg Subsea As | Kobling for bruk i et stigeror, stigeror med en slik kobling og fremgangsmate for a oke operasjonsvinduet til et stigeror |
JP2012526726A (ja) | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
US8839790B2 (en) | 2009-07-29 | 2014-09-23 | Adva Beck Arnon | Nasal inserts |
GB2472327B (en) * | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
US8408427B2 (en) | 2009-09-07 | 2013-04-02 | Mk International Pty Ltd | Single dose nasal spray pump |
US8925544B2 (en) | 2009-12-08 | 2015-01-06 | Medinvent, Llc | Portable nebulizer device |
US9757528B2 (en) * | 2010-08-23 | 2017-09-12 | Darren Rubin | Nebulizer having different negative pressure threshold settings |
JP3193069U (ja) | 2010-09-02 | 2014-09-18 | シプノーズ リミテッド | 経鼻投与装置 |
CN201759968U (zh) * | 2010-09-14 | 2011-03-16 | 刘永辉 | 一种麻醉用喷药装置 |
CA2820554A1 (en) | 2010-11-29 | 2012-06-07 | Sanofi-Aventis Deutschland Gmbh | Medicated module for an inhaler |
WO2012119153A2 (en) * | 2011-03-03 | 2012-09-07 | Impel Neuropharma Inc. | Nasal drug delivery device |
RU2618084C2 (ru) * | 2011-05-09 | 2017-05-02 | Импел Ньюрофарма Инк. | Наконечники для назальной доставки лекарственных средств |
WO2012174481A1 (en) | 2011-06-15 | 2012-12-20 | Nerve Access, Inc. | Pharmaceutical compositions for intranasal administration for the treatment of neurodegenerative disorders |
CN202263268U (zh) * | 2011-07-08 | 2012-06-06 | 宝鸡市德尔医疗器械制造有限责任公司 | 雾化吸入器 |
DE102012201178B3 (de) | 2012-01-27 | 2013-02-14 | Aptar Radolfzell Gmbh | Düseneinheit und Spender mit einer solchen |
AU2013305569A1 (en) | 2012-08-24 | 2015-02-19 | Vr1, Inc. | Composition for the treatment of migraine headaches |
DE102013100473A1 (de) | 2013-01-17 | 2014-07-17 | Seho Systemtechnik Gmbh | Verfahren und Vorrichtung zum Reinigen einer Lötdüse |
CN203139302U (zh) * | 2013-03-19 | 2013-08-21 | 卓效医疗有限公司 | 吸气同步雾化的手持微型雾化器 |
ES2904570T3 (es) | 2013-09-24 | 2022-04-05 | Satsuma Pharmaceuticals Inc | Formulación de DHE intranasal para el tratamiento del dolor de cabeza |
US9603905B2 (en) | 2014-03-13 | 2017-03-28 | The Research Foundation For Mental Hygiene, Inc | Intranasal insulin administration for the minimization of anesthesia-induced memory loss |
NZ741171A (en) | 2015-09-10 | 2022-01-28 | Impel Neuropharma Inc | In-line nasal delivery device |
FR3046553B1 (fr) * | 2016-01-07 | 2018-02-16 | Aptar France Sas | Ensemble de distribution nasale de produit fluide. |
CN109640947A (zh) | 2016-08-05 | 2019-04-16 | 株式会社新日本科学 | 鼻内药物粉末组合物 |
US11000068B2 (en) * | 2017-06-20 | 2021-05-11 | Cascadia Technologies, LLC | Aerosol inhalant producing device with measurable dose and/or other features |
WO2019008439A1 (en) | 2017-07-02 | 2019-01-10 | Dr. Reddy's Laboratories Ltd. | NASAL GALENIC FORMS OF DIHYDROERGOTAMINE |
EP3735244B1 (en) | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3704812A (en) | 1970-06-29 | 1972-12-05 | Ciba Geigy Corp | Multi-component dispenser and valve |
US3921857A (en) | 1973-11-29 | 1975-11-25 | Ciba Geigy Corp | Non-spitting liquid dispensing device |
WO2014179228A1 (en) | 2013-04-28 | 2014-11-06 | Impel Neuropharma Inc. | Medical unit dose container |
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AU2016321345B2 (en) | 2020-12-10 |
WO2017044897A1 (en) | 2017-03-16 |
ZA201801543B (en) | 2022-08-31 |
MA42708A (fr) | 2018-07-04 |
US20240115819A1 (en) | 2024-04-11 |
US20230241334A1 (en) | 2023-08-03 |
IL257845B (en) | 2022-07-01 |
JP6753927B2 (ja) | 2020-09-09 |
JP2018527099A (ja) | 2018-09-20 |
MX2018002895A (es) | 2018-07-06 |
IL257845A (en) | 2018-04-30 |
JP2020185475A (ja) | 2020-11-19 |
US20180256836A1 (en) | 2018-09-13 |
US11266799B2 (en) | 2022-03-08 |
EP3341059A1 (en) | 2018-07-04 |
HK1252257A1 (zh) | 2019-05-24 |
EP3341059B1 (en) | 2022-03-02 |
CA2998182A1 (en) | 2017-03-16 |
CN108601916A (zh) | 2018-09-28 |
US20230095719A1 (en) | 2023-03-30 |
AU2016321345A1 (en) | 2018-04-19 |
EP3341059A4 (en) | 2019-05-08 |
KR20180052662A (ko) | 2018-05-18 |
NZ741171A (en) | 2022-01-28 |
CN108601916B (zh) | 2021-07-09 |
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