JP6983162B2 - 経皮吸収用マイクロ構造体及びその製造方法 - Google Patents
経皮吸収用マイクロ構造体及びその製造方法 Download PDFInfo
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- JP6983162B2 JP6983162B2 JP2018533134A JP2018533134A JP6983162B2 JP 6983162 B2 JP6983162 B2 JP 6983162B2 JP 2018533134 A JP2018533134 A JP 2018533134A JP 2018533134 A JP2018533134 A JP 2018533134A JP 6983162 B2 JP6983162 B2 JP 6983162B2
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Description
実施形態1:マイクロ構造体の製造
1.Aタイプのマイクロ構造体の製造過程
シリコンウエハにフォトリソグラフィ(photolithography)製作技法を用いて陽または陰マスターモールド(positive or negative master mold)を製造した後、前記マスターモールドから硬化性シリコン(PDMS、polydimethylsilozane)を用いて最終の陰モールド(negative mold)を製造した。
シリコンウエハにフォトリソグラフィ(photolithography)製作技法を用いて陽または陰マスターモールド(positive or negative master mold)を製造した後、前記マスターモールドから硬化性シリコン(PDMS、polydimethylsilozane)を用いて最終の陰モールド(negative mold)を製造した。
シリコンウエハにフォトリソグラフィ(photolithography)製作技法を用いて陽または陰マスターモールド(positive or negative master mold)を製造した後、前記マスターモールドから硬化性シリコン(PDMS、polydimethylsilozane)を用いて最終の陰モールド(negative mold)を製造した。
シリコンウエハにフォトリソグラフィ(photolithography)製作技法を用いて陽マスターモールド(positive master mold)を製造した後、前記陽マスターモールドから硬化性シリコン(PDMS、polydimethylsilozane)を用いて陰モールド(negative mold)を製造した。
本発明で製造されたマイクロ構造体の機械的強度は、豚の皮膚を用いたものであり、マイクロ構造体を一定の力で豚の皮膚に透過させた時、皮膚の表皮に発生する孔の個数を確認して比較した(図5a乃至図5e)。
本発明で製造されたマイクロ構造体の皮膚透過度は豚の皮膚に構造体を一定の力で透過した後、透過前後の構造体変形程度を確認して比較した(図6a乃至図6d)。
Claims (6)
- マイクロ構造体の製造方法であって、
(a)生体適合性高分子または粘着剤をマイクロモールドに供給するステップと、
(b)前記生体適合性高分子または粘着剤を前記マイクロモールドの孔に注入するステップと、
(c)前記生体適合性高分子または粘着剤を乾燥させるステップと、
(d)前記マイクロモールドと乾燥された前記生体適合性高分子または粘着剤を分離し、前記マイクロ構造体を形成するステップとを含み、
前記マイクロ構造体は、iii)前記マイクロ構造体の先端から底部まで、円錐と円錐台の順に段差なく接続された2重構造であり、前記円錐の底面と前記円錐台の斜面との間の角度(β2)が鈍角である2重構造、又はiv)前記マイクロ構造体の先端から底部まで、円錐、上側の円錐台、下側の円錐台の順に段差なく接続された3重構造であり、前記円錐の底面と上側の前記円錐台の斜面とのなす角(β3)と、上側の前記円錐台の底面と下側の前記円錐台の斜面とのなす角(β4)が鈍角であり、β3がβ4よりも大きい3重構造を有し、
複数個のマイクロ構造体は、六角形に配列され、
前記生体適合性高分子または粘着剤は、分子量が240−490kDaであるヒアルロン酸であり、
前記注入が、前記マイクロモールドの内部に、500以上760mmHg未満の圧力を印加することにより行われる、製造方法。 - 前記ステップ(c)は(i)常温で36−60時間の間実施するか、(ii)40−60℃で5−16時間の間実施するか、または(iii)60−80℃で2−4時間の間実施することを特徴とする、請求項1に記載の製造方法。
- 前記生体適合性高分子が、カルボキシメチルセルロース(Carboxymethyl cellulose:CMC)、カラギーナン、コンドロイチンサルフェート、デキストランサルフェート、キトサン、ポリリシン(polylysine)、コラーゲン、ゼラチン、カルボキシメチルキチン(carboxymethyl chitin)、フィブリン、アガロース、プルランポリラクタイド、ポリグルコライド(PGA)、ポリラクタイド−グリコライド共重合体(PLGA)、プルランポリアンハイドライド(polyanhydride)、ポリオルトエステル(polyorthoester)、ポリエーテルエステル(polyetherester)、ポリカプロラクトン(polycaprolactones)、ポリエステルアミド(polyesteramide)、ポリブチリック酸、ポリバレリック酸、ポリウレタン、ポリアクリレート、エチレン−ビニルアセテート重合体、アクリル置換セルロースアセテート、非−分解性ポリウレタン、ポリスチレン、ポリビニルクロライド、ポリビニルフルオライド、ポリビニルイミダゾール、クロロスルホネートポリオレフィン(chlorosulphonate polyolefin)、ポリエチレンオキサイド、ポリビニルピロリドン(PVP)、ポリエチレングリコール(PEG)、ポリメタクリレート、ヒドロキシプロピルメチルセルロース(HPMC)、エチルセルロース(EC)、ヒドロキシプロピルセルロース(HPC)、サイクロデキストリン、及びこのような高分子を形成する単量体の共重合体及びセルロースで構成された群から選択された1以上の高分子を追加的に含むことを特徴とする、請求項1に記載の製造方法。
- 前記ステップ(a)で生体適合性高分子の固形分含有量(solid content)は全体マイクロ構造体の組成に対して1−30%(w/v)であることを特徴とする、請求項1に記載の製造方法。
- 前記粘着剤が、シリコーン、ポリウレタン、物理的接着剤、ポリアクリル、エチルセルロース、ヒドロキシメチルセルロース、エチレンビニルアセテート、及びポリイソブチレンで構成された群から選択された1以上の物質を追加的に含むことを特徴とする、請求項1に記載の製造方法。
- 前記複数個のマイクロ構造体は、250−1500μmの間隔(p)で配列されることを特徴とする、請求項1に記載の製造方法。
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MY188756A (en) | 2021-12-29 |
BR112018011936B1 (pt) | 2022-10-04 |
PH12018501256A1 (en) | 2019-02-04 |
HK1252001A1 (zh) | 2019-05-10 |
US20190001109A1 (en) | 2019-01-03 |
EP3398645A4 (en) | 2019-01-09 |
CN108430565A (zh) | 2018-08-21 |
JP6995915B2 (ja) | 2022-02-04 |
KR102064503B1 (ko) | 2020-03-02 |
BR112018011936A2 (pt) | 2018-11-27 |
WO2017116076A1 (ko) | 2017-07-06 |
CA3007753C (en) | 2021-07-06 |
MX2018007934A (es) | 2018-11-09 |
KR20170077809A (ko) | 2017-07-06 |
US11285308B2 (en) | 2022-03-29 |
JP2019505279A (ja) | 2019-02-28 |
CN108430565B (zh) | 2021-07-20 |
UA122353C2 (uk) | 2020-10-26 |
ZA201804095B (en) | 2019-10-30 |
CO2018007679A2 (es) | 2018-08-10 |
CA3007753A1 (en) | 2017-07-06 |
JP2020114428A (ja) | 2020-07-30 |
RU2701361C1 (ru) | 2019-09-27 |
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