JP6951592B2 - 皮膚感染の予防または治療用組成物 - Google Patents
皮膚感染の予防または治療用組成物 Download PDFInfo
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- JP6951592B2 JP6951592B2 JP2020561015A JP2020561015A JP6951592B2 JP 6951592 B2 JP6951592 B2 JP 6951592B2 JP 2020561015 A JP2020561015 A JP 2020561015A JP 2020561015 A JP2020561015 A JP 2020561015A JP 6951592 B2 JP6951592 B2 JP 6951592B2
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Description
1.実験方法:ディスク拡散法(modified clsi method)
2.指標菌および条件(表01)
本明細書による組成物の抗菌活性を判断するためにCandida albicans、Candida prapsilosis、Candida kruseiおよびAspergillus fumigatusを指標菌(indicator)として実験を行った。
図1〜図3は本明細書による組成物のCandida albicansに対する抗菌活性実験結果である抑制帯形成結果である。
図6〜図15は本明細書による組成物のCandida parapsilosisに対する抗菌活性実験結果である抑制帯形成結果である。
図18〜図27は本明細書による組成物のCandida kruseiに対する抗菌活性実験結果である抑制帯形成結果である。
図30〜図39は本明細書による組成物のAspergillus fumigatusに対する抗菌活性実験結果である抑制帯形成結果である。
前述したように、多くの液状医薬品の場合、塩化イオンを含む賦形剤が含まれ、塩酸テルビナフィンと複合剤形の本発明の組成物も沈殿が発生し得る。ただし、マレイン酸とホウ酸ナトリウムをさらに含み、塩酸テルビナフィンの沈殿物生成を防止することができる。以下では塩酸テルビナフィンの沈殿物生成実験について説明する。
Claims (19)
- 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
マレイン酸;および
ホウ酸ナトリウム;を含有し、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または治療用薬学的組成物。 - 前記塩酸テルビナフィンが組成物に対して0.1〜10.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記クロルヘキシジングルコン酸塩が組成物に対して0.1〜20.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記シクロピロクスオラミンが組成物に対して0.1〜10.0重量部で含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- ティーツリーオイル;をさらに含む、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記ティーツリーオイルが組成物に対して0.1〜10.0重量部で含まれる、請求項5に記載の皮膚感染の予防または治療用薬学的組成物。
- エンバク抽出物;をさらに含む、請求項5に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記エンバク抽出物が組成物に対して0.1〜10.0重量部で含まれる、請求項7に記載の皮膚感染の予防または治療用薬学的組成物。
- フィトスフィンゴシン、およびフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つをさらに含む、請求項7に記載の皮膚感染の予防または治療用薬学的組成物。
- 前記組成物が動物に使用される、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。
- 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
ティーツリーオイル、ティーツリーオイルとエンバク抽出物の混合物、ティーツリーオイルとエンバク抽出物とフィトスフィンゴシンの混合物、およびティーツリーオイルとエンバク抽出物とフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つ;
マレイン酸;および
ホウ酸ナトリウム;を含み、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または治療用薬学的組成物。 - 塩酸テルビナフィン;
クロルヘキシジングルコン酸塩;
シクロピロクスオラミン;
マレイン酸;および
ホウ酸ナトリウム;を含み、
pH値の範囲が5.3〜5.7である、皮膚感染の予防または改善用化粧料組成物。 - ティーツリーオイル、ティーツリーオイルとエンバク抽出物の混合物、ティーツリーオイルとエンバク抽出物とフィトスフィンゴシンの混合物、およびティーツリーオイルとエンバク抽出物とフィトスフィンゴシンとセラミドの混合物からなる群より選ばれたいずれか一つをさらに含む、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記組成物の剤形がローション、クリーム、軟膏、シャンプー、スプレー、ゲルまたはシャンプーである、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記塩酸テルビナフィンが組成物に対して0.1〜10.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記クロルヘキシジングルコン酸塩が組成物に対して0.1〜20.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記シクロピロクスオラミンが組成物に対して0.1〜10.0重量部で含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
- 前記組成物に対して、
前記塩酸テルビナフィンが0.1〜2.0重量部;
前記クロルヘキシジングルコン酸塩が0.1〜4.0重量部;
前記シクロピロクスオラミンが0.1〜6.0重量部;
前記マレイン酸が0.5〜2.0重量部および
前記ホウ酸ナトリウムが0.3〜0.5重量部含まれる、請求項1に記載の皮膚感染の予防または治療用薬学的組成物。 - 前記組成物に対して、
前記塩酸テルビナフィンが0.1〜2.0重量部;
前記クロルヘキシジングルコン酸塩が0.1〜4.0重量部;
前記シクロピロクスオラミンが0.1〜6.0重量部;
前記マレイン酸が0.5〜2.0重量部および
前記ホウ酸ナトリウムが0.3〜0.5重量部含まれる、請求項12に記載の皮膚感染の予防または改善用化粧料組成物。
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