JP6901245B2 - IgMを含む組成物を用いて感染関連免疫状態を治療又は予防するための方法 - Google Patents
IgMを含む組成物を用いて感染関連免疫状態を治療又は予防するための方法 Download PDFInfo
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Description
分泌型アルカリホスファターゼ(SEAP)レポーターを駆動するNF-κB依存性プロモーターを含む安定なプラスミドを保有するヒトTHP-1単球細胞株(Invivogen、サンディエゴ、カリフォルニア州、米国)を、NF-κBシグナル伝達経路活性化をモニタリングする手段として用いて本試験を行った。
IgMは大腸菌の細胞壁内毒素LPSにより媒介されるNF-kBシグナル伝達を減衰させることができなかったので(実施例1参照)、精製IgMの(LPS等の細胞壁成分を保有する)インタクトな全細菌(whole bacteria)に対する効果を評価した。
IgMがNF-κB炎症性経路に対する明確な効果を示したので、精製IgMが免疫機能に対してより一般的な効果を有しているかを評価した。抗原により刺激された血液リンパ球、特にT細胞の増殖は、最も基本的な炎症性免疫応答の一つである。
Claims (33)
- 感染により生じる免疫性合併症の治療における使用のための、IgMを含む組成物であって、
前記組成物において用いられるIgMが少なくとも90% (w/v)のIgM純度を有し、
前記感染が、緑膿菌、クレブシエラ・ニューモニエ、クロストリジウム・ディフィシル、又はこれらの組み合わせにより生じる、
組成物。 - 免疫合併症の治療が免疫調節を通して行われることを特徴とする、請求項1に記載の使用のための組成物。
- 免疫調節が、NF-κB誘導の阻害を通して、末梢血単核細胞の増殖の阻害を通して、又はこれらの組み合わせにより行われることを特徴とする、請求項2に記載の使用のための組成物。
- 前記組成物において用いられるIgMが95% (w/v)のIgM純度を有することを特徴とする、請求項1に記載の使用のための組成物。
- 投与される前記組成物の用量が75 mg IgM/患者1kg〜1 g IgM/患者1kgであることを特徴とする、請求項1に記載の使用のための組成物。
- 前記組成物が少なくとも週1回投与されることを特徴とする、請求項5に記載の使用のための組成物。
- IgMが組換え、血漿由来、細胞培養由来、トランスジェニック、又は化学合成されたものであることを特徴とする、請求項1に記載の使用のための組成物。
- IgMが血漿の適切な画分から単離された血漿由来IgMであることを特徴とする、請求項7に記載の使用のための組成物。
- IgMを含む前記組成物が単独で投与されることを特徴とする、請求項1に記載の使用のための組成物。
- IgMを含む前記組成物が、抗炎症分子、小分子抗生物質、天然の抗菌性の分子、天然若しくは合成ペプチド抗菌剤、抗菌特性を有するタンパク質、他の免疫調節剤、又はこれらの組み合わせから選択される1種以上の他の組成物又は分子と一緒に投与されることを特徴とする、請求項1に記載の使用のための組成物。
- 前記他の組成物又は分子が、バンコマイシン、メロペネム、ラクトフェリン、又はこれらの組み合わせであることを特徴とする、請求項10に記載の使用のための組成物。
- 感染の免疫調節のための使用のための、IgMを含む組成物であって、
前記組成物において用いられるIgMが少なくとも90% (w/v)のIgM純度を有し、
前記感染が、緑膿菌、クレブシエラ・ニューモニエ、クロストリジウム・ディフィシル、又はこれらの組み合わせにより生じる、
組成物。 - 免疫調節が、感染又は感染関連症状若しくは状態の治療又は予防のために用いられることを特徴とする、請求項12に記載の使用のための組成物。
- 免疫調節が、NF-κB誘導の阻害を通して、末梢血単核細胞の増殖の阻害を通して、又はこれらの組み合わせにより行われることを特徴とする、請求項12に記載の使用のための組成物。
- 前記組成物において用いられるIgMが95% (w/v)のIgM純度を有することを特徴とする、請求項12に記載の使用のための組成物。
- 投与される前記組成物の用量が75 mg IgM/患者1kg〜1 g IgM/患者1kgであることを特徴とする、請求項12に記載の使用のための組成物。
- 前記組成物が少なくとも週1回投与されることを特徴とする、請求項16に記載の使用のための組成物。
- IgMが組換え、血漿由来、細胞培養由来、トランスジェニック、又は化学合成されたものであることを特徴とする、請求項12に記載の使用のための組成物。
- IgMが血漿の適切な画分から単離された血漿由来IgMであることを特徴とする、請求項18に記載の使用のための組成物。
- IgMを含む前記組成物が単独で投与されることを特徴とする、請求項12に記載の使用のための組成物。
- IgMを含む前記組成物が、抗炎症分子、小分子抗生物質、天然の抗菌性の分子、天然若しくは合成ペプチド抗菌剤、抗菌特性を有するタンパク質、他の免疫調節剤、又はこれらの組み合わせから選択される1種以上の他の組成物又は分子と一緒に投与されることを特徴とする、請求項12に記載の使用のための組成物。
- 前記他の組成物又は分子が、バンコマイシン、メロペネム、ラクトフェリン、又はこれらの組み合わせであることを特徴とする、請求項21に記載の使用のための組成物。
- 敗血症の治療における使用のための、IgMを含む組成物であって、
前記組成物において用いられるIgMが少なくとも90% (w/v)のIgM純度を有し、
前記敗血症が、緑膿菌、クレブシエラ・ニューモニエ、クロストリジウム・ディフィシル、又はこれらの組み合わせにより生じる、
組成物。 - 敗血症の治療が免疫調節を通して行われることを特徴とする、請求項23に記載の使用のための組成物。
- 免疫調節が、NF-κB誘導の阻害を通して、末梢血単核細胞の増殖の阻害を通して、又はこれらの組み合わせにより行われることを特徴とする、請求項24に記載の使用のための組成物。
- 前記組成物において用いられるIgMが、95% (w/v)のIgM純度を有することを特徴とする、請求項23に記載の使用のための組成物。
- 投与される前記組成物の用量が75 mg IgM/患者1kg〜1 g IgM/患者1kgであることを特徴とする、請求項23に記載の使用のための組成物。
- 少なくとも週1回投与されることを特徴とする、請求項27に記載の使用のための組成物。
- IgMが組換え、血漿由来、細胞培養由来、トランスジェニック、又は化学合成されたものであることを特徴とする、請求項23に記載の使用のための組成物。
- IgMが血漿の適切な画分から単離された血漿由来IgMであることを特徴とする、請求項29に記載の使用のための組成物。
- 単独で投与されることを特徴とする、請求項23に記載の使用のための組成物。
- 抗炎症分子、小分子抗生物質、天然の抗菌性の分子、天然若しくは合成ペプチド抗菌剤、抗菌特性を有するタンパク質、他の免疫調節剤、又はこれらの組み合わせから選択される1種以上の他の組成物又は分子と一緒に投与されることを特徴とする、請求項23に記載の使用のための組成物。
- 前記他の組成物又は分子が、バンコマイシン、メロペネム、ラクトフェリン、又はこれらの組み合わせであることを特徴とする、請求項32に記載の使用のための組成物。
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US9913903B2 (en) | 2015-08-06 | 2018-03-13 | Grifols Worldwide Operations Limited | Method for the treatment or prevention of infection-related immune conditions using a composition comprising IgM |
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US4652533A (en) * | 1983-04-28 | 1987-03-24 | Pandex Laboratories, Inc. | Method of solid phase immunoassay incorporating a luminescent label |
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