JP6839223B2 - 薬物送達装置 - Google Patents
薬物送達装置 Download PDFInfo
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- JP6839223B2 JP6839223B2 JP2019082664A JP2019082664A JP6839223B2 JP 6839223 B2 JP6839223 B2 JP 6839223B2 JP 2019082664 A JP2019082664 A JP 2019082664A JP 2019082664 A JP2019082664 A JP 2019082664A JP 6839223 B2 JP6839223 B2 JP 6839223B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
- A61M2005/14252—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1587—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body suitable for being connected to an infusion line after insertion into a patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Description
Claims (17)
- 中央領域と、前記中央領域を囲む外側領域とを有する薬物送達装置であって、
少なくとも部分的に該薬物送達装置の前記中央領域を画定するハウジング上部、及び少なくとも部分的に前記外側領域を画定し、使用者の皮膚に取り外し可能なように取り付けるための皮膚取り付け手段を含む底面を画定するハウジング下部を含むハウジングと、
前記中央領域内に配置されたマイクロニードル組立品と、
前記マイクロニードル組立品と押し要素の間の前記中央領域内に配置され、前記マイクロニードル組立品と流体連通しているレザバーと、
前記中央領域内の前記マイクロニードル組立品の上方に配置され、前記マイクロニードル組立品を通して伝達する下向きの成分及び前記ハウジングを通して伝達される上向きの成分を有する継続的双方向力を提供するように構成されている前記押し要素と、を備え、
前記マイクロニードル組立品が前記ハウジング下部から独立して動くように構成された薬物送達装置。 - 前記継続的双方向力の前記下向きの成分が前記レザバーを通して前記マイクロニードル組立品に伝達される、請求項1に記載の薬物送達装置。
- 前記レザバーが柔軟な部材を含み、前記継続的双方向力の前記下向きの成分が、前記レザバーを加圧する、請求項1に記載の薬物送達装置。
- 前記レザバーが薬物製剤を含有し、前記継続的双方向力の前記下向きの成分が、前記レザバー内の前記薬物製剤に働く、請求項3に記載の薬物送達装置。
- 前記レザバーが、薬物製剤を含有する硬質部材として構成され、前記継続的双方向力の前記下向きの成分が、前記レザバー内に含まれる前記薬物製剤の圧力を増加させることなく、前記マイクロニードル組立品を通して伝達される、請求項1に記載の薬物送達装置。
- 前記継続的双方向力の前記下向きの成分が、前記中央領域を通して前記マイクロニードル組立品に伝達され、前記継続的双方向力の前記上向きの成分が、前記中央領域を通して前記ハウジング上部に伝達される、請求項1に記載の薬物送達装置。
- 前記継続的双方向力の前記下向きの成分が前記押し要素によって加えられる時、前記マイクロニードル組立品が前記ハウジングに対して動くように構成されている、請求項1に記載の薬物送達装置。
- 前記押し要素が、前記ハウジング上部と前記レザバーとの間で圧縮されているバネを備える、請求項1に記載の薬物送達装置。
- 前記レザバーの上方に配置されたプランジャーをさらに備え、
前記バネが前記ハウジング上部と前記プランジャーとの間で圧縮されている、請求項8に記載の薬物送達装置。 - 薬物送達装置であって、
使用者の皮膚に取り外し可能なように取り付けるための皮膚取り付け手段を含む底面を画定するハウジング下部と、
前記ハウジング下部に取り付けられたハウジング上部と、
協働して空洞を画定する前記ハウジング上部及び前記ハウジング下部に取り囲まれ、前記ハウジング下部から分離している、マイクロニードル組立品と、
前記空洞内に配置され、前記マイクロニードル組立品と流体連通しているレザバーと、
前記マイクロニードル組立品及び前記ハウジング上部との間の前記空洞内に配置され、前記ハウジング下部から独立して動き、かつ該薬物送達装置を通して継続的双方向力を提供するように構成された押し要素と、を備え、
前記継続的双方向力が、(i)前記マイクロニードル組立品を介して伝達される下向きの成分と、(ii)前記ハウジング下部に伝達される上向きの成分とを備え、
前記上向きの成分を提供する前記押し要素が前記マイクロニードル組立品から分離され、
前記レザバーが前記マイクロニードル組立品と前記押し要素の間に配置され、前記継続的双方向力の前記下向きの成分が前記レザバーを通して前記マイクロニードル組立品に伝達される、薬物送達装置。 - 前記レザバーが薬物製剤を含有し、
前記継続的双方向力の前記下向きの成分が、前記レザバー内に含まれる前記薬物製剤の
圧力を増加させることなく、前記マイクロニードル組立品を通して伝達される、請求項10に記載の薬物送達装置。 - 前記押し要素が、作動可能であり、作動前の状態において圧縮されている部材を備える、請求項10に記載の薬物送達装置。
- プランジャーをさらに備え、
前記ハウジング上部が開口部を画定し、前記プランジャーの頂部が前記開口部を通って延出し、前記頂部が前記ハウジング上部に対して移動可能であり、前記頂部への下向きの力の適用が、前記マイクロニードル組立品に対してさらなる下向きの力を伝達する、請求項10に記載の薬物送達装置。 - 前記マイクロニードル組立品と、前記レザバーと、前記押し要素とが垂直に整列する、請求項10に記載の薬物送達装置。
- 中央領域と、前記中央領域を囲む外側領域とを有する薬物送達装置であって、
ハウジング上部と、使用者の皮膚に取り外し可能なように取り付けるための皮膚取り付け手段を含む底面を画定するハウジング下部とを含むハウジングと、
該薬物送達装置の前記中央領域内に配置されたマイクロニードル組立品と、
前記中央領域内に配置され、薬物製剤を含有し、前記マイクロニードル組立品と流体連通しているレザバーと、
前記中央領域内の前記マイクロニードル組立品の上に配置され、前記マイクロニードル組立品を通して伝達される下向きの成分、及び前記ハウジングを通して伝達される上向きの成分を有する継続的双方向力を提供する、押し要素と、を備え、
前記レザバーが、前記マイクロニードル組立品と前記押し要素との間に配置され、
前記継続的双方向力の前記下向きの成分が、前記レザバー内の前記薬物製剤の圧力を増加させることなく、前記レザバーを通して前記マイクロニードル組立品に伝達される、薬物送達装置。 - 前記マイクロニードル組立品は、前記ハウジング下部とは独立して動くように構成される、請求項15に記載の薬物送達装置。
- 前記押し要素は、前記ハウジング上部と前記レザバーとの間で圧縮されたバネを備える、請求項15に記載の薬物送達装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201361770639P | 2013-02-28 | 2013-02-28 | |
US61/770,639 | 2013-02-28 |
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JP2015559599A Division JP6522523B2 (ja) | 2013-02-28 | 2014-02-28 | 経皮的薬物送達装置 |
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JP2019162444A JP2019162444A (ja) | 2019-09-26 |
JP6839223B2 true JP6839223B2 (ja) | 2021-03-03 |
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JP2015559599A Active JP6522523B2 (ja) | 2013-02-28 | 2014-02-28 | 経皮的薬物送達装置 |
JP2019082664A Active JP6839223B2 (ja) | 2013-02-28 | 2019-04-24 | 薬物送達装置 |
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Country | Link |
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US (3) | US10183156B2 (ja) |
EP (1) | EP2961471B1 (ja) |
JP (2) | JP6522523B2 (ja) |
KR (3) | KR102295456B1 (ja) |
CN (2) | CN109621083B (ja) |
AU (1) | AU2014222308B2 (ja) |
BR (1) | BR112015020328B1 (ja) |
CA (1) | CA2901568C (ja) |
MX (1) | MX360121B (ja) |
RU (1) | RU2622605C2 (ja) |
WO (1) | WO2014132240A1 (ja) |
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WO2017019526A2 (en) | 2015-07-24 | 2017-02-02 | Kimberly-Clark Worldwide, Inc. | Methods for better delivery of active agents to tumors |
ES2928981T3 (es) * | 2015-12-21 | 2022-11-23 | Medrx Co Ltd | Alojamiento para aplicador de parches de microagujas |
KR101672671B1 (ko) * | 2016-03-03 | 2016-11-03 | 김경원 | 석션 니들 부재와 결합되는 환형 밀착캡을 갖는 오토 인젝터 핸드피스 |
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USD895109S1 (en) * | 2017-10-18 | 2020-09-01 | Roche Diabetes Care, Inc. | Inserter for an infusion set |
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