JP6814223B2 - 送達デバイス - Google Patents
送達デバイス Download PDFInfo
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- JP6814223B2 JP6814223B2 JP2018545305A JP2018545305A JP6814223B2 JP 6814223 B2 JP6814223 B2 JP 6814223B2 JP 2018545305 A JP2018545305 A JP 2018545305A JP 2018545305 A JP2018545305 A JP 2018545305A JP 6814223 B2 JP6814223 B2 JP 6814223B2
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- plunger rod
- rotor
- drive mechanism
- needle cover
- delivery device
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- 230000007246 mechanism Effects 0.000 claims description 43
- 238000002347 injection Methods 0.000 description 39
- 239000007924 injection Substances 0.000 description 39
- 238000012377 drug delivery Methods 0.000 description 13
- 230000000007 visual effect Effects 0.000 description 11
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000005452 bending Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012790 confirmation Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
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- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
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- A61M5/3272—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position having projections following labyrinth paths
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- A—HUMAN NECESSITIES
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- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
- A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A—HUMAN NECESSITIES
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- Vascular Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
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- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
本開示は、送達デバイスに関し、特に、注入がなされたときに、聴覚的、触覚的、および/または視覚的な信号または確認をユーザに提供する、改善された、使い勝手の良い薬剤送達デバイスに関する。
薬剤送達デバイスは、自己投与のために開発されており、すなわち、ユーザは、薬剤送達を自分自身で行う。これは、使用するのが安全で取扱いが容易な薬剤送達デバイスを必要とする。これらの要件を満たすためには、人為的ミスの危険性を最小限に抑える必要があり、投与量を受け取るために実行する必要のある作業の数を減らす必要があり、デバイスは直感的で人間工学的に使用することができる必要がある。
例示的な実施形態によれば、送達デバイスのための駆動機構が開示される。駆動機構は、外面および内面を備える回転子であって、回転子は、第1の位置から第2の位置に回転するように構成されている、回転子と、回転子の外面と係合する内面を備える針カバーとを備える。駆動機構は、回転子によって画定されるキャビティ内に位置決めされたプランジャロッドばねをさらに備える。注入終了指示デバイスは、少なくとも部分的にプランジャロッドばね内に位置決めされ、注入終了指示デバイスは、注入が完了したという信号を駆動機構のユーザに提供する。
例示的な実施形態の特徴と考えられる新規な特徴が、添付の特許請求の範囲に記載されている。しかしながら、例示的な実施形態、ならびに好ましい使用モード、さらなる構造およびその説明が、添付の図面と併せて読むと、本開示の例示的な実施形態の以下の詳細な説明を参照することによって最もよく理解されるであろう。
本出願において、用語「近位部分/端」が使用される場合、これは、患者の薬剤送達部位から最も離れて位置する、送達デバイスの部分/端、またはその部材の部分/端を指す。対応して、用語「遠位部分/端」が使用される場合、これは、患者の薬剤送達部位の最も近くに位置する、送達デバイスの部分/端、またはその部材の部分/端を指す。
Claims (18)
- 送達デバイスのための駆動機構であって、
外面および内面を備える回転子であって、前記回転子は、第1の位置から第2の位置に回転するように構成されている、回転子と、
前記回転子の前記外面と係合する内面を備える針カバーと、
前記回転子の前記内面と係合するように構成されている外面を備える回転可能なプランジャロッドと、
プランジャロッドばねと
を備え、
前記回転子が前記第1の位置から前記第2の位置に回転すると、前記回転可能なプランジャロッドは前記回転子によって回転され、前記プランジャロッドばねは、予張状態から解放されて、前記回転可能なプランジャロッドに力を加え、
カートリッジハウジングのリブに取り外し可能に係合するプランジャロッド保持部分をさらに備え、
前記プランジャロッド保持部分は、前記回転可能なプランジャロッドの外面に沿って設けられたスロットを備え、
前記カートリッジハウジングの前記リブが前記プランジャロッド保持部分に係合している状態で、前記回転可能なプランジャロッドは前記回転子によって回転され、前記回転可能なプランジャロッドの回転が前記プランジャロッド保持部分を前記カートリッジハウジングの前記リブから解放するように作用することで、前記回転可能なプランジャロッドが軸方向において遠位方向に移動することが可能になる、駆動機構。 - 前記回転可能なプランジャロッドの前記外面上の少なくとも1つのリブをさらに備える、請求項1に記載の駆動機構。
- 前記回転子の前記内面から半径方向内向きに突出する少なくとも1つの内側リブをさらに備える、請求項2に記載の駆動機構。
- 前記回転子の前記少なくとも1つの内側リブが、前記回転可能なプランジャロッドの前記外面上の前記少なくとも1つのリブと解放可能に係合するように構成されている、請求項3に記載の駆動機構。
- 前記針カバーの近位方向への移動が、前記回転子を前記第1の位置から前記第2の位置へ移動させ、前記回転子の前記内面から半径方向内向きに突出する前記少なくとも1つの内側リブが、前記回転可能なプランジャロッドの前記外面上の前記少なくとも1つのリブに係合することで、前記回転可能なプランジャロッドが回転する、請求項4に記載の駆動機構。
- 前記回転可能なプランジャロッドを回転させることにより、前記プランジャロッドばねによって生成される力の下で、前記回転可能なプランジャロッドが軸方向において遠位方向に移動することが可能になる、請求項5に記載の駆動機構。
- 前記針カバーの前記内面に設けられ、前記回転子の前記外面に沿って設けられた溝に係合されるピンをさらに備える、請求項1に記載の駆動機構。
- 前記針カバーの近位移動の間、前記針カバーの前記内面に設けられた前記ピンが前記回転子の前記溝内に乗り上げて、前記回転子が前記第1の位置から前記第2の位置に移動する、請求項7に記載の駆動機構。
- 前記回転可能なプランジャロッドは中空プランジャロッドを含む、請求項1に記載の駆動機構。
- 前記プランジャロッドばねは、前記中空プランジャロッドによって画定されたキャビティ内に少なくとも部分的に位置決めされる、請求項9に記載の駆動機構。
- 前記針カバーを遠位方向に付勢する針カバーばねをさらに備える、請求項1に記載の駆動機構。
- 前記送達デバイスの1端に取り付けられた取り外し可能なキャップをさらに備える、請求項11に記載の駆動機構。
- 前記取り外し可能なキャップが前記送達デバイスから取り外されると、前記針カバーばねは前記針カバーを遠位方向に動かす、請求項12に記載の駆動機構。
- 前記取り外し可能なキャップが前記送達デバイスから取り外されると、前記針カバーばねは前記針カバーを遠位方向に動かし、前記回転子が前記第1の位置へと回転する、請求項13に記載の駆動機構。
- 前記回転子が前記第1の位置に回転するとき、前記回転子は前記回転可能なプランジャロッドに対して回転する、請求項14に記載の駆動機構。
- 前記回転可能なプランジャロッドは、容器内の摺動可能なストッパを駆動するように構成された遠位端を備える、請求項1に記載の駆動機構。
- 前記容器は、前記送達デバイスの容器ハウジング内に配置される、請求項16に記載の駆動機構。
- 前記容器ハウジングは前記送達デバイスに固定して取り付けられる、請求項17に記載の駆動機構。
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PCT/EP2017/052293 WO2017148646A2 (en) | 2016-02-29 | 2017-02-02 | Delivery device |
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JP7361032B2 (ja) * | 2017-11-21 | 2023-10-13 | サノフイ | 薬物送達デバイスのための駆動サブアセンブリ |
CA3099230A1 (en) * | 2018-05-24 | 2019-11-28 | Novartis Ag | Automatic drug delivery device |
WO2020146426A1 (en) * | 2019-01-07 | 2020-07-16 | Noble International, Inc. | Injection assist device |
CN114450049A (zh) * | 2019-09-30 | 2022-05-06 | 美国安进公司 | 药物递送装置 |
CA3151476A1 (en) | 2019-09-30 | 2021-04-08 | Amgen Inc. | Drug delivery device |
CN117750989A (zh) * | 2021-08-09 | 2024-03-22 | 艾斯曲尔医疗公司 | 药剂输送装置的子组件 |
EP4285964A1 (en) * | 2022-06-02 | 2023-12-06 | Becton, Dickinson and Company | Indicator for drug delivery device |
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IN2012DN01791A (ja) * | 2009-10-05 | 2015-06-05 | Ericsson Telefon Ab L M | |
CN102665801B (zh) * | 2009-10-08 | 2015-06-17 | Shl集团有限责任公司 | 药物输送装置 |
DK2583710T3 (da) * | 2010-03-31 | 2022-01-17 | Shl Medical Ag | Medikamentafgivelsesanordning, der omfatter feedback-signaleringsmidler |
AU2011274341A1 (en) * | 2010-07-02 | 2013-01-31 | Carebay Holding Ltd., Company No. 681498 | Preservative-free follicle stimulating hormone solution delivery device |
EP2468336A1 (en) * | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2489381A1 (en) * | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
AU2012269770B2 (en) * | 2011-06-17 | 2015-04-16 | Shl Medical Ag | Injection device |
ITFI20110194A1 (it) * | 2011-09-08 | 2013-03-09 | Menarini Int Operations Lu Sa | Dispositivo autoiniettore di dosi di farmaco |
CN103945881B (zh) * | 2011-09-27 | 2016-05-18 | Shl集团有限责任公司 | 具有初始锁定状态、中间注给状态及药物输送状态的医疗输送装置 |
CN102716529B (zh) * | 2012-06-29 | 2014-02-19 | 北京甘甘科技有限公司 | 笔式注射器 |
CH705992A2 (de) * | 2012-10-11 | 2013-06-14 | Tecpharma Licensing Ag | Injektionsvorrichtung. |
WO2014136652A1 (ja) * | 2013-03-08 | 2014-09-12 | テルモ株式会社 | 液体投与具 |
EP3038681B1 (en) * | 2013-08-29 | 2019-11-06 | SHL Medical AG | Medicament delivery device |
TWI577410B (zh) * | 2013-10-25 | 2017-04-11 | 卡貝歐洲有限公司 | 自動注射器的觸發機構 |
US20170246395A1 (en) * | 2016-02-29 | 2017-08-31 | Shl Group Ab | Delivery Device |
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JP2019511944A (ja) | 2019-05-09 |
WO2017148646A2 (en) | 2017-09-08 |
KR102205100B1 (ko) | 2021-01-21 |
TWI639451B (zh) | 2018-11-01 |
KR20180104735A (ko) | 2018-09-21 |
WO2017148646A3 (en) | 2019-01-31 |
US20170246400A1 (en) | 2017-08-31 |
CN109843358A (zh) | 2019-06-04 |
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