JP6689574B2 - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP6689574B2 JP6689574B2 JP2015055047A JP2015055047A JP6689574B2 JP 6689574 B2 JP6689574 B2 JP 6689574B2 JP 2015055047 A JP2015055047 A JP 2015055047A JP 2015055047 A JP2015055047 A JP 2015055047A JP 6689574 B2 JP6689574 B2 JP 6689574B2
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- JP
- Japan
- Prior art keywords
- hyaluronic acid
- salt
- feeling
- component
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 85
- 229920002674 hyaluronan Polymers 0.000 claims description 136
- 229960003160 hyaluronic acid Drugs 0.000 claims description 136
- -1 hyaluronic acid oligosaccharide Chemical class 0.000 claims description 117
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 95
- 150000003839 salts Chemical class 0.000 claims description 83
- 229920001542 oligosaccharide Polymers 0.000 claims description 57
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 51
- 125000002947 alkylene group Chemical group 0.000 claims description 36
- 125000004432 carbon atom Chemical group C* 0.000 claims description 26
- 235000011187 glycerol Nutrition 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 23
- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000005702 oxyalkylene group Chemical group 0.000 claims description 13
- 239000002537 cosmetic Substances 0.000 claims description 10
- 125000006353 oxyethylene group Chemical group 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 27
- 239000000194 fatty acid Substances 0.000 description 24
- 235000014113 dietary fatty acids Nutrition 0.000 description 23
- 229930195729 fatty acid Natural products 0.000 description 23
- 238000000034 method Methods 0.000 description 21
- 230000007480 spreading Effects 0.000 description 20
- 238000003892 spreading Methods 0.000 description 20
- 239000011248 coating agent Substances 0.000 description 14
- 238000000576 coating method Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 14
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 230000035515 penetration Effects 0.000 description 11
- 229910052799 carbon Inorganic materials 0.000 description 10
- 239000004359 castor oil Substances 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 10
- 238000011978 dissolution method Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- 229910052708 sodium Inorganic materials 0.000 description 9
- 239000011734 sodium Substances 0.000 description 9
- 235000015424 sodium Nutrition 0.000 description 9
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 8
- 235000019438 castor oil Nutrition 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 8
- 239000006210 lotion Substances 0.000 description 8
- 229920001451 polypropylene glycol Polymers 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 235000000346 sugar Nutrition 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 239000004166 Lanolin Substances 0.000 description 7
- 239000002585 base Substances 0.000 description 7
- 238000004090 dissolution Methods 0.000 description 7
- 239000002552 dosage form Substances 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 235000019388 lanolin Nutrition 0.000 description 7
- 229940039717 lanolin Drugs 0.000 description 7
- 229920001748 polybutylene Polymers 0.000 description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000000149 penetrating effect Effects 0.000 description 6
- 159000000000 sodium salts Chemical class 0.000 description 6
- 150000008163 sugars Chemical class 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 229920001214 Polysorbate 60 Polymers 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 150000002016 disaccharides Chemical class 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- 150000002772 monosaccharides Chemical class 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 4
- 229920002385 Sodium hyaluronate Polymers 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 229940097043 glucuronic acid Drugs 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000009629 microbiological culture Methods 0.000 description 4
- 229940010747 sodium hyaluronate Drugs 0.000 description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 108010003272 Hyaluronate lyase Proteins 0.000 description 3
- 102000009066 Hyaluronoglucosaminidase Human genes 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229960002773 hyaluronidase Drugs 0.000 description 3
- 230000003301 hydrolyzing effect Effects 0.000 description 3
- 159000000003 magnesium salts Chemical class 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 150000003222 pyridines Chemical class 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000001593 sorbitan monooleate Substances 0.000 description 3
- 229940035049 sorbitan monooleate Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical class CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical group CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004373 Pullulan Substances 0.000 description 2
- 229920001218 Pullulan Polymers 0.000 description 2
- 241001524200 Sinomonas atrocyanea Species 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 241000187747 Streptomyces Species 0.000 description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 229940105990 diglycerin Drugs 0.000 description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 2
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- 239000000686 essence Substances 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
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- 238000001641 gel filtration chromatography Methods 0.000 description 2
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- 238000010438 heat treatment Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WFXHUBZUIFLWCV-UHFFFAOYSA-N (2,2-dimethyl-3-octanoyloxypropyl) octanoate Chemical compound CCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCC WFXHUBZUIFLWCV-UHFFFAOYSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
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- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- ZYJZBFYRVKLOAA-KRWDZBQOSA-N (2s)-2-(hexadecanoylamino)butanedioic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)CC(O)=O ZYJZBFYRVKLOAA-KRWDZBQOSA-N 0.000 description 1
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- FCAXDVKLWVSHGT-KVVVOXFISA-N (z)-docos-13-enoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O FCAXDVKLWVSHGT-KVVVOXFISA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
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- JWKSQNWLEIABLH-UHFFFAOYSA-N 1-octan-2-yloxydodecane Chemical compound CCCCCCCCCCCCOC(C)CCCCCC JWKSQNWLEIABLH-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- MXVBVDSNBADJOC-UHFFFAOYSA-N 2-(4,5-dihydroimidazol-1-yl)-4-hydroxybutanoic acid;sodium Chemical compound [Na].OCCC(C(O)=O)N1CCN=C1 MXVBVDSNBADJOC-UHFFFAOYSA-N 0.000 description 1
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- 229930182470 glycoside Natural products 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
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- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- OGEMCJNRDGZFQF-UHFFFAOYSA-N hexyl 2-benzoyl-4-(diethylamino)-3-hydroxybenzoate Chemical compound CCCCCCOC(=O)C1=CC=C(N(CC)CC)C(O)=C1C(=O)C1=CC=CC=C1 OGEMCJNRDGZFQF-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 229960000367 inositol Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229940071085 lauroyl glutamate Drugs 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229910052744 lithium Inorganic materials 0.000 description 1
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- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
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- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 235000019488 nut oil Nutrition 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- BPHQIXJDBIHMLT-UHFFFAOYSA-N perfluorodecane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F BPHQIXJDBIHMLT-UHFFFAOYSA-N 0.000 description 1
- YVBBRRALBYAZBM-UHFFFAOYSA-N perfluorooctane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F YVBBRRALBYAZBM-UHFFFAOYSA-N 0.000 description 1
- 239000010702 perfluoropolyether Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000003444 phase transfer catalyst Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940043131 pyroglutamate Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
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- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
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- 239000004711 α-olefin Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
(式中、
Zは3〜9個の水酸基を有する化合物の水酸基を除いた残基を表し;
AOは炭素数3〜4のオキシアルキレン基を表し;
EOはオキシエチレン基を表し;
BOは炭素数4のオキシアルキレン基を表し;
aは3〜9を表し;
l、m及びnは、それぞれ、AO、EO及びBOの平均付加モル数であって、1≦l≦50、1≦m≦50及び0.5≦n≦5であり;
AOとEOとの重量比(AO/EO)は1/5〜5/1であり;
AO及びEOはランダム状又はブロック状に付加していてもよい)
項1. (A)ヒアルロン酸及び/又はその塩と、(B)ヒアルロン酸オリゴ糖及び/又はその塩と、(C)下記式(I)で表される、少なくとも1つのアルキレンオキシド誘導体を含有する、外用組成物。
Z−{O(AO)l(EO)m−(BO)nH}a (I)
(式中、
Zは3〜9個の水酸基を有する化合物の水酸基を除いた残基を表し;
AOは炭素数3〜4のオキシアルキレン基を表し;
EOはオキシエチレン基を表し;
BOは炭素数4のオキシアルキレン基を表し;
aは3〜9を表し;
l、m及びnは、それぞれ、AO、EO及びBOの平均付加モル数であって、1≦l≦50、1≦m≦50及び0.5≦n≦5であり;
AOとEOとの重量比(AO/EO)は1/5〜5/1であり;
AO及びEOはランダム状又はブロック状に付加していてもよい)
項2. 前記式(I)において、AOとEOがランダム状に付加している項1記載の外用組成物。
項3. 前記式(I)において、AOがオキシプロピレン基である項1又は2記載の外用組成物。
項4. 前記式(I)において、3〜9個の水酸基を有する化合物がグリセリンである、項1〜3のいずれかに記載の外用組成物。
項5. 前記(A)成分が、重量比で前記(B)成分の同量以上含まれる、項1〜4のいずれかに記載の外用組成物。
項6. 化粧料である、項1〜5のいずれかに記載の外用組成物。
本発明の外用組成物は、(A)ヒアルロン酸及び/又はその塩と、(B)ヒアルロン酸オリゴ糖及び/又はその塩と、(C)下記式(I)で表される、少なくとも1つのアルキレンオキシド誘導体を含有することを特徴とする。以下、本発明の外用組成物について詳述する。
Z−{O(AO)l(EO)m−(BO)nH}a (I)
(式中、
Zは3〜9個の水酸基を有する化合物の水酸基を除いた残基を表し;
AOは炭素数3〜4のオキシアルキレン基を表し;
EOはオキシエチレン基を表し;
BOは炭素数4のオキシアルキレン基を表し;
aは3〜9を表し;
l、m及びnは、それぞれ、AO、EO及びBOの平均付加モル数であって、1≦l≦50、1≦m≦50及び0.5≦n≦5であり;
AOとEOとの重量比(AO/EO)は1/5〜5/1であり;
AO及びEOはランダム状又はブロック状に付加していてもよい)
本発明の外用組成物は、重厚な塗布感及び保湿感を備えさせるために、ヒアルロン酸(所謂、高分子ヒアルロン酸)及び/又はその塩((A)成分と表記することもある)を含有する。
本発明の外用組成物は、前記(A)成分と共に、ヒアルロン酸オリゴ糖及び/又はその塩((B)成分と表記することもある)を含有する。ヒアルロン酸オリゴ糖及び/又はその塩を後述する(C)成分とともに使用することにより、(A)成分が本来備える重厚な塗布感及び保湿感を維持しつつ、べたつきを抑制し、更には塗布時に伸ばし易くなり、浸透感が向上し、外用組成物に優れた使用感を備えさせることが可能になる。また、ヒアルロン酸オリゴ糖及び/又はその塩を使用することにより、(A)成分の水への溶解性を向上させ、(A)成分の溶解に要する時間を短縮することも可能になる。
本発明の外用組成物は、前記(A)成分、(B)成分と共に、下記式(I)で表されるアルキレンオキシド誘導体((C)成分と表記することもある)を含有する。当該アルキレンオキシド誘導体を(B)成分とともに使用することにより、(A)成分が本来備える重厚な塗布感及び保湿感を維持しつつ、べたつきを抑制し、更には塗布時に伸ばし易くなり、浸透感が向上し、外用組成物に優れた使用感を備えさせることが可能になる。
Z−{O(AO)l(EO)m−(BO)nH}a (I)
(式中、
Zは3〜9個の水酸基を有する化合物の水酸基を除いた残基を表し;
AOは炭素数3〜4のオキシアルキレン基を表し;
EOはオキシエチレン基を表し;
BOは炭素数4のオキシアルキレン基を表し;
aは3〜9を表し;
l、m及びnは、それぞれ、AO、EO及びBOの平均付加モル数であって、1≦l≦50、1≦m≦50及び0.5≦n≦5であり;
AOとEOとの重量比(AO/EO)は1/5〜5/1であり;
AO及びEOはランダム状又はブロック状に付加していてもよい)
Gly−[O(PO)s(EO)t−(BO)uH]3 (II)
(式中、
Glyはグリセリンから水酸基を除いた残基を表し;
POはオキシプロピレン基を表し;
EOはオキシエチレン基を表し;
sおよびtはそれぞれPOおよびEOの平均付加モル数であって、1〜50の値であり、
POとEOとの質量比(PO/EO)は1/5〜5/1であって、
BOは炭素数4のオキシアルキレン基を表し;
uはBOの平均付加モル数であって、0.5〜5の値であり;
PO及びEOはランダム状又はブロック状に付加していてもよい)
本発明の外用組成物は、前記(A)、(B)及び(C)成分に加えて、低分子化ヒアルロン酸及び/又はその塩((D)成分と表記することもある)を含んでいてもよい。このような低分子化ヒアルロン酸及び/又はその塩を配合することによって、重厚な塗布感、保湿感、及び伸ばし易さ、特に重厚な塗布感をより一層効果的に向上させることが可能にある。
本発明の外用組成物は、水を基剤として用いて所望の剤型に調製される。本発明の外用組成物において、水の濃度については、外用組成物の剤型等に応じて適宜設定すればよいが、例えば20〜95重量%、好ましくは30〜95重量%、更に好ましくは35〜95重量%が挙げられる。
本発明の外用組成物は、前述する成分の他に、必要に応じて、生理学的に有用な機能性を示す機能性成分が含まれていてもよい。このような機能性成分としては、化粧料や外用医薬品等に配合可能なものであることを限度として特に制限されないが、例えば、水溶性のビタミン類、油溶性のビタミン類、酵素、ペプチド、アミノ酸、ホルモン、各種サイトカイン、各種動植物抽出物、ステロイド剤、保湿剤、美白剤、生薬、抗ヒスタミン剤、収斂剤、細胞賦活剤、角質軟化剤、局所麻酔剤、抗炎症剤、酸化防止剤、抗菌剤、鎮痒剤、皮膚保護剤、血行促進剤、ステロール類等が挙げられる。
本発明の外用組成物は、前記(A)、(B)及び(C)成分と共に、必要に応じて添加される(D)成分、他の機能性成分、基剤、添加剤等を混合し、所望の製剤形態に調製することによって得ることができる。
本発明の外用組成物は、液状、固形状、クリーム状、ジェル状等のいずれの剤型であってもよい。これらの剤型の中でも、液状の外用組成物は、重厚な塗布感、保湿感、伸ばし易さ、及びべたつき抑制等の効果を実感し易いため、本発明の外用組成物の剤型として好適である。
前述するように、ヒアルロン酸オリゴ糖及び/又はその塩には、ヒアルロン酸及び/又はその塩の水への溶解性を向上させる作用がある。従って、本発明は、更に、ヒアルロン酸オリゴ糖及び/又はその塩((B)成分)の存在下で、ヒアルロン酸及び/又はその塩((A)成分)を水に溶解させることを特徴とする、ヒアルロン酸及び/又はその塩の溶解方法を提供する。
以下に示す実施例及び比較例において、「不飽和型ヒアルロン酸オリゴ糖」は、特開2008−35858号公報に記載の方法に従って製造したものを使用した。具体的には、ヒアルロン酸ナトリウムの1重量%水溶液中で、アースロバクター アトロシアネウスJU-01(Arthrobacter atrocyaneus JU-01)株(独立行政法人製品評価技術基盤機構 特許微生物寄託センター 受託番号:NITE P−245)を25℃で120時間静置培養した。その後、0.22μmのメンブレンフィルターで当該菌株を除去し、凍結乾燥することにより不飽和型ヒアルロン酸オリゴ糖を得た。得られたヒアルロン酸オリゴ糖は、2糖(構成単糖数が2)であり、非還元末端に位置するグルクロン酸の4位の炭素原子に結合している水酸基が除去され、4位の炭素原子と5位の炭素原子が二重結合で結合している構造を有していた。
表1に示す所定量のヒアルロン酸と不飽和型ヒアルロン酸オリゴ糖を添加した200mL容の容器に、室温の精製水を所定量添加(容器内の内容物の合計量100g)し、室温でプロペラ攪拌機にて500rpmの速度で撹拌を開始した。撹拌開始からヒアルロン酸のダマがなくなり、ヒアルロン酸が完全に溶解するまでの時間(溶解時間)を計測した。
表2に示す組成の外用組成物を調製した。具体的には、室温の水に、他の含有成分を同時に所定量添加し、室温でプロペラ攪拌機にて500rpmの速度で撹拌することにより、ヒアルロン酸を完全に溶解させたヒアルロン酸組成物を製造した。
<伸ばし易さ>
1点:塗布時に伸ばし難い
10点:塗布時に伸ばし易い
<塗布感>
1点:塗布時に重厚な塗布感がない
10点:塗布時に重厚な塗布感がある
<べたつき感のなさ>
1点:塗布時にべたつく
10点:塗布時にべたつかない
<浸透感>
1点:塗布から15秒後に浸透感がない
10点:塗布から15秒後に浸透感がある
<保湿感>
1点:塗布から15秒後にしっとりとした感じがない
10点:塗布から15秒後にしっとりとした感じがある
Claims (7)
- (A)ヒアルロン酸及び/又はその塩と、(B)ヒアルロン酸オリゴ糖及び/又はその塩と、(C)下記式(I)で表される、少なくとも1つのアルキレンオキシド誘導体を含有する、外用組成物(但し、ヒドロキシアルキル尿素を含む場合を除く)。
Z−{O(AO)l(EO)m−(BO)nH}a (I)
(式中、
Zは3〜9個の水酸基を有する化合物の水酸基を除いた残基を表し;
AOは炭素数3〜4のオキシアルキレン基を表し;
EOはオキシエチレン基を表し;
BOは炭素数4のオキシアルキレン基を表し;
aは3〜9を表し;
l、m及びnは、それぞれ、AO、EO及びBOの平均付加モル数であって、1≦l≦50、1≦m≦50及び0.5≦n≦5であり;
AOとEOとの重量比(AO/EO)は1/5〜5/1であり;
AO及びEOはランダム状又はブロック状に付加していてもよい) - 前記式(I)において、AOとEOがランダム状に付加している請求項1記載の外用組成物。
- 前記式(I)において、AOがオキシプロピレン基である請求項1又は2記載の外用組成物。
- 前記式(I)において、3〜9個の水酸基を有する化合物がグリセリンである、請求項1〜3のいずれかに記載の外用組成物。
- 前記(A)成分が、重量比で前記(B)成分の同量以上含まれる、請求項1〜4のいずれかに記載の外用組成物。
- 化粧料である、請求項1〜5のいずれかに記載の外用組成物。
- 前記(A)成分の平均分子量が110〜250万である、請求項1〜6のいずれかに記載の外用組成物。
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