JP6626111B2 - 心臓調節促進方法およびシステム - Google Patents
心臓調節促進方法およびシステム Download PDFInfo
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
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- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
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- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Cardiology (AREA)
- Neurology (AREA)
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- Biophysics (AREA)
- Physiology (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Electrotherapy Devices (AREA)
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Description
優先権出願の参照による組み込み
本願は、2015年1月5日に出願された米国仮特許出願第62/099,834号の優先権を主張するものである。その出願は、参照によってその全体が本明細書に組み込まれる。
Claims (7)
- 患者の心臓への電気信号の送達を促進するための神経変調システムであって:
近位端、
遠位端、
該近位端から該遠位端に向かって延びている管腔、および
外面
を含む、カテーテル本体と;
該外面上の電極であって、電気信号を患者の肺動脈に送達するように構成された電極と;
該外面上のセンサであって、該患者の血管系内の位置から心臓活動特性を感知するように構成されたセンサと
を含む、カテーテルを含み;さらに
刺激システムを含み、該刺激システムが:
第1系列の電気信号及び第2系列の電気信号を該電極に送達するように構成されたパルス発生器であって、
該第1系列が複数の第1電気信号を含んでおり、
該複数の第1電気信号の各々が複数のパラメータを含んでおり、
該第1系列の該複数の第1電気信号の各々が互いに、該複数のパラメータのうちの第1パラメータの大きさだけ異なっているにすぎず;
該第2系列が複数の第2電気信号を含んでおり、
該複数の第2電気信号の各々が該複数のパラメータを含んでおり、
該第2系列の該複数の第2電気信号の各々が互いに、該複数のパラメータのうちの第2パラメータの大きさだけ異なっているにすぎず、
該第2パラメータが該第1パラメータとは異なっている、パルス発生器と;
該電極への該第1系列の電気信号及び該第2の系列の電気信号の送達に応答した1つ以上の非電気的心臓活動特性を指し示すセンサデータを格納するように構成された非一時的コンピュータ可読媒体と;
該第1パラメータの選択された大きさ及び該第2パラメータの選択された大きさを該センサデータに少なくとも部分的に基づいて決定するように構成されたプロセッサと
を含んでおり、
該非一時的コンピュータ可読媒体が、該第1パラメータの該選択された大きさ及び該第2パラメータの該選択された大きさを格納するように構成されており、
該パルス発生器が、該第1パラメータの該選択された大きさ及び該第2パラメータの該選択された大きさを使用して治療的神経変調信号を該電極に送達するように構成されている、神経変調システム。 - 前記第1パラメータが、下記:極性、パルス発生モード、パルス幅、振幅、周波数、位相、電圧、電流、持続時間、パルス間隔、デューティサイクル、滞留時間、配列、波長または波形のうちの1つである、請求項1に記載の神経変調システム。
- 前記第2パラメータが、下記:極性、パルス発生モード、パルス幅、振幅、周波数、位相、電圧、電流、持続時間、パルス間隔、デューティサイクル、滞留時間、配列、波長または波形のうちの1つである、請求項1又は2に記載の神経変調システム。
- 前記心臓活動特性は、非電気的心臓活動特性を含み、該非電気的心臓活動特性が、圧力特性、加速度特性、音響特性、温度および血液化学特性のうちの少なくとも1つを含む、請求項1から3のいずれかに記載の神経変調システム。
- 前記パルス発生器は、第3系列の電気信号を該電極に送達するように構成され、該第3系列が複数の第3電気信号を含んでおり、該複数の第3電気信号の各々が複数のパラメータを含んでおり、該第3系列の該複数の第3電気信号の各々が互いに、該複数のパラメータのうちの第3パラメータの大きさだけ異なっているにすぎず、該第3パラメータは、前記第1パラメータ及び前記第2パラメータとは異なっている、請求項1から4のいずれかに記載の神経変調システム。
- 前記第1パラメータは振幅であり、前記第2パラメータは周波数である、請求項1から5のいずれかに記載の神経変調システム。
- 前記第1パラメータが電流を含み、前記第2パラメータが周波数およびデューティサイクルのうちの1つを含む、請求項1から5のいずれかに記載の神経変調システム。
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JP2018506328A (ja) | 2018-03-08 |
WO2016111940A1 (en) | 2016-07-14 |
CN107206241A (zh) | 2017-09-26 |
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