JP6542232B2 - 複数又は位置調節可能撹拌機設計のバイオリアクタ - Google Patents
複数又は位置調節可能撹拌機設計のバイオリアクタ Download PDFInfo
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- C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls
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Description
この出願は、出典明示によりその全体がここに援用される2013年9月16日出願の米国仮出願第61/878516号の優先権を主張するものである。
Claims (18)
- 異なった設計の容器を保持する構成とされ、頂部領域と底部領域を備えた支持構造と、
インペラと撹拌機モータを備えた撹拌機システムと
を具備し、
前記撹拌機システムと前記支持構造が、前記支持構造に保持される容器の設計に応じて前記支持構造に対して複数の位置に前記撹拌機モータを位置せしめる構成とされ、
前記複数の位置が、頂部取り付け撹拌機モータ位置と底部取り付け撹拌機モータ位置を含む、バイオリアクタであって、
前記撹拌機モータが前記複数の位置に選択的に取り付け可能であり、
前記異なった設計の容器は、頂部取り付け撹拌機モータ位置において前記撹拌機モータと使用される構成とされる容器、及び底部取り付け撹拌機モータ位置において前記撹拌機モータと使用される構成とされる容器を含む、バイオリアクタ。 - 前記複数の位置が、前記頂部取り付け撹拌機モータ位置と前記底部取り付け撹拌機モータ位置の間に少なくとも一の中間位置を更に含む、請求項1に記載のバイオリアクタ。
- 前記撹拌機モータが可変長シャフトに取り付けられた、請求項1または2に記載のバイオリアクタ。
- 前記支持構造が、頂部領域と底部領域を備え、前記インペラが、前記支持構造の前記頂部領域と底部領域の間の中間位置の範囲で選択的に作動される構成とされた、請求項1に記載のバイオリアクタ。
- 前記インペラが可変長シャフトに取り付けられた、請求項1または2に記載のバイオリアクタ。
- 前記支持構造内に存在し前記撹拌機モータに連結される構成とされた容器を更に備え、該容器が折り畳み可能なバッグである、請求項1から5の何れか一項に記載のバイオリアクタ。
- 前記折り畳み可能なバッグが、頂部取り付け撹拌機モータと共に使用される構成とされた、請求項6に記載のバイオリアクタ。
- 前記折り畳み可能なバッグが、底部取り付け撹拌機モータと共に使用される構成とされた、請求項6に記載のバイオリアクタ。
- 前記支持構造の底部に取り外し可能に位置せしめられる構成とされた、***支持面を持つスペーサを更に備えた、請求項1から8の何れか一項に記載のバイオリアクタ。
- 前記支持構造が、頂部開口部と該頂部開口部を少なくとも部分的に覆う構成とされた取り外し可能な蓋部を具備する、請求項1から9の何れか一項に記載のバイオリアクタ。
- 前記頂部開口部を覆うときと前記頂部開口部から取り外されるときに前記蓋部が前記支持構造に取り付けられる、請求項10に記載のバイオリアクタ。
- 前記支持構造が、内部プローブと外部プローブの双方と共に使用される構成とされた、請求項1から11の何れか一項に記載のバイオリアクタ。
- 支持構造と複数撹拌機モータシステムを備えたバイオリアクタを操作する方法であって、
頂部取り付け撹拌機バッグと底部取り付け撹拌機バッグからなる群からバイオリアクタバッグを選択し、
前記支持構造の頂部取り付け撹拌機モータと底部取り付け撹拌機モータから選択し、
前記選択されたバイオリアクタバッグを前記支持構造中に配し、
前記選択されたバイオリアクタバッグを前記選択された撹拌機モータと連結する
ことを含む、方法。 - 前記バイオリアクタ内のスペーサの存在を確認することを更に含む、請求項13に記載の方法。
- 前記バイオリアクタ内に前記スペーサを配することを更に含む、請求項14に記載の方法。
- 前記バイオリアクタ内から前記スペーサを取り除くことを更に含む、請求項14に記載の方法。
- 支持構造連結具にバッグ連結具を取り付けることを更に含む、請求項13から16の何れか一項に記載の方法。
- 前記頂部取り付け撹拌機モータの垂直位置を変えることを更に含む、請求項13から17の何れか一項に記載の方法。
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CN (2) | CN110172406B (ja) |
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