JP6285953B2 - パーソナルケア組成物中の共融混合物 - Google Patents
パーソナルケア組成物中の共融混合物 Download PDFInfo
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- JP6285953B2 JP6285953B2 JP2015548312A JP2015548312A JP6285953B2 JP 6285953 B2 JP6285953 B2 JP 6285953B2 JP 2015548312 A JP2015548312 A JP 2015548312A JP 2015548312 A JP2015548312 A JP 2015548312A JP 6285953 B2 JP6285953 B2 JP 6285953B2
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- A61K2800/244—Endothermic; Cooling; Cooling sensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Description
共融系は、同じ成分より成る他のいずれの混合物のうち最も低い融点を有する化学化合物または元素の混合物であり、この最も低い融点にて平衡である液体および固体の組成は同じである。本組成は「共融組成」として公知であり、対応する溶融温度は「共融温度」として公知である。
本発明の三元共融混合物は12−HSAを含む。12−HSAが酸形態で使用されるのは、これがL−メントールおよびL−メンチルラクテートと共に三元共融混合物を形成するためである。さらなる利点は、その酸形態の12−HSAが、とりわけ12−HSAがヒトの皮膚温度(すなわち約37℃)または室温にて液体である共融混合物の一部であるならば、より良好な生物学的利用能を有し得ることである。他の脂肪酸と同様に、12−HSAの見かけのpKaは、8より大であると予想される。好ましくは、本発明の活性共融混合物は、3から4の間のpHを有する。
メントールは、透明または白色であり、室温にて固体である、ろう状の結晶性物質である。メントールは、皮膚を和らげ冷やすため、公知のように、スキンケア製品および毛髪ケア製品などのパーソナルケア製品に使用される。
本発明のパーソナルケア組成物は:i)本発明による活性共融混合物およびii)化粧品的に許容される担体を含む。
(1)10から20個の炭素原子を有する、脂肪酸のアルケニルエステルまたはアルキルエステル。その例としては、イソアラキジルネオペンタノエート、イソノニルイソナノノエート、オレイルミリステート、オレイルステアレートおよびオレイルオレエートが挙げられる。
本発明の共融混合物は、その共融特性、すなわちより低い融点を失うことなくパーソナルケア組成物に処方できることが見出された。このことにより、共融混合物を個別に作製することによって実施することができ、事前に生成した共融混合物をパーソナルケア組成物の他の成分と組合せることができる。
メトラーDSC823を熱分析に使用して、融点を測定した。「純粋な」、すなわちL−メントール,L−メンチルラクテートおよび12−HSAのみを含む混合物では、温度範囲を−70から100℃に、走査速度を2℃/分にそれぞれ設定した。
表1の成分および表2Aおよび2Bに挙げた量を用いて、以下のように調製した、L−メントール、L−メンチルラクテートおよび12−HSAの混合物
3つの構成成分、L−メントール、L−メンチルラクテートおよび12−HSAを秤量して、次に乳鉢および乳棒によって均質な混合物が得られるまで粉砕することによって混合した。室温にて溶融を始めた混合物を、透明な液体が生成されるまで粉砕によって混合した。
これらの混合物の融点を測定し、結果を表2Aおよび2Bに示す。特定の混合物がより低い融点を有することが明らかに示されている。重量比が4:6であり、12−HSAの濃度が3つの構成成分をまとめた総重量に対して1重量%であるL−メントールおよびL−メンチルラクテートの共融組成物で、約−52℃の最も低い融点が測定された。この組成物は、本三元系の「真の」共融組成物に近いと考えられる。
[実施例2]
L−メントール、L−メンチルラクテートおよび12−HSAの事前に生成された混合物を含む表3Aによるパーソナルケア組成物(PCC1)を、以下のプロトコルを使用して調製した。
[実施例3]
を含む表3Bによるパーソナルケア組成物を、以下のプロトコルを使用して調製した。PCC2は、12−HSAを含むが、L−メントールおよびL−メンチルラクテートを含んでいない。PCC3において、L−メントール、L−メンチルラクテートおよび12−HSAを(すなわち事前に生成された共融混合物としてではなく)個別に添加した。
PCC1およびPCC2のDSC曲線を測定して(中圧るつぼ(120μl))、図1に示した。
Claims (13)
- L−メントール、L−メンチルラクテートおよび12−ヒドロキシステアリン酸の活性共融混合物であって、L−メントールのL−メンチルラクテートに対する重量比が2:8から9:1であり;前記共融混合物の総重量に基づいて計算した12−ヒドロキシステアリン酸の濃度が0.1から17重量%であり;前記共融混合物が40℃より低い融点を有する、活性共融混合物。
- 前記L−メントールのL−メンチルラクテートに対する重量比が2:8から8:2である、請求項1に記載の活性共融混合物。
- 前記共融混合物の総重量に基づいて計算した12−ヒドロキシステアリン酸の濃度が0.1から15重量%である、請求項1または請求項2に記載の活性共融混合物。
- 前記混合物が37℃より低い融点を有する、請求項1から3のいずれか一項に記載の活性共融混合物。
- i)請求項1から4のいずれか一項に記載の活性共融混合物およびii)化粧品的に許容される担体を含む、パーソナルケア組成物。
- パーソナルケア組成物全体に基づいて計算した、20重量%までの前記共融混合物を含む、請求項5に記載のパーソナルケア組成物。
- 0.005から15重量%の12−ヒドロキシステアリン酸を含む、請求項5または請求項6に記載のパーソナルケア組成物。
- 日焼け止め剤をさらに含む、請求項5から7のいずれか一項に記載のパーソナルケア組成物。
- ビタミンをさらに含む、請求項5から8のいずれか一項に記載のパーソナルケア組成物。
- 洗い流さないスキンローションおよびクリーム、シャンプー、毛髪コンディショナー、シャワージェル、化粧石鹸、発汗抑制剤、デオドラント、シェービングクリーム、口紅、ファンデーションおよび日焼け止め剤ローションより選択される、請求項5から9のいずれか一項に記載のパーソナルケア組成物。
- シャンプーまたは毛髪コンディショナーである、請求項5から10のいずれか一項に記載のパーソナルケア組成物。
- L−メントール、L−メンチルラクテートおよび12−ヒドロキシステアリン酸の前記事前に生成した活性共融混合物を前記パーソナルケア組成物の残りの成分の一部または全部と混合するステップを含む、請求項5から11のいずれか一項に記載のパーソナルケア組成物を調製する方法。
- 請求項5から11のいずれか一項に記載のパーソナルケア組成物をヒトの皮膚に適用する方法。
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CN2012087071 | 2012-12-20 | ||
CNPCT/CN2012/087071 | 2012-12-20 | ||
EP13152644 | 2013-01-25 | ||
EP13152644.4 | 2013-01-25 | ||
PCT/EP2013/074687 WO2014095255A1 (en) | 2012-12-20 | 2013-11-26 | Eutectic mixtures in personal care compositions |
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JP2016503764A JP2016503764A (ja) | 2016-02-08 |
JP6285953B2 true JP6285953B2 (ja) | 2018-02-28 |
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US (1) | US20150297484A1 (ja) |
EP (1) | EP2934456B1 (ja) |
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US10660836B2 (en) * | 2015-12-22 | 2020-05-26 | Conopco, Inc. | Hydroxy functionalized solvent based skin benefit composition |
EP3442495B1 (en) * | 2016-04-13 | 2020-07-15 | DSM IP Assets B.V. | 10-hydroxystearic acid compositions |
FR3059232B1 (fr) * | 2016-11-28 | 2019-09-13 | L'oreal | Composition cosmetique comprenant l'acide 12-hydroxystearique, une amine organique et un tensioactif |
WO2022023547A1 (en) * | 2020-07-31 | 2022-02-03 | Centre National De La Recherche Scientifique | Non-ionic hydrophobic deep eutectics as a deodorizing agent |
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US6897195B2 (en) * | 2002-07-24 | 2005-05-24 | Nanjing Zhongshi Chemical Co. | Composition of menthol and menthyl lactate, its preparation method and its applications as a cooling agent |
WO2007115593A1 (en) * | 2006-04-11 | 2007-10-18 | Symrise Gmbh & Co. Kg | Composition of menthyl lactate and a mixture of menthol isomers |
US8846651B2 (en) * | 2007-03-01 | 2014-09-30 | Takasago International Corporation | Lipid composition having excellent shape retention property and product |
JP5312847B2 (ja) * | 2008-05-30 | 2013-10-09 | 株式会社マンダム | 非水系温感皮膚洗浄用組成物 |
EP2174642A1 (en) * | 2008-10-10 | 2010-04-14 | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House | Use of Personal Care Composition |
CN103260594B (zh) * | 2010-11-11 | 2015-11-25 | 荷兰联合利华有限公司 | 包含12-羟基硬脂酸的留存型非固体皮肤调理组合物 |
EP2457554A1 (de) * | 2010-11-24 | 2012-05-30 | Symrise AG | Menthol enthaltende Mischung |
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2013
- 2013-11-26 US US14/651,674 patent/US20150297484A1/en not_active Abandoned
- 2013-11-26 WO PCT/EP2013/074687 patent/WO2014095255A1/en active Application Filing
- 2013-11-26 EP EP13795756.9A patent/EP2934456B1/en active Active
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US20150297484A1 (en) | 2015-10-22 |
EP2934456A1 (en) | 2015-10-28 |
EP2934456B1 (en) | 2016-03-02 |
WO2014095255A1 (en) | 2014-06-26 |
JP2016503764A (ja) | 2016-02-08 |
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