JP6231499B2 - ホウ酸を含む自己防腐油分散体 - Google Patents
ホウ酸を含む自己防腐油分散体 Download PDFInfo
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- JP6231499B2 JP6231499B2 JP2014558119A JP2014558119A JP6231499B2 JP 6231499 B2 JP6231499 B2 JP 6231499B2 JP 2014558119 A JP2014558119 A JP 2014558119A JP 2014558119 A JP2014558119 A JP 2014558119A JP 6231499 B2 JP6231499 B2 JP 6231499B2
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- oil
- oil dispersion
- borate
- boric acid
- dispersion according
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- 239000004533 oil dispersion Substances 0.000 title claims description 145
- 239000004327 boric acid Substances 0.000 title claims description 60
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- -1 tricopper diborate Chemical compound 0.000 claims description 60
- 239000000203 mixture Substances 0.000 claims description 58
- 239000003921 oil Substances 0.000 claims description 58
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- 239000003755 preservative agent Substances 0.000 claims description 42
- 230000002335 preservative effect Effects 0.000 claims description 30
- 239000012071 phase Substances 0.000 claims description 27
- 230000002421 anti-septic effect Effects 0.000 claims description 25
- 239000003093 cationic surfactant Substances 0.000 claims description 18
- 239000008346 aqueous phase Substances 0.000 claims description 15
- 239000006185 dispersion Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000013543 active substance Substances 0.000 claims description 14
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- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 13
- 125000002091 cationic group Chemical group 0.000 claims description 13
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 10
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- 239000003242 anti bacterial agent Substances 0.000 claims description 9
- 229910021538 borax Inorganic materials 0.000 claims description 9
- 239000003102 growth factor Substances 0.000 claims description 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
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- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 7
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- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 6
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- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims description 6
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- 229960001950 benzethonium chloride Drugs 0.000 claims description 6
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims description 6
- 229960004324 betaxolol Drugs 0.000 claims description 6
- CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 6
- 235000019438 castor oil Nutrition 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims description 6
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- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 claims description 6
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 6
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 6
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Description
本発明において、以下の言語は、以下の意味を有する:「防腐活性を有する組成物」または「防腐組成物」は、微生物および/もしくは真菌性不純物および/もしくは増殖、またはもしあれば、少しの微生物および/もしくは真菌性増殖から防腐される組成物、または、薬局方の防腐効果の要求を満足する組成物を言及する。
油相成分(油および活性剤)を、同じビーカーに連続的に量り取り、次いで、わずかに加熱(40℃)しながら磁気的に撹拌した。水相成分(ホウ酸、界面活性剤、等張化剤、緩衝液)を、同じビーカーに連続的に量り取り、次いで、わずかに加熱(40℃)しながら磁気的に撹拌した。両方の相を65℃に加熱した。油相に水相を素早く添加してエマルションを形成し、その後素早く75℃に加熱した。エマルション液滴サイズをその後、POLYTRON PT 6100を用いて5分間高剪断混合して減少させた。エマルションは乳白色となった。エマルションの温度を、氷浴を用いて20℃まで冷却した。最後のエマルションを10000psiの圧力で、5分間連続して循環させて、マイクロフルイダイザー(C5,Avestin)で均一化して得た。エマルションの温度を25℃に冷却した。次いで、0.1MのHClまたは0.1MのNaOH溶液を用いて、そのpHを8.00に調整した。窒素バブリングを用いて、エマルションをガラスバイアル内で調製し、次いで、オートクレーブ中、121℃で20分滅菌した。
実施例1のエマルション1〜6に欧州薬局方(第7版、モノグラフ5.1.3.)における防腐効果試験を行った。ホウ酸を除いたエマルション1’〜6’(実施例1のエマルション1〜6と同一である)も比較のために試験した。
この実施例は、インビボウサギモデルにおいて、実施例1のホウ酸または二ホウ酸三銅を含有するカチオン性エマルションの眼に対する許容性(ocular tolerance)を評価することを目的とする。
Claims (21)
- 分散された油相、水相および少なくとも1つのカチオン性界面活性剤を包含している、カチオン性の油分散体であって、
前記分散された油相は、前記油分散体の総重量において0.5重量%〜5重量%の範囲の量の油を含み、
前記カチオン性界面活性剤の量は、前記油分散体の総重量において0.0001重量%〜10重量%の範囲であり、
前記油分散体は、ホウ酸またはその塩を、前記油分散体の総重量において0.005重量%〜0.075重量%の量で含み、前記ホウ酸またはその塩の量が、前記油分散体が自己防腐されるように防腐に効果的な量であり、前記油分散体がソルビン酸およびリン脂質を含まない、カチオン性の油分散体。 - 前記分散された油相は、1重量%〜5重量%の範囲の量の前記油を含む、請求項1に記載の油分散体。
- 前記分散された油相は、1重量%〜2重量%の範囲の量の前記油を含む、請求項1又は請求項2に記載の油分散体。
- 前記油分散体は、0.005重量%〜5重量%の範囲の量の前記少なくとも1つのカチオン性界面活性剤を含む、請求項1〜3のいずれか1項に記載の油分散体。
- 前記油分散体は、0.01重量%〜2重量%の範囲の量の前記少なくとも1つのカチオン性界面活性剤を含む、請求項1〜4のいずれか1項に記載の油分散体。
- USPおよび/またはPh.Eur.の防腐剤有効性要件に従うのに十分な防腐活性を有する、請求項1〜5のいずれか1項に記載の油分散体。
- 水中油型エマルションである、請求項1〜6のいずれか1項に記載の油分散体。
- ホウ酸またはその塩の量が、0.008〜0.05重量%の範囲である、請求項1〜7のいずれか1項に記載の油分散体。
- ホウ酸またはその塩の量が、0.01〜0.05重量%の範囲である、請求項1〜8のいずれか1項に記載の油分散体。
- ホウ酸またはその塩の量が、0.01〜0.02重量%の範囲である、請求項1〜9のいずれか1項に記載の油分散体。
- ホウ酸またはその塩がホウ酸、ホウ酸ナトリウム、メタホウ酸ナトリウム、ホウ酸カルシウム、ホウ砂、二ホウ酸三銅、ホウ酸トリオレイル、ホウ酸リチウム、ホウ酸トリス(トリメチルシリル)、ホウ酸トリエチル、テトラフルオロホウ酸カリウム、ホウ酸二水素二ナトリウム、ホウ酸マンガン、ホウ酸オレイル、ホウ酸トリペンチル、ホウ酸トリブチル、ホウ酸トリメチル、ホウ酸トリドデシル、ホウ酸トリアザニウムまたはそれらの混合物の形態である、請求項1〜10のいずれか1項に記載の油分散体。
- 分散された油相が、鉱油(ワセリンまたは流動パラフィンなど);中鎖トリグリセリド(MCT);トリグリセリド油、植物油(ヒマシ油、トウモロコシ油、オリーブ油、大豆油、ゴマ油、綿実油、甘扁桃油など)または任意の好適な植物油;脂肪酸、ミリスチン酸イソプロピル、油性脂肪アルコール、ソルビトールと脂肪酸とのエステル、油性スクロースエステルまたはそれらの混合物から選択される油を含む、請求項1〜11のいずれか1項に記載の油分散体。
- 前記カチオン性界面活性剤が、塩化セタルコニウム(CKC)、塩化ベンゼトニウム、セトリミド、カチオン性脂質、オレイルアミン、ステアリルアミン、DOTAP(N−[1−(2,3−ジオレオイロキシ)プロピル]−N,N,N−トリメチルアンモニウム)塩化物、DOPE(ジオレイルホスファチジルエタノールアミン)、ポリ(エチレンイミン)(PEI)、ポリ−L−リジン(PLL)またはそれらの混合物から選択される、請求項1〜12のいずれか1項に記載の油分散体。
- 非イオン性界面活性剤を含む、請求項1〜13のいずれか1項に記載の油分散体。
- 非イオン性界面活性剤が、チロキサポール、ポロキサマー(ポロキサマー282もしくはポロキサマー188などまたはPluronic F−68LF(登録商標)もしくはLutrol F68(登録商標)など)、ポリソルベート(ポリソルベート20もしくはポリソルベート80など)、ソルトール、ポリオキシエチレン脂肪酸エステル(Emulphor(登録商標)など)、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンヒマシ油誘導体(Cremophor EL(登録商標)またはCremophor RH(登録商標)、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンステアリン酸エステルなど)、ラウリル硫酸ナトリウム、ソルビタンエステル、ビタミンE誘導体(ビタミンE−トコフェロールポリエチレングリコールコハク酸エステルなど)またはそれらの混合物から選択される、請求項14に記載の油分散体。
- 治療用活性剤をさらに含む、請求項1〜15のいずれか1項に記載の油分散体。
- 前記治療用活性剤が、抗アレルギー剤(クロモグリク酸ナトリウム、アンタゾリン、メタピリジン(methapyriline)、クロロフェニラミン、セチリジン、オロパタジン(olapatadine)、ケトチフェン、アゼラスチン、エピナスチン、エメダスチン、レボカバスチン(levocabastive)、テルフェナジン、アステミゾールおよびロラタジン、ピリラミンまたはプロフェンピリダミンなど);合成グルココルチコイドおよびミネラルコルチコイドならびにコレステロール代謝由来のより一般的なホルモン形態(プロゲステロン、エストロゲン、男性ホルモン(テストステロンDHEAなど)およびそれらの誘導体など);抗炎症薬(コルチゾン、ヒドロコルチゾン、酢酸ヒドロコルチゾン、デキサメサゾン、デキサメサゾン21−リン酸塩、フルオロキノロン(fluorocinolone)、メドリソン、プレドニゾン、メチルプレドニゾロン、酢酸プレドニゾロン、フルオロメトロン(fluoromethalone)、トリアムシノロン、ベタメタゾン、ロテプレドノール、フルメタゾン、モメタゾン、ダナゾール、ベクロメタゾン、ジフルプレドナートおよびトリアムシノロンアセトニドならびにそれらの誘導体など);非ステロイド系抗炎症薬(サリチル酸塩、インドメタシン、イブプロフェン、ジクロフェナク、フルルビプロフェン、2−アリールプロピオン酸、N−アリルアンスラニル酸、オキシカム、スルホンアニリド、ピラゾリジン誘導体、アリールアルカン酸、3−ベンゾフェニル酢酸および誘導体、ピロキシカムおよびCOX2阻害剤(ロフェコキシブ、ジクロフェナク、ニメスリド、ネパフェナクなど)など);抗新生物薬(カルムスチン、シスプラチン、マイトマイシンおよびフルオロウラシルなど);免疫学的な薬品(ワクチンおよび免疫刺激剤など);インスリン、カルシトニン、副甲状腺ホルモンおよびペプチドおよびバソプレッシン視床下部放出因子;βアドレナリン遮断薬(マレイン酸チモロール、レボブノロールHClおよびベタキソロールHCl、チモロールベース、ベタキソロール、アテノロール、ビファンドール(befundol)、メチプラノロール、フォルスコリン、カルテオロール(cartrolol)、エピネフリン、ピバロイル(dipivalyl)、オキソノロール、アセタゾラミドベースおよびメタゾラミドなど);サイトカイン、インターロイキン、プロスタグランジン(抗プロスタグランジン、およびプロスタグランジン前駆体も)ラタノプロスト、ビマトプロスト、フルプロストまたはトラボプロスト、および成長因子(表皮成長因子、線維芽細胞増殖因子、血小板由来成長因子、形質転換成長因子β、毛様体神経栄養成長因子、グリア由来神経栄養因子、NGF、EPO、PLGFなどの成長因子);抗血管新生化合物(VEGF阻害剤、VEGF溶解性受容体、VEGFトラップ、VEGF抗体、VEGFトラップ、抗VEGF−siRNAなど);抗体または抗体フラグメント、オリゴアプタマー、アプタマーおよび遺伝子フラグメント(オリゴヌクレオチド、プラスミド、リボザイム、小干渉RNA、核酸フラグメント、ペプチド、アンチセンス配列);免疫刺激剤(天然シクロスポリンまたは合成シクロスポリン、エンドキサン、シロリムス、タクロリムス、サリドマイド、タモキシフェンなど);分泌促進剤(ピロカルピンまたはセラメリン(celameline)など);ムチン分泌促進剤(15(S)−HETE、エカベトまたはジクアホソルなど);抗血栓溶解剤および血管拡張薬(rtPA、ウロキナーゼ、プラスミン、一酸化窒素ドナーなど);アンドロゲン模倣体、アマニ油サプリメント、アデノシンA3受容体アゴニスト、スクアレン;抗酸化剤(ルテイン、ビタミン、とりわけビタミンAなど);カルボニックアンヒドラーゼ阻害剤(ブリンゾラミド、ドルゾラミド、アセタゾラミド、メタゾラミド、ジクロロフェナミドなど);交感神経様作用薬(ブリモニジン、アプラクロニジン、ジピベフリン、エピネフリンなど);副交感神経興奮薬(ピロカルビンなど);コリンエステラーゼ阻害剤(フィゾスチグミン、エコチオフェートなど);抗ウイルス剤(イドクスウリジン、トリフルオロチミジン(trifluorotymidine)、アシクロビア、バラシクロビル、ガンシクロビル、シドフォビルおよびインターフェロンなど);抗生物質(アミノグリコシド、カルバセフェム、カルバペネム、セファロスポリン、糖ペプチド、ペニシリン、ポリペプチド、キノロン、スルホンアミド、テトラサイクリン、クロルテトラサイクリン、バシトラシン、ネオマイシン、ポリミキシン、グラミシジン、セファレキシン、オキシテトラサイクリン、クロラムフェニコール、カナマイシン、リファンピシン、トブラマイシン、ゲンタマイシン、シプロフロキサシン、アミノシド、エリスロマイシン、セフタジジム、バンコマイシン、イミペネムなど);抗真菌剤(ポリエン抗生物質、アゾール誘導体、イミダゾール、トリアゾール、アリルアミン、アンホテリシンBおよびミコナゾールなど);抗菌剤(スルホンアミド、スルファジアジン、スルファセタミド、スルファメチゾールおよびスルフイソキサゾール、ニトロフラゾンおよびプロピオン酸ナトリウムなど);および/またはそれらの誘導体;および/またはそれらのプロドラッグ;ならびに/またはそれらの前駆体;ならびに/または許容できるそれらの塩;単独または組み合わせ、から選択される、請求項16に記載の油分散体。
- 眼疾患または眼の状態の治療に使用するための、請求項1〜17のいずれか1項に記載の油分散体。
- カチオン性界面活性剤を含む水相および油相を乳化する工程および混合する工程を含む、請求項1〜18のいずれか1項に記載の油分散体の製造プロセス。
- 請求項1〜18のいずれか1項に記載の油分散体を包含しているマルチドーズ容器。
- カチオン性の油分散体へのホウ酸またはその塩の使用であって、
防腐促進剤として、カチオン性の油分散体の総重量において0.005重量%〜0.075重量%の範囲の量でのホウ酸またはその塩の使用であり、
前記油分散体は、分散された油相、水相および少なくとも1つのカチオン性界面活性剤を含み、
前記分散された油相は、前記油分散体の総重量において0.5重量%〜5重量%の範囲の量の油を含み、
前記カチオン性界面活性剤の量は、前記油分散体の総重量において0.0001重量%〜10重量%の範囲であり、
前記油分散体は、リン脂質を含まない、使用。
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EP12156652.5A EP2630952A1 (en) | 2012-02-23 | 2012-02-23 | Self-preserved oil dispersions comprising boric acid |
PCT/EP2013/053556 WO2013124415A1 (en) | 2012-02-23 | 2013-02-22 | Self-preserved oil dispersions comprising boric |
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HK (2) | HK1203153A1 (ja) |
IN (1) | IN2014DN06853A (ja) |
MX (1) | MX2014010005A (ja) |
MY (1) | MY169504A (ja) |
NZ (1) | NZ627861A (ja) |
PH (1) | PH12014501906A1 (ja) |
SG (1) | SG11201405098PA (ja) |
TW (1) | TWI564032B (ja) |
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US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
EP3174542A4 (en) | 2014-07-29 | 2018-01-03 | TherapeuticsMD, Inc. | Transdermal cream |
CA2976120A1 (en) * | 2015-02-24 | 2016-09-01 | The Board Of Trustees Of The University Of Illinois | Use of brimonidine for treating dry eye syndrome |
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CN110996904A (zh) | 2017-05-19 | 2020-04-10 | 奥古根有限公司 | 眼用组合物及使用方法 |
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MY198184A (en) * | 2018-09-21 | 2023-08-09 | Petroliam Nasional Berhad | Ionic liquids formulation as an environmentally friendly oil dispersant |
CN108853016A (zh) * | 2018-09-26 | 2018-11-23 | 广州大光制药有限公司 | 一种地夸磷索钠滴眼液及其制备方法 |
CA3162536A1 (en) * | 2019-12-18 | 2021-06-24 | Anja VOGT | Emulsions of bioactive lipophilic compounds including oils |
GR1010012B (el) * | 2020-05-12 | 2021-05-27 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση περιεχον κυκλοσπορινη |
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EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
TWI478730B (zh) * | 2009-12-03 | 2015-04-01 | Alcon Res Ltd | 眼科乳劑 |
WO2013008714A1 (ja) * | 2011-07-08 | 2013-01-17 | ロート製薬株式会社 | 眼科用水性組成物 |
EP2630952A1 (en) * | 2012-02-23 | 2013-08-28 | Novagali Pharma S.A. | Self-preserved oil dispersions comprising boric acid |
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2012
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2013
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- 2013-02-22 CA CA2862932A patent/CA2862932A1/en not_active Abandoned
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- 2013-02-22 US US14/380,655 patent/US9682147B2/en not_active Expired - Fee Related
- 2013-02-22 CN CN201380009668.6A patent/CN104220048A/zh active Pending
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Also Published As
Publication number | Publication date |
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TWI564032B (zh) | 2017-01-01 |
MX2014010005A (es) | 2015-03-09 |
UA112669C2 (uk) | 2016-10-10 |
NZ627861A (en) | 2016-02-26 |
JP2015509494A (ja) | 2015-03-30 |
AU2013224043B2 (en) | 2017-07-27 |
IN2014DN06853A (ja) | 2015-05-22 |
CN104220048A (zh) | 2014-12-17 |
MY169504A (en) | 2019-04-15 |
AU2013224043A1 (en) | 2014-08-21 |
WO2013124415A1 (en) | 2013-08-29 |
EP2630952A1 (en) | 2013-08-28 |
EA201400869A1 (ru) | 2014-12-30 |
HK1203153A1 (en) | 2015-10-23 |
PH12014501906A1 (en) | 2014-11-24 |
EP2816998A1 (en) | 2014-12-31 |
CA2862932A1 (en) | 2013-08-29 |
JP2018039828A (ja) | 2018-03-15 |
HK1203154A1 (en) | 2015-10-23 |
US9682147B2 (en) | 2017-06-20 |
US20150025020A1 (en) | 2015-01-22 |
TW201347786A (zh) | 2013-12-01 |
SG11201405098PA (en) | 2014-09-26 |
KR20140124405A (ko) | 2014-10-24 |
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