JP6163549B2 - 高周波神経調節のために低周波源を合成するためのシステム - Google Patents
高周波神経調節のために低周波源を合成するためのシステム Download PDFInfo
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- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36189—Control systems using modulation techniques
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37235—Aspects of the external programmer
- A61N1/37247—User interfaces, e.g. input or presentation means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36178—Burst or pulse train parameters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
- A61N1/39—Heart defibrillators
- A61N1/3956—Implantable devices for applying electric shocks to the heart, e.g. for cardioversion
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Description
Claims (19)
- 高周波神経調節治療を行うための神経調節システム(10)であって、
治療的に調節すべき組織に隣接して配置されるように構成された共通の電極を含むリード(12)と、
前記共通の電極を含む複数の電極と、
複数の電気端子(58)と、
調節出力回路(50)と、
スイッチングネットワーク(68)と、
制御回路(76)と、を有し、
前記複数の電気端子(58)は、それぞれの複数の電極(26)に結合され、前記共通の電極に前記リードを介して結合された共通の電気端子を含み、
前記調節出力回路(50)は、複数の個別電気パルス列を複数のパルス頻度でそれぞれ発生させるように構成され、
前記スイッチングネットワークは、前記複数の電気端子(58)と前記調節出力回路(50)の間に結合され、
前記制御回路(76)は、前記複数の個別電気パルス列を前記複数の電気端子(58)のうちの少なくとも2つから、前記共通の電極に結合された前記共通の電気端子(58)までそれぞれ同時に伝達するように、前記スイッチングネットワーク(68)を作動させ、それにより、複数の個別電気パルス列の任意の複数のパルス頻度よりも大きく且つ1KHzに等しいか又はそれよりも高い平均パルス頻度を有する組合せ電気パルス列を前記共通の電気端子のところに生成して、高周波神経調節治療を前記共通の電極から、調節すべき組織に行うように構成される、神経調節システム(10)。 - 前記平均パルス頻度は、50KHz未満である、請求項1に記載の神経調節システム(10)。
- 前記共通の電気端子における前記組合せ電気パルス列は、すべて正である一連のパルスを含む、請求項1に記載の神経調節システム(10)。
- 前記平均パルス頻度は、前記複数のパルス頻度の和に等しい、請求項1に記載の神経調節システム(10)。
- 前記複数のパルス頻度のうちの少なくとも2つは互いに同じである、請求項1に記載の神経調節システム(10)。
- 前記複数のパルス頻度のうちの少なくとも2つは互いに異なる、請求項1に記載の神経調節システム(10)。
- 前記調節出力回路(50)は、別の複数の個別電気パルス列を別のそれぞれの複数のパルス頻度で発生させるように更に構成され、
前記制御回路(76)は、別の複数の個別電気パルス列をそれぞれ別の複数の電気端子(58)から別の共通の電気端子まで同時に伝達するように、前記スイッチングネットワーク(68)を作動させるように更に構成され、それにより、IKHzよりも高い別の平均パルス頻度を有する別の組合せ電気パルス列を生成する、請求項1に記載の神経調節システム(10)。 - 前記調節出力回路(50)は、前記複数の個別電気パルス列を発生させるための単一の電源(60)を含む、請求項1に記載の神経調節システム(10)。
- 前記調節出力回路(50)は、前記複数の個別電気パルス列をそれぞれ発生させる複数の電源(60)を含む、請求項1に記載の神経調節システム(10)。
- 更に、ユーザインタフェース(18)を有し、前記ユーザインタフェースは、前記共通の電気端子(58)に対応する電極(26)を特定するユーザからの入力を受信するように構成され、
前記制御回路(76)は、前記共通の電気端子(58)に対応する電極(26)を特定するユーザからの入力に応答して、前記共通の電気端子(58)を選択するように構成される、請求項1に記載の神経調節システム(10)。 - 前記制御回路(76)は、前記共通の電気端子(58)に対応する前記電極(26)を特定するユーザからの入力に応答して、前記複数の電気端子(58)を自動的に選択するように構成される、請求項10に記載の神経調節システム(10)。
- 前記ユーザインタフェース(18)は、前記複数の電気端子(58)に対応する電極(26)を特定するユーザからの入力を受信するように更に構成され、
前記制御回路(76)は、前記複数の電気端子(58)に対応する電極(26)を特定するユーザの入力に応答して、前記複数の電気端子(58)を選択するように構成される、請求項10に記載の神経調節システム(10)。 - 前記ユーザインタフェース(18)は、ある電気端子(58)に対応する電極(26)を特定するユーザからの入力を受信するように更に構成され、
前記制御回路(76)は、前記ある電気端子(58)に対応する電極(26)を特定するユーザの入力に応答して、前記ある電気端子(58)を含まない前記複数の電気端子(58)を選択するように構成される、請求項10に記載の神経調節システム(10)。 - 前記調節出力回路(50)は、パルス振幅、パルス持続時間、及びパルス形状のうちの1つを含む調節パラメータの異なる値に従って、前記複数の個別電気パルス列のうちの少なくとも2つを発生させるように構成される、請求項1に記載の神経調節システム(10)。
- 前記制御回路(76)は、個別電気パルス列のそれぞれのパルスが互いに均一に離間するように、前記スイッチングネットワーク(68)を作動させるように構成される、請求項1に記載の神経調節システム(10)。
- 前記制御回路(76)は、前記複数の個別電気パルス列のうちの少なくとも1つのパルスが、前記組合せ電気パルス列のパルス間の時間間隔を最小時間間隔に制限する仕方で互いに可変的に離間されるように、前記スイッチングネットワーク(68)を作動させるように構成される、請求項1に記載の神経調節システム(10)。
- 前記複数の個別電気パルス列の各々における少なくとも1つのパルスは多相である、請求項1に記載の神経調節システム(10)。
- 前記制御回路(76)は、前記個別電気パルス列の各々を、循環的に変化する調節パラメータのセットに従って発生させるように、前記調節出力回路(50)に命令するように構成される、請求項1に記載の神経調節システム(10)。
- 前記制御回路(76)は、前記複数の個別電気パルス列をバーストパターンで繰返し発生させるように、前記調節出力回路(50)に命令するように構成される、請求項1に記載の神経調節システム(10)。
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US201261666833P | 2012-06-30 | 2012-06-30 | |
US61/666,833 | 2012-06-30 | ||
PCT/US2013/048686 WO2014005075A1 (en) | 2012-06-30 | 2013-06-28 | System for compounding low-frequency sources for high-frequency neuromodulation |
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JP2015521532A JP2015521532A (ja) | 2015-07-30 |
JP6163549B2 true JP6163549B2 (ja) | 2017-07-12 |
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US (2) | US9339655B2 (ja) |
EP (1) | EP2866888B1 (ja) |
JP (1) | JP6163549B2 (ja) |
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WO (1) | WO2014005075A1 (ja) |
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