JP6059706B2 - 用量設定機構及び注射デバイス - Google Patents
用量設定機構及び注射デバイス Download PDFInfo
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000013777 protein digestion Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 230000003248 secreting effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960004532 somatropin Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical class [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
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Description
ここで一つの実施態様において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、及び/又は、ペプチド、蛋白質、多糖類、ワクチン、DNA、RNA、酵素、抗体、又はそのフラグメント、ホルモン、又はオリゴヌクレオチド、又は上記の薬学的に活性な化合物の混合物であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病関連の合併症、深部静脈又は肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症、及び/又は、関節リウマチの処置、及び/又は、予防に有用であり、
ここで、更なる実施態様において、薬学的に活性な化合物は、糖尿病、又は糖尿病性網膜症などの糖尿病に関連する合併症の処置、及び/又は、予防のための少なくとも1つのペプチドを含み、
ここで、更なる実施態様において、薬学的に活性な化合物は、少なくとも1つのヒトインスリン、又はヒトインスリン類似体若しくは誘導体、グルカゴン様ペプチド(GLP−1)、又はその類似体若しくは誘導体、又はエキセンジン−3又はエキセンジン−4、若しくはエキセンジン−3又はエキセンジン−4の類似体若しくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2;
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2;
desPro36エキセンジン−4(1−39);
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);又は
desPro36[Asp28]エキセンジン−4(1−39);
desPro36[IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39);
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39);
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);
ここで、基−Lys6−NH2は、エキセンジン−4誘導体のC−末端と結合してもよく;
desPro36エキセンジンー4(1−39)Lys6−NH2(AVE0010);
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desAsp28,Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28 Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
desMet(O)14,Asp28,Pro36,Pro37,Pro38 エキセンジン−4(1−39)−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Asn−(Glu)5,desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2;
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2;
H−(Lys)6−des Pro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2;
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
又は前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容可能な塩若しくは溶媒和物;
から選択される。
1:用量設定機構;
2:ハウジング部材;
3:ナンバースリーブ(用量設定部材);
3a:突出部;
4:駆動スリーブ(駆動部材);
4′:遠位駆動部材;
4′′:近位駆動部材;
4′′′:カプラ;
4a:フランジ;
4b:スプライン;
4c:スプライン;
5:(第二の)クラッチ部材;
5a、5b:クラッチ歯;
5c:溝;
5d:ステップ;
5e:傾斜歯;
6:クリッカー;
6a、6b:クリッカー歯;
6c:溝;
6d:傾斜歯;
6′:第一のクリッカー部材;
6′′:第二のクリッカー部材;
7:クリッカースプリング;
8:ピストンロッド;
9:ボタン;
Claims (13)
- 薬物送達デバイス、好ましくは、再設定可能薬物送達デバイス用の用量設定機構であって、機構は:
用量設定部材(3)、
用量の投薬中、ピストンロッドを遠位方向に駆動させるための駆動部材(4)、ここで駆動部材(4)は、近位駆動部材(4′′)及び遠位駆動部材(4′)を含んでなり、
近位駆動部材(4′′)及び遠位駆動部材(4′)を解放可能に連結するための第一のクラッチ、
用量の設定中及び用量の投薬中、近位駆動部材(4′′)及び遠位駆動部材(4′)を連結状態に付勢するためのスプリング手段(7)、及び
近位駆動部材(4′′)及び用量設定部材(3)に関連付けられた係合手段(3a、4a)、
を含んでなり、
係合手段(3a、4a)は、近位駆動部材(4′′)の近位端から突出するフィンガ上に設けられたフック(4a)、及び用量設定部材(3)の近位端上の対応する内側に突出
するフランジ(3a)を含み、これにより、用量の投薬中、近位駆動部材(4′′)が用量設定部材(3)を遠位方向に引き込むが、用量設定部材(3)に対して近位方向への近位駆動部材(4′′)の相対的な軸方向運動を可能とすることを特徴とする、上記用量設定機構。 - 請求項1に記載の用量設定機構であって、機構は、使用者により機構にかけられる投薬力を伝達するための用量ボタンを更に含んでなる再設定可能機構であり、ここで係合手段(3a、4a)は、用量ボタンが用量投薬中又はその後に続いて押圧されたときにのみ、用量設定部材(3)に対する近位駆動部材(4′′)の、近位方向への相対的な軸方向運動を可能にし、そして再設定中で用量ボタンが押し下げされないとき、相対的な軸方向運動に抵抗することを特徴とする、上記用量設定機構。
- 第一のクラッチが、用量の設定中及び用量の投薬中、近位駆動部材(4′′)及び遠位駆動部材(4′)を回転連結し、そして機構の再設定中、近位駆動部材(4′′)及び遠
位駆動部材(4′)を回転連結解除することを特徴とする、請求項1又は2に記載の用量設定機構。 - 近位駆動部材(4′′)が、用量設定部材(3)に対して近位方向に移動しなかった場合、第一のクラッチは、回転連結解除することになり、ピストンロッドの再設定を可能にすることを特徴とする、請求項1〜3のいずれか1項に記載の用量設定機構。
- 近位駆動部材(4′′)及び用量設定部材(3)を解放可能に連結するための第二のクラッチを更に含んでなる請求項1〜4のいずれか1項に記載の用量設定機構であって、第二のクラッチ(5)が、近位駆動部材(4′′)上に設けられたスプライン(4b)を係合する少なくとも一つの軸方向の溝(5c)を有する管状エレメントを含むことを特徴とする、上記用量設定機構。
- 請求項5に記載の用量設定機構であって、少なくとも一つの軸方向の溝(5c)が、小さい幅を有する溝(5c)の第一の部分から、大きい幅を有する溝の第二の部分への遷移部に位置するステップ(5d)を備え、ここでスプライン(4b)の幅が、スプラインが溝(5c)の両部分内で摺動することを可能とするように選択されることを特徴とする、上記用量設定機構。
- 軸方向の溝(5c)内のステップ(5d)が、再設定中、近位駆動部材(4′′)の近位運動を阻止することを特徴とする、請求項6に記載の用量設定機構。
- スプライン(4b)を溝(5c)に対してある角度位置に付勢し及び/又は保持するための手段を更に含んでなる、請求項5又は6に記載の用量設定機構。
- スプライン(4b)を付勢し及び/又は保持するための手段は、機構の再設定中、第二のクラッチ(5)及び近位駆動部材(4′′)を解放可能に連結するためのクリッカー機構(6)を含むことを特徴とする、請求項8に記載の用量設定機構。
- クリッカー機構(6)は、二つのクリッカー部分を含み、ここで第一のクリッカー部分(6′)は、クラッチ(5)に回転して解放可能に連結され、第二のクリッカー部分(6′′)は、近位駆動部材(4′′)に回転固定され、そして二つのクリッカー部分(6′,6′′)は、互いに回転解放可能に連結されることを特徴とする、請求項9に記載の用量設定機構。
- 請求項9又は10に記載の用量設定機構であって、第一のクリッカー部分(6′)が、
対応するクリッカー溝(6c)に係合するクリッカースプライン(4c)により、近位駆動部材(4′′)に回転固定され、ここで、クリッカースプライン(4c)及び/又はクリッカー溝(6c)は、丸みを帯びた外形を有することを特徴とする、上記用量設定機構。 - 第二のクラッチ(5)が、用量の設定中、用量設定部材(3)及び駆動部材(4)を回転連結し、及び用量の投薬中、用量設定部材(3)及び駆動部材(4)を回転連結解除することを特徴とする、請求項1〜11のいずれか1項に記載の用量設定機構。
- 請求項1〜12のいずれか1項に記載の用量設定機構を含んでなる注射デバイス。
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EP11159758.9 | 2011-03-25 | ||
PCT/EP2012/055058 WO2012130705A1 (en) | 2011-03-25 | 2012-03-22 | Dose setting mechanism and injection device |
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GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
JP6422969B2 (ja) * | 2013-11-15 | 2018-11-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用のアセンブリおよび薬物送達デバイス |
EP2891503A1 (en) * | 2014-01-02 | 2015-07-08 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device |
CN106456888B (zh) * | 2014-06-26 | 2019-12-31 | 诺和诺德股份有限公司 | 笔形扭簧驱动注射装置 |
TW201603847A (zh) * | 2014-07-01 | 2016-02-01 | 賽諾菲公司 | 注射裝置及組裝方法 |
TW201618821A (zh) * | 2014-10-09 | 2016-06-01 | 賽諾菲公司 | 驅動套筒、藥物傳輸裝置及組裝藥物傳輸裝置的方法 |
PL414382A1 (pl) | 2015-10-15 | 2017-04-24 | Copernicus Spółka Z Ograniczoną Odpowiedzialnością | Mechanizm nastawczy, w szczególności do dozowania |
CN105944186B (zh) * | 2016-05-18 | 2019-08-02 | 苏州鹏烨医疗科技有限公司 | 一种注射笔 |
US11292922B2 (en) * | 2017-05-12 | 2022-04-05 | Inhibit Coatings Limited | Composite resins containing silver nanoparticles |
US10688247B2 (en) | 2017-07-13 | 2020-06-23 | Haselmeier Ag | Injection device with flexible dose selection |
US11969583B2 (en) | 2018-07-17 | 2024-04-30 | Medmix Switzerland Ag | Injection device with dose interruption fail safe |
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GB9007113D0 (en) * | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
US5725508A (en) * | 1994-06-22 | 1998-03-10 | Becton Dickinson And Company | Quick connect medication delivery pen |
WO2006024461A1 (en) * | 2004-09-02 | 2006-03-09 | Sanofi-Aventis Deutschland Gmbh | Method of assembly of drug delivery devices |
ES2427146T3 (es) | 2004-10-04 | 2013-10-29 | Sanofi-Aventis Deutschland Gmbh | Mecanismo accionador para un dispositivo de descarga de fármacos |
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WO2006045526A1 (en) * | 2004-10-21 | 2006-05-04 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
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CA2773928A1 (en) | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Injection device |
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