JP6034466B2 - ポイントオブケア・テストの結果を読み取るためのハンドヘルド・スキャナ・システム及び方法 - Google Patents
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Description
一態様では、診断分析の実行のためのシステムについて説明される。システムの諸実施形態は、テスト・デバイス及び/又はスキャニング・デバイスを含むことができる。例えばテスト・デバイスは、好適なスキャニング・デバイスと共に、サンプル中の検体を検出するために使用することができる。ある諸実施形態では、サンプル中のタンパク質、核酸、及び/又は小分子などの検体を検出し、その有無を判断する際に使用するために、テスト・デバイス及び/又はスキャニング・デバイスが提供可能である。
前述のように、開示された診断分析システムはテスト・デバイス及びスキャニング・デバイスを含むことが可能であり、デバイスはサンプル内の1つ又は複数の問題の検体を検出するように互いに関連して使用可能であって、サンプルはテスト・デバイスによって処理され、検体はスキャニング・デバイスによって検出されることが可能である。いくつかの実施では、テスト・デバイス及びスキャニング・デバイスは別々の実施形態として提供可能であり、それぞれ、本明細書で説明されるように、それらの対応する機能の少なくとも一部を提供するように構成される。
図4及び図5は、スキャニング・デバイス215の例示的実施形態を示す。前述のように、スキャニング・デバイス215は、エネルギー放出源225、光学アセンブリ230、検出器235、並びにマイクロプロセッサ240及び関連付けられたメモリを含むことが可能であり、それぞれシャーシ245内に配設される。スキャニング・デバイス215は、容易に持ち運べるよう構成可能であり、バッテリ充電可能であり、ユーザが手に持つことが可能であり、ユーザのポケットに十分入るように小型であることが可能である。シャーシ245の遠位部分付近には、以下でより詳細に説明するように、スキャニング・デバイス215が診断レーンを含むテスト・デバイスを読み取る際に通過するアパチャ255を有するインターフェース領域250がある。テスト・デバイスの読み取りを実行するために、シャーシ245は、インターフェース領域250が診断レーン方向を指示した状態で、テスト・デバイスの診断レーンの上を掃引される。スキャニング・デバイス215のシャーシ245は、テスト・デバイスに関してユーザが自由に動かすように構成可能であり、その逆もまた可能である。ある諸実施形態では、テスト・デバイスはスキャニング・デバイス215のシャーシ245内に挿入又は装填されない。
押しボタン、キーパッド、マウス、及びその他ユーザの入力を受け取るためのものなどの、1つ又は複数のユーザ入力モジュール775を含むことができる。加えて、デバイス715は、検出器35及び235に対応可能な1つ又は複数の検出器モジュール735、並びに、源25及び225に対応可能な1つ又は複数のエミッタ/源モジュール725を含むことができる
サンプル収集デバイス(SCD)は、同様に、本明細書で説明される診断分析システムに含められることを理解されたい。一般に、サンプルは、サンプルをテスト・デバイスに印加するための準備を行い、スキャナを介して結果を読み取るSCDを使用して、処理可能である。例えばいくつかの実施形態では、サンプルは、SCD(例えば検出及び捕捉プローブ、及び/又は抽出試薬)内に存在する試薬に接触する、SCD及び1つ又は複数の検体から取得又はこれに追加することができる。その後サンプルは処理され、SCDを介してテスト・デバイスへ移送され、スキャナで読み取られることが可能である。
Claims (16)
- 1つ以上のテスト・ライン及び1つ以上のしるしを有するテスト・ストリップを含むテスト・デバイスと、スキャニング・デバイスと、を備える診断分析システムであって、前記スキャニング・デバイスは、
i)電磁放射線の源と、
ii)前記電磁放射線を誘導するように配置された光学アセンブリと、
iii)前記テスト・ストリップからの放射又は反射を受け取るように配置された検出器であって、前記1つ以上のテスト・ラインからの放射又は反射を検出するように構成された第1検出器と、前記1つ以上のしるしからの放射又は反射を検出するように構成された第2検出器と、を備える検出器と、
iv)マイクロプロセッサと、
v)シャーシと、を備え、
前記テスト・デバイス及び前記スキャニング・デバイスは、前記スキャニング・デバイスの動作中に互いに対して移動可能なように構成され、前記マイクロプロセッサは、前記しるし及び前記テスト・ラインの1つ以上に少なくとも部分的に基づいてテスト結果データを生成するように構成される、診断分析システム。 - 前記しるしは、各しるしがテスト・ラインに対応するように前記1つ以上のテスト・ラインに隣接して位置決めされる、請求項1に記載のシステム。
- 前記テスト・デバイスは、窓を有する本体をさらに備え、前記本体は、前記窓を通過する前記源からの出力に対して前記1つ以上のテスト・ラインが露出可能なように構成される、請求項1に記載のシステム。
- 前記テスト・デバイス及び前記スキャニング・デバイスは、少なくとも1つの平面内で互いに対して自由に移動可能なように構成される、請求項1に記載のシステム。
- 前記シャーシは、ハンドヘルド・シャーシとして構成され、前記シャーシの先端領域付近にテスト・デバイス・インターフェースをさらに備える、請求項1に記載のシステム。
- 前記テスト・デバイス・インターフェースに結合された遮蔽体をさらに備え、前記遮蔽体は、前記スキャニング・デバイスのアパチャを通過して前記スキャニング・デバイスに入って来る周辺光を遮蔽するように、前記アパチャを囲むように構成される、請求項5に記載のシステム。
- 前記ハンドヘルド・シャーシは、前記テスト・デバイス・インターフェース付近の前記シャーシの前記先端領域から離れるように延在する並行レールを備える、請求項5に記載のシステム。
- 前記テスト・デバイスは、前記ハンドヘルド・シャーシの前記並行レールを受け入れるように形作られた1対の縦方向チャネルを備える、請求項7に記載のシステム。
- 前記マイクロプロセッサは、前記テスト・デバイスと前記スキャニング・デバイスとの間の相対的な動きを補償するように、前記テスト結果データを生成するように構成される、請求項1に記載のシステム。
- 前記補償は、前記テスト・デバイスと前記スキャニング・デバイスとの間の前記相対的な動きの間の可変速度の補償を含む、請求項9に記載のシステム。
- 前記マイクロプロセッサは、前記テスト・ストリップと前記スキャニング・デバイスとの間の相対的な角度オフセットを補償するように、前記テスト結果データを生成するように構成される、請求項1に記載のシステム。
- 前記テスト・ラインには捕捉部分が固定化される、請求項1に記載のシステム。
- 前記テスト・デバイスは基板を含み、前記基板は、捕捉部分が、特定の検体と複合体を形成された対応の捕捉プローブに反応することを確実にする1つ以上の制御ラインをさらに備える、請求項1に記載のシステム。
- 前記検出器は電荷結合素子(CCD)を備える、請求項1に記載のシステム。
- 問題の検体を検出するためにサンプルを分析する方法であって、
サンプル収集デバイスからのサンプルをテスト・デバイスに提供するステップであって、前記テスト・デバイスが、1つ以上の問題の検体を直接的又は間接的に明確に結合する捕捉部分が固定化された1つ以上のテスト・ラインを備え、1つ以上のしるしが、前記1つ以上のテスト・ラインに隣接する前記テスト・デバイスの表面上に位置決めされる、提供するステップと、
スキャニング・デバイスに対して前記テスト・デバイスを移動させるステップと、
前記テスト・ラインの1つ以上及び前記しるしの1つ以上を読み取るステップと、を含み、
前記読み取るステップは、
前記スキャニング・デバイスの第1検出器で、前記1つ以上のテスト・ラインからの放射又は反射を検出し、前記スキャニング・デバイスの第2検出器で、前記1つ以上のしるしからの放射又は反射を検出するステップと、
前記読み取りに少なくとも部分的に基づいてテスト結果データを生成するステップと、
前記テスト結果データをメモリに格納するステップと、を含む、方法。 - 前記第1検出器及び前記第2検出器の少なくとも1つは電荷結合素子(CCD)である、請求項15に記載の方法。
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ES2890752T3 (es) | 2012-02-06 | 2022-01-21 | Univ California | Lector de prueba de diagnóstico rápido portátil |
US9207181B2 (en) * | 2012-03-01 | 2015-12-08 | Quidel Corporation | System and apparatus for point-of-care diagnostics |
JP5935121B2 (ja) * | 2012-07-18 | 2016-06-15 | 多摩川精機株式会社 | データ入力システム、マウスおよびマウスパッド |
BR112015001639A2 (pt) * | 2012-07-24 | 2017-07-04 | Fio Corp | dispositivo, sistema, método e meio legível por computador de análise universal de teste de diagnóstico rápido de imunoensaio |
EP2892587B1 (en) * | 2012-09-04 | 2024-07-03 | Fenwal, Inc. | Interface detector for blood processing system |
TW201417002A (zh) * | 2012-10-25 | 2014-05-01 | Roland Taiwan Electronic Music Corp | 行動化建置產品履歷系統及產線作業之管控方法 |
GB201221015D0 (en) * | 2012-11-22 | 2013-01-09 | Microlab Devices Ltd | Test strip nd methods and apparatus for reading the same |
EP2746750A1 (de) * | 2012-12-22 | 2014-06-25 | Zendia GmbH | PoC-Testsystem und -verfahren mit mobiler Rechnereinheit |
EP2781910B1 (en) | 2013-03-21 | 2024-05-15 | Microdiscovery Gmbh | Portable reader module, portable reader, and method for quantitative analysis of an assay |
JP6127229B2 (ja) * | 2013-07-30 | 2017-05-17 | 多摩川精機株式会社 | データ入力システム |
WO2015024553A1 (de) * | 2013-08-20 | 2015-02-26 | opTricon Entwicklungsgesellschaft für Optische Technologien mbH | Vorrichtung zur digitalen ablesung für schnelltests |
TW201514861A (zh) * | 2013-10-08 | 2015-04-16 | Hui-Qi Gu | 檢測卡匣讀取裝置及其讀取方法 |
TWI560437B (en) * | 2013-11-19 | 2016-12-01 | Univ Nat Tsing Hua | Fluorescence excitation device and portable fluorescence analysis system with the same |
US9989466B2 (en) | 2013-12-06 | 2018-06-05 | Quidel Corporation | Method for reducing analyzer variability using a normalization target |
TW201527756A (zh) * | 2014-01-10 | 2015-07-16 | Nat Univ Tsing Hua | 提供食品安全地圖之方法、電腦程式產品、和系統 |
WO2016022152A1 (en) * | 2014-08-08 | 2016-02-11 | Empire Technology Development Llc | Quality control of dairy products using chromatic profiles |
US9752935B2 (en) * | 2014-08-29 | 2017-09-05 | Marqmetrix, Inc. | Portable analytical equipment |
US9568432B2 (en) * | 2014-09-26 | 2017-02-14 | Intel Corporation | Sensor apparatus to determine a value of a chemical parameter based on a color shade and methods thereof |
US20160122794A1 (en) * | 2014-10-30 | 2016-05-05 | Sightline Innovation Inc. | System, method and apparatus for pathogen detection |
GB201506992D0 (en) * | 2014-11-14 | 2015-06-10 | Nplex Pty Ltd | A portable in-vitro diagnostic detector |
EP3078975B1 (en) | 2015-04-10 | 2021-06-09 | Nokia Technologies Oy | An apparatus and method for sensing |
CN104914239A (zh) * | 2015-06-29 | 2015-09-16 | 上海交通大学 | 一种免疫层析试纸条检测设备 |
CN105699339B (zh) * | 2016-02-01 | 2018-07-03 | 北京理工大学 | 一种激光诱导长波红外胶体金试纸定量检测装置 |
AU2017232344B2 (en) | 2016-03-14 | 2022-08-04 | Pfizer Inc. | Selectively vented biological assay devices and associated methods |
DK3430378T3 (da) | 2016-03-14 | 2022-10-24 | Lucira Health Inc | Indretninger og fremgangsmåder til modifikation af optiske egenskaber |
CN107657190A (zh) * | 2016-07-25 | 2018-02-02 | 昆山研达电脑科技有限公司 | 扫描方法 |
US11080848B2 (en) | 2017-04-06 | 2021-08-03 | Lucira Health, Inc. | Image-based disease diagnostics using a mobile device |
KR102005621B1 (ko) * | 2017-06-21 | 2019-07-30 | 주식회사 나노바이오라이프 | 면역 크로마토크래피 신속 진단 키트 및 이를 이용한 검사 방법 |
US10121036B1 (en) | 2017-06-30 | 2018-11-06 | Danny Klein | System and method for collecting environmental test data |
WO2019050837A1 (en) * | 2017-09-06 | 2019-03-14 | Clemson University Research Foundation | COUPON DESIGN WITH ENHANCED COLOR SENSITIVITY FOR LIQUID-BASED CHEMICAL ANALYSIS OF LIQUIDS |
EP3769345B1 (en) | 2019-04-10 | 2023-12-20 | Google LLC | Portable rapid large area thin film photosinterer |
MX2019005940A (es) * | 2019-05-21 | 2019-10-11 | Atso Corp Affairs S A De C V | Biomarcadores relacionados a cancer. |
WO2021102175A1 (en) * | 2019-11-19 | 2021-05-27 | Ivd Vision, Llc | Methods and compositions for lateral flow analyte assays |
JP7133247B2 (ja) * | 2021-02-04 | 2022-09-08 | 株式会社Icst | 検査器具、検査キットおよび検査方法 |
JP6976621B1 (ja) * | 2021-02-04 | 2021-12-08 | 株式会社Icst | 検査器具、検査キットおよび検査方法 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5408535A (en) * | 1993-09-07 | 1995-04-18 | Miles Inc. | Video test strip reader and method for evaluating test strips |
US20010041843A1 (en) | 1999-02-02 | 2001-11-15 | Mark Modell | Spectral volume microprobe arrays |
US6394952B1 (en) * | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
US6551842B1 (en) * | 1999-03-26 | 2003-04-22 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US7390675B2 (en) * | 1999-10-15 | 2008-06-24 | Christopher Feistel | Multi-functional and configurable assay |
EP1102101A1 (de) | 1999-11-22 | 2001-05-23 | Leica Microsystems Heidelberg GmbH | Laserscanmikroskop |
JP4335414B2 (ja) * | 2000-02-02 | 2009-09-30 | 大塚製薬株式会社 | 試験紙測定方法 |
US20020137053A1 (en) * | 2000-07-19 | 2002-09-26 | Dana Ault-Riche | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening |
EP1249696B1 (en) * | 2000-09-25 | 2012-09-19 | Panasonic Corporation | Device for chromatographic quantitative measurement |
JP2002206088A (ja) * | 2000-11-08 | 2002-07-26 | Hitachi Maxell Ltd | 蛍光錯体およびインク組成物 |
US6630680B2 (en) * | 2000-12-25 | 2003-10-07 | Fuji Photo Film Co., Ltd. | Scanner having confocal optical system, method for producing focus position data of confocal optical system of scanner having confocal optical system and method for producing digital data of scanner having confocal optical system |
EP1493014A2 (en) * | 2001-04-11 | 2005-01-05 | Burstein Technologies, Inc. | Multi-parameter assays including analysis discs and methods relating thereto |
US7365849B2 (en) * | 2001-12-27 | 2008-04-29 | Taiwan Unison Biotechnology, Inc. | Portable, scanning and analyzing apparatus |
US20040096363A1 (en) * | 2002-11-18 | 2004-05-20 | Larry Porter | Point-of-care assay reader and analyzer |
JP2004170217A (ja) * | 2002-11-19 | 2004-06-17 | Hamamatsu Photonics Kk | 呈色測定装置 |
JP4578478B2 (ja) * | 2003-04-10 | 2010-11-10 | ケント ボーヒース, | バクテリオファージを使用した微生物を検出するための装置および方法 |
US7097103B2 (en) * | 2003-05-22 | 2006-08-29 | Wen-Chao Tseng | Method of automatically detecting a test result of a probe zone of a test strip |
US7444005B2 (en) * | 2003-11-04 | 2008-10-28 | Becton, Dickinson And Company | Apparatus and method for using optical mouse engine to determine speed, direction, position of scanned device and to obtain quantitative or qualitative data from same |
FI116261B (fi) * | 2003-11-06 | 2005-10-14 | Valtion Teknillinen | Järjestelmä ja menetelmä ja palvelin kuvatiedon analysoimiseksi sekä lukijalaite kooditiedon määrittämiseksi |
US20060292040A1 (en) * | 2005-06-16 | 2006-12-28 | James Wickstead | Hand held test reader |
US7339673B2 (en) * | 2004-03-05 | 2008-03-04 | Siemens Healthcare Diagnostics Inc. | Miniature optical readhead for optical diagnostic device |
US8128871B2 (en) * | 2005-04-22 | 2012-03-06 | Alverix, Inc. | Lateral flow assay systems and methods |
CN2706765Y (zh) * | 2004-04-23 | 2005-06-29 | 中国人民解放军军事医学科学院微生物流行病研究所 | 基于上转换发光技术免疫层析试纸条 |
US7335898B2 (en) * | 2004-07-23 | 2008-02-26 | Ge Healthcare Niagara Inc. | Method and apparatus for fluorescent confocal microscopy |
JP2006208386A (ja) * | 2005-01-26 | 2006-08-10 | Agilent Technol Inc | 複数の標識を有するアッセイテスト細片及びその読み取り法 |
US7768638B2 (en) * | 2005-03-18 | 2010-08-03 | Illumina, Inc. | Systems for and methods of facilitating focusing an optical scanner |
KR101255400B1 (ko) * | 2005-05-23 | 2013-04-17 | 파디아 에이비 | 2 단계 횡 유동 검사 방법 및 장치 |
US7572460B2 (en) * | 2005-10-25 | 2009-08-11 | Rodrigo Rodriguez-Kabana | Hydrogen cyanamide pesticide formulations |
EP1801568A1 (de) * | 2005-12-21 | 2007-06-27 | Micronas Holding GmbH | Teststreifen und Verfahren zum Messen einer Analytkonzentration in einer Probe eines biologischen Fluids |
ES2433377T3 (es) * | 2006-02-21 | 2013-12-10 | Nexus Dx, Inc. | Procedimientos y composiciones para la detección de analitos |
US8789756B2 (en) * | 2006-02-25 | 2014-07-29 | Roche Diagnostics Operations, Inc. | Test element coding apparatuses, systems and methods |
WO2009014787A2 (en) | 2007-04-30 | 2009-01-29 | Nanogen, Inc. | Multianalyte assay |
US8940495B2 (en) * | 2008-02-29 | 2015-01-27 | BioMedomics, Inc | Rapid and sensitive method for quantitative determination of the level of heparin—PF4 complex induced immunoglobulin antibodies |
US8012770B2 (en) * | 2009-07-31 | 2011-09-06 | Invisible Sentinel, Inc. | Device for detection of antigens and uses thereof |
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CN104237539A (zh) | 2014-12-24 |
JP5893552B2 (ja) | 2016-03-23 |
US8638441B2 (en) | 2014-01-28 |
WO2010118185A2 (en) | 2010-10-14 |
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WO2010118185A3 (en) | 2011-01-13 |
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