JP5969522B2 - 改善された透析液再生のための吸着剤カートリッジの構成 - Google Patents
改善された透析液再生のための吸着剤カートリッジの構成 Download PDFInfo
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
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- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1668—Details of containers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1668—Details of containers
- A61M1/167—Flexible packaging for solid concentrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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Description
本出願は、2013年2月2日に出願された米国仮特許出願第61/760,079の優先権を主張するが、その全体的な内容は参照によって本明細書に組み入れられる。
特に定義されない限り、本明細書で使用される専門用語及び科学用語はすべて一般に、当業者によって共通して理解されるものと同じ意味を有する。本明細書で提供される定義は、明細書、特許請求の範囲及び図面の他の部分において、文脈及び提供される他の生得的な意味を考慮しないで、又はその使用によって厳格に解釈されるべきではない。
Upreは透析前の尿素のレベルであり
Upostは透析後の尿素のレベルであり
URRは尿素除去「比率」として正式に定義され、実践上、非公式に上記式で示されるように100%を乗じてパーセントとして表される。
モジュール方式透析システム
実施例
含水酸化ジルコニウムの合成
含水酸化ジルコニウムのカラム試験
リン酸ジルコニウムのカラム試験
混合チャンバーを伴う二段階吸着剤カートリッジ
Claims (20)
- 血液透析の間に透析液を再生するためのシステムにおいて、
第1の選択された再生物質を含有する第1の再生モジュール(50)と、
前記第1の選択された再生物質を含有する第2の再生モジュール(52)と、
第1の混合チャンバー(48)とを含み、
流体の第1の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記第1の選択された再生物質と流体連通する前記第1の再生モジュール(50)を通って流れ、前記第1の混合チャンバー(48)に戻り、流体の第2の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記第1の選択された再生物質と流体連通する前記第2の再生モジュール(52)を通って流れる、システム。 - 第1の混合チャンバーに入る流体の第1の入口の流れが、第1の混合チャンバーにて、第1の混合チャンバーに入る流体の第2の入口の流れと混合される、請求項1のシステム。
- 第1の混合チャンバーがさらに静的ミキサー要素を含む、請求項2のシステム。
- 混合チャンバーが第1の入口の流れを第2の入口の流れから分離する半透膜をさらに含み、溶質が第1の入口の流れから第2の入口の流れに拡散する、請求項2のシステム。
- 第2の入口の流れが、第1の混合チャンバーに戻る第1の出口の流れの少なくとも一部を含む、請求項2のシステム。
- 第1の出口の流れと第2の出口の流れが実質的に同一の成分濃度を有する、請求項2のシステム。
- 第1の再生モジュールが第1の選択された再生物質の総処理能力で作動する、請求項1のシステム。
- 流体が透析液溶液を含み、第1の選択された再生物質が透析液溶液から老廃物種を取り除く、請求項1のシステム。
- 流体が濾液溶液を含み、第1の選択された再生物質が濾液溶液から老廃物種を取り除く、請求項1のシステム。
- 第1の選択された再生物質が、ウレアーゼ、アルミナ、リン酸ジルコニウム、酸化ジルコニウム、又は活性炭の少なくとも1つを含む、請求項1のシステム。
- 第2の再生モジュールがさらに第2の選択された再生物質を含有し、第1の選択された再生物質が流体から第1の老廃物種を取り除き、第2の選択された再生物質が流体から第2の老廃物種を取り除く、請求項1のシステム。
- 第1の選択された再生物質が、ウレアーゼ、アルミナ、リン酸ジルコニウム、酸化ジルコニウム、又は活性炭の少なくとも1つを含み、第2の選択された再生物質が、ウレアーゼ、アルミナ、リン酸ジルコニウム、酸化ジルコニウム、又は活性炭の少なくとも1つを含む、請求項11のシステム。
- 第1の選択された再生物質が、ウレアーゼ、アルミナ、酸化ジルコニウム及び活性炭の少なくとも1つを含み、第2の選択された再生物質が、リン酸ジルコニウムを含む、請求項11のシステム。
- 第1の選択された再生物質を含有する第3の再生モジュールと、
第2の混合チャンバーとをさらに含み、
流体の第3の出口の流れが第2の混合チャンバーを出て第1の混合チャンバーを通って流れ、流体の第4の出口の流れが第2の混合チャンバーを出て第3の再生モジュールを通って流れ、流体の第3の入口の流れが第2の混合チャンバーに入り、第4の入口の流れが第2の混合チャンバーに入り、第1の入口の流れが第3の出口の流れから成り、第4の入口の流れが第2の出口の流れから成る、請求項1のシステム。 - 流体が第1の混合チャンバーを通って流れるように作動する第1のポンプをさらに含む、請求項1のシステム。
- 第1の混合チャンバーと第2の再生モジュールとの間で第2の出口の流れが流れるように作動する第2のポンプをさらに含む、請求項1のシステム。
- 血液透析の間に透析液を再生するためのシステムにおいて、
再生物質を含有する再生モジュールと、
前記再生物質を含有する混合チャンバーとを含み、
流体の第1の流れが前記再生物質と流体連通する前記混合チャンバーに初回通過入口を通って入り、流体の第2の流れが前記混合チャンバーを初回通過出口を通って出て、前記混合チャンバーに二回通過入口を通って再び入り、流体の第3の流れが前記混合チャンバーを出て前記再生物質と流体連通する前記再生モジュールを通って流れる、システム。 - 透析システムにおいて、
血液から透析液への溶質の移動を円滑にする透析器(20)と、
第1の選択された再生物質を含有する第1の再生モジュール(50)と、
前記第1の選択された再生物質を含有する第2の再生モジュール(52)と、
第1の混合チャンバー(48)とを含み、
前記透析液の第1の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記再生物質と流体連通する前記第1の再生モジュール(50)を通って流れ、前記第1の混合チャンバー(48)に戻り、前記透析液の第2の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記再生物質と流体連通する前記第2の再生モジュール(52)を通って流れ、前記透析器(20)を通って流れる、透析システム。 - 濾過システムにおいて、
血液からの濾液の除去を促進するフィルター(101)と、
第1の選択された再生物質を含有する第1の再生モジュール(50)と、
前記第1の選択された再生物質を含有する第2の再生モジュール(52)と、
第1の混合チャンバー(48)とを含み、
前記濾液の第1の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記再生物質と流体連通する前記第1の再生モジュール(50)を通って流れ、前記第1の混合チャンバー(48)に戻り、前記濾液の第2の出口の流れが前記第1の混合チャンバー(48)を連続して出て、前記再生物質と流体連通する前記第2の再生モジュール(52)を通って流れ、前記フィルター(101)を通って流れる、濾過システム。 - 請求項1に記載の透析液を再生するためのシステムを動かす方法において、
流体の第1の出口の流れを、第1の混合チャンバーから、第1の選択された再生物質を含有する第1の再生モジュールに運ぶ工程と、
再生物質と流体連通する第1の出口の流れから、老廃物種を取り除く工程と、
第1の出口の流れを、第1の再生モジュールから第1の混合チャンバーに戻す工程と、
第1の混合チャンバーに入る流体の第1の入口の流れを、第1の再生モジュールから第1の混合チャンバーに戻された第1の出口の流れと混合する工程と、
流体の第2の出口の流れを、第1の混合チャンバーから、第1の選択された再生物質を含有する第2の再生モジュールに運ぶ工程と、
再生物質と流体連通する第2の出口の流れから、老廃物種を取り除く工程とを含む、方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US201361760079P | 2013-02-02 | 2013-02-02 | |
US61/760,079 | 2013-02-02 | ||
US13/836,973 US9144640B2 (en) | 2013-02-02 | 2013-03-15 | Sorbent cartridge configurations for improved dialysate regeneration |
US13/836,973 | 2013-03-15 |
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JP2014204958A JP2014204958A (ja) | 2014-10-30 |
JP5969522B2 true JP5969522B2 (ja) | 2016-08-17 |
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US (2) | US9144640B2 (ja) |
EP (1) | EP2762178B1 (ja) |
JP (1) | JP5969522B2 (ja) |
WO (1) | WO2014121238A1 (ja) |
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