JP5948367B2 - 吻合のためのスキャホールド形成システムおよび方法 - Google Patents
吻合のためのスキャホールド形成システムおよび方法 Download PDFInfo
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Description
結論
前述のさまざまな本発明の実施の形態の説明は、例証および説明の目的で提示されている。本発明を開示された正確な形態に限定することは意図されていない。多くの変更、変形および微調整は当業者には明白であろう。例えば、人工装具のスキャホールドシステムおよび関係する方法の実施の形態は、食道、心臓(例えば冠状動脈)、肝臓(例えば、肝管、胆管など)、膵臓(例えば膵管)、胆嚢(胆嚢管)、脳(例えば大脳動脈)、大動脈、頸動脈、大腿部または他の末梢動脈または静脈などに見られるものなど、あらゆる体腔の吻合部位に位置合わせし、スキャホールディングするように構成することができる。スキャホールドは、特定の位置に送達および展開するように形成し、寸法化し、コーティングし、その他適合させることができる。また、スキャホールドの実施の形態は、さまざまな小児および新生児の用途用に、寸法化するか、または別の方法で適合させることができる。
Claims (19)
- 胃腸管内の吻合の治癒を促進するために、患者の胃腸管内の吻合部位に配置するための組織スキャホールドであって、前記組織スキャホールドが、
2つの外側部と、中間部と、各外側部に連結している少なくとも1つの保持要素と、を備えた、径方向へ拡張可能なスキャホールド構造、および
少なくとも前記中間部を覆う障壁層
を備え、
前記スキャホールド構造の少なくとも一部がストリップからなり、
前記保持要素が、吻合創治癒の期間中に前記吻合部位において前記組織スキャホールドを保持するよう前記スキャホールド構造が拡張される際に、前記胃腸管の組織壁を係合するように構成され、
前記障壁層が、スキャホールド構造が拡張される際に、形を柔軟に変えることにより前記吻合部位の組織壁を係合するように構成され、それによって、吻合の対向する胃腸組織において流体シールを提供し、
前記障壁層と前記スキャホールド構造が、移植後、前記障壁層が前記スキャホールド構造より長持ちするような分解速度を有するよう構成され、
前記スキャホールド構造の中間部が、前記胃腸管内のぜん動収縮の間、前記吻合において前記シールを形成および維持するのに十分な半径方向剛性を有するよう構成され、
前記スキャホールド構造の中間部におけるストリップ厚さが、前記中間部が前記外側部よりも大きい半径方向剛性を有するように、前記外側部におけるストリップ厚さよりも大きく、
前記スキャホールド構造が拡張される際に、前記障壁層を含む前記中間部による係合の前に、前記外側部および前記保持要素が前記胃腸管の組織壁に係合するように、前記中間部が、前記外側部よりも大きい半径方向剛性を有するように構成され、
前記組織スキャホールドが半径方向に拡張すると、前記吻合の対向する組織層の位置合わせを維持し、前記胃腸管内の前記ぜん動収縮により引き起こされる張力から前記吻合が破損するのを防ぐように、該組織スキャホールドが前記吻合に圧縮力を印加する、
組織スキャホールド。 - 前記障壁層が生物学的材料を含むことを特徴とする請求項1記載の組織スキャホールド。
- 前記生物学的材料が、増殖因子、VEGF、抗炎症剤または抗菌剤のうち少なくとも1つを含むことを特徴とする請求項2記載の組織スキャホールド。
- 前記組織スキャホールドの少なくとも一部が、生体再吸収性の材料を含むことを特徴とする請求項1記載の組織スキャホールド。
- 前記生体再吸収性の材料が、ポリグリコール酸、ポリ乳酸、またはポリグリコール酸とポリ乳酸の混合物を含むことを特徴とする請求項4記載の組織スキャホールド。
- 前記スキャホールド構造が、複数の軸方向に隣接したセルを含むことを特徴とする請求項1記載の組織スキャホールド。
- 前記組織スキャホールドの軸長が、前記スキャホールド構造が拡張される際に、短くなることを特徴とする請求項1記載の組織スキャホールド。
- 前記スキャホールド構造が、拡張可能な装置またはインフレータブル・バルーンのうちの1つによって拡張可能であることを特徴とする請求項1記載の組織スキャホールド。
- 前記スキャホールド構造が部分的に拡張される際に、前記スキャホールド構造が、前記スキャホールド構造の横軸に対して外向きに張り出した形状を有することを特徴とする請求項1記載の組織スキャホールド。
- 前記障壁層が、前記スキャホールド構造全体にわたり配置された管状の部材を含むことを特徴とする請求項1記載の組織スキャホールド。
- 前記障壁層が、フルオロポリマー、PTFE、ポリエチレン、PETまたはナイロンのうちの1つを含むことを特徴とする請求項1記載の組織スキャホールド。
- 前記スキャホールド構造が、前記胃腸管の湾曲に適合して曲がるよう十分な柔軟性を有することを特徴とする請求項1記載の組織スキャホールド。
- 前記スキャホールド構造が、拡張状態において実質的に管状の形状を有することを特徴とする請求項1記載の組織スキャホールド。
- 前記スキャホールド構造が、拡張状態において実質的にT字形の形状を有し、
前記形状が、端側吻合部に配置されるように構成されることを特徴とする請求項1記載の組織スキャホールド。 - 前記スキャホールド構造が、拡張状態において実質的にS字形の形状を有し、
前記形状が、側側吻合部に配置されるように構成されることを特徴とする請求項1記載の組織スキャホールド。 - 前記スキャホールド構造が、拡張状態において曲線形状を有し、
前記形状が湾曲した体腔に配置されるように構成されることを特徴とする請求項1記載の組織スキャホールド。 - 前記保持要素がフックであることを特徴とする請求項1記載の組織スキャホールド。
- 吻合の治癒を促進するために、胃腸管内の吻合部位に配置するための組織スキャホールドであって、前記組織スキャホールドが、
伸長可能な部材により結合され、中間部および2つの側部を含む3個のセクションを形成する、伸長可能な蛇行セルを備えた、径方向へ拡張可能なスキャホールド構造と、
前記2つの側部の各々に連結した少なくとも1つの保持要素と、
少なくとも前記中間部を覆う障壁層と、
を備え、
前記保持要素が、前記スキャホールド構造が拡張される際に、前記胃腸管の組織壁に係合し、吻合創治癒の期間中に前記吻合部位において前記組織スキャホールドを保持するよう構成され、
前記障壁層が、前記組織スキャホールドの拡張の際に、形を柔軟に変えることにより前記吻合に接している前記組織壁に係合し、吻合の対向する胃腸組織において流体シールを提供するよう構成され、
前記スキャホールド構造が拡張される際に、前記組織スキャホールドの軸方向長さが短くなり、それにより、内方向の圧縮力が前記吻合に働き、前記吻合の対向する胃腸組織層の位置合わせを維持し、
前記スキャホールド構造が拡張される際に、前記障壁層を含む前記中間部による係合の前に、前記2つの側部および前記保持要素が前記胃腸管の組織壁に係合するように、前記中間部が、前記2つの側部よりも大きい半径方向剛性を有するように構成されている、
組織スキャホールド。 - 前記組織スキャホールドの軸長が、前記スキャホールド構造が半径方向に拡張される際に、短くなり、
前記保持要素が、前記スキャホールド構造が拡張される際に吻合の対向する胃腸組織層を物理的に寄せるよう構成されているとともに、前記保持要素が、該胃腸組織層に係合するよう構成されており、
前記胃腸組織層の各々が、1つ以上の保持要素により個別に係合されることを特徴とする請求項7記載の組織スキャホールド。
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- 2009-07-28 CN CN200980129597.7A patent/CN102112069B/zh not_active Expired - Fee Related
- 2009-07-28 JP JP2011521252A patent/JP2011529381A/ja active Pending
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Publication number | Priority date | Publication date | Assignee | Title |
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JP7437353B2 (ja) | 2017-10-30 | 2024-02-22 | 株式会社日立製作所 | エレベータ分析システム及びエレベータ分析方法 |
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WO2010014628A3 (en) | 2010-05-06 |
US9820746B2 (en) | 2017-11-21 |
WO2010014628A2 (en) | 2010-02-04 |
US20100023132A1 (en) | 2010-01-28 |
EP2317954A2 (en) | 2011-05-11 |
EP2317954A4 (en) | 2017-06-21 |
JP2014221208A (ja) | 2014-11-27 |
CN102112069A (zh) | 2011-06-29 |
CN102112069B (zh) | 2014-08-20 |
AU2009276716B2 (en) | 2014-11-06 |
AU2009276716A1 (en) | 2010-02-04 |
JP2011529381A (ja) | 2011-12-08 |
US20180042612A1 (en) | 2018-02-15 |
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