JP5936410B2 - ひまし油配合テープ - Google Patents
ひまし油配合テープ Download PDFInfo
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- JP5936410B2 JP5936410B2 JP2012070276A JP2012070276A JP5936410B2 JP 5936410 B2 JP5936410 B2 JP 5936410B2 JP 2012070276 A JP2012070276 A JP 2012070276A JP 2012070276 A JP2012070276 A JP 2012070276A JP 5936410 B2 JP5936410 B2 JP 5936410B2
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- Prior art keywords
- castor oil
- meth
- pressure
- sensitive adhesive
- acrylic
- Prior art date
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- 239000004359 castor oil Substances 0.000 title claims description 51
- 235000019438 castor oil Nutrition 0.000 title claims description 51
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 title claims description 51
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 36
- 239000000178 monomer Substances 0.000 claims description 31
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 18
- 229920001577 copolymer Polymers 0.000 claims description 14
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000010410 layer Substances 0.000 claims description 9
- 239000004745 nonwoven fabric Substances 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 7
- 239000003431 cross linking reagent Substances 0.000 claims description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 239000003522 acrylic cement Substances 0.000 claims description 5
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 230000000740 bleeding effect Effects 0.000 claims 1
- -1 2-ethylhexyl Chemical group 0.000 description 22
- 239000004744 fabric Substances 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 125000000217 alkyl group Chemical group 0.000 description 13
- 239000000835 fiber Substances 0.000 description 13
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 12
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
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- 239000003814 drug Substances 0.000 description 11
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- 125000004432 carbon atom Chemical group C* 0.000 description 5
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- 229920002633 Kraton (polymer) Polymers 0.000 description 4
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- 238000010521 absorption reaction Methods 0.000 description 4
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- 229920001971 elastomer Polymers 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
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- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 239000011086 glassine Substances 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
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- 239000011259 mixed solution Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
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- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
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- 239000013464 silicone adhesive Substances 0.000 description 2
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- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- DCRYNQTXGUTACA-UHFFFAOYSA-N 1-ethenylpiperazine Chemical compound C=CN1CCNCC1 DCRYNQTXGUTACA-UHFFFAOYSA-N 0.000 description 1
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- BFYSJBXFEVRVII-UHFFFAOYSA-N 1-prop-1-enylpyrrolidin-2-one Chemical compound CC=CN1CCCC1=O BFYSJBXFEVRVII-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- PGMMQIGGQSIEGH-UHFFFAOYSA-N 2-ethenyl-1,3-oxazole Chemical compound C=CC1=NC=CO1 PGMMQIGGQSIEGH-UHFFFAOYSA-N 0.000 description 1
- MZNSQRLUUXWLSB-UHFFFAOYSA-N 2-ethenyl-1h-pyrrole Chemical compound C=CC1=CC=CN1 MZNSQRLUUXWLSB-UHFFFAOYSA-N 0.000 description 1
- ZDHWTWWXCXEGIC-UHFFFAOYSA-N 2-ethenylpyrimidine Chemical compound C=CC1=NC=CC=N1 ZDHWTWWXCXEGIC-UHFFFAOYSA-N 0.000 description 1
- FTQIHXSOVBEZCY-UHFFFAOYSA-N 2-methyl-3-(prop-2-enoylamino)propanoic acid Chemical compound OC(=O)C(C)CNC(=O)C=C FTQIHXSOVBEZCY-UHFFFAOYSA-N 0.000 description 1
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- YYIOIHBNJMVSBH-UHFFFAOYSA-N 2-prop-2-enoyloxynaphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=C(OC(=O)C=C)C=CC2=C1 YYIOIHBNJMVSBH-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
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- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
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- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- RQAKESSLMFZVMC-UHFFFAOYSA-N n-ethenylacetamide Chemical compound CC(=O)NC=C RQAKESSLMFZVMC-UHFFFAOYSA-N 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- Adhesives Or Adhesive Processes (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Plant Substances (AREA)
- Adhesive Tapes (AREA)
Description
ここに粘着剤層とは、粘着剤、架橋剤、ひまし油を含む支持体上の全成分をいう。
布帛を構成する繊維は1種又は2種以上を使用できる。また、繊維は疎水性のものが好ましく、上記の例示した繊維の中でも、ポリエチレン、ポリプロピレン等のポリオレフィン繊維、ポリオレフィン(好ましくはポリプロピレン)とポリエステル(好ましくはポリエチレンテレフタレート)の分割繊維等が特に好ましい。また、ポリオレフィンとポリエステルの分割繊維にあっては、ポリオレフィンとポリエステルの含有比率(ポリオレフィン/ポリエステル)は、30〜70/70〜30(重量%)が好ましく、特に好ましくは40〜60/60〜40(重量%)である。
布帛の形態は、特に限定されず、編布、織布、不織布等が挙げられるが、経済性、汎用性、加工性等の点から不織布が好ましく、ポリエチレン、ポリプロピレン等のポリオレフィン繊維の不織布、ポリプロピレンとポリエステルの分割繊維の不織布が特に好ましい。
当該プラスチックフィルムの厚み(単層フィルムの場合はその厚み、多層フィルムの場合は複数層のトータル厚み)は1〜50μm程度が好ましく、特に好ましくは5〜15μm程度である。
1. 主モノマーが40〜60重量%のアクリル酸メトキシエチル、第2モノマーが30〜40重量%の(メタ)アクリル酸ラウリル、及び第3モノマーが10〜25重量%の極性モノマーのみを組み合わせた共重合体からなり、前記極性モノマーが、アクリル酸及びアクリル酸2−ヒドロキシエチルの内の少なくとも1種と、N−ビニル−2−ピロリドンとである共重合体であるアクリル系粘着剤(HiPAS10;コスメディ製薬(株)製)
2. アクリル酸とアルキル酸アルキルエステルとの共重合体であるアクリル系粘着剤(MASCOS20:コスメディ製薬(株)製)
3. アクリル酸とアルキル酸アルキルエステルとの共重合体であるアクリル系粘着剤(MSCOS08;コスメディ製薬(株)製)
4. アクリル酸アルキルエステルとメタクリル酸アルキルエステルとの共重合体であるアクリル系粘着剤(MAS811;コスメディ製薬(株)製)
5. スチレン−イソプレン−スチレン共重合体であるゴム系粘着剤(Kraton D1163 JSP;ジェイエスアール クレイトンエラストマー(株)製)
6. スチレン−エチレン−ブチレン−エチレン共重合体であるゴム系粘着剤(Kraton G1726MS;Kraton Polymers U.S.LLC製)
7. シリコーン系粘着剤(Dow Corning MD7−4502 Silicone Adhesive;東レ・ダウコーニング(株)製)
ひまし油(マルトクA;伊藤製油(株)製)と粘着剤を表1の配合比(重量%)に基づき混合し、各実施例及び比較例用の混合液を作成した。また、ひまし油に替えて、精製オリーブ油(サミット精油(株)製)又はツバキ油(大島椿:大島椿(株)製)を用いて比較例用の混合液を作成した。
この際、アクリル系の粘着剤には2種類の架橋剤を加えた。架橋剤1はサンパスタ HD−739D(ビッグテクノス(株)製)、架橋剤2はアセチルアセトンアルミニウム(キシダ化学(株)製)である。
各テープ剤の性状についての検討結果を表2にまとめる。
ここにブリードとは、粘着剤とひまし油が相溶しないことによって、ひまし油が粘着剤から滲みだしてくる現象をいう。このブリードがあると、皮膚へのひまし油の浸透が促進されるというメリットがあるが、粘着性が損なわれるというデメリットがある。しかし、HiPAS10を用いると、ブリードによるひまし油の高い浸透性と良好な粘着性の両方を実現でき、HiPAS10はアクリル系の中で最も好ましい粘着剤と考えられる。
実施例1はブリードがないためにひまし油の効果がやや低いが、一応効果が認められることから比較例1と比較すればより好ましい組成と判断できる。
すなわち、、薬剤が類似していても同じ粘着剤が好ましいとはいえず、ある薬剤に対し最適な粘着剤を類似薬剤に適した粘着剤から簡単に類推することはできない。粘着剤は投与する薬剤毎に研究を行い最適化する必要がある。
10cm×14cmの大きさの実施例1、実施例4、実施例5、実施例8、比較例1、比較例2のテープ剤、及びガーゼにひまし油を含侵させた湿布を、5人の被験者の膝に約3時間貼付した後の、膝皮膚の外観を比較評価した。その結果を、表3にまとめる。
Claims (6)
- ひまし油にアクリル系粘着剤を配合し支持体上に保持し、ひまし油がブリードしていることを特徴とするひまし油テープ剤。
- 粘着剤層中のひまし油の含有量が60〜95重量%であることを特徴とする請求項1に記載のひまし油テープ剤。
- アクリル系粘着剤が、(メタ)アクリル酸アルコキシアルキルを主モノマーとする共重合体であることを特徴とする請求項1又は請求項2に記載のひまし油テープ剤。
- アクリル系粘着剤が、主モノマーとして40〜60重量%のアクリル酸メトキシエチル、第2モノマーとして30〜40重量%の(メタ)アクリル酸ラウリル、及び第3モノマーとして10〜25重量%の極性モノマーのみを組み合わせた共重合体からなり、前記極性モノマーが、アクリル酸及びアクリル酸2−ヒドロキシエチルの内の少なくとも1種と、N−ビニル−2−ピロリドンとである共重合体であることを特徴とする請求項3に記載のひまし油テープ剤。
- 支持体が不織布であることを特徴とする請求項1ないし請求項4のいずれか1項に記載のひまし油テープ剤。
- 粘着剤が架橋剤により架橋されてなることを特徴とする請求項1ないし請求項4のいずれか1項に記載のひまし油テープ剤。
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