JP5845807B2 - 炭酸含有内用液 - Google Patents
炭酸含有内用液 Download PDFInfo
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- JP5845807B2 JP5845807B2 JP2011236775A JP2011236775A JP5845807B2 JP 5845807 B2 JP5845807 B2 JP 5845807B2 JP 2011236775 A JP2011236775 A JP 2011236775A JP 2011236775 A JP2011236775 A JP 2011236775A JP 5845807 B2 JP5845807 B2 JP 5845807B2
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- 239000007788 liquid Substances 0.000 title claims description 38
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 50
- 239000001569 carbon dioxide Substances 0.000 claims description 23
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 23
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 18
- -1 fatty acid ester Chemical class 0.000 claims description 15
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- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
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- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
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- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
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- 230000000202 analgesic effect Effects 0.000 description 1
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
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- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Description
従って、本発明の課題は、前記の生薬と二酸化炭素を含有し、外観が良好で服用感にも優れた内用液を提供することにある。
また、本発明は、(A)ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる1種又は2種以上、並びに(B)ポリオキシエチレンポリオキシプロピレングリコール及び/又はポリオキシエチレンソルビタン脂肪酸エステルを含有する内用液に、二酸化炭素を封入することを特徴とする炭酸含有内用液の泡状着色物の発生抑制方法を提供するものである。
ポリオキシエチレンポリオキシプロピレングリコールのポリオキシエチレン数は20〜200が好ましく、ポリオキシプロピレン数は20〜70が好ましい。ポリオキシエチレンソルビタン脂肪酸エステルとしては、ポリオキシエチレンソルビタンC8-22脂肪酸エステルが好ましく、ポリオキシエチレンソルビタンモノC8-22脂肪酸エステルがより好ましい。またポリオキシエチレンソルビタン脂肪酸エステルのポリオキシエチレン数は、10〜40が好ましく、10〜30がより好ましく、約20が特に好ましい。より具体例にはポリオキシエチレンソルビタンモノラウリン酸エステル、ポリオキシエチレンソルビタンモノステアリン酸エステル、ポリオシキエチレンソルビタントリステアリン酸エステル、ポリオキシエチレンソルビタンモノオレイン酸エステルが挙げられ、ポリオキシエチレンソルビタンモノオレイン酸エステルが特に好ましい。
これらの成分は、1種を用いてもよいし、2種を組み合わせて用いてもよい。
ショウキョウ流エキス5mL、ポリオキシエチレンポリオキシプロピレングリコール(プルロニックF68)0.5g、クエン酸7g、水酸化ナトリウム適量、果糖ブドウ糖液糖40g、香料適量を精製水1000mLに溶解し、これに二酸化炭素をガスボリュームが2.5となるように封入して内用液を得た。
実施例1と同様にして、表1〜表12の内用液を製造した。
(1)二酸化炭素封入時の泡状着色物の発生の有無
二酸化炭素封入時の着色物の発生の有無を以下の基準で評価した。着色物が発生した状態の写真を図1に、着色物の発生が抑制された状態の写真を図2に示す。
着色物の析出が認められる:△
着色物の析出がほとんどない:○
着色物の析出が全くない:◎
得られた内用液を5名のパネラーが服用し、その服用感を評価した。
やや服用しにくい:△
服用しやすい:○
非常に服用しやすい:◎
得られた内用液を60℃に3週間保存後、2ヶ月冷蔵保存し、外観を評価した。
外観の劣化を生じる :△
ほとんど外観の劣化を生じない:○
外観の劣化を生じない :◎
一方、成分(B)に代えて、種々の非イオン性界面活性剤、消泡剤や増粘剤を添加しても十分な効果は得られなかった。
Claims (4)
- (A)ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる1種又は2種以上、並びに(B)ポリオキシエチレンポリオキシプロピレングリコール及び/又はポリオキシエチレンソルビタン脂肪酸エステルを含有し、(C)二酸化炭素を封入してなる炭酸含有内用液。
- 成分(A)の含有量が、肝臓水解物を除く生薬の原生薬換算量及び/又は肝臓水解物の含有量の合計で0.01〜1.5w/v%である請求項1記載の炭酸含有内用液。
- 成分(B)の含有量が0.001〜1.0w/v%である請求項1又は2記載の炭酸含有内用液。
- (A)ショウキョウ、肝臓水解物、ゴミシ、シゴカ及びイカリソウから選ばれる1種又は2種以上、並びに(B)ポリオキシエチレンポリオキシプロピレングリコール及び/又はポリオキシエチレンソルビタン脂肪酸エステルを含有する内用液に、二酸化炭素を封入することを特徴とする炭酸含有内用液の泡状着色物の発生抑制方法。
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JP2011236775A JP5845807B2 (ja) | 2011-10-28 | 2011-10-28 | 炭酸含有内用液 |
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JP2011236775A JP5845807B2 (ja) | 2011-10-28 | 2011-10-28 | 炭酸含有内用液 |
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JP2013095670A JP2013095670A (ja) | 2013-05-20 |
JP5845807B2 true JP5845807B2 (ja) | 2016-01-20 |
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JP6804190B2 (ja) * | 2015-11-25 | 2020-12-23 | エスエス製薬株式会社 | 医薬組成物 |
JP7167480B2 (ja) * | 2017-10-20 | 2022-11-09 | 大正製薬株式会社 | 経口液体組成物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54126188A (en) * | 1978-03-20 | 1979-10-01 | Crown Cork Japan | Antiifoaming container for beverage containing carbon dioxide |
JPH0657117B2 (ja) * | 1987-04-17 | 1994-08-03 | 熊本県 | 澄明生姜液及び澄明生姜液を用いた新規な飲料及びそれらの製造方法 |
KR890001471A (ko) * | 1987-07-22 | 1989-03-27 | 김성배 | 탄산음료 원액 조성물 |
KR890011553A (ko) * | 1988-01-11 | 1989-08-21 | 김성배 | 새로운 탄산음료 |
JP3864431B2 (ja) * | 1995-06-12 | 2006-12-27 | ゼリア新薬工業株式会社 | カンゾウの抽出物を配合した安定な液剤 |
JP4403587B2 (ja) * | 1998-07-21 | 2010-01-27 | 大正製薬株式会社 | 低pHで安定な生薬エキス配合液剤 |
RU2460381C2 (ru) * | 2006-11-29 | 2012-09-10 | Тос. Бентли энд Сон Лимитед | Улучшение газированных напитков или в связи с газированными напитками |
JP5665306B2 (ja) * | 2009-11-20 | 2015-02-04 | サントリー食品インターナショナル株式会社 | 高甘味度甘味料を含有する炭酸飲料 |
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