JP5801382B2 - 生体組織再生のための医療用デバイスおよび方法 - Google Patents
生体組織再生のための医療用デバイスおよび方法 Download PDFInfo
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- JP5801382B2 JP5801382B2 JP2013509157A JP2013509157A JP5801382B2 JP 5801382 B2 JP5801382 B2 JP 5801382B2 JP 2013509157 A JP2013509157 A JP 2013509157A JP 2013509157 A JP2013509157 A JP 2013509157A JP 5801382 B2 JP5801382 B2 JP 5801382B2
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B14/00—Use of inorganic materials as fillers, e.g. pigments, for mortars, concrete or artificial stone; Treatment of inorganic materials specially adapted to enhance their filling properties in mortars, concrete or artificial stone
- C04B14/38—Fibrous materials; Whiskers
- C04B14/42—Glass
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B26/00—Compositions of mortars, concrete or artificial stone, containing only organic binders, e.g. polymer or resin concrete
- C04B26/02—Macromolecular compounds
- C04B26/04—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B26/00—Compositions of mortars, concrete or artificial stone, containing only organic binders, e.g. polymer or resin concrete
- C04B26/02—Macromolecular compounds
- C04B26/28—Polysaccharides or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
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- C04B26/00—Compositions of mortars, concrete or artificial stone, containing only organic binders, e.g. polymer or resin concrete
- C04B26/02—Macromolecular compounds
- C04B26/28—Polysaccharides or derivatives thereof
- C04B26/285—Cellulose or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Ceramic Engineering (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Composite Materials (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Civil Engineering (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Description
本発明は、組織欠損部の修復のための合成人工補綴組織スキャフォールドを提供する。本明細書で使用される、種々の類似語を含む概念である用語「合成人工補綴組織スキャフォールド」および「骨組織スキャフォールド」および「組織スキャフォールド」および「合成人工骨」等々は、本明細書全体を通して相互互換的に使用されている。一実施形態では、合成人工補綴組織スキャフォールドは、生体組織内に移植されると生体吸収性である。一実施形態では、合成人工補綴組織スキャフォールドは、生体組織内に移植されると骨伝導性である。一実施形態では、合成人工補綴組織スキャフォールドは、生体組織内に移植されると骨刺激性である。一実施形態では、合成人工補綴組織スキャフォールドは、生体組織内に移植されると耐荷重性である。
Claims (7)
- 合成人工骨補綴を製造する方法であって、
塑性的に成形可能なバッチを得るため、ガラス繊維を接着剤、孔形成剤および液体と混合するステップであって、前記ガラス繊維と前記接着剤は、生体活性組成物の前駆物質である組成物を含んでおり、前記接着剤は、酸化カルシウム、燐酸塩、又は、酸化カルシウムと燐酸塩の混合物を含んでいる、ステップと、
前記ガラス繊維を分散させる前記塑性成形可能なバッチを前記接着剤および前記孔形成剤と混合して、均質な塊体である成形可能なバッチを得るステップであって、前記ガラス繊維は重なり合い絡み合う状態である、ステップと、
前記成形可能なバッチを所望形状に成形して成形物を得るステップと、
ほぼ全ての液体を除去するために前記成形物を乾燥するステップと、
前記孔形成剤を除去するステップと、
前記ガラス繊維を前記接着剤と反応させるべく前記成形物を加熱して、生体活性組成物を含んだ多孔質繊維スキャフォールドを形成するステップと、
を含んでいることを特徴とする方法。 - 前記ガラス繊維はシリカガラス繊維を含んでいることを特徴とする請求項1記載の方法。
- 前記ガラス繊維は酸化カルシウムの含有量が30重量%未満であるカルシウム/ケイ酸塩繊維を含んでいることを特徴とする請求項1記載の方法。
- 前記ガラス繊維はリン酸塩ガラス繊維を含んでいることを特徴とする請求項1記載の方法。
- 前記接着剤は前記ガラス繊維のコーティング剤となることを特徴とする請求項1記載の方法。
- 前記成形物は、前記生体活性組成物の脱ガラス化温度を超える温度に加熱されることを特徴とする請求項1記載の方法。
- 前記成形物に前駆物質を混入するステップ、及び、前記ガラス繊維を当該前駆物質と反応させるための第二の加熱ステップ、を更に含んでいることを特徴とする請求項1記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33196110P | 2010-05-06 | 2010-05-06 | |
US61/331,961 | 2010-05-06 | ||
PCT/US2011/034880 WO2012024004A2 (en) | 2010-05-05 | 2011-05-03 | Devices and methods for tissue engineering |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013534834A JP2013534834A (ja) | 2013-09-09 |
JP5801382B2 true JP5801382B2 (ja) | 2015-10-28 |
Family
ID=45605597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013509157A Expired - Fee Related JP5801382B2 (ja) | 2010-05-06 | 2011-05-03 | 生体組織再生のための医療用デバイスおよび方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20120219635A1 (ja) |
EP (1) | EP2566530A4 (ja) |
JP (1) | JP5801382B2 (ja) |
CN (1) | CN102905734A (ja) |
BR (1) | BR112012028020B8 (ja) |
CA (1) | CA2797976A1 (ja) |
IL (1) | IL222479A (ja) |
WO (1) | WO2012024004A2 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5792736B2 (ja) | 2009-10-29 | 2015-10-14 | プロシディアン・インコーポレイテッドProsidyan,Inc. | 人工的に作り出した多孔性を有する動的な生体活性骨移植材料 |
WO2011059746A1 (en) | 2009-10-29 | 2011-05-19 | Prosidyan, Inc. | Dynamic bioactive bone graft material and methods for handling |
US8883195B2 (en) | 2013-03-14 | 2014-11-11 | Prosidyan, Inc. | Bioactive porous bone graft implants |
US9381274B2 (en) | 2013-03-14 | 2016-07-05 | Prosidyan, Inc. | Bone graft implants containing allograft |
US8889178B2 (en) | 2013-03-14 | 2014-11-18 | Prosidyan, Inc | Bioactive porous bone graft compositions in synthetic containment |
KR101677066B1 (ko) * | 2013-04-12 | 2016-11-17 | 모사이 코퍼레이션. | 생활성 유리 지지체 및 이의 제조방법 |
CN103520771B (zh) * | 2013-10-23 | 2015-04-22 | 北京纪元联合生物技术有限公司 | 一种复合生物活性材料微区雕刻仿生人工骨的方法 |
JP2023512533A (ja) * | 2020-01-30 | 2023-03-27 | エスディーアイピー イノベーションズ プロプリエタリー リミテッド | 骨成長及び組織結合のさらなる向上を目的とする、内外吸収性を備えた生体吸収性インプラント並びにその製造方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9902976D0 (en) * | 1999-02-11 | 1999-03-31 | Giltech Ltd | Composite |
SE528080C2 (sv) * | 2004-08-18 | 2006-08-29 | Doxa Ab | Kemiskt bundet keramiskt material |
US20060216321A1 (en) * | 2005-03-24 | 2006-09-28 | Sdgi Holdings, Inc. | Solvent based processing technologies for making tissue/polymer composites |
US7567817B2 (en) * | 2007-05-14 | 2009-07-28 | Geo2 Technologies, Inc. | Method and apparatus for an extruded ceramic biosoluble fiber substrate |
CA2767714C (en) * | 2009-07-10 | 2017-09-26 | Bio2 Technologies, Inc. | Resorbable three-dimensional tissue scaffold fabricated from bioactive glass fibers bonded by bioactive glass |
-
2011
- 2011-05-03 EP EP11818496.9A patent/EP2566530A4/en not_active Withdrawn
- 2011-05-03 CN CN2011800222730A patent/CN102905734A/zh active Pending
- 2011-05-03 JP JP2013509157A patent/JP5801382B2/ja not_active Expired - Fee Related
- 2011-05-03 CA CA2797976A patent/CA2797976A1/en not_active Abandoned
- 2011-05-03 BR BR112012028020A patent/BR112012028020B8/pt not_active IP Right Cessation
- 2011-05-03 WO PCT/US2011/034880 patent/WO2012024004A2/en active Application Filing
- 2011-05-03 US US13/099,447 patent/US20120219635A1/en not_active Abandoned
-
2012
- 2012-10-16 IL IL222479A patent/IL222479A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BR112012028020B8 (pt) | 2023-05-16 |
WO2012024004A3 (en) | 2012-04-12 |
EP2566530A2 (en) | 2013-03-13 |
CA2797976A1 (en) | 2012-02-23 |
WO2012024004A2 (en) | 2012-02-23 |
CN102905734A (zh) | 2013-01-30 |
BR112012028020B1 (pt) | 2018-11-27 |
IL222479A (en) | 2016-12-29 |
US20120219635A1 (en) | 2012-08-30 |
IL222479A0 (en) | 2012-12-31 |
BR112012028020A2 (pt) | 2018-05-22 |
JP2013534834A (ja) | 2013-09-09 |
EP2566530A4 (en) | 2016-02-10 |
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