JP5711735B2 - 生体組織工学のためのデバイスおよび方法 - Google Patents
生体組織工学のためのデバイスおよび方法 Download PDFInfo
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- JP5711735B2 JP5711735B2 JP2012519718A JP2012519718A JP5711735B2 JP 5711735 B2 JP5711735 B2 JP 5711735B2 JP 2012519718 A JP2012519718 A JP 2012519718A JP 2012519718 A JP2012519718 A JP 2012519718A JP 5711735 B2 JP5711735 B2 JP 5711735B2
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- tissue scaffold
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- bone
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- Surgical Instruments (AREA)
Description
本発明は、組織欠損の修復のための、合成人工器官組織スキャフォールドを提供する。本明細書で使用される、種々の形態での用語「合成人工器官組織スキャフォールド」および「骨組織スキャフォールド」および「組織スキャフォールド」および「合成人工骨」は、本明細書全体を通して相互互換的に使用される場合がある。一実施形態では、合成人工器官組織スキャフォールドは、生体組織に移植された場合、生体吸収性のあるものである。一実施形態では、合成人工器官組織スキャフォールドは、生体組織に移植された場合、骨伝導性のあるものである。一実施形態では、合成人工器官組織スキャフォールドは、生体組織に移植された場合、骨刺激性のあるものである。一実施形態では、合成人工器官組織スキャフォールドは、生体組織に移植された場合、耐荷重性のあるものである。
本開示内容をさらに説明し、その理解を促進するために以下の実施例を掲載する。これらの特定の実施例は、開示の説明のためのものであり、いかなる方法でも限定を意図するものではない。
Claims (9)
- 吸収性三次元組織スキャフォールドであって、
生体活性ガラス繊維と、
前記生体活性ガラス繊維の少なくとも一部に接着すると共にこれを被覆するところの、1〜100ナノメートルのナノ粒径を有する生体活性ガラスと、
前記生体活性ガラスが前記生体活性ガラス繊維に接着する間に、熱分解、熱劣化または溶剤抽出によって除去される有機バインダおよび孔形成剤によって決定される孔径、孔径分布および細孔相互接続性を有してなる、前記三次元組織スキャフォールド内にある細孔空間と、
を備え、
前記細孔空間の空隙率は、当該吸収性三次元組織スキャフォールドにおいて40%〜85%である、吸収性三次元組織スキャフォールド。 - 前記生体活性ガラス繊維および前記生体活性ガラスは、均一な組成を有する、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記三次元組織スキャフォールド内の前記細孔空間の孔径は、100μm〜500μmである、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記孔径は、二峰性のサイズ分布を有する、請求項4に記載の吸収性三次元組織スキャフォールド。
- 複数の前記生体活性ガラス繊維が、隣接する生体活性ガラス繊維と接着し、生体活性ガラス繊維の束を提供する、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記生体活性ガラス繊維は、炭酸ナトリウムと、炭酸カルシウムと、五酸化リンと、45モル%から60モル%のシリカとを含み、リンに対するカルシウムのモル比が2から10である、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記生体活性ガラス繊維は、13−93ガラス繊維から構成される、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記生体活性ガラス繊維の直径は、1μmから200μmの範囲である、請求項1に記載の吸収性三次元組織スキャフォールド。
- 前記生体活性ガラス繊維の直径は、5μmから100μmの範囲である、請求項8に記載の吸収性三次元組織スキャフォールド。
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US61/234,768 | 2009-08-18 | ||
PCT/US2010/041331 WO2011005933A2 (en) | 2009-07-10 | 2010-07-08 | Devices and methods for tissue engineering |
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