JP5785263B2 - アレルゲン不活性化剤組成物、物品、及び方法 - Google Patents
アレルゲン不活性化剤組成物、物品、及び方法 Download PDFInfo
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- JP5785263B2 JP5785263B2 JP2013532873A JP2013532873A JP5785263B2 JP 5785263 B2 JP5785263 B2 JP 5785263B2 JP 2013532873 A JP2013532873 A JP 2013532873A JP 2013532873 A JP2013532873 A JP 2013532873A JP 5785263 B2 JP5785263 B2 JP 5785263B2
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- 150000001875 compounds Chemical class 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 239000012190 activator Substances 0.000 claims description 11
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- 238000001035 drying Methods 0.000 claims description 6
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 4
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- 229910052708 sodium Inorganic materials 0.000 claims description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 3
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
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- 108010061629 Dermatophagoides pteronyssinus antigen p 1 Proteins 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
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- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
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- 230000015556 catabolic process Effects 0.000 description 2
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- 230000036425 denaturation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical compound C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
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- WQNHWIYLCRZRLR-UHFFFAOYSA-N 2-(3-hydroxy-2,5-dioxooxolan-3-yl)acetic acid Chemical compound OC(=O)CC1(O)CC(=O)OC1=O WQNHWIYLCRZRLR-UHFFFAOYSA-N 0.000 description 1
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- -1 Der f Proteins 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010051841 Exposure to allergen Diseases 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000392810 Inbio Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000036284 Rhinitis seasonal Diseases 0.000 description 1
- 206010048908 Seasonal allergy Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
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- 230000000996 additive effect Effects 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229960004275 glycolic acid Drugs 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 230000000937 inactivator Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
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- 150000002894 organic compounds Chemical class 0.000 description 1
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical class N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
- 201000004338 pollen allergy Diseases 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 239000000376 reactant Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
- C11D1/22—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds
- C11D1/24—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aromatic compounds containing ester or ether groups directly attached to the nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D39/00—Filtering material for liquid or gaseous fluids
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/244—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing sulfur or phosphorus
- D06M13/248—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing sulfur or phosphorus with compounds containing sulfur
- D06M13/272—Unsaturated compounds containing sulfur atoms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/04—Additives and treatments of the filtering material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Textile Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
有効成分として式1の化合物を10重量%、クエン酸無水物を4.5重量%、EDTA塩を0.5重量%、エタノールを5重量%、及び水を80重量%含むアレルゲン不活性化剤を調製した。スパンボンド式不織布(重量:80g/sqm)をフィルタとして使用した。ドーピング工程及び乾燥工程によりアレルゲン不活性化剤をフィルタにコーティングして試験用サンプルを得た。この試験で使用したサンプルの寸法は5mm×5mmであった。
ELIZA試験で使用したアレルゲンは、
1)イエダニの残留物:Der p 1、Der f 1、Der p 2、及びDer f 2
2)花粉:Bet v 1(即ち、樺の木花粉)
3)ペットの残留物:Can f 1(即ち、ペットのふけ)
各抗原ごとにELISA試験キット(Inbio GmbH(Julich、Germany))を使用し、各抗原をPBSに溶解させて、250ng/mLの試験用アレルゲン溶液を準備した。ELISAキット製造業者の説明書に従って他の試薬を調製した。
各サンプルを5mm×5mmの寸法に切断した後、25℃のアレルゲン溶液(250ng/mL)300uLに1時間にわたって浸漬させた。1時間浸漬させた後、溶液(上澄み)100uLを、抗体でコーティングされた96ウェルマイクロプレートに注ぎ込んだ。マイクロプレートリーダーを使用してマイクロプレートの吸光度を405nmで測定した後、各サンプル中のアレルゲン濃度を測定した。
アレルゲン不活性化の効率を算出するため、マイクロプレートリーダーを405nmで使用して、サンプルの入った反応液中の各抗原の濃度を測定した。
実施例1〜6及び比較例1〜5:有効成分としての様々な種類の界面活性剤の試験
式1の様々な化合物をアレルゲン不活性化剤の有効成分として含むサンプル(実施例1〜6)、界面活性剤を有さないサンプル(比較例1)、及び式1の化合物の代わりに他の界面活性剤を含むサンプル(比較例2〜5)を使用して、Der p 1の除去効率を測定した。ここでは、サンプル中の有効成分のコーティング量は、1g/m2であった。
Der f 1を試験アレルゲンとし、次の成分を含むアレルゲン不活性化剤を使用して、アレルゲン不活性化効果を測定した。結果を表2に示す。
4種類のイエダニ(Der p 1、Der f 、Der p 2、及びDer f 2)、及びヘキサデシルジフェニルオキシド二スルホン酸二ナトリウムを有効成分として含むアレルゲン不活性化剤を使用して除去効率を測定し、試験は、サンプル中の全有効成分のコーティング量を変化させて(即ち、0.5、1、2、3、4、及び8g/m2)行った。結果を表3に示す。
Bet v 1及びCan f 1をタンパク質濃度250ng/mLで試験アレルゲンとして使用し、ヘキサデシルジフェニルオキシド二スルホン酸二ナトリウムを有効成分として含むアレルゲン不活性化剤を使用して除去効率を測定し、試験は、サンプル中の有効成分のコーティング量を変化させて(即ち、0.5、1、2、3、4、及び8g/m2)行った。結果を表4に示す。
サンプルシートを供給フィルタ(feefilter)に取り付けた後、RAP(空気清浄器)ユニットに取り付けた。空気清浄器を作動させた後、1g/m2の有効成分で処理した不織布シートを使用して、耐久性試験を1ヵ月にわたって実施した(実施例23)。Der p 1、Can f 1及びBet v 1を試験アレルゲンとして使用した。未処理サンプルに対しても同じ試験を行った。
以下に、本願発明に関連する発明の実施形態について列挙する。
[実施形態1]
次の式1の化合物、
Xは、H、Na、K、Mg、又はCaを表す。)を含むアレルゲン不活性化剤。
[実施形態2]
クエン酸、リンゴ酸、酒石酸、安息香酸、乳酸、グリコール酸、アスコルビン酸、没食子酸、グルコン酸、及びマレイン酸からなる群から選択される少なくとも1つの有機酸を更に含む、実施形態1に記載のアレルゲン不活性化剤。
[実施形態3]
前記有機酸がクエン酸である、実施形態2に記載のアレルゲン不活性化剤。
[実施形態4]
エチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)を更に含む、実施形態1に記載のアレルゲン不活性化剤。
[実施形態5]
エチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)と、
1つ以上のC 1 〜C 6 アルコールと、
水と、
を更に含む、実施形態1又は2に記載のアレルゲン不活性化剤。
[実施形態6]
前記式1の化合物が、ヘキサデシルジフェニルオキシド二スルホン酸ナトリウムである、実施形態1又は2に記載のアレルゲン不活性化剤。
[実施形態7]
前記組成物が、前記組成物100重量%に対して、
0.5〜50重量%の前記式1の化合物と、
0.5〜50重量%の前記有機酸と、
0.2〜2重量%のエチレンジアミン四酢酸の四ナトリウム塩(EDTA四ナトリウム)と、
1〜20重量%の1種以上のC 1 〜C 6 アルコールと、
バランス量の水と、
を含む、実施形態2に記載のアレルゲン不活性化剤。
[実施形態8]
前記組成物が、前記組成物100重量%に対して、
5〜20重量%の前記式1の化合物と、
5〜20重量%の前記有機酸と、
0.5〜1重量%のEDTA四ナトリウムと、
4〜10重量%の1種以上のC 1 〜C 6 アルコールと、
バランス量の水と、
を含む、実施形態7に記載のアレルゲン不活性化剤。
[実施形態9]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用したフィルタ。
[実施形態10]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用したスプレー。
[実施形態11]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した布地。
[実施形態12]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した不織布。
[実施形態13]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した繊維。
[実施形態14]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤を使用した洗剤。
[実施形態15]
実施形態1〜8のいずれか一項に記載のアレルゲン不活性化剤の使用方法であって、
前記アレルゲン活性化剤を液体形態で準備する工程と、
前記アレルゲン活性化剤を基材の表面に適用する工程と、
を含む、方法。
[実施形態16]
前記基材を乾燥させて前記アレルゲン活性化剤の少なくとも一部を前記基材の表面から除去する工程を更に含む、実施形態15に記載の方法。
[実施形態17]
前記基材を乾燥させて前記アレルゲン活性化剤の少なくとも一部を前記基材の表面から除去する工程が、前記基材を加熱することを含む、実施形態16に記載の方法。
[実施形態18]
前記基材が、充填剤、繊維、布地、不織布物品、及びフィルタから選択される、実施形態15〜17のいずれか一項に記載の方法。
[実施形態19]
前記基材がフィルタである、実施形態18に記載の方法。
[実施形態20]
前記フィルタが、HVACフィルタ、乗物の室内エアフィルタ、又は個人向けエアフィルタ(呼吸用マスク)である、実施形態19に記載の方法。
Claims (3)
- クエン酸、リンゴ酸、酒石酸、安息香酸、乳酸、グリコール酸、アスコルビン酸、没食子酸、グルコン酸、及びマレイン酸からなる群から選択される少なくとも1つの有機酸を更に含む、請求項1に記載のアレルゲン不活性化剤。
- 請求項1又は2に記載のアレルゲン不活性化剤の使用方法であって、
前記アレルゲン活性化剤を液体形態で準備する工程と、
前記アレルゲン活性化剤を基材の表面に適用する工程と、
前記基材を乾燥させて前記アレルゲン活性化剤の少なくとも一部を前記基材の表面から除去する工程であって、任意で前記基材を加熱することを含む、工程と、
を含む方法。
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PCT/US2011/054708 WO2012047848A2 (en) | 2010-10-05 | 2011-10-04 | Allergen deactivator composition, articles and methods |
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