JP5778964B2 - 油性製剤 - Google Patents
油性製剤 Download PDFInfo
- Publication number
- JP5778964B2 JP5778964B2 JP2011080851A JP2011080851A JP5778964B2 JP 5778964 B2 JP5778964 B2 JP 5778964B2 JP 2011080851 A JP2011080851 A JP 2011080851A JP 2011080851 A JP2011080851 A JP 2011080851A JP 5778964 B2 JP5778964 B2 JP 5778964B2
- Authority
- JP
- Japan
- Prior art keywords
- oil
- acid
- oily
- diphenhydramine
- odor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims description 41
- 229960000520 diphenhydramine Drugs 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
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- 229940031578 diisopropyl adipate Drugs 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims 4
- 235000019645 odor Nutrition 0.000 description 27
- 239000003921 oil Substances 0.000 description 19
- 235000019198 oils Nutrition 0.000 description 19
- -1 pH adjusters Substances 0.000 description 19
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 16
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Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
表1および2に記載の処方に従って、配合成分を混合し、流動パラフィンを100mlになるように添加して、油性製剤を得た。
流動パラフィン(SUS粘度:350):流動パラフィンNo.350(三光化学工業(株)製)
流動パラフィン(SUS粘度:70):軽質流動パラフィンNo.70(三光化学工業(株)製)
トリオクタノイン:NIKKOL Trifat S−308(日光ケミカルズ(株)製)
ジフェンヒドラミン:ジフェンヒドラミン(金剛化学(株)製)
イソステアリン酸:イソステアリン酸EX(高級アルコール工業(株)製)
ガラス瓶に油性製剤を入れ、一夜放置した。翌日の外観を以下の基準に従って目視評価した。
◎:無色透明
○:淡有色透明
▲:濃有色透明または半透明
×:白濁または白色沈殿
ガラス瓶に油性製剤を入れ、一夜放置する。翌日のヘッドスペースの臭気を以下の基準に従って官能評価した(n=4)。
5:強い臭気
4:楽に感知できる臭気
3:弱い臭気
2:探せばわかる弱い臭気
1:臭気なし
伸び向上剤として、アジピン酸ジイソプロピルを使用し、表3に記載の処方に従って、配合成分を混合し、流動パラフィンを100mlになるように添加して、油性製剤を得た。各製剤について、前述の評価を行った結果を表3に示す。
表4に示す処方に従い、各成分を秤量し、流動パラフィンを100mlになるように添加して撹拌し、油性製剤を調製した。種々の任意成分を配合しているが、いずれも製剤が白濁することなく、臭気が十分に抑制されていた。
Claims (5)
- 油性基剤、ジフェンヒドラミン、および常温で液体である炭素数8以上の分岐型飽和脂肪酸を含む油性製剤(ただし、貼付剤を除く)。
- ジフェンヒドラミン100重量部に対して、常温で液体である炭素数8以上の分岐型飽和脂肪酸を50重量部以上含有する請求項1記載の油性製剤。
- ジフェンヒドラミン100重量部に対して、常温で液体である炭素数8以上の分岐型飽和脂肪酸を200重量部以上含有する請求項2記載の油性製剤。
- さらに、アジピン酸ジイソプロピルを含有する請求項1〜3のいずれかに記載の油性製剤。
- 油性基剤およびジフェンヒドラミンを含む油性製剤(ただし、貼付剤を除く)の臭気抑制方法であって、臭気抑制剤として常温で液体である炭素数8以上の分岐型飽和脂肪酸を使用することを特徴とする方法。
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