JP5750098B2 - 磁性材料の加熱のための装置及び方法 - Google Patents
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
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- A—HUMAN NECESSITIES
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- A61B5/0515—Magnetic particle imaging
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
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- G—PHYSICS
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Description
低磁場強度を持つ第1サブ領域と高磁場強度を持つ第2サブ領域が作用領域内に形成されるような、その磁場強度の空間内パターンを持つ選択磁場を発生させるための選択手段、
磁性材料の磁化が局所的に変化するように駆動磁場を用いて作用領域内の2つのサブ領域の空間位置を変化させるための駆動手段、及び
上記内接球の中心領域が加熱されるような期間と周波数で、上記内接球の周囲の位置のシーケンスに沿って第1サブ領域の空間位置を変化させるように駆動手段を制御するための制御手段。
1.磁性粒子内部の磁化のネール反転(熱緩和駆動)
2.流体懸濁液中の磁性粒子のブラウン回転(環境に対する)
極座標r=r;Θ=2πft 等号 x=r cos(2πf.t);y=r cos(2πf.t+π/2)
Claims (14)
- 作用領域内の内接球の中心領域に位置する磁性材料の加熱のための装置であって、
低磁場強度を持つ第1サブ領域と高磁場強度を持つ第2サブ領域が前記作用領域内に形成されるような、その磁場強度の空間内パターンを持つ選択磁場を発生させるための選択手段と、
前記磁性材料の磁化が局所的に変化するように駆動磁場を用いて前記作用領域内の前記2つのサブ領域の空間位置を変化させるための駆動手段と、
前記内接球の前記中心領域が加熱されるような期間と周波数で、前記内接球の周囲の位置のシーケンスに沿って前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御するための制御手段とを有する、装置。 - 前記制御手段が、前記内接球の周囲の位置の2次元シーケンスに沿って、前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項1に記載の装置。
- 前記制御手段が、前記内接球の周囲の円に沿って前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項2に記載の装置。
- 前記制御手段が、前記内接球の周囲の位置の3次元シーケンスに沿って、前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項1に記載の装置。
- 前記制御手段が、前記内接球の周囲の球にわたって、前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項4に記載の装置。
- 前記制御手段が、定角速度で前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項1に記載の装置。
- 前記制御手段が、1乃至100kHzの範囲の周波数で前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御する、請求項1に記載の装置。
- 前記周波数が10乃至30kHzの範囲である、請求項7に記載の装置。
- 前記作用領域内の前記磁化に依存する検出信号を取得するための受信手段であって、該磁化は前記第1及び第2サブ領域の前記空間位置の変化によって影響される、受信手段と、
前記取得された検出信号から少なくとも前記中心領域の画像を再構成するための処理手段とをさらに有する、請求項1に記載の装置。 - 磁性材料が単磁区磁性ナノ粒子を有する、請求項1に記載の装置。
- 前記単磁区磁性ナノ粒子がコロイド的に安定化された単磁区磁性ナノ粒子である、請求項10に記載の装置。
- 磁性材料が、リポソーム、ポリマーソーム、又は、疎水性膜によって分離される水の粘度と等しい若しくは同様の粘度の内部体積を持つ小胞に包まれる、単磁区磁性ナノ粒子を有し、前記磁性粒子は前記内部体積内に配置される、請求項1に記載の装置。
- 前記単磁区磁性ナノ粒子がコロイド的に安定化された単磁区磁性ナノ粒子である、請求項12に記載の装置。
- 作用領域内の内接球の中心領域に位置する磁性材料の加熱のための装置の作動方法であって、前記装置が選択手段と、駆動手段と、制御手段とを有する方法において、
前記選択手段が、低磁場強度を持つ第1サブ領域と高磁場強度を持つ第2サブ領域が作用領域内に形成されるような、その磁場強度の空間内パターンを持つ選択磁場を発生させるステップと、
前記駆動手段が、前記磁性材料の磁化が局所的に変化するように駆動磁場を用いて前記作用領域内の前記2つのサブ領域の前記空間位置を変化させるステップと、
前記制御手段が、前記内接球の前記中心領域が加熱されるような期間と周波数で、前記内接球の周囲の位置のシーケンスに沿って前記第1サブ領域の前記空間位置を変化させるように前記駆動手段を制御するステップとを有する、方法。
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EP09159802 | 2009-05-08 | ||
EP09159802.9 | 2009-05-08 | ||
PCT/IB2010/051699 WO2010128418A1 (en) | 2009-05-08 | 2010-04-19 | Arrangement and method for heating of a magnetic material |
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US (1) | US9451900B2 (ja) |
EP (1) | EP2427108A1 (ja) |
JP (1) | JP5750098B2 (ja) |
CN (1) | CN102421359B (ja) |
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WO (1) | WO2010128418A1 (ja) |
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KR101772686B1 (ko) | 2016-02-02 | 2017-08-29 | 연세대학교 원주산학협력단 | 나노입자 약물 전달 장치 및 그의 제어 방법 |
EP4085827A1 (en) | 2016-07-12 | 2022-11-09 | Magnetic Insight, Inc. | Magnetic particle imaging |
TWI711425B (zh) * | 2017-10-13 | 2020-12-01 | 謝振傑 | 非侵入式熱消融裝置 |
EP3545835B1 (en) * | 2018-03-29 | 2022-03-30 | Julius-Maximilians-Universität Würzburg | System and method for generating a traveling field free line |
US11554269B2 (en) * | 2019-02-01 | 2023-01-17 | Weinberg Medical Physics, Inc. | Method, system and components for selective magnetic particle motion |
US11890488B2 (en) | 2019-03-13 | 2024-02-06 | Magnetic Insight, Inc. | Magnetic particle actuation |
CN110354392B (zh) * | 2019-08-02 | 2024-07-19 | 北京大学第三医院(北京大学第三临床医学院) | 一种用于热疗的线圈机构、发热装置及热疗设备 |
CN111013019A (zh) * | 2019-10-30 | 2020-04-17 | 南京逐路电子科技有限公司 | 磁感应热疗控温装置 |
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AUPP008197A0 (en) * | 1997-10-29 | 1997-11-20 | Paragon Medical Limited | Improved targeted hysteresis hyperthermia as a method for treating diseased tissue |
US6470220B1 (en) * | 1999-03-29 | 2002-10-22 | The Regents Of The University Of California | Diagnosis and treatment of cancers using in vivo magnetic domains |
DE10151778A1 (de) | 2001-10-19 | 2003-05-08 | Philips Corp Intellectual Pty | Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel |
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JP2012525900A (ja) | 2012-10-25 |
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RU2011149781A (ru) | 2013-06-20 |
WO2010128418A1 (en) | 2010-11-11 |
US20120058441A1 (en) | 2012-03-08 |
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US9451900B2 (en) | 2016-09-27 |
RU2536700C2 (ru) | 2014-12-27 |
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