JP5727934B2 - 強心配糖体抽出プロセスおよび組成物 - Google Patents
強心配糖体抽出プロセスおよび組成物 Download PDFInfo
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- JP5727934B2 JP5727934B2 JP2011532187A JP2011532187A JP5727934B2 JP 5727934 B2 JP5727934 B2 JP 5727934B2 JP 2011532187 A JP2011532187 A JP 2011532187A JP 2011532187 A JP2011532187 A JP 2011532187A JP 5727934 B2 JP5727934 B2 JP 5727934B2
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- Prior art keywords
- cardiac glycoside
- aloe
- plant species
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- extraction mixture
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims (14)
- 強心配糖体を抽出する方法であって、
強心配糖体植物種を、抽出混合物を形成するために選択される条件のもとでアロエと混合する工程であって、ここで該強心配糖体植物種が、キョウチクトウ科(Apocynaceae)、アブラナ科(Brassicaceae)、オオバコ科(Plantaginaceae)、ナギイカダ科(Ruscaceae)またはヒアシンス科(Hyacinthaceae)から選択される科に属する工程;
前記抽出混合物を、強心配糖体を前記強心配糖体植物種から抽出するために選択される条件のもとで状態調節して、それにより、残存強心配糖体植物種と、強心配糖体アロエ混合物とを含む状態調節された抽出混合物を形成する工程であって、ここで該状態調節することが、該状態調節された抽出混合物を形成するために、該抽出混合物を40℃〜100℃の範囲における温度に加熱することを含む工程;
前記強心配糖体アロエ混合物の少なくとも一部を前記残存強心配糖体植物種から分離して、それにより、強心配糖体アロエ抽出物を形成する工程を含み、
前記強心配糖体アロエ抽出物は、前記強心配糖体植物種から抽出される強心配糖体を含み、かつ、
前記強心配糖体アロエ抽出物は前記残存強心配糖体植物種を実質的に含まない、方法。 - 前記強心配糖体植物が、ネリウム・インジクイム(Nerium indicuim)またはネリウム・オレアンデル(Nerium oleander)の種に属する、請求項1に記載の方法。
- 前記状態調節することが、前記抽出混合物を1時間〜10時間の範囲における加熱時間にわたって加熱することを含む、請求項1または2に記載の方法。
- 前記分離することが、前記状態調節された抽出混合物を、ろ過、遠心分離およびデカンテーションからなる群から選択される分離方法に供することを含む、請求項1〜3のいずれか一項に記載の方法。
- 前記抽出混合物が、1重量部〜50重量部の範囲における量の前記強心配糖体植物種と、1重量部〜100重量部の範囲における量の前記アロエとを含む、請求項1〜4のいずれか一項に記載の方法。
- 前記抽出混合物が、アルコール、ケトンおよびエステルからなる群から選択される補助剤を含む、請求項1〜5のいずれか一項に記載の方法。
- 強心配糖体植物種から得られる強心配糖体アロエ抽出物を含む強心配糖体アロエ組成物であって、
該強心配糖体アロエ抽出物が該強心配糖体植物種からアロエによって抽出され、
該強心配糖体植物種が、キョウチクトウ科(Apocynaceae)、アブラナ科(Brassicaceae)、オオバコ科(Plantaginaceae)、ナギイカダ科(Ruscaceae)またはヒアシンス科(Hyacinthaceae)から選択される科に属する、強心配糖体アロエ組成物。 - 前記強心配糖体植物種がネリウム・オレアンデル(Nerium oleander)である、請求項7に記載の強心配糖体アロエ組成物。
- 請求項7または8に記載される強心配糖体アロエ組成物および医薬的に許容されるキャリアを含む医薬組成物。
- ピルまたは舌下用組成物の形態である、請求項9に記載の医薬組成物。
- 前記医薬的に許容されるキャリアが皮膚用作用因を含む、請求項9に記載の医薬組成物。
- 化粧用組成物の形態である、請求項11に記載の医薬組成物。
- 請求項9〜12のいずれか一項に記載される医薬組成物を含有する、皮膚状態を処置するための医薬組成物。
- 前記皮膚状態が、膿瘍、乾燥肌、日光損傷皮膚、加齢皮膚、にきび、光線性角化症、老年性色素斑、肝斑、火傷、日焼け、熱傷、放射線熱傷、***ヘルペス、鶏眼、湿疹、乾癬、白癬、疥癬、皮膚ガン、基底皮膚ガン、扁平上皮皮膚ガン、メラノーマ皮膚ガン、懸垂線維腫およびいぼからなる群から選択される、請求項13に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10513308P | 2008-10-14 | 2008-10-14 | |
US61/105,133 | 2008-10-14 | ||
PCT/US2009/060523 WO2010045243A1 (en) | 2008-10-14 | 2009-10-13 | Process for extracting cardiac glycodides and compositions |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012505894A JP2012505894A (ja) | 2012-03-08 |
JP2012505894A5 JP2012505894A5 (ja) | 2012-11-15 |
JP5727934B2 true JP5727934B2 (ja) | 2015-06-03 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011532187A Expired - Fee Related JP5727934B2 (ja) | 2008-10-14 | 2009-10-13 | 強心配糖体抽出プロセスおよび組成物 |
Country Status (11)
Country | Link |
---|---|
US (3) | US8524286B2 (ja) |
EP (1) | EP2346518B1 (ja) |
JP (1) | JP5727934B2 (ja) |
KR (1) | KR101717301B1 (ja) |
CN (1) | CN102186487B (ja) |
AU (1) | AU2009303460B9 (ja) |
CA (1) | CA2739029C (ja) |
MX (1) | MX2011003940A (ja) |
RU (1) | RU2530654C2 (ja) |
WO (1) | WO2010045243A1 (ja) |
ZA (1) | ZA201102765B (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007089688A2 (en) * | 2006-01-31 | 2007-08-09 | The University Of Toledo | Na/k-atpase ligand |
CN101541319B (zh) | 2006-10-31 | 2013-09-18 | 托莱多大学 | Src和Src家族激酶的Na+/K+-ATP酶特异性肽抑制剂/激活剂 |
CA2739029C (en) * | 2008-10-14 | 2018-07-10 | Nerium Biotechnology, Inc. | Process for extracting cardiac glycosides from plants and compositions comprising cardiac glycosides from nerium oleander |
CA2774486C (en) | 2009-09-16 | 2019-06-04 | The University Of Toledo | Hydroxy xanthone-based na/k atpase ligands useful in treating cardiac hypertrophy, and congestive heart failure |
US8691947B2 (en) | 2010-01-13 | 2014-04-08 | The University Of Toledo | Materials related to sodium/potassium adenosine triphosphatase and Src |
US9066974B1 (en) | 2010-11-13 | 2015-06-30 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
US8597695B1 (en) | 2010-11-13 | 2013-12-03 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
US8541382B2 (en) * | 2010-11-13 | 2013-09-24 | Sirbal Ltd. | Cardiac glycoside analogs in combination with emodin for cancer therapy |
US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
US20170049687A1 (en) | 2015-07-29 | 2017-02-23 | Sirbal Ltd. | Herbal Combinations For Treating Scalp Conditions |
EP2768498B1 (en) * | 2011-10-20 | 2020-03-04 | Nerium Biotechnology, Inc. | Therapeutic combination for the treatment of cancer |
US9265716B2 (en) | 2012-12-11 | 2016-02-23 | Avon Products, Inc. | Hoya carnosa extracts and methods of use |
US8865231B2 (en) | 2012-12-11 | 2014-10-21 | Avon Products, Inc. | Hoya carnosa extracts and methods of use |
WO2014163717A1 (en) * | 2013-03-11 | 2014-10-09 | Avon Products, Inc. | Hoya carnosa extracts and methods of use |
EP3498288A1 (en) | 2013-12-02 | 2019-06-19 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
US10307446B2 (en) | 2014-03-21 | 2019-06-04 | St&T International, Inc. | Cannabis extraction method and compositions |
CN109897083A (zh) * | 2017-12-07 | 2019-06-18 | 天津中医药大学 | 强心苷类化合物及其制备方法与应用 |
AU2019249123A1 (en) * | 2018-04-02 | 2020-10-08 | Nerium Biotechnology, Inc. | Plant-based Nerium oleander extracts and methods |
EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
JP7153083B2 (ja) | 2020-03-31 | 2022-10-13 | フェニックス・バイオテクノロジー・インコーポレイテッド | コロナウイルス感染を治療するための方法および組成物 |
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CA2739029C (en) * | 2008-10-14 | 2018-07-10 | Nerium Biotechnology, Inc. | Process for extracting cardiac glycosides from plants and compositions comprising cardiac glycosides from nerium oleander |
EP2768498B1 (en) * | 2011-10-20 | 2020-03-04 | Nerium Biotechnology, Inc. | Therapeutic combination for the treatment of cancer |
-
2009
- 2009-10-13 CA CA2739029A patent/CA2739029C/en not_active Expired - Fee Related
- 2009-10-13 KR KR1020117010865A patent/KR101717301B1/ko active IP Right Grant
- 2009-10-13 CN CN2009801407775A patent/CN102186487B/zh not_active Expired - Fee Related
- 2009-10-13 MX MX2011003940A patent/MX2011003940A/es active IP Right Grant
- 2009-10-13 JP JP2011532187A patent/JP5727934B2/ja not_active Expired - Fee Related
- 2009-10-13 RU RU2011113151/15A patent/RU2530654C2/ru active
- 2009-10-13 US US12/578,436 patent/US8524286B2/en active Active
- 2009-10-13 WO PCT/US2009/060523 patent/WO2010045243A1/en active Application Filing
- 2009-10-13 EP EP09748575.9A patent/EP2346518B1/en active Active
- 2009-10-13 AU AU2009303460A patent/AU2009303460B9/en not_active Ceased
-
2011
- 2011-04-13 ZA ZA2011/02765A patent/ZA201102765B/en unknown
-
2013
- 2013-07-17 US US13/944,720 patent/US10323055B2/en active Active
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2019
- 2019-03-22 US US16/362,319 patent/US20190233457A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2346518A1 (en) | 2011-07-27 |
RU2530654C2 (ru) | 2014-10-10 |
EP2346518B1 (en) | 2020-09-02 |
MX2011003940A (es) | 2011-06-21 |
CA2739029A1 (en) | 2010-04-22 |
KR20110073570A (ko) | 2011-06-29 |
AU2009303460B2 (en) | 2014-09-25 |
WO2010045243A1 (en) | 2010-04-22 |
CA2739029C (en) | 2018-07-10 |
KR101717301B1 (ko) | 2017-03-16 |
RU2011113151A (ru) | 2012-11-27 |
CN102186487A (zh) | 2011-09-14 |
US20100092585A1 (en) | 2010-04-15 |
JP2012505894A (ja) | 2012-03-08 |
CN102186487B (zh) | 2013-05-15 |
AU2009303460B9 (en) | 2014-12-18 |
US8524286B2 (en) | 2013-09-03 |
US10323055B2 (en) | 2019-06-18 |
US20130303470A1 (en) | 2013-11-14 |
AU2009303460A1 (en) | 2010-04-22 |
ZA201102765B (en) | 2018-11-28 |
US20190233457A1 (en) | 2019-08-01 |
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