JP5696479B2 - 化学品製造用中空糸膜モジュールおよび化学品の製造方法 - Google Patents
化学品製造用中空糸膜モジュールおよび化学品の製造方法 Download PDFInfo
- Publication number
- JP5696479B2 JP5696479B2 JP2010550381A JP2010550381A JP5696479B2 JP 5696479 B2 JP5696479 B2 JP 5696479B2 JP 2010550381 A JP2010550381 A JP 2010550381A JP 2010550381 A JP2010550381 A JP 2010550381A JP 5696479 B2 JP5696479 B2 JP 5696479B2
- Authority
- JP
- Japan
- Prior art keywords
- hollow fiber
- fiber membrane
- fermentation
- chemical
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012528 membrane Substances 0.000 title claims description 368
- 239000012510 hollow fiber Substances 0.000 title claims description 258
- 238000012824 chemical production Methods 0.000 title claims description 12
- 238000000034 method Methods 0.000 title description 42
- 238000000855 fermentation Methods 0.000 claims description 167
- 230000004151 fermentation Effects 0.000 claims description 167
- 239000000126 substance Substances 0.000 claims description 87
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical class O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 68
- 229920000642 polymer Polymers 0.000 claims description 62
- 238000004519 manufacturing process Methods 0.000 claims description 54
- 244000005700 microbiome Species 0.000 claims description 47
- 239000000047 product Substances 0.000 claims description 45
- 229920005989 resin Polymers 0.000 claims description 37
- 239000011347 resin Substances 0.000 claims description 37
- 210000004748 cultured cell Anatomy 0.000 claims description 33
- 229920006395 saturated elastomer Polymers 0.000 claims description 33
- 239000007788 liquid Substances 0.000 claims description 26
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 24
- 229930195729 fatty acid Natural products 0.000 claims description 24
- 239000000194 fatty acid Substances 0.000 claims description 24
- 229920001567 vinyl ester resin Polymers 0.000 claims description 24
- 150000004665 fatty acids Chemical class 0.000 claims description 20
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 20
- 229920002678 cellulose Polymers 0.000 claims description 19
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 13
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 13
- 230000014759 maintenance of location Effects 0.000 claims description 10
- 239000002033 PVDF binder Substances 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims description 9
- -1 propion oxide Polymers 0.000 claims description 9
- 230000000717 retained effect Effects 0.000 claims description 5
- 229920005749 polyurethane resin Polymers 0.000 claims description 3
- 238000000926 separation method Methods 0.000 description 83
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 48
- 239000000243 solution Substances 0.000 description 46
- 239000011148 porous material Substances 0.000 description 34
- 229930182843 D-Lactic acid Natural products 0.000 description 26
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 26
- 229940022769 d- lactic acid Drugs 0.000 description 26
- 238000001914 filtration Methods 0.000 description 25
- 239000004310 lactic acid Substances 0.000 description 24
- 235000014655 lactic acid Nutrition 0.000 description 24
- 230000001954 sterilising effect Effects 0.000 description 24
- 238000004659 sterilization and disinfection Methods 0.000 description 24
- 238000004140 cleaning Methods 0.000 description 21
- 239000002904 solvent Substances 0.000 description 21
- 230000007423 decrease Effects 0.000 description 17
- 230000035699 permeability Effects 0.000 description 17
- 238000005406 washing Methods 0.000 description 15
- 239000002609 medium Substances 0.000 description 14
- 238000011049 filling Methods 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 12
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 11
- 239000000306 component Substances 0.000 description 10
- 241000186660 Lactobacillus Species 0.000 description 9
- 229940039696 lactobacillus Drugs 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 229920001519 homopolymer Polymers 0.000 description 7
- 229920002492 poly(sulfone) Polymers 0.000 description 7
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 5
- 150000007524 organic acids Chemical class 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000002351 wastewater Substances 0.000 description 5
- 241000206594 Carnobacterium Species 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000013365 dairy product Nutrition 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 238000007654 immersion Methods 0.000 description 4
- 238000005374 membrane filtration Methods 0.000 description 4
- 235000005985 organic acids Nutrition 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 241000204117 Sporolactobacillus Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000005273 aeration Methods 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 238000011001 backwashing Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 235000013379 molasses Nutrition 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229920000620 organic polymer Polymers 0.000 description 3
- 239000007800 oxidant agent Substances 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 238000010979 pH adjustment Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000005201 scrubbing Methods 0.000 description 3
- 239000002689 soil Substances 0.000 description 3
- 229920003002 synthetic resin Polymers 0.000 description 3
- 239000000057 synthetic resin Substances 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920008347 Cellulose acetate propionate Polymers 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- 241000194036 Lactococcus Species 0.000 description 2
- 241000192132 Leuconostoc Species 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- 239000004695 Polyether sulfone Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 241001464969 Sporolactobacillus laevolacticus Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 241000500334 Tetragenococcus Species 0.000 description 2
- 241001422033 Thestylus Species 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000012136 culture method Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 229920006015 heat resistant resin Polymers 0.000 description 2
- HCDGVLDPFQMKDK-UHFFFAOYSA-N hexafluoropropylene Chemical group FC(F)=C(F)C(F)(F)F HCDGVLDPFQMKDK-UHFFFAOYSA-N 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 239000012533 medium component Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229920006350 polyacrylonitrile resin Polymers 0.000 description 2
- 229920006393 polyether sulfone Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000001223 reverse osmosis Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000193818 Atopobium Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- YPSIXSGKHOISQD-UHFFFAOYSA-N C=C.F.Cl.Cl.Cl Chemical compound C=C.F.Cl.Cl.Cl YPSIXSGKHOISQD-UHFFFAOYSA-N 0.000 description 1
- CHDVXKLFZBWKEN-UHFFFAOYSA-N C=C.F.F.F.Cl Chemical compound C=C.F.F.F.Cl CHDVXKLFZBWKEN-UHFFFAOYSA-N 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 241000186031 Corynebacteriaceae Species 0.000 description 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- 244000017020 Ipomoea batatas Species 0.000 description 1
- 235000002678 Ipomoea batatas Nutrition 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 241000186716 Lactobacillus agilis Species 0.000 description 1
- 241000186712 Lactobacillus animalis Species 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241000500356 Lactobacillus dextrinicus Species 0.000 description 1
- 241000186605 Lactobacillus paracasei Species 0.000 description 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 description 1
- 241000186870 Lactobacillus ruminis Species 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 241000194041 Lactococcus lactis subsp. lactis Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 241000202223 Oenococcus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000192001 Pediococcus Species 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004734 Polyphenylene sulfide Substances 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 241000204115 Sporolactobacillus inulinus Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 235000014969 Streptococcus diacetilactis Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- 241000207194 Vagococcus Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001345 alkine derivatives Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229920006231 aramid fiber Polymers 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 239000012461 cellulose resin Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000010840 domestic wastewater Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical compound FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000004388 gamma ray sterilization Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010559 graft polymerization reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 235000020121 low-fat milk Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002905 metal composite material Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 125000001477 organic nitrogen group Chemical group 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920013716 polyethylene resin Polymers 0.000 description 1
- 229920000069 polyphenylene sulfide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 235000020083 shōchū Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
- B01D63/022—Encapsulating hollow fibres
- B01D63/0221—Encapsulating hollow fibres using a mould
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/021—Manufacturing thereof
- B01D63/022—Encapsulating hollow fibres
- B01D63/023—Encapsulating materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/30—Polyalkenyl halides
- B01D71/32—Polyalkenyl halides containing fluorine atoms
- B01D71/34—Polyvinylidene fluoride
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/56—Lactic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Manufacturing & Machinery (AREA)
- Sustainable Development (AREA)
- General Chemical & Material Sciences (AREA)
- Water Supply & Treatment (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Description
Tetragenococcus)、カルノバクテリウム属(Genus Carnobacterium)、カルノバクテリウム属(Genus Carnobacterium)、カルノバクテリウム属(Genus
Carnobacterium)、カルノバクテリウム属(Genus Carnobacterium)、バゴコッカス属(Genus Vagococcus)、ロイコノストック属(Genus
Leuconostoc)、オエノコッカス属(Genus Oenococcus)、アトポビウム属(Genus Atopobium)、ストレプトコッカス属(Genus
Streptococcus)、エンテロコッカス属(Genus Enterococcus)、ラクトコッカス属(Genus Lactococcus)およびスポロラクトバチルス属(Genus
Sporolactobacillus)に属する細菌が挙げられる。
laevolacticus)またはスポロラクトバチルス・イヌリナス(Sporolactobacillus inulinus)が使用できる。さらに好ましくは、スポロラクトバチルス・ラエボラクティカス
ATCC 23492、ATCC 23493、ATCC 23494、ATCC 23495、ATCC 23496、ATCC 223549、IAM12326、IAM
12327、IAM 12328、IAM 12329、IAM 12330、IAM 12331、IAM 12379、DSM 2315、DSM 6477、DSM 6510、DSM
6511、DSM 6763、DSM 6764、DSM 6771などとスポロラクトバチルス・イヌリナスJCM 6014などが挙げられる。
animalis)、ラクトバシラス・アジリス(Lactobacillus agilis)、ラクトバシラス・アビアリエス(Lactobacillus aviaries)、ラクトバシラス・カゼイ(Lactobacillus
casei)、ラクトバシラス・デルブレッキ(Lactobacillus delbruekii)、ラクトバシラス・パラカゼイ(Lactobacillus paracasei)、ラクトバシラス・ラムノサス(Lactobacillus
rhamnosus)、ラクトバシラス・ルミニス(Lactobacillus ruminis)、ラクトバシラス・サリバリス(Lactobacillus salivarius)、ラクトバシラス・シャーピイ(Lactobacillus
sharpeae)、ラクトバシラス・デクストリニクス(Pediococcus dextrinicus)、およびラクトコッカス・ラクティス(Lactococcus
lactis)などが挙げられ、これらを選択して、L−乳酸の生産に用いることが可能である。
重量平均分子量41.7万のフッ化ビニリデンホモポリマーとγ−ブチロラクトンとを、それぞれ38重量%と62重量%の割合で170℃の温度で溶解した。この高分子溶液をγ−ブチロラクトンを中空部形成液体として随伴させながら口金から吐出し、温度20℃のγ−ブチロラクトン80重量%水溶液からなる冷却浴中で固化して球状構造からなる中空糸膜を作製した。次いで、重量平均分子量28.4万のフッ化ビニリデンホモポリマーを14重量%、セルロースアセテートプロピオネート(イーストマンケミカル社製、CAP482−0.5)を1重量%、N−メチル−2−ピロリドンを77重量%、T−20Cを5重量%、水を3重量%の割合で95℃の温度で混合溶解して高分子溶液を調製した。この製膜原液を、球状構造からなる中空糸膜の表面に均一に塗布し、すぐに水浴中で凝固させて球状構造層の上に三次元編目構造を形成させた中空糸膜を作製した。得られた中空糸膜の被処理水側表面の平均細孔径は、0.04μmであった。次に、上記の分離膜である中空糸多孔性膜について純水透水量を評価したところ、5.5×10-9m3/m2/s/Paであった。透水量の測定は、逆浸透膜による25℃の温度の精製水を用い、ヘッド高さ1mで行った。
分離膜モジュールケースにはポリスルホン樹脂製筒状容器である成型品を用いて中空糸膜モジュールを作製した。形状は図1のように、モジュールケース横下部にも発酵培養液が導入できるノズルを有するものを使用した。分離膜として参考例1で作製した中空糸膜を用い、121℃の飽和水蒸気と1時間接触させた。飽和水蒸気との接触には、TOMY社製のオートクレーブ「LSX−700」を使用した。中空糸膜を前記モジュールケース内に挿入し、ウレタン樹脂(サンユレック社製、SA−7068A/SA−7068B、2剤を重量比が64:100となるように混合)を用いてモジュールケースと中空糸膜の両端を接着した。モジュール上端は中空糸膜を開口させるために、余分な接着部は切り落として用いた。
発酵槽容量:2(L)
発酵槽有効容積:1.5(L)
使用分離膜:ポリフッ化ビニリデン中空糸膜60本(有効長8cm、総有効膜面積 0.020(m2))
温度調整:37(℃)
発酵槽通気量:窒素ガス0.2(L/min)
発酵槽攪拌速度:600(rpm)
pH調整:3N Ca(OH)2によりpH6に調整
乳酸発酵培地供給:発酵槽液量が約1.5Lで一定になる様に制御して添加
発酵液循環装置による循環液量:2(L/min)
膜濾過流量制御:吸引ポンプによる流量制御
間欠的な濾過処理:濾過処理(9分間)〜濾過停止処理(1分間)の周期運転
膜濾過流束:0.01(m/day)以上0.3(m/day)以下の範囲で膜間差圧が20kPa以下となる様に可変。膜間差圧が範囲を超えて上昇し続けた場合は、連続発酵を終了した。
移動相:5 mM p-トルエンスルホン酸(0.8 mL/min)
反応相:5 mM p-トルエンスルホン酸、20 mM ビストリス、0.1 mM EDTA・2Na(0.8 mL/min)
検出方法:電気伝導度
カラム温度:45℃
なお、乳酸の光学純度の分析は、以下の条件下で行った。
カラム:TSK-gel Enantio L1(東ソー社製)
移動相 :1 mM 硫酸銅水溶液
流速:1.0 mL/分
検出方法 :UV 254 nm
温度 :30℃
L-乳酸の光学純度は、次式(i)で計算される。
光学純度(%)=100×(L-D)/(D+L) ・・・(i)
また、D-乳酸の光学純度は、次式(ii)で計算される。
光学純度(%)=100×(D-L)/(D+L) ・・・(ii)
ここで、LはL-乳酸の濃度を表し、DはD-乳酸の濃度を表す。
分離膜モジュールケースには図2のような形状のポリスルホン樹脂製筒状容器である成型品を用いて中空糸膜モジュールを作製した。分離膜として参考例1で作製した中空糸膜を用い、モジュールケースの全長の2倍の長さに切り出した後、121℃の飽和水蒸気と1時間接触させた。滅菌した中空糸膜を半分の長さに折り曲げ、ウレタン樹脂(サンユレック社製、SA−7068A/SA−7068B、2剤を重量比が64:100となるように混合)を注入したポリスルホン樹脂製のキャップ内に中空糸の折り曲げ部を挿入し、小束を7つ作成した。この際、小束1つあたりの中空糸膜本数は750本とし、中空糸膜のモジュール充填率は45%であった。24時間、乾燥させた小束を前記モジュールケース内に小束を挿入し、ウレタン樹脂(サンユレック社製、SA−7068A/SA−7068B、2剤を重量比が64:100となるように混合)を用いてモジュールケースと各小束を接着した。モジュール上部は中空糸膜を開口させるために、余分な接着部は切り落として用いた。
分離膜として参考例1で作製した中空糸膜を用い、105℃の飽和水蒸気と1時間接触させた。実施例2と同様に中空糸膜モジュールを製作し、連続培養を行った。
分離膜として参考例1で作製した中空糸膜を用い、110℃の飽和水蒸気と1時間接触させた。実施例2と同様に中空糸膜モジュールを製作し、連続培養を行った。
分離膜として参考例1で作製した中空糸膜を用い、130℃の飽和水蒸気と1時間接触させた。実施例2と同様に中空糸膜モジュールを製作し、連続培養を行った。
分離膜として参考例1で作製した中空糸膜を用い、140℃の飽和水蒸気と1時間接触させた。実施例2と同様に中空糸膜モジュールを製作し、連続培養を行った。
分離膜として参考例1で作製した中空糸膜を用い、150℃の飽和水蒸気と1時間接触させた。実施例2と同様に中空糸膜モジュールを製作し、連続培養を行った。
分離膜モジュールとして、中空糸膜閉塞部材4および小束閉塞部材5をウレタン樹脂(サンユレック社製、SA−7238A/SA−7238B、2剤を重量比が45:100となるように混合)を用いる他は、実施例1と同様にしてモジュールを製作した。中空糸膜集束部材4および小束閉塞部材5に使用したウレタン樹脂の硬度は57、121℃の飽和水蒸気と24時間接触させた後の、硬度の保持率は56%であった。この分離膜モジュールを用いて、実施例1と同じ条件でD−乳酸の製造を行った。
2 中空糸膜
2a 小束
3 筒状ケース
4 中空糸膜集束部材
5 小束閉塞部材
6 上キャップ
7 下キャップ
8 発酵培養液流入口
9 濾過液出口
10 発酵培養液出口
11 小束容器
12 発酵槽
13 濾過ポンプ
14 発酵培養液循環ポンプ
15 気体供給装置
16 撹拌機
17 培地供給ポンプ
18 pH調整溶液供給ポンプ
19 pHセンサ・制御装置
20 温度調節器
Claims (6)
- 微生物もしくは培養細胞の発酵培養液を中空糸膜で濾過し、濾液から化学品を回収し、さらに濃縮液を該発酵培養液に保持または還流し、かつ、発酵原料を該発酵培養液に追加する連続発酵において使用される化学品製造用中空糸膜モジュールであって、
ポリフッ化ビニリデン径系樹脂を含有する多数本の中空糸膜束が筒状ケースに収納され、
該中空糸膜束の少なくとも一方の端部は、中空糸膜集束部材によって中空糸膜の端面が開口された状態で該筒状ケースに固定されており、
該中空糸膜集束部材が、タイプDデュロメータ硬度が50以上80以下程度のポリウレタン樹脂であり、121℃の飽和水蒸気と24時間接触させた後の硬度の保持率が95%以上である合成樹脂からなることを特徴とする
化学品製造用中空糸膜モジュール。 - 該中空糸膜束の一方の端部が、中空糸膜集束部材によって中空糸膜の端面が開口された状態で該筒状ケースに固定され、
該中空糸膜束の他方の端部が、複数の小束に分割され、該小束単位で小束閉塞部材によって中空糸膜の端面が閉塞されていることを特徴とする、
請求項1に記載の化学品製造用中空糸膜モジュール。 - 中空糸膜が、フッ素樹脂系高分子を含む中空糸膜を、110℃以上135℃以下の飽和水蒸気と接触させて得られたものであることを特徴とする、
請求項1または2に記載の化学品製造用中空糸膜モジュール。 - 中空糸膜が、フッ素樹脂系高分子を含む中空糸膜を、120℃以上130℃以下の飽和水蒸気と接触させて得られたものであることを特徴とする、
請求項1または2に記載の化学品製造用中空糸膜モジュール。 - 中空糸膜が、脂肪酸ビニルエステル、ビニルピロリドン、エチレンオキサイド、プロピオンオキサイドから選ばれる少なくとも1種を有する親水性高分子、またはセルロースエステルを含有する、
請求項1〜4のいずれかに記載の化学品製造用中空糸膜モジュール。 - 請求項1〜5のいずれかに記載の化学品製造用中空糸膜モジュールを使用する化学品の製造方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010550381A JP5696479B2 (ja) | 2009-11-10 | 2010-11-10 | 化学品製造用中空糸膜モジュールおよび化学品の製造方法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009256778 | 2009-11-10 | ||
JP2009256778 | 2009-11-10 | ||
PCT/JP2010/069969 WO2011058983A1 (ja) | 2009-11-10 | 2010-11-10 | 化学品製造用中空糸膜モジュールおよび化学品の製造方法 |
JP2010550381A JP5696479B2 (ja) | 2009-11-10 | 2010-11-10 | 化学品製造用中空糸膜モジュールおよび化学品の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2011058983A1 JPWO2011058983A1 (ja) | 2013-04-04 |
JP5696479B2 true JP5696479B2 (ja) | 2015-04-08 |
Family
ID=43991641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010550381A Expired - Fee Related JP5696479B2 (ja) | 2009-11-10 | 2010-11-10 | 化学品製造用中空糸膜モジュールおよび化学品の製造方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20120270286A1 (ja) |
EP (1) | EP2500083A4 (ja) |
JP (1) | JP5696479B2 (ja) |
KR (1) | KR20120095959A (ja) |
CN (1) | CN102596375A (ja) |
AU (1) | AU2010319104B2 (ja) |
BR (1) | BR112012010949A2 (ja) |
CA (1) | CA2778765A1 (ja) |
MY (1) | MY162764A (ja) |
RU (1) | RU2012124107A (ja) |
TW (1) | TW201125973A (ja) |
WO (1) | WO2011058983A1 (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103282109A (zh) * | 2010-12-27 | 2013-09-04 | 东丽株式会社 | 中空丝膜组件和化学品的制造方法 |
ES2807501T3 (es) * | 2010-12-28 | 2021-02-23 | Toray Industries | Módulo de membranas de fibra hueca |
US20150050694A1 (en) * | 2012-03-16 | 2015-02-19 | Toray Industries, Inc. | Method of sterilizing separation membrane module, method of producing chemical by continuous fermentation, and membrane separation-type continuous fermentation apparatus |
PL2836289T3 (pl) * | 2012-04-09 | 2022-03-21 | Lifesaver Ip Limited | Zbiornik na wodę i moduł filtracyjny z włókien kanalikowych do niego |
CN104321419B (zh) * | 2012-04-27 | 2016-11-23 | 旭化成株式会社 | 细胞培养***和细胞培养方法 |
CN110172405A (zh) * | 2012-08-20 | 2019-08-27 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
JP5873033B2 (ja) * | 2013-01-31 | 2016-03-01 | 旭化成ケミカルズ株式会社 | 中空糸膜モジュールの接着固定部における接着剤の選定方法、中空糸膜モジュールの製造方法 |
KR102261438B1 (ko) * | 2013-12-27 | 2021-06-07 | 도레이 카부시키가이샤 | 중공사막 모듈 |
KR102414290B1 (ko) * | 2016-04-15 | 2022-06-29 | 베링거 인겔하임 인터내셔날 게엠베하 | 세포 보유 장치 및 방법 |
DE102016224627A1 (de) * | 2016-12-09 | 2018-06-14 | Fresenius Medical Care Deutschland Gmbh | Hohlfasermembran mit verbesserter Trennleistung und Herstellung einer Hohlfasermembran mit verbesserter Trennleistung |
CN110832081B (zh) * | 2017-06-30 | 2023-06-27 | 东丽株式会社 | 基于连续发酵的化学品的制造方法及制造装置 |
GB201718917D0 (en) | 2017-11-16 | 2018-01-03 | Ge Healthcare Bioprocess R&D Ab | Method and system for manufacturing of biopharmaceutical products |
JP7432511B2 (ja) * | 2018-03-08 | 2024-02-16 | レプリゲン・コーポレイション | 接線流深層濾過システムおよびそれを使用する濾過方法 |
EP3801844A4 (en) | 2018-05-25 | 2022-07-13 | Repligen Corporation | TANGENTIAL FLOW FILTRATION SYSTEMS AND PROCESSES |
US11617991B2 (en) * | 2019-07-31 | 2023-04-04 | Toray Industries, Inc. | Separation film |
WO2021230112A1 (ja) * | 2020-05-15 | 2021-11-18 | 東レ株式会社 | カートリッジ式中空糸膜モジュールの製造方法 |
CN113481100A (zh) * | 2021-07-14 | 2021-10-08 | 天津工业大学 | 一种透气型生物培养瓶盖及其制备方法、使用方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008099667A (ja) * | 2006-09-21 | 2008-05-01 | Toray Ind Inc | アルコール製造方法及び製造装置 |
JP2008237101A (ja) * | 2007-03-27 | 2008-10-09 | Toray Ind Inc | 連続発酵による化学品の製造法 |
JP2010029108A (ja) * | 2008-07-29 | 2010-02-12 | Toray Ind Inc | 連続発酵による化学品の製造方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4840769A (en) * | 1985-04-18 | 1989-06-20 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for sterilizing a filtration device |
JPH0557154A (ja) * | 1991-09-02 | 1993-03-09 | Toray Ind Inc | 中空糸膜モジユール |
US5593406A (en) * | 1992-05-01 | 1997-01-14 | Hemostatic Surgery Corporation | Endoscopic instrument with auto-regulating heater and method of using same |
JPH06296834A (ja) * | 1993-04-20 | 1994-10-25 | Kanegafuchi Chem Ind Co Ltd | 中空糸型フィルター |
JPH0760074A (ja) | 1993-08-27 | 1995-03-07 | Kuraray Co Ltd | 中空糸膜モジュール |
JPH0871378A (ja) * | 1994-09-09 | 1996-03-19 | Kanegafuchi Chem Ind Co Ltd | 中空糸膜ポッティング用ウレタン樹脂 |
ES2237760T3 (es) * | 1995-06-30 | 2005-08-01 | Toray Industries, Inc. | Procedimiento de fabricacion de una membrana semipermeable de fibras huecas de polisulfona. |
WO1999016808A1 (en) * | 1997-09-26 | 1999-04-08 | The Dow Chemical Company | High service temperature polyurethane elastomers |
JP2005230813A (ja) * | 2004-01-20 | 2005-09-02 | Toray Ind Inc | 中空糸膜モジュール |
EP1803756A4 (en) * | 2004-10-19 | 2012-06-20 | Nippon Polyurethane Kogyo Kk | POLYURETHANE RESIN COMPOSITION, PROCESS FOR PRODUCING SEALING MATERIALS, AND PROCESS FOR PRODUCING HOLLOW FIBER MEMBRANE MODULES |
JP5055767B2 (ja) * | 2005-12-27 | 2012-10-24 | 日本ポリウレタン工業株式会社 | ポリウレタン樹脂形成性組成物、シール材及び中空糸膜モジュール |
JP5082496B2 (ja) | 2006-02-24 | 2012-11-28 | 東レ株式会社 | 連続発酵による化学品の製造方法および連続発酵装置 |
JP5624318B2 (ja) * | 2006-10-04 | 2014-11-12 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | ポリウレタンベースの包埋用組成物 |
-
2010
- 2010-11-10 CN CN2010800509609A patent/CN102596375A/zh active Pending
- 2010-11-10 WO PCT/JP2010/069969 patent/WO2011058983A1/ja active Application Filing
- 2010-11-10 RU RU2012124107/05A patent/RU2012124107A/ru not_active Application Discontinuation
- 2010-11-10 MY MYPI2012002005A patent/MY162764A/en unknown
- 2010-11-10 US US13/508,918 patent/US20120270286A1/en not_active Abandoned
- 2010-11-10 EP EP10829942.1A patent/EP2500083A4/en not_active Withdrawn
- 2010-11-10 AU AU2010319104A patent/AU2010319104B2/en not_active Ceased
- 2010-11-10 KR KR1020127014865A patent/KR20120095959A/ko not_active Application Discontinuation
- 2010-11-10 JP JP2010550381A patent/JP5696479B2/ja not_active Expired - Fee Related
- 2010-11-10 TW TW099138595A patent/TW201125973A/zh unknown
- 2010-11-10 BR BR112012010949A patent/BR112012010949A2/pt not_active IP Right Cessation
- 2010-11-10 CA CA2778765A patent/CA2778765A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008099667A (ja) * | 2006-09-21 | 2008-05-01 | Toray Ind Inc | アルコール製造方法及び製造装置 |
JP2008237101A (ja) * | 2007-03-27 | 2008-10-09 | Toray Ind Inc | 連続発酵による化学品の製造法 |
JP2010029108A (ja) * | 2008-07-29 | 2010-02-12 | Toray Ind Inc | 連続発酵による化学品の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2011058983A1 (ja) | 2013-04-04 |
TW201125973A (en) | 2011-08-01 |
AU2010319104A1 (en) | 2012-05-17 |
US20120270286A1 (en) | 2012-10-25 |
MY162764A (en) | 2017-07-14 |
EP2500083A4 (en) | 2014-08-13 |
BR112012010949A2 (pt) | 2017-11-07 |
WO2011058983A1 (ja) | 2011-05-19 |
AU2010319104B2 (en) | 2015-05-07 |
KR20120095959A (ko) | 2012-08-29 |
CN102596375A (zh) | 2012-07-18 |
EP2500083A1 (en) | 2012-09-19 |
CA2778765A1 (en) | 2011-05-19 |
RU2012124107A (ru) | 2013-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5696479B2 (ja) | 化学品製造用中空糸膜モジュールおよび化学品の製造方法 | |
JP6287860B2 (ja) | ろ過装置、化学品の製造装置およびろ過装置の運転方法 | |
JP5862561B2 (ja) | 連続発酵による化学品の製造方法 | |
WO2012090556A1 (ja) | 連続発酵による化学品の製造方法 | |
JP2010029108A (ja) | 連続発酵による化学品の製造方法 | |
WO2011093241A1 (ja) | 連続発酵による化学品の製造方法 | |
JP5287029B2 (ja) | 連続発酵による化学品の製造方法 | |
JP2008104453A (ja) | 連続発酵によるカダベリンの製造方法 | |
JP2012161288A (ja) | 化学品の製造装置および化学品の製造方法 | |
JP5223520B2 (ja) | 連続発酵による化学品の製造方法 | |
JP2013226486A (ja) | 分離膜モジュールの滅菌方法、化学品の製造方法および膜分離型連続発酵装置 | |
JP2008048721A (ja) | 連続発酵装置 | |
JP2012179019A (ja) | 連続発酵による化学品の製造方法 | |
JP2013128470A (ja) | 分離膜モジュールの滅菌方法、化学品の製造方法、分離膜モジュールの滅菌用装置および膜分離型連続発酵装置 | |
JP2013188149A (ja) | 分離膜モジュールの蒸気滅菌方法、連続発酵による化学品の製造方法および膜分離型連続発酵装置 | |
JP2008131931A (ja) | 連続発酵による乳酸の製造方法 | |
JP2012135249A (ja) | 連続発酵による化学品の製造方法 | |
JP2012016290A (ja) | 連続発酵によるl−乳酸の製造方法 | |
JP2008199948A (ja) | 連続発酵生産物の製造方法 | |
JP2013188150A (ja) | 分離膜モジュールの蒸気滅菌方法、連続発酵による化学品の製造方法、分離膜モジュールの滅菌用装置および膜分離型連続発酵装置 | |
JP2008017837A (ja) | ピルビン酸の製造方法 | |
JP2012210184A (ja) | 連続発酵による化学品の製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131029 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141007 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141208 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150113 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150126 |
|
LAPS | Cancellation because of no payment of annual fees |