JP5685539B2 - 制御放出可能な抗菌剤を備えた医療デバイス - Google Patents
制御放出可能な抗菌剤を備えた医療デバイス Download PDFInfo
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- JP5685539B2 JP5685539B2 JP2011530496A JP2011530496A JP5685539B2 JP 5685539 B2 JP5685539 B2 JP 5685539B2 JP 2011530496 A JP2011530496 A JP 2011530496A JP 2011530496 A JP2011530496 A JP 2011530496A JP 5685539 B2 JP5685539 B2 JP 5685539B2
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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Description
以下の詳細な説明において、本発明の好ましい実施態様を記載する。しかし、異なる実施態様の特徴は、実施態様間で交換可能であり、そして特に具体的な記載がなければ異なるやり方を組み合わせてもよいことは理解すべきである。親水性医療デバイスは、多くの異なる目的に、そして種々のタイプの体腔への挿入に使用することができる。しかし、以下の議論は、特に、好ましい使用領域、尿道カテーテルに関するが、本発明は、この特定のタイプのカテーテル又はこの特定のタイプの医療デバイスにさえ制限されることはない。本発明の概念は、いずれか特定のタイプの機器に制限されることなく、さまざまなタイプの医療デバイスを使用することができることは、当業者にとって明白である。
実験のため、一般に商品名メリフレックス(Meliflex)の下で販売されている、材料ポリプロペン(Polypropene)、ポリエテンポリアミド及びスチレン−エタン/ブテン−スチレンコポリマーの組み合わせの基体材料を用いてカテーテルを調製した。
A)抗菌銀コーティングを有するが、親水性コーティングのないカテーテル。
B)A)よりも高い銀濃度の抗菌銀コーティングを有し、かつ親水性コーティングを有するカテーテル。
C)A)とほぼ同じ濃度の抗菌銀コーティングを有し、かつ親水性コーティングを有するカテーテル。特に、A)及びC)によるカテーテルは、カテーテルA)が親水性コーティングを有してない他は、本質的に同一であった。
・銀の浸出量は、群B及びCよりも、親水性コーティングを有しない群Aでより有意に変化している。この効果は、より長い浸出時間についてさらにより顕著である。
・結果的に、親水性コーティングは、抗菌コーティングからの銀イオンの放出をより予測可能及び制御可能にする安定化効果を有すると結論付けることができる。
・浸出した銀の平均量は、コーティング中にほぼ同じ総量の銀を有する群A及びCについてはほぼ同じであった。
・従って、親水性コーティングは、抗菌コーティングからの全体レベルの銀イオンの放出に対して明確な作用を示さないと結論付けることができる。
・銀イオンの放出レベルで見られた変動の低下における大きな改善は、群B及びCについてはほぼ同じであった。同時に、群Bの銀の総量は、群Cと比較して約2倍であった。従って、このポジティブな効果は、抗菌コーティング中の銀イオンの総量に依存しないことは明らかである。
さて、本発明を、種々の実施態様に関連して議論してきた。しかしながら、当業者には当然のことながら、いくつかのさらなる別法が可能である。例えば、微量作用金属を含む多くの他のタイプの抗菌コーティングも、他のタイプの親水性コーティングも、使用することができる。さらに、血管カテーテルなどのような尿道カテーテルとは別のタイプのカテーテルに、又は親水性コーティングを有する別のタイプの医療デバイスに本発明を使用することは可能である。
Claims (19)
- 基体材料、該基体材料の表面の少なくとも一部の上に配置された親水性表面コーティング、及び該基体材料と該親水性表面コーティングとの間に配置された微量作用金属を含む抗菌層を含み、ここで、該親水性表面コーティングは、5〜30μmの範囲の乾燥時の厚さを有し、それによって、前記厚さが、親水性表面コーティングを通して微量作用金属イオンの制御放出を与えるのに十分大きい医療デバイス。
- 親水性表面コーティングは、10μmを超える乾燥時の厚さを有する、請求項1に記載の医療デバイス。
- 親水性表面コーティングは、10〜20μmの範囲の乾燥時の厚さを有する、請求項1又は2に記載の医療デバイス。
- 抗菌層の微量作用金属は、銀を含む、請求項1〜3のいずれか1項に記載の医療デバイス。
- 抗菌層の微量作用金属は、さらに金及び/又は白金金属から選ばれる安定剤を含む、請求項1〜4のいずれか1項に記載の医療デバイス。
- 親水性表面コーティング及び抗菌層は、0.01〜1.0マイクログラム/cm2の範囲で微量作用金属の遊離イオンの制御放出を与えるように適合される、請求項1〜5のいずれか1項に記載の医療デバイス。
- 親水性表面コーティング及び抗菌層は、0.05〜0.5マイクログラム/cm 2 の範囲で微量作用金属の遊離イオンの制御放出を与えるように適合される、請求項1〜6のいずれか1項に記載の医療デバイス。
- 親水性表面コーティング及び抗菌層は0.10〜0.30マイクログラム/cm 2 の範囲で微量作用金属の遊離イオンの制御放出を与えるように適合される、請求項1〜7のいずれか1項に記載の医療デバイス。
- 親水性表面コーティングは、湿潤液体で濡らしたときに表面摩擦が有意に低下する親水性ポリマーを含む、請求項1〜8のいずれか1項に記載の医療デバイス。
- 親水性表面コーティングは、湿潤液体で濡らしたときに表面摩擦が有意に低下するポリビニルピロリドン(PVP)を含む、請求項1〜9のいずれか1項に記載の医療デバイス。
- 親水性ポリマーは、ポリビニル化合物、ポリラクタム、多糖類、誘導体化多糖類、ヒドロキシプロピルセルロース、メチルセルロース、ポリウレタン、ポリアクリレート、ポリヒドロキシアクリレート、ポリメタクリレート、ポリアクリルアミド、ポリアルキレンオキシド、ポリビニルアルコール、ポリアミド、ポリアクリル酸、上述ポリマーのコポリマー、ビニル化合物とアクリレート又は無水物とのコポリマー、ビニルピロリドンとヒドロキシエチルメチルアクリレートとのコポリマー、ポリビニルピロリドンのカチオン性コポリマー、及びポリメチルビニルエーテルとマレイン酸無水物とのコポリマーの少なくとも1つである、請求項1〜10のいずれか1項に記載の医療デバイス。
- 親水性ポリマーは、ポリビニルピロリドン、ヘパリン、デキストラン、キサンタンガム、ポリエチレンオキシドの少なくとも1つである請求項1〜11のいずれか1項に記載の医療デバイス。
- 医療デバイスは、カテーテルである、請求項1〜12のいずれか1項に記載の医療デバイス。
- 前記カテーテルが尿道カテーテルである、請求項1〜13項のいずれか1項に記載の医療デバイス。
- 親水性表面コーティングは、浸透圧を高める化合物をさらに含む、請求項1〜14のいずれか1項に記載の医療デバイス。
- 基体材料を備え;
該基体材料の表面の少なくとも一部の上に抗菌層を配置し;そして
該抗菌層の上面上に親水性表面コーティングを配置する:工程を含み、
ここで、該親水性表面コーティングは、5〜30μmの範囲の厚さを有し、それによって前記厚さは、親水性表面コーティングを通して微量作用金属イオンの制御放出を与えるのに十分大きい、微量作用金属を含む抗菌層からの微量作用金属イオンの制御可能な放出を備えた医療デバイスの製造方法。 - 親水性コーティングは、ポリ尿素ネットワークを形成し、それによって該ポリ尿素ネットワークは、基体中の活性水素基に共有結合を形成する、請求項16に記載の方法。
- 基体材料をコーティングする工程は、基体の表面に、最初にイソシアネート化合物0.05〜40%(質量/体積)を含む溶液、そしてその後、ポリビニルピロリドン0.5〜50%(質量/体積)を含む溶液を順に塗布し、そして高温で硬化するサブ工程を含む、請求項17に記載の方法。
- 親水性コーティングは、照射によって基体に架橋される、請求項16に記載の方法。
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US10527808P | 2008-10-14 | 2008-10-14 | |
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US61/105,278 | 2008-10-14 | ||
EP08166578.8A EP2177238B1 (en) | 2008-10-14 | 2008-10-14 | Medical device with controllably releasable antibacterial agent |
PCT/EP2009/063188 WO2010043565A1 (en) | 2008-10-14 | 2009-10-09 | Medical device with controllably releasable antibacterial agent |
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Publication Number | Publication Date |
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JP2012504995A JP2012504995A (ja) | 2012-03-01 |
JP5685539B2 true JP5685539B2 (ja) | 2015-03-18 |
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BR (1) | BRPI0920314B1 (ja) |
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Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8025120B2 (en) * | 2009-06-26 | 2011-09-27 | Eddy Patrick E | Stethoscope and antimicrobial cover |
DK2338535T3 (da) * | 2009-12-18 | 2012-09-24 | Dentsply Ih Ab | Medicinsk indretning til anvendelse i kort tid med hurtigt frigivende antibakterielt middel |
JP5607470B2 (ja) * | 2010-09-14 | 2014-10-15 | 公益財団法人かずさDna研究所 | 基材表面親水化処理方法及び被処理物の製造装置 |
WO2014074147A1 (en) | 2012-11-12 | 2014-05-15 | Hollister Incorporated | Intermittent catheter assembly and kit |
AU2013345395B2 (en) | 2012-11-14 | 2017-02-23 | Hollister Incorporated | Disposable catheter with selectively degradable inner core |
LT3065793T (lt) | 2013-11-08 | 2021-05-10 | Hollister Incorporated | Kateteriai su oleofiline danga |
LT3079748T (lt) | 2013-12-12 | 2020-07-27 | Hollister Incorporated | Srove nuplaunamas suyrantis kateteris |
HUE051611T2 (hu) | 2013-12-12 | 2021-03-01 | Hollister Inc | Toalettben lehúzható katéterek |
ES2864540T3 (es) | 2013-12-12 | 2021-10-14 | Hollister Inc | Catéteres desechables por el inodoro |
US10463833B2 (en) | 2013-12-12 | 2019-11-05 | Hollister Incorporated | Flushable catheters |
AU2015306630B2 (en) | 2014-08-26 | 2018-12-13 | C.R. Bard, Inc | Urinary catheter |
DK3283136T3 (da) * | 2015-04-16 | 2021-06-28 | Hollister Inc | Hydrofile belægninger og fremgangsmåder til dannelse heraf |
WO2016205383A1 (en) | 2015-06-17 | 2016-12-22 | Hollister Incorporated | Selectively water disintegrable materials and catheters made of such materials |
US10493232B2 (en) | 2015-07-20 | 2019-12-03 | Strataca Systems Limited | Ureteral catheters, bladder catheters, systems, kits and methods for inducing negative pressure to increase renal function |
PL3325078T3 (pl) | 2015-07-20 | 2020-08-24 | Strataca Systems Limited | Cewnik moczowodowy i cewnik do pęcherza moczowego |
US11541205B2 (en) | 2015-07-20 | 2023-01-03 | Roivios Limited | Coated urinary catheter or ureteral stent and method |
US10512713B2 (en) | 2015-07-20 | 2019-12-24 | Strataca Systems Limited | Method of removing excess fluid from a patient with hemodilution |
US10918827B2 (en) | 2015-07-20 | 2021-02-16 | Strataca Systems Limited | Catheter device and method for inducing negative pressure in a patient's bladder |
US10926062B2 (en) | 2015-07-20 | 2021-02-23 | Strataca Systems Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
US11040172B2 (en) | 2015-07-20 | 2021-06-22 | Strataca Systems Limited | Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion |
DK3484535T3 (da) | 2016-07-14 | 2022-02-28 | Hollister Inc | Hygiejniske medicinske indretninger med hydrofil belægning og fremgangsmåder til dannelse deraf |
US10967082B2 (en) | 2017-11-08 | 2021-04-06 | Parasol Medical, Llc | Method of limiting the spread of norovirus within a cruise ship |
US10864058B2 (en) | 2018-03-28 | 2020-12-15 | Parasol Medical, Llc | Antimicrobial treatment for a surgical headlamp system |
JP2022515321A (ja) * | 2018-11-30 | 2022-02-18 | ロイヴィオス リミテッド | コーティングおよび/または含浸された尿管カテーテルまたはステントならびに方法 |
WO2020255079A1 (en) * | 2019-06-21 | 2020-12-24 | Bar-Ilan University | Improved medical tubing and method for producing said tubing |
EP3760243A1 (en) * | 2019-07-04 | 2021-01-06 | Dentsply IH AB | Antibacterial article comprising a polymer matrix with aligned nanoscale flakes or platelets |
EP4049689A1 (en) | 2021-02-25 | 2022-08-31 | Dentsply IH AB | Medical device with substrate comprising natural fibers |
CN113616859A (zh) * | 2021-07-08 | 2021-11-09 | 深圳先进技术研究院 | 一种抗菌润滑涂层及其制备方法和应用 |
CN114767944B (zh) * | 2022-03-14 | 2023-06-20 | 四川大学华西医院 | 具备超亲水能力的抗菌抗凝涂层材料及其制备方法与应用 |
WO2023215683A1 (en) * | 2022-05-06 | 2023-11-09 | Hollister Incorporated | Hydrophilic urinary catheter products with microcapsules of anti-bacterial agents |
CN116570768B (zh) * | 2023-03-10 | 2024-02-02 | 浙江大学 | 一种多层力学仿生缓释抗菌气管补片及其制备方法 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4054139A (en) * | 1975-11-20 | 1977-10-18 | Crossley Kent B | Oligodynamic catheter |
SE430695B (sv) | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | Forfarande for framstellning av en hydrofil beleggning samt enligt forfarandet framstellda medicinska artiklar |
SE8504501D0 (sv) | 1985-09-30 | 1985-09-30 | Astra Meditec Ab | Method of forming an improved hydrophilic coating on a polymer surface |
US5290548A (en) * | 1987-04-10 | 1994-03-01 | University Of Florida | Surface modified ocular implants, surgical instruments, devices, prostheses, contact lenses and the like |
US5320908A (en) | 1989-05-04 | 1994-06-14 | Ad Tech Holdings Limited | Deposition of an extremely thin silver layer on a nonconducting substrate |
FI95816C (fi) | 1989-05-04 | 1996-03-25 | Ad Tech Holdings Ltd | Antimikrobinen esine ja menetelmä sen valmistamiseksi |
EP0991702B2 (en) | 1997-06-20 | 2017-07-19 | Coloplast A/S | A hydrophilic coating |
US6468521B1 (en) | 1998-08-14 | 2002-10-22 | Coloplast A/S | Stabilized compositions having antibacterial activity |
US6329488B1 (en) * | 1998-11-10 | 2001-12-11 | C. R. Bard, Inc. | Silane copolymer coatings |
MXPA02004673A (es) * | 1999-11-05 | 2004-09-10 | Bard Inc C R | Composiciones polimericas de silano que contienen agentes activos. |
US7179849B2 (en) | 1999-12-15 | 2007-02-20 | C. R. Bard, Inc. | Antimicrobial compositions containing colloids of oligodynamic metals |
US6579539B2 (en) * | 1999-12-22 | 2003-06-17 | C. R. Bard, Inc. | Dual mode antimicrobial compositions |
JP2004517690A (ja) * | 2000-12-18 | 2004-06-17 | シャーウッド サーヴィシス アクチェンゲゼルシャフト | 滑性のあるコーティング |
US7820284B2 (en) * | 2001-12-03 | 2010-10-26 | C.R. Bard Inc. | Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same |
US7060051B2 (en) * | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
SE0303525D0 (sv) * | 2003-12-22 | 2003-12-22 | Astra Tech Ab | Catheter assembly with osmolality-increasing |
US20080125513A1 (en) * | 2004-06-30 | 2008-05-29 | Soeren Kristiansen | Hydrophilic, Water-Swellable, Cross-Linked Matrix Having Incorporated Therein an Anti-Microbial Polymer |
US20060009839A1 (en) * | 2004-07-12 | 2006-01-12 | Scimed Life Systems, Inc. | Composite vascular graft including bioactive agent coating and biodegradable sheath |
EP1688470A1 (en) | 2005-02-04 | 2006-08-09 | Bioservice S.p.A. | Hydrophilic coated products and process for their production |
US8747882B2 (en) | 2005-04-21 | 2014-06-10 | Astra Tech Ab | Catheter assembly with bactericidal effect |
US7691476B2 (en) * | 2005-06-02 | 2010-04-06 | Surmodics, Inc. | Hydrophilic polymeric coatings for medical articles |
DK2279767T3 (da) * | 2005-07-18 | 2012-11-26 | Dentsply Ih Ab | Urinvejskateter |
WO2007050685A2 (en) * | 2005-10-27 | 2007-05-03 | C.R. Bard, Inc. | Enhanced pre-wetted intermittent catheter with lubricious coating |
-
2008
- 2008-10-14 EP EP08166578.8A patent/EP2177238B1/en not_active Not-in-force
-
2009
- 2009-10-09 JP JP2011530496A patent/JP5685539B2/ja not_active Expired - Fee Related
- 2009-10-09 WO PCT/EP2009/063188 patent/WO2010043565A1/en active Application Filing
- 2009-10-09 CA CA2736932A patent/CA2736932C/en not_active Expired - Fee Related
- 2009-10-09 US US12/576,358 patent/US20100086580A1/en not_active Abandoned
- 2009-10-09 CN CN2009801398653A patent/CN102176928A/zh active Pending
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BRPI0920314B1 (pt) | 2018-07-17 |
US20100086580A1 (en) | 2010-04-08 |
AU2009305471A1 (en) | 2010-04-22 |
BRPI0920314A2 (pt) | 2016-02-23 |
CN102176928A (zh) | 2011-09-07 |
CA2736932A1 (en) | 2010-04-22 |
CA2736932C (en) | 2017-03-07 |
EP2177238B1 (en) | 2016-11-09 |
WO2010043565A1 (en) | 2010-04-22 |
EP2177238A1 (en) | 2010-04-21 |
AU2009305471B2 (en) | 2013-11-14 |
JP2012504995A (ja) | 2012-03-01 |
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